Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients.

Abstract:

:Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients. The purpose of the present study was to describe brain gray matter abnormalities associated with AS pain. A total of 61 AS patients and 52 healthy controls (HCs) were included in this study. Using voxel-based morphometrics, we detected abnormal gray matter volume in AS patients. Based on the voxel-wise analysis, the gray matter volume in the left putamen of the AS group was increased significantly compared with that of the HC group. In addition, we found that the gray matter volume of the left putamen was positively correlated with the duration of AS and total back pain scores, whereas it was not significantly correlated with Bath Ankylosing Spondylitis Disease Activity Index scores, C-reactive protein, or erythrocyte sedimentation rate in AS patients. Taken together, our findings improve our understanding of the neural substrates of pain in AS and provide evidence of AS-related neurological impairment. Hence, further investigation of the pathophysiology of the left putamen in AS is warranted.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Hua K,Wang P,Lan Z,Li M,Zhao W,Wang T,Li S,Ma X,Li C,Fu S,Yin Y,Liu P,Fang J,Li T,Jiang G

doi

10.3389/fneur.2020.607646

subject

Has Abstract

pub_date

2020-11-30 00:00:00

pages

607646

issn

1664-2295

journal_volume

11

pub_type

杂志文章
  • Intracochlear Perfusion of Tumor Necrosis Factor-Alpha Induces Sensorineural Hearing Loss and Synaptic Degeneration in Guinea Pigs.

    abstract::Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, including sensorineural h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01353

    authors: Katsumi S,Sahin MI,Lewis RM,Iyer JS,Landegger LD,Stankovic KM

    更新日期:2020-02-10 00:00:00

  • A Practical Approach to Managing Patients With Myasthenia Gravis-Opinions and a Review of the Literature.

    abstract::When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. The...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00604

    authors: Farrugia ME,Goodfellow JA

    更新日期:2020-07-07 00:00:00

  • Hemodynamic Characteristics Associated With Paraclinoid Aneurysm Recurrence in Patients After Embolization.

    abstract::Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using hemodynamic numerical simulation and the influence of embolization on recurrence after embolization. Methods: From January 2016 to December 2017, we enrolled a total of 113 paraclinoidal aneurysms treated ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00429

    authors: Sheng B,Wu D,Yuan J,Xu S,Li Z,Dong J,Lai N,Fang X

    更新日期:2019-04-25 00:00:00

  • Gut-Brain Axis: Potential Factors Involved in the Pathogenesis of Parkinson's Disease.

    abstract::Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00849

    authors: Chao YX,Gulam MY,Chia NSJ,Feng L,Rotzschke O,Tan EK

    更新日期:2020-08-25 00:00:00

  • The Crucial Changes of Sit-to-Stand Phases in Subacute Stroke Survivors Identified by Movement Decomposition Analysis.

    abstract:Objective:The aim of this study was to detect the key changes during sit-to-stand (STS) movement cycle in hemiparetic stroke survivors using a five-phase kinematic and kinetic analysis. Methods:Twenty-five subacute stroke survivors and 17 age-matched healthy adults participated in this study. The kinematic and kinetic...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00185

    authors: Mao YR,Wu XQ,Zhao JL,Lo WLA,Chen L,Ding MH,Xu ZQ,Bian RH,Huang DF,Li L

    更新日期:2018-03-26 00:00:00

  • Motor Nerve Conduction Tests in Carpal Tunnel Syndrome.

    abstract::Background: For the preoperatively often required confirmation of clinically defined carpal tunnel syndrome (CTS), sensory as well as motor nerve conduction studies can be applied. The aim of this study was to test the sensitivity of specific motor nerve conduction tests in comparison with, as well as in addition to, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00149

    authors: Kasius KM,Claes F,Verhagen WIM,Meulstee J

    更新日期:2019-03-14 00:00:00

  • Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature Review.

    abstract::Mutations in the Potassium channel subfamily T member 1 (KCNT1) gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from the age of 10. The patient had four types of epileptic seizures,...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00064

    authors: Jia Y,Lin Y,Li J,Li M,Zhang Y,Hou Y,Liu A,Zhang L,Li L,Xiang P,Ye J,Huang Z,Wang Y

    更新日期:2019-02-05 00:00:00

  • Spatial Navigation Is Distinctively Impaired in Persistent Postural Perceptual Dizziness.

