Dynamic Alterations of Spontaneous Neural Activity in Parkinson's Disease: A Resting-State fMRI Study.

Abstract:

:Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs. Methods: Twenty-eight patients with PD and 28 demographically matched HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and neuropsychological tests. A dynamic method was used to calculate the dALFFs of rs-fMRI data obtained from all subjects. The dALFF alterations were compared between the PD and HC groups, and the correlations between dALFF variability and disease duration/neuropsychological tests were further calculated. Then, the statistical differences in dALFF between both groups were selected as classification features to help distinguish patients with PD from HCs through a linear support vector machine (SVM) classifier. The classifier performance was assessed using a permutation test (repeated 5,000 times). Results: Significantly increased dALFF was detected in the left precuneus in patients with PD compared to HCs, and dALFF variability in this region was positively correlated with disease duration. Our results show that 80.36% (p < 0.001) subjects were correctly classified based on the SVM classifier by using the leave-one-out cross-validation method. Conclusion: Patients with PD exhibited abnormal dynamic brain activity in the left precuneus, and the dALFF variability could distinguish PD from HCs with high accuracy. Our results showed novel insights into the pathophysiological mechanisms of PD.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Zhang C,Dou B,Wang J,Xu K,Zhang H,Sami MU,Hu C,Rong Y,Xiao Q,Chen N,Li K

doi

10.3389/fneur.2019.01052

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

1052

issn

1664-2295

journal_volume

10

pub_type

杂志文章
  • TuberOus SClerosis Registry to Increase Disease Awareness: A Review on Alignment of Its Planning, Execution, and Publications With European Medicines Agency Guidelines.

    abstract::Patient registries offer a powerful and practical means of real-world data collection system for rare diseases. Many guidelines have been released to standardize patient registries, although most of them do not address issues specific to rare disease patient registries. In November 2018, the European Medicines Agency ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00365

    authors: Marques R,Thole H,Ruiz de Morales JG

    更新日期:2020-05-15 00:00:00

  • Surface Electromyography in Physiotherapist Educational Program in France: Enhancing Learning sEMG in Stretching Practice.

    abstract::Surface electromyography (sEMG) is a non-invasive method, which may be used in France by health practitioners without medical degree, such as physiotherapists, who are taught in Institutes of physiotherapy. However, very few hours are devoted to sEMG teaching in physiotherapist educational programs, especially in a fo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.584304

    authors: Portero P,Dogadov AA,Servière C,Quaine F

    更新日期:2020-12-03 00:00:00

  • Hemodynamics of Prefrontal Cortex in Ornithine Transcarbamylase Deficiency: A Twin Case Study.

    abstract::Ornithine transcarbamylase deficiency (OTCD) is the most common form of urea cycle disorder characterized by the presence of hyperammonemia (HA). In patients with OTCD, HA is known to cause impairments in domains of executive function and working memory. Monitoring OTCD progression and investigating neurocognitive bio...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00809

    authors: Anderson AA,Gropman A,Le Mons C,Stratakis CA,Gandjbakhche AH

    更新日期:2020-08-14 00:00:00

  • Transcranial Direct Current Stimulation in Patients with Prolonged Disorders of Consciousness: Combined Behavioral and Event-Related Potential Evidence.

    abstract:Background:The electrophysiological evidence supporting the therapeutic efficacy of multiple transcranial direct current stimulation (tDCS) sessions on consciousness improvement in patients with prolonged disorders of consciousness (DOCs) has not been firmly established. Objectives:To assess the effects of repeated tD...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00620

    authors: Zhang Y,Song W,Du J,Huo S,Shan G,Li R

    更新日期:2017-11-21 00:00:00

  • Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-AD Biomarkers.

    abstract:INTRODUCTION:Core cerebrospinal fluid (CSF) biomarkers - Aβ42, Tau, and phosphorylated Tau (pTau) - have been recently incorporated in the revised criteria for Alzheimer's disease (AD). However, their widespread clinical application lacks standardization. Pre-analytical sample handling and storage play an important rol...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2015.00153

    authors: Leitão MJ,Baldeiras I,Herukka SK,Pikkarainen M,Leinonen V,Simonsen AH,Perret-Liaudet A,Fourier A,Quadrio I,Veiga PM,de Oliveira CR

