A Novel Network Pharmacology Strategy to Decode Metabolic Biomarkers and Targets Interactions for Depression.

abstract：:Background: The clinical and etiological heterogeneity of mood disorders impede identification of effective treatments for the individual patient. This highlights a need for early neuronal and behavioral biomarkers for treatment efficacy, which can provide a basis for more personalized treatments. The present systemat...

journal_title：Frontiers in psychiatry

authors： Seeberg I,Kjaerstad HL,Miskowiak KW

更新日期：2018-07-26 00:00:00

abstract：:Introduction: Recent research in Western countries has indicated that family interventions in schizophrenia and other psychotic disorders can reduce patient relapse and improve medication compliance. Few studies have addressed Chinese and Asian populations. This study tested the long-term effects of a 9-month family-l...

journal_title：Frontiers in psychiatry

authors： Chien WT,Bressington D,Chan SWC

更新日期：2018-12-18 00:00:00

abstract：:As the population ages and the number of people living with dementia or mild cognitive impairment (MCI) continues to increase, it is critical to identify creative and innovative ways to support and improve their quality of life. Motion-based technology has shown significant potential for people living with dementia or...

journal_title：Frontiers in psychiatry

authors： Astell AJ,Czarnuch S,Dove E

更新日期：2018-05-11 00:00:00

abstract：:Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive psychotic symptoms remains undetermined. This network meta-analysis (NMA) investigates the consiste...

journal_title：Frontiers in psychiatry

authors： Davies C,Radua J,Cipriani A,Stahl D,Provenzani U,McGuire P,Fusar-Poli P

更新日期：2018-06-12 00:00:00

abstract：Background:Recent meta-analyses reported placebo response rate in antidepressant trials to be stable since the 1970s. These meta-analyses however were limited in considering only linear time trends, assessed trial-level covariates based on single-model hypothesis testing only, and did not adjust for small-study effects...

journal_title：Frontiers in psychiatry

authors： Holper L

更新日期：2020-07-28 00:00:00

abstract：:Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventi...

journal_title：Frontiers in psychiatry

authors： Lou YT,Li XL,Wang Y,Ji GJ,Zang YF,Wang J,Feng JH

更新日期：2020-12-17 00:00:00

abstract：:Objective: Despite the fact that autism spectrum disorder (ASD) is a common psychiatric diagnosis, knowledge about the special behavioral and neurobiological female phenotype is still scarce. The present study aimed to investigate neural correlates of empathy for physical and social pain and to assess the impact of eg...

journal_title：Frontiers in psychiatry

authors： Stroth S,Paye L,Kamp-Becker I,Wermter AK,Krach S,Paulus FM,Müller-Pinzler L

更新日期：2019-06-18 00:00:00

abstract：:Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, and it refers to both a state symptom in various psychiatric disorders and a personality trait. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Anhedonia...

journal_title：Frontiers in psychiatry

authors： Hatzigiakoumis DS,Martinotti G,Giannantonio MD,Janiri L

更新日期：2011-03-17 00:00:00

abstract：Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

journal_title：Frontiers in psychiatry

authors： Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

更新日期：2020-09-08 00:00:00

abstract：:Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling pathways. Morphine abuse is frequently linked to excessive drinking. Morphine exerts its actions mainly via the seven transmembrane G-protein-coupled mu opioid recept...

journal_title：Frontiers in psychiatry

authors： Chang SL,Huang W,Han H,Sariyer IK

更新日期：2019-01-22 00:00:00

abstract：:Several studies investigated the role of resilience as a mediating factor for psychopathological phenotypes. The aim of the current study is to explore the putative role of resilience as a mediator between different vulnerability factors and depressive symptoms. One hundred and fifty patients with a major depressive d...

journal_title：Frontiers in psychiatry

authors： Collazzoni A,Stratta P,Pacitti F,Rossi A,Santarelli V,Bustini M,Talevi D,Socci V,Rossi R

更新日期：2020-02-28 00:00:00

abstract：:This paper focuses on depression that precedes an onset of manifest bipolar disorder as early stage bipolar disorder. First, we review how to pragmatically identify the clinical characteristics of patients presenting with an episode of depression who subsequently go on to develop episodes of mania or hypomania. The ex...

journal_title：Frontiers in psychiatry

authors： O'Donovan C,Alda M

更新日期：2020-06-11 00:00:00

abstract：:Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We...

journal_title：Frontiers in psychiatry

authors： Térémetz M,Carment L,Brénugat-Herne L,Croca M,Bleton JP,Krebs MO,Maier MA,Amado I,Lindberg PG

更新日期：2017-07-10 00:00:00

abstract：:Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all ...

journal_title：Frontiers in psychiatry

authors： Håkansson A,Karlsson A,Widinghoff C

更新日期：2018-09-07 00:00:00

abstract：:Background: In the past 3 decades, there has been an increase in the number of studies assessing exercise as a form of treatment for substance use disorders (SUDs). While a variety of substance types and outcomes have been assessed, exercise intensities have never been systematically examined. Consequently, it remains...

journal_title：Frontiers in psychiatry

authors： Colledge F,Gerber M,Pühse U,Ludyga S

更新日期：2018-12-04 00:00:00

abstract：:Therapies for Tourette syndrome (TS) are insufficient, and novel therapies are needed. Fecal microbiota transplantation (FMT) has been a potential therapy for several neurological diseases. Here, we report a preliminary study to investigate the effects of FMT on patients with TS. Five patients with TS received a singl...