    abstract::Objective: To determine whether performance in a virtual spatial navigational task is poorer in persistent postural perceptual dizziness (PPPD) patients than in healthy volunteers and patients suffering other vestibular disorders. Methods: Subjects were asked to perform three virtual Morris water maze spatial navigati...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01361

    authors: Breinbauer HA,Contreras MD,Lira JP,Guevara C,Castillo L,Ruëdlinger K,Muñoz D,Delano PH

    更新日期:2020-01-09 00:00:00

  • Role of Decompressive Craniectomy in Ischemic Stroke.

    abstract::Ischemic stroke is one of the leading causes for death and disability worldwide. In patients with large space-occupying infarction, the subsequent edema complicated by transtentorial herniation poses a lethal threat. Especially in patients with malignant middle cerebral artery infarction, brain swelling secondary to t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.01119

    authors: Pallesen LP,Barlinn K,Puetz V

    更新日期:2019-01-09 00:00:00

  • A SCANO Nomogram for Individualized Prediction of the Probability of 1-Year Unfavorable Outcomes in Chinese Acute Ischemic Stroke Patients.

    abstract::Background and Purpose: Accurate prediction of functional outcomes after stroke would provide evidence for reasonable poststroke management. This study aimed to develop and validate a nomogram for individualized prediction of 1-year unfavorable outcomes in Chinese acute ischemic stroke (AIS) patients. Methods: We gath...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00531

    authors: Li X,Wang F,Zhao Z,Sun C,Liao J,Li X,Huang C,Nyame L,Zhao Z,Zheng X,Zhou J,Li M,Zou J

    更新日期:2020-06-30 00:00:00

  • Why Cognitive-Cognitive Dual-Task Testing Assessment Should Be Implemented in Studies on Multiple Sclerosis and in Regular Clinical Practice.

    abstract::Cognitive impairment is prevalent and disabling in multiple sclerosis (MS) and is severely impacting quality of life (QoL). Aside its routine assessment in clinical care, it should more often be implemented as endpoint/outcome measure in clinical trials. However, a fundamental aspect-often neglected in clinical practi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00905

    authors: Beste C,Ziemssen T

    更新日期:2020-08-28 00:00:00

  • Acute Injection of Omega-3 Triglyceride Emulsion Provides Very Similar Protection as Hypothermia in a Neonatal Mouse Model of Hypoxic-Ischemic Brain Injury.

    abstract::Therapeutic hypothermia (HT) is a currently accepted treatment for neonatal asphyxia and is a promising strategy in adult stroke therapy. We previously reported that acute administration of docosahexaenoic acid (DHA) triglyceride emulsion (tri-DHA) protects against hypoxic-ischemic (HI) injury in neonatal mice. We que...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.618419

    authors: Manual Kollareth DJ,Zirpoli H,Ten VS,Deckelbaum RJ

    更新日期:2021-01-15 00:00:00

  • Cervical and Ocular Vestibular-Evoked Myogenic Potentials in Patients With Intracochlear Schwannomas.

    abstract::Objective: To evaluate ocular and cervical vestibular evoked myogenic potentials (oVEMPs and cVEMPs) in patients with solely intracochlear localization of an intralabyrinthine schwannoma (ILS). Study Design: Retrospective analysis of a series of cases. Setting: Monocentric study at a tertiary referral center. Patients...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.549817

    authors: Fröhlich L,Curthoys IS,Kösling S,Obrist D,Rahne T,Plontke SK

    更新日期:2020-10-27 00:00:00

  • Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target?

    abstract::Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway during sleep leading to intermittent hypoxia (IH). OSA has been associated with all components of the metabolic syndrome as well as with non-alcoholic fatty liver disease (NAFLD). NAFLD is a common condition ranging in severity from uncomplicat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00149

    authors: Mirrakhimov AE,Polotsky VY

    更新日期:2012-10-17 00:00:00

  • Nomogram for Stability Stratification of Small Intracranial Aneurysm Based on Clinical and Morphological Risk Factors.

