A SCANO Nomogram for Individualized Prediction of the Probability of 1-Year Unfavorable Outcomes in Chinese Acute Ischemic Stroke Patients.

abstract：:Gait disturbances are one of the principal and most incapacitating symptoms of Parkinson's disease (PD). In addition, walking economy is impaired in PD patients and could contribute to excess fatigue in this population. An important number of studies have shown that treadmill training can improve kinematic parameters ...

journal_title：Frontiers in neurology

authors： Fernández-Del-Olmo MA,Sanchez JA,Bello O,Lopez-Alonso V,Márquez G,Morenilla L,Castro X,Giraldez M,Santos-García D

更新日期：2014-09-26 00:00:00

abstract：:Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate the individual and combined outcome prediction a...

journal_title：Frontiers in neurology

authors： Lagerstedt L,Azurmendi L,Tenovuo O,Katila AJ,Takala RSK,Blennow K,Newcombe VFJ,Maanpää HR,Tallus J,Hossain I,van Gils M,Menon DK,Hutchinson PJ,Zetterberg H,Posti JP,Sanchez JC

更新日期：2020-06-02 00:00:00

abstract：:Background: Essential tremor (ET) is a common, progressive neurological syndrome with bilateral upper-limb dysfunction of at least 3-year duration, with or without tremor in other body locations. This disorder has a negative impact on daily function and quality of life. A single oral therapy has been approved by FDA f...

journal_title：Frontiers in neurology

authors： Papapetropoulos S,Lee MS,Boyer S,Newbold EJ

更新日期：2019-06-11 00:00:00

abstract：:When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. The...

journal_title：Frontiers in neurology

authors： Farrugia ME,Goodfellow JA

更新日期：2020-07-07 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of death worldwide. Depending on the severity of the injury, TBI can reflect a broad range of consequences such as speech impairment, memory disturbances, and premature death. In this study, embryonic neural stem cells (ENSC) were isolated from E14 mouse embryos and cultur...

journal_title：Frontiers in neurology

authors： Nasser M,Ballout N,Mantash S,Bejjani F,Najdi F,Ramadan N,Soueid J,Zibara K,Kobeissy F

更新日期：2018-10-24 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterized by multi-system involvement. Affected organ system includes skeletal muscle, heart, gastro-intestinal system and the brain. In this review, we evaluate the evidence for alterations in insulin signaling and their relation to clinical...

journal_title：Frontiers in neurology

authors： Nieuwenhuis S,Okkersen K,Widomska J,Blom P,'t Hoen PAC,van Engelen B,Glennon JC

更新日期：2019-11-26 00:00:00

abstract：:Takotsubo cardiomyopathy (TTC) is an acute and reversible cardiac wall motion abnormality of the left myocardium. Although many studies focused on etiology, diagnostic and treatment of TTC, precise clinical guidelines on TTC are not available. Research revealed emotional and physical triggering factors of TTC and emph...

journal_title：Frontiers in neurology

authors： Buchmann SJ,Lehmann D,Stevens CE

更新日期：2019-08-22 00:00:00

abstract：:Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...

journal_title：Frontiers in neurology

authors： Guingab-Cagmat JD,Cagmat EB,Hayes RL,Anagli J

更新日期：2013-05-31 00:00:00

abstract：:Traumatic brain injury (TBI) due to explosive blast exposure is a leading combat casualty. It is also implicated as a key contributor to war related mental health diseases. A clinically important consequence of all types of TBI is a high risk for development of seizures and epilepsy. Seizures have been reported in pat...

journal_title：Frontiers in neurology

authors： Kovacs SK,Leonessa F,Ling GS

更新日期：2014-04-09 00:00:00

abstract：:Adolescents with traumatic brain injury (TBI) typically demonstrate good recovery of previously acquired skills. However, higher-order and later emergent cognitive functions are often impaired and linked to poor outcomes in academic and social/behavioral domains. Few control trials exist that test cognitive treatment ...

journal_title：Frontiers in neurology

authors： Cook LG,Chapman SB,Elliott AC,Evenson NN,Vinton K

更新日期：2014-06-11 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of motor neurons in the spinal cord, and comprises a broad clinical spectrum. With the advent of new therapies (e.g., Nusinersen) for patients of all ages and disease stages, sensitive clinical measures are needed to det...

