Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target?


:Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway during sleep leading to intermittent hypoxia (IH). OSA has been associated with all components of the metabolic syndrome as well as with non-alcoholic fatty liver disease (NAFLD). NAFLD is a common condition ranging in severity from uncomplicated hepatic steatosis to steatohepatitis (NASH), liver fibrosis, and cirrhosis. The gold standard for the diagnosis and staging of NAFLD is liver biopsy. Obesity and insulin resistance lead to liver steatosis, but the causes of the progression to NASH are not known. Emerging evidence suggests that OSA may play a role in the progression of hepatic steatosis and the development of NASH. Several cross-sectional studies showed that the severity of IH in patients with OSA predicted the severity of NAFLD on liver biopsy. However, neither prospective nor interventional studies with continuous positive airway pressure treatment have been performed. Studies in a mouse model showed that IH causes triglyceride accumulation in the liver and liver injury as well as hepatic inflammation. The mouse model provided insight in the pathogenesis of liver injury showing that (1) IH accelerates the progression of hepatic steatosis by inducing adipose tissue lipolysis and increasing free fatty acids (FFA) flux into the liver; (2) IH up-regulates lipid biosynthetic pathways in the liver; (3) IH induces oxidative stress in the liver; (4) IH up-regulates hypoxia inducible factor 1 alpha and possibly HIF-2 alpha, which may increase hepatic steatosis and induce liver inflammation and fibrosis. However, the role of FFA and different transcription factors in the pathogenesis of IH-induced NAFLD is yet to be established. Thus, multiple lines of evidence suggest that IH of OSA may contribute to the progression of NAFLD but definitive clinical studies and experiments in the mouse model have yet to be done.


Front Neurol


Frontiers in neurology


Mirrakhimov AE,Polotsky VY




Has Abstract


2012-10-17 00:00:00








  • Longitudinal Bedside Assessments of Brain Networks in Disorders of Consciousness: Case Reports From the Field.

    abstract::Clinicians are regularly faced with the difficult challenge of diagnosing consciousness after severe brain injury. As such, as many as 40% of minimally conscious patients who demonstrate fluctuations in arousal and awareness are known to be misdiagnosed as unresponsive/vegetative based on clinical consensus. Further, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Bareham CA,Allanson J,Roberts N,Hutchinson PJA,Pickard JD,Menon DK,Chennu S

    更新日期:2018-08-21 00:00:00

  • Postural and Intention Tremors: A Detailed Clinical Study of Essential Tremor vs. Parkinson's Disease.

    abstract:BACKGROUND:An estimated 30-50% of essential tremor (ET) diagnoses are incorrect, and the true diagnosis in those patients is often Parkinson's disease (PD) or other tremor disorders. There are general statements about the tremor in these ET and PD, but published data on the more subtle characteristics of tremor are sur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sternberg EJ,Alcalay RN,Levy OA,Louis ED

    更新日期:2013-05-10 00:00:00

  • Cochlear Implantation of Bilaterally Deafened Patients with Tinnitus Induces Sustained Decrease of Tinnitus-Related Distress.

    abstract:OBJECTIVE:Tinnitus is a common symptom of hearing impairment. Patients who are bilaterally hard of hearing are often affected by tinnitus. However, they cannot undergo any of the standard tinnitus therapies, since they rely on hearing. Cochlear implantation (CI) used to treat severe hearing disabilities, such as bilate...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Knopke S,Szczepek AJ,Häussler SM,Gräbel S,Olze H

    更新日期:2017-04-25 00:00:00

  • Muscle Fatigue Post-stroke Elicited From Kilohertz-Frequency Subthreshold Nerve Stimulation.

    abstract::Purpose: Rapid muscle fatigue limits clinical applications of functional electrical stimulation (FES) for individuals with motor impairments. This study aimed to characterize the sustainability of muscle force elicited with a novel transcutaneous nerve stimulation technique. Method: A hemiplegic chronic stroke survivo...

