Effects of Higher Serum Lipid Levels on the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis.

Abstract:

:Background: The causal relationship between serum lipid levels and the risk of Parkinson's disease (PD) remains largely uncertain. We summarized the existing controversial evidence on this topic. Methods: We searched the electronic databases for observational studies from January 1988 to March 2020. We applied random-effects models to calculate pooled relative risk (RR) with their 95% confidence intervals (CI). Random-effects dose-response meta-analyses were further conducted to explore the dose-risk relationship. Results: Twelve cohort studies and three case-control studies were included in this meta-analysis. Higher levels of serum low-density lipoprotein cholesterol (LDL-C) were inversely associated with the subsequent risk of PD (RR 0.73, 95% CI 0.57-0.93), whereas, there were no associations between serum levels of total cholesterol (TC) (RR 0.91, 95% CI 0.73-1.13), high-density lipoprotein cholesterol (HDL-C) (RR 0.97, 95% CI 0.73-1.27), or triglycerides (TG) (RR 0.85, 95% CI 0.55-1.29) and the risk of PD. Further dose-response meta-analysis revealed that every 38.6 mg/dL (1mmol/L) increase in serum LDL-C correlates with a 7% decreased risk of PD. Conclusions: Our paper supports the protective effect of higher serum LDL-C on the subsequent risk of PD. More prospective cohort studies are warranted to confirm the conclusion, and further fundamental researches are needed to elucidate the underlying biological mechanisms.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Jiang Z,Xu X,Gu X,Ou R,Luo X,Shang H,Song W

doi

10.3389/fneur.2020.00597

subject

Has Abstract

pub_date

2020-06-26 00:00:00

pages

597

issn

1664-2295

journal_volume

11

pub_type

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  • Sonification of Arm Movements in Stroke Rehabilitation - A Novel Approach in Neurologic Music Therapy.

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    更新日期:2017-04-25 00:00:00

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    doi:10.3389/fneur.2019.00252

    authors: Srinivasan S,Vyas K,McAvoy M,Calvaresi P,Khan OF,Langer R,Anderson DG,Herr H

    更新日期:2019-03-22 00:00:00

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    doi:10.3389/fneur.2020.609938

    authors: Liu X,Cao Z,Gu H,Yang K,Ji R,Li Z,Zhao X,Wang Y

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    pub_type:

    doi:10.3389/fneur.2019.00064

    authors: Jia Y,Lin Y,Li J,Li M,Zhang Y,Hou Y,Liu A,Zhang L,Li L,Xiang P,Ye J,Huang Z,Wang Y

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