Tradipitant in the Treatment of Motion Sickness: A Randomized, Double-Blind, Placebo-Controlled Study.

abstract：:Spontaneous intracerebral hemorrhage (SICH) is the most lethal type of stroke. Half of these deaths occur within the acute phase. Frequently observed deterioration during the acute phase is often due to rebleeding or peri-hematomal expansion. The exact pathogenesis that leads to rebleeding or peri-hemorrhagic edema re...

journal_title：Frontiers in neurology

authors： Babi MA,James ML

更新日期：2017-01-19 00:00:00

abstract：:Background: Sphingosine 1-phosphate (S1P) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result, S1P may contribute to the pathogenesis of stroke. Objective: This study aimed to evaluate the...

journal_title：Frontiers in neurology

authors： Liu J,Sugimoto K,Cao Y,Mori M,Guo L,Tan G

更新日期：2020-09-08 00:00:00

abstract：:Background: Perinatal and perioperative brain injury is a fundamental problem in infants with severe congenital heart disease undergoing neonatal cardiac surgery with cardiopulmonary bypass. An impaired neuromotor and neurocognitive development is encountered and associated with a reduction in quality of life. New neu...

journal_title：Frontiers in neurology

authors： Stegeman R,Lamur KD,van den Hoogen A,Breur JMPJ,Groenendaal F,Jansen NJG,Benders MJNL

更新日期：2018-07-03 00:00:00

abstract：:Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respec...

journal_title：Frontiers in neurology

authors： Talhada D,Santos CRA,Gonçalves I,Ruscher K

更新日期：2019-10-18 00:00:00

abstract：:Background: Phosphatidylinositol binding clathrin assembly protein (PICALM) rs541458 C allele has been identified and validated to be associated with a reduction of Alzheimer's disease (AD) risk. Nevertheless, the exact mechanisms through which the variant exert its disease-relevant association remain to be elucidated...

journal_title：Frontiers in neurology

authors： Zhuang L,Liu X,Shi Y,Liu X,Luo B

更新日期：2019-05-08 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is a prevalent sleep-related complaint across the general population and has been reported to be associated with headache. Tension-type headache (TTH) is the most commonly encountered headache and accounts for a significant amount of disease burden. However, the association between E...

journal_title：Frontiers in neurology

authors： Kim KM,Kim J,Cho SJ,Kim WJ,Yang KI,Yun CH,Chu MK

更新日期：2019-12-03 00:00:00

abstract：Background:There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive endovascular clot retrieval or thrombolysis therapies, or for whom standard treatment has failed. We have recently shown that human amniotic epithelial cells (hAECs) ...

journal_title：Frontiers in neurology

authors： Phan TG,Ma H,Lim R,Sobey CG,Wallace EM

更新日期：2018-06-07 00:00:00

abstract：:Background: In people with multiple sclerosis (MS), optic neuritis (ON) results in inner retinal layer thinning, and reduced density of the retinal microvasculature. Objective: To compare inter-eye differences (IEDs) in macular optical coherence tomography (OCT) and OCT angiography (OCTA) measures in MS patients with ...

journal_title：Frontiers in neurology

authors： Murphy OC,Kalaitzidis G,Vasileiou E,Filippatou AG,Lambe J,Ehrhardt H,Pellegrini N,Sotirchos ES,Luciano NJ,Liu Y,Fitzgerald KC,Prince JL,Calabresi PA,Saidha S

更新日期：2020-12-15 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopamine neurons. Since a seminal report was published in the early twentieth century, a growing body of literature has suggested that patients with PD display characteristic personality traits, such as cautiousness and inflexibil...

journal_title：Frontiers in neurology

authors： Abe N,Kawasaki I,Hosokawa H,Baba T,Takeda A

更新日期：2018-05-24 00:00:00

abstract：:Neurosyphilis, which is caused by Treponema pallidum, is a rare sexually transmitted disease involving the central nervous system (CNS). Among all the sub-categories, spinal syphilitic gumma is extremely rare. In previous literature, limited cases of spinal syphilitic gumma have been reported, most of which underwent ...

