Binge-Like Exposure to Ethanol Enhances Morphine's Anti-nociception in B6 Mice.

Abstract:

:Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling pathways. Morphine abuse is frequently linked to excessive drinking. Morphine exerts its actions mainly via the seven transmembrane G-protein-coupled mu opioid receptors (MORs). Opioid use disorders (OUDs) include combination of opioids with alcohol, leading to opioid overdose-related deaths. We hypothesized that binge drinking potentiates onset and progression of OUD. Using C57BL/6J (B6) mice, we first characterized time-dependent inflammatory gene expression change as molecular markers using qRT-PCR within 24 h after binge-like exposure to high-dose, high-concentration ethanol (EtOH). The mice were given one injection of EtOH (5 g/kg, 42% v/v, i.g.) and sacrificed at 2.5 h, 5 h, 7.5 h, or 24 h later. Inflammatory cytokines interleukin (IL)-1β, IL-6, and IL-18 were elevated in both the striatum (STr) and the nucleus accumbens (NAc) of the mice. We then investigated the expression profile of MOR in the STr at 2 min, 5 h, or 24 h after the first EtOH injection and at 24 h and 48 h after the third injection. This binge-like exposure to EtOH upregulated MOR expression in the STr and NAc, an effect that could enhance morphine's anti-nociception. Therefore, we examined the impact of binge-like exposure to EtOH on morphine's anti-nociception at the behavioral level. The mice were treated with or without 3-d binge-like exposure to EtOH, and the anti-nociceptive changes were evaluated using the hot-plate test 24 h after the final (3rd) EtOH injection with or without a cumulative subcutaneous dose (0, 0.1, 0.3, 1.0, and 3.0 mg/kg) of morphine at intervals of 30 min. The response curve of the mice given EtOH was shifted to the left, showing enhanced latency to response to morphine up to 3 mg/kg. Furthermore, co-treatment with the MOR antagonist naltrexone blocked morphine's anti-nociception in animals given either EtOH or saline. This confirms that MOR is involved in binge-like exposure to EtOH-induced changes in morphine's anti-nociception. Our results suggest that EtOH enhanced latency to analgesic response to morphine, and such effect might initiate the onset and progression of OUDs.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Chang SL,Huang W,Han H,Sariyer IK

doi

10.3389/fpsyt.2018.00756

subject

Has Abstract

pub_date

2019-01-22 00:00:00

pages

756

issn

1664-0640

journal_volume

9

pub_type

杂志文章
  • Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation.

    abstract::Over half of those diagnosed with post-traumatic stress disorder (PTSD) have comorbid major depressive disorder (MDD), and rates are even higher among military veterans. Transcranial magnetic stimulation (TMS) may be a safe and efficacious treatment for PTSD, both with and without comorbid MDD. Still, the mechanism of...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00605

    authors: Petrosino NJ,Zandvakili A,Carpenter LL,Philip NS

    更新日期:2018-11-20 00:00:00

  • 25 Hz Magnetic Seizure Therapy Is Feasible but Not Optimal for Chinese Patients With Schizophrenia: A Case Series.

    abstract::Magnetic seizure therapy (MST) is a potential alternative to electroconvulsive therapy (ECT), but there is currently a lack of reports about MST in Chinese patients with schizophrenia. Our objective was to investigate the feasibility and acceptability of add-on MST in the treatment of patients with schizophrenia. Eigh...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2018.00224

    authors: Jiang J,Li Q,Sheng J,Yang F,Cao X,Zhang T,Jia Y,Wang J,Li C

    更新日期:2018-05-29 00:00:00

  • How Prevalent is "Food Addiction"?

    abstract::Increasing evidence suggests that binge eating-related disorders could be related to addiction-like eating patterns due to the addictive potential of hyperpalatable foods. Subsequently, important implications have been derived for treatment of those disorders and even political actions. However, studies on the prevale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00061

    authors: Meule A

    更新日期:2011-11-03 00:00:00

  • Effectiveness of Transitional Interventions in Improving Patient Outcomes and Service Use After Discharge From Psychiatric Inpatient Care: A Systematic Review and Meta-Analysis.

