Self and the Brain. The Immune Metaphor.

Abstract:

:One of the fundamental questions in neuroscience is how brain activity relates to conscious experience. Even though self-consciousness is considered an emergent property of the brain network, a quantum physics-based theory assigns a momentum of consciousness to the single neuron level. In this work, we present a brain self theory from an evolutionary biological perspective by analogy with the immune self. In this scheme, perinatal reactivity to self inputs would guide the selection of neocortical neurons within the subplate, similarly to T lymphocytes in the thymus. Such self-driven neuronal selection would enable effective discrimination of external inputs and avoid harmful "autoreactive" responses. Multiple experimental and clinical evidences for this model are provided. Based on this self tenet, we outline the postulates of the so-called autophrenic diseases, to then make the case for schizophrenia, an archetypic disease with rupture of the self. Implications of this model are discussed, along with potential experimental verification.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Sánchez-Ramón S,Faure F

doi

10.3389/fpsyt.2020.540676

subject

Has Abstract

pub_date

2020-09-29 00:00:00

pages

540676

issn

1664-0640

journal_volume

11

pub_type

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