journal_title：Frontiers in neurology

authors： Cui L,Xu Z,Hou H

更新日期：2020-01-15 00:00:00

abstract：:To date, conflicting results about the role of vitamins in amyotrophic lateral sclerosis (ALS) have been reported along with a lack of systematic studies on all types of serum vitamins in patients with ALS. Moreover, extensive studies have been conducted on vitamins in other neurodegenerative diseases; however, whethe...

journal_title：Frontiers in neurology

authors： Wang M,Liu Z,Sun W,Yuan Y,Jiao B,Zhang X,Shen L,Jiang H,Xia K,Tang B,Wang J

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Spinocerebellar ataxia type 2 (SCA2) is an inherited and still incurable neurodegenerative disorder. Evidence suggests that pro-oxidant agents as well as factors involved in antioxidant cellular defenses are part of SCA2 physiopathology. AIM:To assess the influence of superoxide dismutase (SOD3) and catalas...

journal_title：Frontiers in neurology

authors： Almaguer-Gotay D,Almaguer-Mederos LE,Aguilera-Rodríguez R,Rodríguez-Labrada R,Cuello-Almarales D,Estupiñán-Domínguez A,Velázquez-Pérez LC,González-Zaldívar Y,Vázquez-Mojena Y

更新日期：2017-06-13 00:00:00

abstract：:The benefits of hemicraniectomy for malignant middle cerebral artery (MCA) stroke may not be apparent in the 3- to 6-months in which final outcomes are assessed in research studies. We present the case of a 15-year-old who underwent hemicraniectomy for malignant MCA stroke and was significantly disabled 3 and 6 months...

journal_title：Frontiers in neurology

authors： Mittal A,Mittal G,Partikian A,Liebeskind D,Sanossian N

更新日期：2012-08-02 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the health of millions of people in the United States and worldwide. Currently, there are no approved therapies that can halt or reverse the clinical progression of AD. Traditionally, AD is characterized first by the appearance of a...

journal_title：Frontiers in neurology

authors： Hanslik KL,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:Purpose: The use of optical coherence tomography (OCT) of the retina to detect inner retinal degeneration is being investigated as a potential biomarker for mild cognitive impairment (MCI) and Alzheimer's disease (AD), and an overwhelming body of evidence indicates that discovery of disease-modifying treatments for AD...

journal_title：Frontiers in neurology

authors： Mejia-Vergara AJ,Restrepo-Jimenez P,Pelak VS

更新日期：2020-10-16 00:00:00

abstract：:Background and objective: The trajectories of long-term and domain-specific cognitive alterations over a decade after stroke are largely unknown. This study aims to investigate the dynamic alterations of domain-specific cognitive performance among young stroke survivors over 10 years after their first stroke. Methods:...

journal_title：Frontiers in neurology

authors： Elgh E,Hu X

更新日期：2019-02-12 00:00:00

abstract：:Non-motor symptoms of Parkinson's disease (PD) have been receiving increasing attention. Approximately half of patients with PD have experience PD-related pain. We investigated the effect and mechanism of acupuncture in patients with PD who have pain. PD patients with pain were divided into acupuncture group and contr...

journal_title：Frontiers in neurology

authors： Yu SW,Lin SH,Tsai CC,Chaudhuri KR,Huang YC,Chen YS,Yeh BY,Wu YR,Wang JJ

更新日期：2019-10-22 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the presence of renal cysts and specific extrarenal abnormalities. ADPKD is caused by mutations in either PKD1 or PKD2 genes that encode for integral membrane proteins Polycystin-1 (PC1) and Polycystin-2 (PC2), respectively. Ex...

journal_title：Frontiers in neurology

authors： Thomas C,Zühlsdorf A,Hörtnagel K,Mulahasanovic L,Grauer OM,Kümpers P,Wiendl H,Meuth SG

更新日期：2018-05-25 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, including sensorineural h...

journal_title：Frontiers in neurology

authors： Katsumi S,Sahin MI,Lewis RM,Iyer JS,Landegger LD,Stankovic KM

更新日期：2020-02-10 00:00:00

abstract：:When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. The...