    更新日期:2015-07-08 00:00:00

  • Occipital Lobe Epilepsy With Ictal Fear: Evidence From a Stereo-Electroencephalography (sEEG) Case.

    abstract::Ictal fear-a relatively rare phenomenon-is a semiological characteristic of epilepsy. Most patients with epilepsy with ictal fear have an epileptic zone in the mesial temporal lobe, which is the classical brain area involved in emotion processing. Herein, we report a case of epilepsy with ictal fear as the first manif...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2018.00644

    authors: Wang J,Wang Q,Wang M,Luan G,Zhou J,Guan Y,Yan Z

    更新日期:2018-08-07 00:00:00

  • First Attack and Clinical Presentation of Hemiplegic Migraine in Pediatric Age: A Multicenter Retrospective Study and Literature Review.

    abstract::Background: Data on clinical presentation of Hemiplegic Migraine (HM) are quite limited in the literature, particularly in the pediatric age. The aim of the present study is to describe in detail the phenotypic features at onset and during the first years of disease of sporadic (SHM) and familial (FHM) pediatric hemip...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01079

    authors: Toldo I,Brunello F,Morao V,Perissinotto E,Valeriani M,Pruna D,Tozzi E,Moscano F,Farello G,Frusciante R,Carotenuto M,Lisotto C,Ruffatti S,Maggioni F,Termine C,Di Rosa G,Nosadini M,Sartori S,Battistella PA

    更新日期:2019-10-15 00:00:00

  • Short-Term Test-Retest Reliability of Electrically Evoked Cortical Auditory Potentials in Adult Cochlear Implant Recipients.

    abstract::Background: Late latency auditory evoked potentials (LLAEPs) provide objective evidence of an individual's central auditory processing abilities. Electrically evoked cortical auditory evoked potentials (eCAEPs) are a type of LLAEP that provides an objective measure of aided speech perception and auditory processing ab...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00305

    authors: Pike M,Biagio-de Jager L,le Roux T,Hofmeyr LM

    更新日期:2020-04-28 00:00:00

  • The vestibular implant: quo vadis?

    abstract:OBJECTIVE:To assess the progress of the development of the vestibular implant (VI) and its feasibility short-term. DATA SOURCES:A search was performed in Pubmed, Medline, and Embase. Key words used were "vestibular prosth*" and "VI." The only search limit was language: English or Dutch. Additional sources were medical...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2011.00047

    authors: van de Berg R,Guinand N,Stokroos RJ,Guyot JP,Kingma H

    更新日期:2011-08-11 00:00:00

  • Erratum: Standards in Pupillography.

    abstract::[This corrects the article DOI: 10.3389/fneur.2019.00129.]. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fneur.2019.00371

    authors: Frontiers Production Office.

    更新日期:2019-03-27 00:00:00

  • Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke.

    abstract:BACKGROUND:The present review investigated which findings in vascular imaging techniques can be used to predict clinical outcome and the risk of symptomatic intracerebral hemorrhage (sICH) in patients who underwent intravenous thrombolytic treatment. METHODS:Publications were searched, and the inclusion criteria were ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2016.00077

    authors: Nogueira RC,Bor-Seng-Shu E,Saeed NP,Teixeira MJ,Panerai RB,Robinson TG

    更新日期:2016-05-18 00:00:00

  • Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis.

    abstract::Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00525

    authors: Czekóová K,Shaw DJ,Saxunová K,Dufek M,Mareček R,Vaníček J,Brázdil M

    更新日期:2019-05-21 00:00:00

  • Poststroke Depression Biomarkers: A Narrative Review.

    abstract::Poststroke depression (PSD) is the most prevalent psychiatric disorder after stroke, which is independently correlated with negative clinical outcome. The identification of specific biomarkers could help to increase the sensitivity of PSD diagnosis and elucidate its pathophysiological mechanisms. The aim of current st...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.00577

    authors: Levada OA,Troyan AS

    更新日期:2018-07-16 00:00:00

  • Risk Factors of External Ventricular Drain Infection: Proposing a Model for Future Studies.

    abstract::Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this rev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00226

    authors: Sorinola A,Buki A,Sandor J,Czeiter E

    更新日期:2019-03-15 00:00:00

  • N-acetylcysteine Amide Ameliorates Blast-Induced Changes in Blood-Brain Barrier Integrity in Rats.