    abstract::Background: The transition from psychiatric hospital to community is often hindered by challenges that influence community adjustment and continuity of care. Transitional interventions with bridging components are provided prior to discharge and continue beyond inpatient care. They provide continuity of care and may b...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2019.00969

    authors: Hegedüs A,Kozel B,Richter D,Behrens J

    更新日期:2020-01-21 00:00:00

  • Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats.

    abstract::Aims: Expression of inflammatory cytokines in the brain has been reported to be involved in the pathogenesis of and susceptibility to depression. Jumonji domain-containing 3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate microglial activation, has been regarded as a crucial element in th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00471

    authors: Wang R,Wang W,Xu J,Liu D,Jiang H,Pan F

    更新日期:2018-10-11 00:00:00

  • Deficits in agency in schizophrenia, and additional deficits in body image, body schema, and internal timing, in passivity symptoms.

    abstract::Individuals with schizophrenia, particularly those with passivity symptoms, may not feel in control of their actions, believing them to be controlled by external agents. Cognitive operations that contribute to these symptoms may include abnormal processing in agency as well as body representations that deal with body ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00126

    authors: Graham KT,Martin-Iverson MT,Holmes NP,Jablensky A,Waters F

    更新日期:2014-09-10 00:00:00

  • Nonsuicidal Self-Injury: Its Associations With Pathological Internet Use and Psychopathology Among Adolescents.

    abstract:Background/Hypotheses:As risk factors for nonsuicidal self-injury (NSSI), most studies highlight the importance of internalising disorders, while only a few researches show the connection between externalising disorders and NSSI. Although some papers have introduced the idea that increasing prevalence rates of NSSI are...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00814

    authors: Mészáros G,Győri D,Horváth LO,Szentiványi D,Balázs J

    更新日期:2020-08-14 00:00:00

  • Pharmacological modulation of the short-lasting effects of antagonistic direct current-stimulation over the human motor cortex.

    abstract::Combined administration of transcranial direct current-stimulation (tDCS) with either pergolide (PER) or d-cycloserine (d-CYC) can prolong the excitability-diminishing effects of cathodal, or the excitability enhancing effect of anodal stimulation for up to 24 h poststimulation. However, it remains unclear whether the...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00067

    authors: Chaieb L,Antal A,Terney D,Paulus W

    更新日期:2012-07-05 00:00:00

  • School-Based Prevention Targeting Non-Suicidal Self-injury: A Pilot Study.

    abstract::Non-suicidal self-injury (NSSI) is prevalent in adolescence and is associated with increased risk for a variety of subsequent negative mental health outcomes, necessitating an evidence-based preventive approach. This pilot study examines the potential iatrogenic effects and feasibility of an evidence-based school prog...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00437

    authors: Baetens I,Decruy C,Vatandoost S,Vanderhaegen B,Kiekens G

    更新日期:2020-05-29 00:00:00

  • Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis.

    abstract::Cognitive performance at illness onset may predict outcomes in first-episode psychosis (FEP), and the change in cognition may associate with clinical changes. Cognitive testing was administered to 54 FEP participants 2 months after entering treatment and to 39 participants after 1 year. We investigated whether baselin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.603933

    authors: Lindgren M,Holm M,Kieseppä T,Suvisaari J

    更新日期:2020-12-04 00:00:00

  • Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.

    abstract::Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certain...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.00381

    authors: Shao X,Zhu G

    更新日期:2020-05-13 00:00:00

  • Using EEG-Guided Basket and Umbrella Trials in Psychiatry: A Precision Medicine Approach for Cognitive Impairment in Schizophrenia.

    abstract::Due to advances over the last several decades, many fields of medicine are moving toward a precision medicine approach where treatments are tailored to nuanced patient factors. While in some disciplines these innovations are commonplace leading to unique biomarker-guided experimental medicine trials, there are no such...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00554

    authors: Joshi YB,Light GA

    更新日期:2018-11-19 00:00:00

  • Criminal Responsibility Scale: Development and Validation of a Psychometric Tool Structured in Clinical Vignettes for Criminal Responsibility Assessments in Brazil.

    abstract::Criminal responsibility assessment is undertaken by psychologists or psychiatrists to assess offenders' legal capacities, which vary among countries or regional legislations. There are two psychometric tools (i.e., checklists) validated for criminal responsibility assessment: the Roger Criminal Responsibility Scale, a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.579243

    authors: Meyer LF,Leal CCS,Omena AAS,Mecler K,Valença AM

    更新日期:2020-11-27 00:00:00

  • The Role of Mental Imagery in Depression: Negative Mental Imagery Induces Strong Implicit and Explicit Affect in Depression.