journal_title：Frontiers in neurology

authors： Farrugia ME,Goodfellow JA

更新日期：2020-07-07 00:00:00

abstract：:Background and Purpose: The effect of uric acid (UA) levels on severity and prognosis of spontaneous intracerebral hemorrhage (ICH) remains controversial. We aimed to explore the association of admission UA levels with stroke severity and outcomes in ICH patients. Materials and Methods: The patients enrolled in this s...

journal_title：Frontiers in neurology

authors： Liu X,Cao Z,Gu H,Yang K,Ji R,Li Z,Zhao X,Wang Y

更新日期：2020-12-03 00:00:00

abstract：:Background: Cognitive impairments in temporal lobe epilepsy (TLE) patients has been described as a chronically progressive feature of the disease. However, how severe recurrent seizures modify neuronal circuits in the human brain and subsequently degrade cognitive function, remains largely unknown. Here, we aimed to i...

journal_title：Frontiers in neurology

authors： Qin L,Jiang W,Zheng J,Zhou X,Zhang Z,Liu J

更新日期：2020-07-21 00:00:00

abstract：:Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. In this mini review, we focus on the hypothesis of distur...

journal_title：Frontiers in neurology

authors： Samuelsson K,Press R

更新日期：2018-02-12 00:00:00

abstract：:The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these para...

journal_title：Frontiers in neurology

authors： Sarmento A,Aliverti A,Marques L,Pennati F,Dourado-Júnior ME,Fregonezi G,Resqueti V

更新日期：2018-05-02 00:00:00

abstract：:Objective: The aims of this study were to compare the characteristics of three motor subtype classifications in patients with de novo Parkinson's disease (PD) and to find the most suitable motor subtype classification for identifying non-motor symptoms (NMSs). Methods: According to previous studies, a total of 256 pat...

journal_title：Frontiers in neurology

authors： Ren J,Hua P,Li Y,Pan C,Yan L,Yu C,Zhang L,Xu P,Zhang M,Liu W

更新日期：2020-12-23 00:00:00

abstract：Background and Objectives:Benign paroxysmal positional vertigo (BPPV) recurs frequently. This study aims to determine that each patient with BPPV has a predilection for a specific canal and the type of recurred BPPV can be predicted from that observed during the previous attack. Methods:The involved side (right, left,...

journal_title：Frontiers in neurology

authors： Kim HJ,Kim JS

更新日期：2017-12-15 00:00:00

abstract：:Background and Purpose: Accurate prediction of functional outcomes after stroke would provide evidence for reasonable poststroke management. This study aimed to develop and validate a nomogram for individualized prediction of 1-year unfavorable outcomes in Chinese acute ischemic stroke (AIS) patients. Methods: We gath...

journal_title：Frontiers in neurology

authors： Li X,Wang F,Zhao Z,Sun C,Liao J,Li X,Huang C,Nyame L,Zhao Z,Zheng X,Zhou J,Li M,Zou J

更新日期：2020-06-30 00:00:00

abstract：:Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients. The purpose of the present study was to describe brain gray matter abnormalities a...

journal_title：Frontiers in neurology

authors： Hua K,Wang P,Lan Z,Li M,Zhao W,Wang T,Li S,Ma X,Li C,Fu S,Yin Y,Liu P,Fang J,Li T,Jiang G

更新日期：2020-11-30 00:00:00

abstract：:Mutations of the voltage-gated sodium channel SCN8A have been identified in approximately 1% of nearly 1,500 children with early-infantile epileptic encephalopathies (EIEE) who have been tested by DNA sequencing. EIEE caused by mutation of SCN8A is designated EIEE13 (OMIM #614558). Affected children have seizure onset...

journal_title：Frontiers in neurology

authors： Wagnon JL,Meisler MH

更新日期：2015-05-15 00:00:00

abstract：:Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs. Methods: Twenty-eight patients with PD and 28 demographically...

journal_title：Frontiers in neurology

authors： Zhang C,Dou B,Wang J,Xu K,Zhang H,Sami MU,Hu C,Rong Y,Xiao Q,Chen N,Li K

更新日期：2019-10-01 00:00:00