    abstract::Background and Purpose: Stability stratification of intracranial aneurysms (IAs) is crucial for individualized clinical management, especially for small IAs. We aim to develop and validate a nomogram based on clinical and morphological risk factors for individualized instability stratification of small IAs. Methods: S...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.598740

    authors: Zhu W,Li W,Tian Z,Zhang M,Zhang Y,Wang K,Zhang Y,Yang X,Liu J

    更新日期:2021-01-15 00:00:00

  • The Role of Decompressive Craniectomy in the Context of Severe Traumatic Brain Injury: Summary of Results and Analysis of the Confidence Level of Conclusions From Systematic Reviews and Meta-Analyses.

    abstract::Introduction: Traumatic brain injury (TBI) is a global epidemic. The incidence of TBI in low and middle-income countries (LMICs) is three times greater than in high-income countries (HICs). Decompressive craniectomy (DC) is a surgical procedure to reduce intracranial pressure (ICP) and prevent secondary injury. Multip...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01063

    authors: Rubiano AM,Carney N,Khan AA,Ammirati M

    更新日期:2019-10-10 00:00:00

  • Correlational Analysis of ALS Progression and Serum NfL Measured by Simoa Assay in Chinese Patients.

    abstract::Background: Neurofilament light chain (NFL) was believed to be a promising biomarker for the diagnosis of Amyotrophic lateral sclerosis (ALS) and disease burden evaluation. Objective: To determine the serum NFL level and its clinical relevance, including its association with disease severity [evaluated by the ALS Func...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.579094

    authors: Sugimoto K,Han Y,Song Y,Gao Y

    更新日期:2020-12-03 00:00:00

  • Ocular Tremor in Parkinson's Disease: Discussion, Debate, and Controversy.

    abstract::The identification of ocular tremor in a small cohort of patients with Parkinson's disease (PD) had lay somewhat dormant until the recent report of a pervasive ocular tremor as a universal finding in a large PD cohort that was, however, generally absent from a cohort of age-matched healthy subjects. The reported tremo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00134

    authors: Kaski D,Bronstein AM

    更新日期:2017-04-24 00:00:00

  • A Novel Variant in ABCD1 Gene Presenting as Adolescent-Onset Atypical Adrenomyeloneuropathy With Spastic Ataxia.

    abstract::X-linked adrenoleukodystrophy (X-ALD) is a rare neurological disorder with a highly complex clinical presentation. Adrenal function, spinal cord, peripheral nerves, and cerebral white matter are commonly affected in adult-onset male patients. Here, we report a family with unusual presentation of X-ALD. The 19-year-old...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2018.00271

    authors: Chen Y,Zhang J,Wang J,Wang K

    更新日期:2018-04-23 00:00:00

  • Cerebrospinal Fluid Concentrations of Neuronal Proteins Are Reduced in Primary Angiitis of the Central Nervous System.

    abstract::Primary angiitis of the central nervous system (PACNS) is a rare autoimmune vasculitis limited to the CNS often causing substantial disability. Understanding of this disease is impaired by the lack of available biomaterial. Here, we collected cerebrospinal fluid (CSF) from patients with PACNS and matched controls and ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00407

    authors: Ruland T,Wolbert J,Gottschalk MG,König S,Schulte-Mecklenbeck A,Minnerup J,Meuth SG,Groß CC,Wiendl H,Meyer Zu Hörste G

    更新日期:2018-06-05 00:00:00

  • Prevalence of Vestibular Disorder in Older People Who Experience Dizziness.

    abstract::Dizziness and imbalance are clinically poorly defined terms, which affect ~30% of people over 65 years of age. In these people, it is often difficult to define the primary cause of dizziness, as it can stem from cardiovascular, vestibular, psychological, and neuromuscular causes. However, identification of the primary...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2015.00268

    authors: Chau AT,Menant JC,Hübner PP,Lord SR,Migliaccio AA

    更新日期:2015-12-24 00:00:00

  • Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China.

    abstract::The relationship between body mass index (BMI) and stroke type has remained controversial despite studies demonstrating that BMI is related to stroke risk, especially in specific groups. We assessed the age- and sex-associated impacts of BMI on stroke type in a low-income, poorly educated population in China. The asso...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00456

    authors: Gu H,Shao S,Liu J,Fan Z,Chen Y,Ni J,Wang C,Tu J,Ning X,Lou Y,Li B,Wang J

    更新日期:2019-05-01 00:00:00

  • Uric Acid and Clinical Outcomes Among Intracerebral Hemorrhage Patients: Results From the China Stroke Center Alliance.