    abstract::Mental imagery, seeing with the mind's eyes, can induce stronger positive as well as negative affect compared to verbal processing. Given this emotion-amplifying effect, it appears likely that mental images play an important role in affective disorders. According to the subcomponents model of depression, depressed moo...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2015.00094

    authors: Görgen SM,Joormann J,Hiller W,Witthöft M

    更新日期:2015-07-07 00:00:00

  • Preliminary Reliability and Validity of the DMRS-SR-30, a Novel Self-Report Measure Based on the Defense Mechanisms Rating Scales.

    abstract::Defense mechanisms are psychological factors that influence emotional distress and quality of life. There are a number of measures assessing the construct of defense mechanisms, but only few available instruments reflect the gold-standard theoretical hierarchical organization of defenses. We report on the development ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00870

    authors: Di Giuseppe M,Perry JC,Lucchesi M,Michelini M,Vitiello S,Piantanida A,Fabiani M,Maffei S,Conversano C

    更新日期:2020-08-26 00:00:00

  • Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome.

    abstract::Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularly for those with more severe intellectual disabilities and/or cognitive decline. We previously developed th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00158

    authors: Startin CM,Lowe B,Hamburg S,Hithersay R,Strydom A,LonDownS Consortium.

    更新日期:2019-04-16 00:00:00

  • Self-Regulation of Breathing as an Adjunctive Treatment of Insomnia.

    abstract::Sleep is a quiescent behavioral state during which complex homeostatic functions essential to health and well-being occur. Insomnia is a very common psychiatric disorder leading to a myriad of detrimental effects including loss of concentration, memory, and performance as well as disease. Current pharmaceutical treatm...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00780

    authors: Jerath R,Beveridge C,Barnes VA

    更新日期:2019-01-29 00:00:00

  • Resilience as a Mediator Between Interpersonal Risk Factors and Hopelessness in Depression.

    abstract::Several studies investigated the role of resilience as a mediating factor for psychopathological phenotypes. The aim of the current study is to explore the putative role of resilience as a mediator between different vulnerability factors and depressive symptoms. One hundred and fifty patients with a major depressive d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00010

    authors: Collazzoni A,Stratta P,Pacitti F,Rossi A,Santarelli V,Bustini M,Talevi D,Socci V,Rossi R

    更新日期:2020-02-28 00:00:00

  • Regional Cerebral Associations Between Psychometric Tests and Imaging Biomarkers in Alzheimer's Disease.

    abstract::Recently, imaging biomarkers have gained importance for the characterization of patients with Alzheimer's disease; however, the relationship between regional biomarker expression and cognitive function remains unclear. In our study, we investigated associations between scores on CERAD neuropsychological assessment bat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00793

    authors: Hedderich DM,Drost R,Goldhardt O,Ortner M,Müller-Sarnowski F,Diehl-Schmid J,Zimmer C,Förstl H,Yakushev I,Jahn T,Grimmer T

    更新日期:2020-08-13 00:00:00

  • Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons.

    abstract::Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumpti...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00410

    authors: Hsu TM,McCutcheon JE,Roitman MF

    更新日期:2018-09-03 00:00:00

  • Emergency Presentations to Child and Adolescent Psychiatry: Nonsuicidal Self-Injury and Suicidality.

    abstract::Nonsuicidal Self-Injury (NSSI) and suicidality are common reasons for emergency presentations in child and adolescent psychiatry. Therefore, we focused on reasons for emergency presentations as well as specific characteristics of those presenting with NSSI or suicidality to an emergeny psychiatric service. We analyzed...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00979

    authors: Franzen M,Keller F,Brown RC,Plener PL

    更新日期:2020-01-17 00:00:00

  • Mental Health Symptoms and Work-Related Stressors in Hospital Midwives and NICU Nurses: A Mixed Methods Study.

    abstract::Hospital midwives and neonatal intensive care (NICU) nurses frequently encounter work-related stressors and are therefore vulnerable to developing mental health problems, such as secondary traumatic stress, burnout, anxiety, and depression. However, so far, the exact nature of these work-related stressors (traumatic v...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00364

    authors: Favrod C,Jan du Chêne L,Martin Soelch C,Garthus-Niegel S,Tolsa JF,Legault F,Briet V,Horsch A