journal_title：Frontiers in neurology

authors： Kruse T,Lehmann HC,Braumann B,Fink GR,Wunderlich G

更新日期：2020-02-25 00:00:00

abstract：:Background/Objective: Stroke is a leading global cause of adult disability. As the population ages as well as suffers co-morbidities, it is expected that the stroke burden will increase further. There are no established safe and effective restorative treatments to facilitate a good functional outcome in stroke patient...

journal_title：Frontiers in neurology

authors： Mu J,Bakreen A,Juntunen M,Korhonen P,Oinonen E,Cui L,Myllyniemi M,Zhao S,Miettinen S,Jolkkonen J

更新日期：2019-03-26 00:00:00

abstract：:Microglia are activated during pathological events in the brain and are capable of releasing various types of inflammatory cytokines. Here, we demonstrate that the addition of 5% microglia activated by 1 μg/ml lipopolysaccharides (LPS) to hippocampal cultures upregulates Na(+) current densities (INavD) of bipolar as w...

journal_title：Frontiers in neurology

authors： Klapal L,Igelhorst BA,Dietzel-Meyer ID

更新日期：2016-03-30 00:00:00

abstract：:Introduction: People with stroke often have impaired stepping responses following balance perturbations, which increases their risk of falling. Computer-controlled movable platforms are promising tools for delivering perturbation-based balance training under safe and standardized circumstances. Purpose: This proof-of-...

journal_title：Frontiers in neurology

authors： van Duijnhoven HJR,Roelofs JMB,den Boer JJ,Lem FC,Hofman R,van Bon GEA,Geurts ACH,Weerdesteyn V

更新日期：2018-11-22 00:00:00

abstract：:Despite extensive research, the functions of the basal ganglia (BG) in movement control have not been fully understood. Eye movements, particularly saccades, are convenient indicators of BG function. Here, we review the main oculomotor findings reported in Parkinson's disease (PD) and genetic parkinsonian syndromes. P...

journal_title：Frontiers in neurology

authors： Pretegiani E,Optican LM

更新日期：2017-11-09 00:00:00

abstract：OBJECTIVE:Rotational vestibular function declines with age resulting in saccades as a compensatory mechanism to improve impaired gaze stability. Small reductions in rotational vestibulo-ocular reflex (VOR) gain that would be considered clinically normal have been associated with compensatory saccades. We evaluated whet...

journal_title：Frontiers in neurology

authors： Anson ER,Bigelow RT,Carey JP,Xue QL,Studenski S,Schubert MC,Weber KP,Agrawal Y

更新日期：2016-07-18 00:00:00

abstract：:Background: Pediatric migraine is among the most common primary or comorbid neurologic disorders in children. Psychological stressors are widely acknowledged as potential triggers involved in recurring episodes of pediatric migraine. As the COVID-19 emergency may have affected the levels of stress perceived by childre...

journal_title：Frontiers in neurology

authors： Dallavalle G,Pezzotti E,Provenzi L,Toni F,Carpani A,Borgatti R

更新日期：2020-10-08 00:00:00

abstract：:Background: Strokes have a huge impact on patients' quality of life. Although there are potentially effective secondary preventions and treatment options for stroke patients, adherence is mostly low. Low disease and treatment-related knowledge and, consequently, a lack of informed decision-making in stroke patients ma...

journal_title：Frontiers in neurology

authors： Alegiani AC,Rahn AC,Steckelberg A,Thomalla G,Heesen C,Köpke S

更新日期：2020-12-07 00:00:00

abstract：:There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal flu...

journal_title：Frontiers in neurology

authors： Poesen K,Van Damme P

更新日期：2019-01-18 00:00:00

abstract：:To date, conflicting results about the role of vitamins in amyotrophic lateral sclerosis (ALS) have been reported along with a lack of systematic studies on all types of serum vitamins in patients with ALS. Moreover, extensive studies have been conducted on vitamins in other neurodegenerative diseases; however, whethe...