    abstract::Background and Purpose: The effect of uric acid (UA) levels on severity and prognosis of spontaneous intracerebral hemorrhage (ICH) remains controversial. We aimed to explore the association of admission UA levels with stroke severity and outcomes in ICH patients. Materials and Methods: The patients enrolled in this s...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.609938

    authors: Liu X,Cao Z,Gu H,Yang K,Ji R,Li Z,Zhao X,Wang Y

    更新日期:2020-12-03 00:00:00

  • Predictors for Psychological Distress 2 Months After Mild Traumatic Brain Injury.

    abstract::Objective: To predict psychological distress at 2 months for patients with mild traumatic brain injury. Method: A prospective cohort study of 162 patients with mild traumatic brain injury (MTBI) admitted consecutively to an outpatient clinic at Haukeland University Hospital, Norway. Demographic data were obtained from...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00639

    authors: Vikane E,Frøyland K,Næss HL,Aßmus J,Skouen JS

    更新日期:2019-06-18 00:00:00

  • Treating Patients Like Athletes: Sports Science Applied to Parkinson's Disease.

    abstract::The evidence demonstrating the benefits of exercise is indisputable for healthy subjects, and more recently, it is growing for Parkinson's disease (PD) patients. Due to its easy access, low cost, social facilitation and, above all, the symptomatic effect, clinical exercise may have a profound impact on PD management. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00228

    authors: Bouça-Machado R,Venturelli M,Tinazzi M,Schena F,Ferreira JJ

    更新日期:2020-04-02 00:00:00

  • Transplantation of Embryonic Neural Stem Cells and Differentiated Cells in a Controlled Cortical Impact (CCI) Model of Adult Mouse Somatosensory Cortex.

    abstract::Traumatic brain injury (TBI) is a major cause of death worldwide. Depending on the severity of the injury, TBI can reflect a broad range of consequences such as speech impairment, memory disturbances, and premature death. In this study, embryonic neural stem cells (ENSC) were isolated from E14 mouse embryos and cultur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00895

    authors: Nasser M,Ballout N,Mantash S,Bejjani F,Najdi F,Ramadan N,Soueid J,Zibara K,Kobeissy F

    更新日期:2018-10-24 00:00:00

  • Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces.

    abstract::Objectives: Enlarged perivascular spaces in the basal ganglia (BG-EPVS) share common vascular risk factors with atherosclerosis. However, little is known about the relationship between steno-occlusive middle cerebral artery (MCA) and BG-EPVS. In this cross-sectional study, we aimed to test the hypothesis that severe M...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00293

    authors: Du H,Chen C,Ye C,Lin F,Wei J,Xia P,Chen R,Wu S,Yuan Q,Chen H,Xiao Y,Liu N

    更新日期:2020-04-23 00:00:00

  • Cellular Biology of Tau Diversity and Pathogenic Conformers.

    abstract::Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and cell biology of this cytoplasmic protein. Tau's wayward properties may derive from germline mutations in the case of frontotemporal lobar degeneration (FTLD-MAPT)...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.590199

    authors: Kang SG,Eskandari-Sedighi G,Hromadkova L,Safar JG,Westaway D

    更新日期:2020-11-12 00:00:00

  • Examining the Utility of Resective Epilepsy Surgery in Children With Electrical Status Epilepticus in Sleep: Long Term Clinical and Electrophysiological Outcomes.

    abstract::Background: Electrical Status Epilepticus in Sleep (ESES) is an epileptic encephalopathy syndrome characterized by infrequent clinical seizures and prominent interictal burden during slow wave sleep associated with cognitive deficits and behavioral dysfunction. Medical treatment with anti-epileptic drugs is often unsu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01397

    authors: Marashly A,Koop J,Loman M,Lee YW,Lew SM

    更新日期:2020-01-15 00:00:00

  • Consumer Demand for Online Dizziness Information: If You Build it, They may Come.

    abstract:OBJECTIVE:Dizziness is a common reason patients present to doctors, but effective diagnostic tests and treatments for dizziness are underused. The internet is a way to disseminate medical information and is emerging as an intervention platform. The objective of this study was to describe internet searches for dizziness...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00050

    authors: Kerber KA,Skolarus LE,Callaghan BC,Zheng K,Zhang Y,An LC,Burke JF

    更新日期:2014-04-16 00:00:00