    journal_title:Frontiers in neurology



    authors: Zheng Y,Shin H,Hu X

    更新日期:2018-12-04 00:00:00

  • Progressive Cerebral Small Vessel Disease Caused by an Autoimmune Response to Intravesical Bacille-Calmette-Guérin Treatment.

    abstract::Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer. We present the case of an 83-years-old male patient with rapid progressive symptoms of dementia up to mutism as well as tonic seizures. Immune-mediate...

    journal_title:Frontiers in neurology



    authors: Becker A,Grunwald IQ,Unger MM,Behnke S,Spiegel J,Yilmaz U,Walter S,Faßbender K

    更新日期:2020-10-26 00:00:00

  • α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation.

    abstract:Background:Temporal lobe epilepsy (TLE) is one of the most drug-resistant types of epilepsy with about 80% of TLE patients falling into this category. Increasing evidence suggests that neuroinflammation, which has a critical role in the epileptogenesis of TLE, is associated with microglial activation. Therefore, agents...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Liu HJ,Lai X,Xu Y,Miao JK,Li C,Liu JY,Hua YY,Ma Q,Chen Q

    更新日期:2017-12-14 00:00:00

  • Aberrant Oscillatory Activity during Simple Movement in Task-Specific Focal Hand Dystonia.

    abstract::In task-specific focal hand dystonia (tspFHD), the temporal dynamics of cortical activity in the motor system and how these processes are related to impairments in sensory and motor function are poorly understood. Here, we use time-frequency reconstructions of magnetoencephalographic (MEG) data to elaborate the tempor...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hinkley LB,Dolberg R,Honma S,Findlay A,Byl NN,Nagarajan SS

    更新日期:2012-11-28 00:00:00

  • Hemorrhagic Transformation in Ischemic Moyamoya Disease: Clinical Characteristics, Radiological Features, and Outcomes.

    abstract::Objective: Hemorrhagic transformation (HT) in ischemic moyamoya disease (MMD), reasonably defined as hemorrhage events in patients with ischemic onset manifestation, leads to a poor outcome. This study aims to reveal factors associated with HT in patients with ischemic onset manifestation and to assess the outcome of ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lu J,Li Z,Zhao Y,Chen X,Shi G,Zhao J

    更新日期:2020-06-25 00:00:00

  • Improvement After Vestibular Rehabilitation Not Explained by Improved Passive VOR Gain.

    abstract::Gaze stability exercises are a critical component of vestibular rehabilitation for individuals with vestibular hypofunction and many studies reveal the rehabilitation improves functional performance. However, few studies have examined the vestibular physiologic mechanisms (semicircular canal; otolith) responsible for ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Millar JL,Gimmon Y,Roberts D,Schubert MC

    更新日期:2020-02-20 00:00:00

  • Cranioplasty Following Decompressive Craniectomy.

    abstract::Cranioplasty (CP) after decompressive craniectomy (DC) for trauma is a neurosurgical procedure that aims to restore esthesis, improve cerebrospinal fluid (CSF) dynamics, and provide cerebral protection. In turn, this can facilitate neurological rehabilitation and potentially enhance neurological recovery. However, CP ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Iaccarino C,Kolias AG,Roumy LG,Fountas K,Adeleye AO

    更新日期:2020-01-29 00:00:00

  • Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke.

    abstract::Study Objectives: Coronary artery disease is considered to be the major cause of death amongst patients with ischemic stroke. The coronary artery calcium (CAC) score is related not only to sleep-disordered breathing, but also with future risk of cardiovascular mortality. We investigated the association between the sev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cho KH,Lee DH,Kim KM,Choi YH,Nam HS,Heo JH,Heo K,Kim YD

    更新日期:2019-07-31 00:00:00

  • Pathomechanisms of a CLCN1 Mutation Found in a Russian Family Suffering From Becker's Myotonia.