journal_title：Frontiers in neurology

authors： Wang M,Liu Z,Sun W,Yuan Y,Jiao B,Zhang X,Shen L,Jiang H,Xia K,Tang B,Wang J

更新日期：2020-06-18 00:00:00

abstract：:Background and Purpose: The relationship between cerebral microbleeds (CMBs) and prognosis in patients with ischemic stroke is still unclear. Our aim here was to verify the relationship between CMBs and functional outcomes in patients with minor ischemic stroke treated with antiplatelet therapy. Methods: We retrospect...

journal_title：Frontiers in neurology

authors： Sakuta K,Yaguchi H,Sato T,Komatsu T,Sakai K,Mitsumura H,Matsushima S,Iguchi Y

更新日期：2020-06-16 00:00:00

abstract：:Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. In each disease, tau self-assembles abnormally to form filaments that deposit in the brain. Tau is a nativ...

journal_title：Frontiers in neurology

authors： Oakley SS,Maina MB,Marshall KE,Al-Hilaly YK,Harrington CR,Wischik CM,Serpell LC

更新日期：2020-11-12 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the health of millions of people in the United States and worldwide. Currently, there are no approved therapies that can halt or reverse the clinical progression of AD. Traditionally, AD is characterized first by the appearance of a...

journal_title：Frontiers in neurology

authors： Hanslik KL,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer. We present the case of an 83-years-old male patient with rapid progressive symptoms of dementia up to mutism as well as tonic seizures. Immune-mediate...

journal_title：Frontiers in neurology

authors： Becker A,Grunwald IQ,Unger MM,Behnke S,Spiegel J,Yilmaz U,Walter S,Faßbender K

更新日期：2020-10-26 00:00:00

abstract：:Object: Predicting whether intramedullary slitlike cavity (SC) will worsen over time or remain stable is an outstanding clinical challenge. The aim of this study was to identify early features of SC (clinical and magnetic resonance imaging [MRI] findings). Methods: We prospectively included all patients referred to ou...

journal_title：Frontiers in neurology

authors： Faillot M,Morar S,Delphine S,El-Mendili M,Ducreux D,Parker F,Aghakhani N

更新日期：2020-06-12 00:00:00

abstract：:Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablatio...

journal_title：Frontiers in neurology

authors： Jang C,Park HJ,Chang WS,Pae C,Chang JW

更新日期：2016-10-24 00:00:00

abstract：:Background: Data on clinical presentation of Hemiplegic Migraine (HM) are quite limited in the literature, particularly in the pediatric age. The aim of the present study is to describe in detail the phenotypic features at onset and during the first years of disease of sporadic (SHM) and familial (FHM) pediatric hemip...

journal_title：Frontiers in neurology

authors： Toldo I,Brunello F,Morao V,Perissinotto E,Valeriani M,Pruna D,Tozzi E,Moscano F,Farello G,Frusciante R,Carotenuto M,Lisotto C,Ruffatti S,Maggioni F,Termine C,Di Rosa G,Nosadini M,Sartori S,Battistella PA

更新日期：2019-10-15 00:00:00

abstract：:Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using hemodynamic numerical simulation and the influence of embolization on recurrence after embolization. Methods: From January 2016 to December 2017, we enrolled a total of 113 paraclinoidal aneurysms treated ...

journal_title：Frontiers in neurology

authors： Sheng B,Wu D,Yuan J,Xu S,Li Z,Dong J,Lai N,Fang X

更新日期：2019-04-25 00:00:00

abstract：:The most frequent neurodegenerative diseases (NDs) are Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD-TDP). Neuropathologically, NDs are characterized by abnormal intracellular and extra-cellular protein deposits and by disease-specific ne...

journal_title：Frontiers in neurology

authors： Grinberg LT,Rueb U,Heinsen H

更新日期：2011-07-11 00:00:00

abstract：:Study Objectives: To clarify the effects of sleep duration on stroke and stroke subtypes, we adopted a Mendelian randomization (MR) approach to evaluate their causal relationship. Methods: A genome-wide association study including 446,118 participants from UK biobank was used to identify instruments for short sleep, l...

journal_title：Frontiers in neurology

authors： Lu H,Wu PF,Li RZ,Zhang W,Huang GX

更新日期：2020-10-07 00:00:00