journal_title：Frontiers in psychiatry

authors： Zhao HJ,Luo X,Shi YC,Li JF,Pan F,Ren RR,Peng LH,Shi XY,Yang G,Wang J,Hu LY,Zou LP,Yang YS

更新日期：2020-12-23 00:00:00

abstract：:Current diagnoses of schizophrenia and related psychiatric disorders are classified by phenomenological principles and clinical descriptions while ruling out other symptoms and conditions. Specific biomarkers are needed to assist the current diagnostic system. However, complicated gene and environment interactions ind...

journal_title：Frontiers in psychiatry

authors： Jiang W,King TZ,Turner JA

更新日期：2019-07-12 00:00:00

abstract：:Background: Patients with schizophrenia show abnormal spontaneous oscillatory activity in scalp-level electroencephalographic (EEG) responses across multiple frequency bands. While oscillations play an essential role in the transmission of information across neural networks, few studies have assessed the frequency-spe...

journal_title：Frontiers in psychiatry

authors： Koshiyama D,Miyakoshi M,Tanaka-Koshiyama K,Joshi YB,Molina JL,Sprock J,Braff DL,Light GA

更新日期：2020-11-27 00:00:00

abstract：:Voxel-based morphometry (VBM) is a commonly used method to study volumetric variations on a whole brain basis. However, it is often criticized for potential confounds, mainly based on imperfect spatial registration. We therefore aimed to evaluate if VBM and "gold standard" manual volumetry are measuring the same effec...

journal_title：Frontiers in psychiatry

authors： Focke NK,Trost S,Paulus W,Falkai P,Gruber O

更新日期：2014-04-08 00:00:00

abstract：:Burnout syndrome is a state of total exhaustion related to work conditions and stress from work. Recent findings suggest that logotherapy and the concepts of existential meaning and life fulfilment could provide a useful framework for explaining and potentially preventing burnout. This review article summarizes and re...

journal_title：Frontiers in psychiatry

authors： Riethof N,Bob P

更新日期：2019-06-14 00:00:00

abstract：:Background: People who receive involuntary treatment are some of the most vulnerable in psychiatric services. They are more likely to have poorer social and clinical outcomes and to be disillusioned with and disengaged from care. Research indicates that patients' experience in the first week of involuntary treatment i...

journal_title：Frontiers in psychiatry

authors： Burn E,Conneely M,Leverton M,Giacco D

更新日期：2019-07-04 00:00:00

abstract：:The impact of COVID-19 on the elderly is devastating, and nursing homes are struggling to provide the best care to the most fragile. The urgency and severity of the pandemic forces the use of segregation in restricted areas and confinement in individual rooms as desperate strategies to avoid the spread of disease and ...

journal_title：Frontiers in psychiatry

authors： Muntsant A,Giménez-Llort L

更新日期：2020-11-24 00:00:00

abstract：:In the brain of female mammals, including humans, a number of physiological and behavioral changes occur as a result of sex hormone exposure. Estradiol and progesterone regulate several brain functions, including learning and memory. Sex hormones contribute to shape the central nervous system by modulating the formati...

journal_title：Frontiers in psychiatry

authors： Hansberg-Pastor V,González-Arenas A,Piña-Medina AG,Camacho-Arroyo I

更新日期：2015-11-20 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fpsyt.2019.00931.]. ...

journal_title：Frontiers in psychiatry

authors： Pompili M

更新日期：2020-02-27 00:00:00

abstract：:Suicide is the most severe consequence of depression which has become a leading cause of disability and a global disease burden. Recent evidence indicates a central role of small molecules in the pathogenesis of depression and associated suicidal behaviors. However, there lacks a systemic exploration of small molecule...

journal_title：Frontiers in psychiatry

authors： Liu S

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its var...

journal_title：Frontiers in psychiatry

authors： Ahn WY,Ramesh D,Moeller FG,Vassileva J

更新日期：2016-03-10 00:00:00

abstract：:Background: When persons with a mental illness present a danger to themselves or others, involuntary hospital admission can be used to initiate an immediate inpatient treatment. Often, the patients have the right to appeal against compulsory admission. These processes are implemented in most mental health-care systems...

journal_title：Frontiers in psychiatry

authors： Arnold BD,Moeller J,Hochstrasser L,Schneeberger AR,Borgwardt S,Lang UE,Huber CG

更新日期：2019-08-09 00:00:00

abstract：:In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experience...

journal_title：Frontiers in psychiatry

authors： Schultze-Lutter F,Debbané M,Theodoridou A,Wood SJ,Raballo A,Michel C,Schmidt SJ,Kindler J,Ruhrmann S,Uhlhaas PJ

更新日期：2016-01-28 00:00:00

abstract：:Sleep is a quiescent behavioral state during which complex homeostatic functions essential to health and well-being occur. Insomnia is a very common psychiatric disorder leading to a myriad of detrimental effects including loss of concentration, memory, and performance as well as disease. Current pharmaceutical treatm...

journal_title：Frontiers in psychiatry

authors： Jerath R,Beveridge C,Barnes VA

更新日期：2019-01-29 00:00:00

abstract：:Eating disorders (EDs) are serious psychopathologies characterized by a persistent disturbance in eating or eating-related behavior. Studies have shown EDs' detrimental consequences not only for patients, but also for their families. Nevertheless, a specific group that has so far been neglected, in both the research a...

journal_title：Frontiers in psychiatry

authors： Maon I,Horesh D,Gvion Y

更新日期：2020-06-30 00:00:00