    更新日期:2018-08-20 00:00:00

  • Self and the Brain. The Immune Metaphor.

    abstract::One of the fundamental questions in neuroscience is how brain activity relates to conscious experience. Even though self-consciousness is considered an emergent property of the brain network, a quantum physics-based theory assigns a momentum of consciousness to the single neuron level. In this work, we present a brain...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.540676

    authors: Sánchez-Ramón S,Faure F

    更新日期:2020-09-29 00:00:00

  • Effect of Aerobic Exercise on Improving Symptoms of Individuals With Schizophrenia: A Single Blinded Randomized Control Study.

    abstract::Introduction: Antipsychotic treatment can improve the symptoms of schizophrenia; however, residual symptoms after antipsychotic treatment are frequent. The effects of exercise on the symptoms of schizophrenic patients under antipsychotic treatment are inconclusive. The aim of this randomized case-control study was to ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00167

    authors: Wang PW,Lin HC,Su CY,Chen MD,Lin KC,Ko CH,Yen CF

    更新日期:2018-05-15 00:00:00

  • Cognitive and Affective Empathy in Eating Disorders: A Systematic Review and Meta-Analysis.

    abstract::Background: Recent models of eating disorders (EDs) have proposed social and emotional difficulties as key factors in the development and maintenance of the illness. While a number of studies have demonstrated difficulties in theory of mind and emotion recognition, little is known about empathic abilities in those wit...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2019.00102

    authors: Kerr-Gaffney J,Harrison A,Tchanturia K

    更新日期:2019-03-04 00:00:00

  • Raising Placebo Efficacy in Antidepressant Trials Across Decades Explained by Small-Study Effects: A Meta-Reanalysis.

    abstract:Background:Recent meta-analyses reported placebo response rate in antidepressant trials to be stable since the 1970s. These meta-analyses however were limited in considering only linear time trends, assessed trial-level covariates based on single-model hypothesis testing only, and did not adjust for small-study effects...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2020.00633

    authors: Holper L

    更新日期:2020-07-28 00:00:00

  • Perceived Paternal Involvement, Relationship Satisfaction, Mothers' Mental Health and Parenting Stress: A Multi-Sample Path Analysis.

    abstract::Research has demonstrated the short- and long-term impacts of maternal mental health and well-being on children's emotional and behavioral outcomes. It is thus important to better understand the antecedents of maternal depression and stress. The aim of this study was to determine whether the contribution of perceived ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.578682

    authors: deMontigny F,Gervais C,Pierce T,Lavigne G

    更新日期:2020-11-02 00:00:00

  • Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.

    abstract::Butyrylcholinesterase (BChE) efficiently hydrolyzes acetylcholine (ACh) at high concentrations when acetylcholinesterase (AChE) is substrate-inhibited. Recent studies have shown that BChE also has a function that is independent of ACh, but it has not been fully explored. Low BChE expression is accompanied with higher ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.564843

    authors: Chen S,Lin Z,Tan KL,Chen R,Su W,Zhao H,Tan Q,Tan W

    更新日期:2020-09-11 00:00:00

  • A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders: Study Protocol.

    abstract::Patients with severe mental disorders die on average 20 years prior to the general population. This mortality gap is mainly due to the higher prevalence of physical diseases and the adoption of unhealthy lifestyle behaviors.The LIFESTYLE trial aims to evaluate the efficacy of a new psychosocial group intervention (inc...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2018.00235

    authors: Sampogna G,Fiorillo A,Luciano M,Del Vecchio V,Steardo L Jr,Pocai B,Barone M,Amore M,Pacitti F,Dell'Osso L,Di Lorenzo G,Maj M,LIFESTYLE Working Group.

    更新日期:2018-06-07 00:00:00

  • Characterizing Treatment-Resistant Anorexia Nervosa.

    abstract::Background: The issue of treatment resistance in eating disorder care is controversial. Prior research has identified multiple failed treatment attempts as a common criterion for severe and enduring anorexia nervosa, but little is known about patients who have multiple failed treatment attempts. This study was designe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.542206

    authors: Smith S,Woodside DB

    更新日期:2021-01-08 00:00:00