    abstract::Traumatic brain injury resulting from exposure to blast overpressure (BOP) is associated with neuropathology including impairment of the blood-brain barrier (BBB). This study examined the effects of repeated exposure to primary BOP and post-blast treatment with an antioxidant, N-acetylcysteine amide (NACA) on the inte...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00650

    authors: Kawoos U,Abutarboush R,Zarriello S,Qadri A,Ahlers ST,McCarron RM,Chavko M

    更新日期:2019-06-26 00:00:00

  • Hemorrhagic Cerebrovascular Pathology in the Pediatric Population.

    abstract::Hemorrhagic cerebrovascular disease in the pediatric population can have devastating and long-term effects. Progress in the fields of genetics, neuroimaging, pharmacology, and surgical techniques has led to improved diagnosis and management of pediatric cerebrovascular diseases. In this review we discuss the current e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.01055

    authors: Guerrero WR,Dandapat S,Ortega-Gutierrez S

    更新日期:2020-09-17 00:00:00

  • Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury.

    abstract::The endothelium is a thin monolayer of specialized cells that lines the luminal wall of blood vessels and constitutes the critical innermost portion of the physical barrier between the blood and the brain termed the blood-brain barrier (BBB). Aberrant changes in the endothelium occur in many neuropathological states, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00582

    authors: Lutton EM,Farney SK,Andrews AM,Shuvaev VV,Chuang GY,Muzykantov VR,Ramirez SH

    更新日期:2019-06-06 00:00:00

  • GNE Myopathy With Novel Mutations and Pronounced Paraspinal Muscle Atrophy.

    abstract::GNE myopathy is characterized by distal muscle weakness, and caused by recessive mutations in GNE. Its onset is characteristically in young adulthood, although a broad spectrum of onset age is known to exist. A large number of mutations in GNE are pathogenic and this clinical phenotype can be difficult to differentiat...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2018.00942

    authors: Soule T,Phan C,White C,Resch L,Lacson A,Martens K,Pfeffer G

    更新日期:2018-11-08 00:00:00

  • Abnormal Brain Network Topology During Non-rapid Eye Movement Sleep and Its Correlation With Cognitive Behavioral Abnormalities in Narcolepsy Type 1.

    abstract::Objective: Simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) were applied to investigate the abnormalities in the topological characteristics of functional brain networks during non-rapid eye movement(NREM)sleep. And we investigated its relationship with cognitive abnormalities...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.617827

    authors: Zhu X,Ni K,Tan H,Liu Y,Zeng Y,Yu B,Guo Q,Xiao L

    更新日期:2021-01-11 00:00:00

  • α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation.

    abstract:Background:Temporal lobe epilepsy (TLE) is one of the most drug-resistant types of epilepsy with about 80% of TLE patients falling into this category. Increasing evidence suggests that neuroinflammation, which has a critical role in the epileptogenesis of TLE, is associated with microglial activation. Therefore, agents...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00661

    authors: Liu HJ,Lai X,Xu Y,Miao JK,Li C,Liu JY,Hua YY,Ma Q,Chen Q

    更新日期:2017-12-14 00:00:00

  • Case Report: 18F-MK6240 Tau Positron Emission Tomography Pattern Resembling Chronic Traumatic Encephalopathy in a Retired Australian Rules Football Player.

    abstract::Introduction: It remains unclear if tau imaging may assist diagnosis of chronic traumatic encephalopathy (CTE). Flortaucipir PET has shown superior frontal with medial temporal tau binding consistent with the provisional neuropathological criteria for mid-stage CTE in group-level analyses of retired symptomatic NFL pl...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.598980

    authors: Krishnadas N,Doré V,Lamb F,Groot C,McCrory P,Guzman R,Mulligan R,Huang K,O'Donnell M,Ponsford J,Hopwood M,Villemagne VL,Rowe CC

    更新日期:2020-12-22 00:00:00

  • The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the health of millions of people in the United States and worldwide. Currently, there are no approved therapies that can halt or reverse the clinical progression of AD. Traditionally, AD is characterized first by the appearance of a...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.570711

    authors: Hanslik KL,Ulland TK

    更新日期:2020-09-18 00:00:00

  • Microscopic Polyangiitis With Selective Involvement of Central and Peripheral Nervous System: A Case Report.