    abstract::Objective: Myotonia congenita (MC) is a rare muscle disease characterized by sarcolemma over-excitability inducing skeletal muscle stiffness. It can be inherited either as an autosomal dominant (Thomsen's disease) or an autosomal recessive (Becker's disease) trait. Both types are caused by loss-of-function mutations i...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Altamura C,Ivanova EA,Imbrici P,Conte E,Camerino GM,Dadali EL,Polyakov AV,Kurbatov SA,Girolamo F,Carratù MR,Desaphy JF

    更新日期:2020-09-04 00:00:00

  • Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology.

    abstract::Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: La Morgia C,Carelli V,Carbonelli M

    更新日期:2018-12-07 00:00:00

  • Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease.

    abstract::Lifestyle factors such as intellectual stimulation, cognitive and social engagement, nutrition, and various types of exercise appear to reduce the risk for common age-associated disorders such as Alzheimer's disease (AD) and vascular dementia. In fact, many studies have suggested that promoting physical activity can h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Foster PP,Rosenblatt KP,Kuljiš RO

    更新日期:2011-05-06 00:00:00

  • Gene-Related Cerebellar Neurodegeneration in SCA3/MJD: A Case-Controlled Imaging-Genetic Study.

    abstract::Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is one of the nine polyglutamine (polyQ) diseases and is caused by a CAG repeat expansion within the coding sequence of the ATXN3 gene. Few multimodal imaging analyses of the macro- and micro-structural changes have been performed. Methods: In...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Peng H,Liang X,Long Z,Chen Z,Shi Y,Xia K,Meng L,Tang B,Qiu R,Jiang H

    更新日期:2019-09-24 00:00:00

  • Electroencephalography Network Effects of Corpus Callosotomy in Patients with Lennox-Gastaut Syndrome.

    abstract:OBJECTIVES:This study aimed to investigate the functional network effects of corpus callosotomy (CC), a well-recognized palliative surgical therapy for patients with Lennox-Gastaut syndrome (LGS). Specifically, we sought to gain insight into the effects of CC on LGS remission, based on brain networks in LGS by calculat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Liang JG,Lee D,Youn SE,Kim HD,Kim NY

    更新日期:2017-09-04 00:00:00

  • 3D Cinema and Headache: The First Evidential Relation and Analysis of Involved Factors.

    abstract:BACKGROUND:A possible link between 3D movies and headache (HA) has never been a target of specific and systematic investigations. The aim of this study was to investigate the relationship between 3D cinema and HA and to evaluate possible risk factors of developing HA during or after watching a 3D movie. METHODS:This w...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Braschinsky M,Raidvee A,Sabre L,Zmachinskaja N,Zukovskaja O,Karask A,Saar B,Rakitin A

    更新日期:2016-03-23 00:00:00

  • Association of Blood Pressure at Successful Recanalization and Parenchymal Hemorrhage After Mechanical Thrombectomy With General Anesthesia.

    abstract::Background: This study aims to investigate the association between blood pressure (BP) at the time of recanalization and hemorrhagic transformation in large vessel occlusion (LVO) patients following mechanical thrombectomy (MT) with general anesthesia. Methods: We retrospectively reviewed our data base for patients wi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cheng H,Xu C,Jin X,Chen Y,Zheng X,Shi F,He X,Hao Y,Jiang Y,Zhang J,Chen Z

    更新日期:2020-11-17 00:00:00

  • Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation.

    abstract:AIMS:Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts. Here, we explore the nature, the time course, and the role of the complement system in this damage. METHODS:The ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Granados-Durán P,López-Ávalos MD,Cifuentes M,Pérez-Martín M,Fernández-Arjona MD,Hughes TR,Johnson K,Morgan BP,Fernández-Llebrez P,Grondona JM

    更新日期:2017-03-07 00:00:00

  • Expression of Human Endogenous Retrovirus-K in Spinal and Bulbar Muscular Atrophy.

    abstract::Background: Spinal and Bulbar Muscular Atrophy (SBMA) is caused by the extension of the polyglutamine tract within the androgen receptor (AR) gene, and results in a multisystem presentation, including the degeneration of lower motor neurons. The androgen receptor (AR) is known to modulate the expression of endogenous ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rex C,Nadeau MJ,Douville R,Schellenberg K

    更新日期:2019-09-04 00:00:00

  • Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies.

    abstract::We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Seneviratne U,Boston RC,Cook MJ,D'Souza WJ

    更新日期:2018-02-19 00:00:00

  • Fasting versus post-challenge triglycerides and pre-existing cavitating lacunes: a berlin "cream & sugar" substudy.

    abstract:BACKGROUND AND PURPOSE:Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacun...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Leonards CO,Wang L,Fiebach JB,Endres M,Ebinger M

    更新日期:2013-07-10 00:00:00

  • Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex.

    abstract:BACKGROUND:Recent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation. CASE PRESENTATION:Her...

    journal_title:Frontiers in neurology



    authors: Vlaskamp C,Poil SS,Jansen F,Linkenkaer-Hansen K,Durston S,Oranje B,Bruining H

    更新日期:2017-09-08 00:00:00

  • Herpes Zoster Radiculomyelitis With Aquaporin-4 Antibodies: A Case Report and Literature Review.

    abstract::Background: The relationship between varicella-zoster virus (VZV)-associated myelitis and aquaporin-4 immunoglobulin-G (AQP4-IgG) remains unknown. Case Report: We report a case of acute radiculomyelitis with longitudinal extensive hyperintensity signals traversing the brainstem until the upper thoracic cord in a 55-ye...

    journal_title:Frontiers in neurology



    authors: Eguchi H,Takeshige H,Nakajima S,Kanou M,Nakajima A,Fuse A,Fukae J,Miwa H,Shimo Y

    更新日期:2020-11-23 00:00:00

  • Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease.

    abstract::Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furt...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Troncoso-Escudero P,Parra A,Nassif M,Vidal RL

    更新日期:2018-10-15 00:00:00

  • Patient Benefit Following Bimodal CI-provision: Self-reported Abilities vs. Hearing Status.

    abstract::Objectives: Patient-reported outcomes gain importance for the assessment of auditory abilities in cochlear implant users and for the evaluation of auditory rehabilitation. Aims of the study were to explore the interrelation of self-reported improvements in auditory ability with improvements in speech comprehension and...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wallhäusser-Franke E,Balkenhol T,Hetjens S,Rotter N,Servais JJ

    更新日期:2018-09-10 00:00:00

  • The Patterns of Recurrences in Idiopathic Benign Paroxysmal Positional Vertigo and Self-treatment Evaluation.

    abstract:Background and Objectives:Benign paroxysmal positional vertigo (BPPV) recurs frequently. This study aims to determine that each patient with BPPV has a predilection for a specific canal and the type of recurred BPPV can be predicted from that observed during the previous attack. Methods:The involved side (right, left,...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kim HJ,Kim JS

    更新日期:2017-12-15 00:00:00

  • Transplantation of Embryonic Neural Stem Cells and Differentiated Cells in a Controlled Cortical Impact (CCI) Model of Adult Mouse Somatosensory Cortex.

    abstract::Traumatic brain injury (TBI) is a major cause of death worldwide. Depending on the severity of the injury, TBI can reflect a broad range of consequences such as speech impairment, memory disturbances, and premature death. In this study, embryonic neural stem cells (ENSC) were isolated from E14 mouse embryos and cultur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Nasser M,Ballout N,Mantash S,Bejjani F,Najdi F,Ramadan N,Soueid J,Zibara K,Kobeissy F

    更新日期:2018-10-24 00:00:00

  • Endocrine Crosstalk Between Skeletal Muscle and the Brain.

    abstract::Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones which can exert autoc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Delezie J,Handschin C

    更新日期:2018-08-24 00:00:00

  • The Dominant-Subthalamic Nucleus Phenomenon in Bilateral Deep Brain Stimulation for Parkinson's Disease: Evidence from a Gait Analysis Study.

    abstract:Background:It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives:Since disability in...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rizzone MG,Ferrarin M,Lanotte MM,Lopiano L,Carpinella I

    更新日期:2017-10-30 00:00:00