    abstract::Background: Microscopic polyangiitis (MPA) is a necrotizing vasculitis that affects predominantly small-sized vessels in many organ systems. The disease generally causes glomerulonephritis, pulmonary damage, arthritis, and neuropathy. An exclusive involvement of both central nervous system (CNS) and peripheral nervous...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.00269

    authors: Arienti F,Franco G,Monfrini E,Santaniello A,Bresolin N,Saetti MC,Di Fonzo A

    更新日期:2020-04-28 00:00:00

  • Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study.

    abstract::This study presents the first implementation of functional ultrasound (fUS) imaging of the spinal cord to monitor local hemodynamic response to epidural electrical spinal cord stimulation (SCS) on two small and large animal models. SCS has been successfully applied to control chronic refractory pain and recently was e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00279

    authors: Song P,Cuellar CA,Tang S,Islam R,Wen H,Huang C,Manduca A,Trzasko JD,Knudsen BE,Lee KH,Chen S,Lavrov IA

    更新日期:2019-03-26 00:00:00

  • Sex-Specific Differences in Rodents Following a Single Primary Blast Exposure: Focus on the Monoamine and Galanin Systems.

    abstract::Most blast-induced traumatic brain injuries (bTBI) are mild in severity and culpable for the lingering and persistent neuropsychological complaints in affected individuals. There is evidence that the prevalence of symptoms post-exposure may be sex-specific. Our laboratory has focused on changes in the monoamine and th...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.540144

    authors: Kawa L,Arborelius UP,Hökfelt T,Risling M

    更新日期:2020-10-15 00:00:00

  • Default Mode Network Connectivity Predicts Emotion Recognition and Social Integration After Traumatic Brain Injury.

    abstract::Moderate-severe traumatic brain injury (TBI) may result in difficulty with emotion recognition, which has negative implications for social functioning. As aspects of social cognition have been linked to resting-state functional connectivity (RSFC) in the default mode network (DMN), we sought to determine whether DMN c...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00825

    authors: Lancaster K,Venkatesan UM,Lengenfelder J,Genova HM

    更新日期:2019-08-09 00:00:00

  • Role of intravenous levetiracetam in seizure prophylaxis of severe traumatic brain injury patients.

    abstract::Traumatic brain injury (TBI) can cause seizures and the development of epilepsy. The incidence of seizures varies from 21% in patients with severe brain injuries to 50% in patients with war-related penetrating TBI. In the acute and sub-acute periods following injury, seizures can lead to increased intracranial pressur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2013.00170

    authors: Kirmani BF,Mungall D,Ling G

    更新日期:2013-11-01 00:00:00

  • Alterations of Elastic Property of Spastic Muscle With Its Joint Resistance Evaluated From Shear Wave Elastography and Biomechanical Model.

    abstract::This study aims to quantify passive muscle stiffness of spastic wrist flexors in stroke survivors using shear wave elastography (SWE) and to correlate with neural and non-neural contributors estimated from a biomechanical model to hyper-resistance measured during passive wrist extension. Fifteen hemiplegic individuals...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00736

    authors: Leng Y,Wang Z,Bian R,Lo WLA,Xie X,Wang R,Huang D,Li L

    更新日期:2019-07-10 00:00:00

  • Case Report: Candida dubliniensis as a Cause of Chronic Meningitis.

    abstract::Background:Candida dubliniensis is closely related to Candida albicans and rarely isolated in clinical specimens. C. dubliniensis is increasingly recognized as a pathogen in immunocompromised hosts. We present the third known case of Candida dubliniensis meningitis in a young immunocompetent host. Case Presentation: A...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.601242

    authors: Tahir M,Peseski AM,Jordan SJ

    更新日期:2020-12-08 00:00:00

  • Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus Improves Patient Outcomes: A Nationwide Hospital-Based Survey in Japan.

    abstract::Background and Purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted a cross-sectional study using data from a nationwide epidemiological sur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00421

    authors: Nakajima M,Miyajima M,Ogino I,Akiba C,Kawamura K,Kurosawa M,Kuriyama N,Watanabe Y,Fukushima W,Mori E,Kato T,Sugano H,Karagiozov K,Arai H

    更新日期:2018-06-07 00:00:00