Centrality of Early Synaptopathy in Parkinson's Disease.

abstract：:A synthetic peptide with antisecretory activity, antisecretory factor (AF)-16, improves injury-related deficits in water and ion transport and decreases intracranial pressure after experimental cold lesion injury and encephalitis although its role in traumatic brain injury (TBI) is unknown. AF-16 or an inactive refere...

journal_title：Frontiers in neurology

authors： Clausen F,Hansson HA,Raud J,Marklund N

更新日期：2017-02-14 00:00:00

abstract：:Background: Little is known about sleep and circadian rhythms in survivors of acute respiratory failure (ARF) after hospital discharge. Objectives: To examine sleep and rest-activity circadian rhythms in ARF survivors 3 months after hospital discharge, and to compare them with a community-dwelling population. Methods:...

journal_title：Frontiers in neurology

authors： Yang PL,Ward TM,Burr RL,Kapur VK,McCurry SM,Vitiello MV,Hough CL,Parsons EC

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Before implementation in clinical practice, biomarker assays need to be thoroughly analytically validated. There is currently a strong interest in implementation of the ratio of amyloid-β peptide 1-42 and 1-40 (Aβ42/Aβ40) in clinical routine. Therefore, in this study, we compared the analytical performance o...

journal_title：Frontiers in neurology

authors： van Waalwijk van Doorn LJC,Kulic L,Koel-Simmelink MJA,Kuiperij HB,Versleijen AAM,Struyfs H,Twaalfhoven HAM,Fourier A,Engelborghs S,Perret-Liaudet A,Lehmann S,Verbeek MM,Vanmechelen EJM,Teunissen CE

更新日期：2017-07-03 00:00:00

abstract：:Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized...

journal_title：Frontiers in neurology

authors： Aldridge GM,Birnschein A,Denburg NL,Narayanan NS

更新日期：2018-03-12 00:00:00

abstract：:Methamphetamine (METH) use, referred to as methamphetamine use disorder (MUD), results in neurocognitive decline, a characteristic shared with HIV-associated neurocognitive disorders (HAND). MUD exacerbates HAND partly through glutamate dysregulation. Astrocyte excitatory amino acid transporter (EAAT)-2 is responsible...

journal_title：Frontiers in neurology

authors： Cisneros IE,Ghorpade A,Borgmann K

更新日期：2020-11-25 00:00:00

abstract：:There is currently no therapeutic drug treatment for traumatic brain injury (TBI) despite decades of experimental clinical trials. This may be because the mechanistic pathways for improving TBI outcomes have yet to be identified and exploited. As such, there remains a need to seek out new molecular targets and their d...

journal_title：Frontiers in neurology

authors： Hook G,Jacobsen JS,Grabstein K,Kindy M,Hook V

更新日期：2015-09-02 00:00:00

abstract：:Huntington's Disease (HD) is a genetic neurodegenerative disease caused by a CAG expansion in the gene encoding Huntingtin (Htt). It is characterized by chorea, cognitive, and psychiatric disorders. The most affected brain region is the striatum, and the clinical symptoms are directly correlated to the rate of striata...

journal_title：Frontiers in neurology

authors： Moumné L,Betuing S,Caboche J

更新日期：2013-10-23 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the health of millions of people in the United States and worldwide. Currently, there are no approved therapies that can halt or reverse the clinical progression of AD. Traditionally, AD is characterized first by the appearance of a...

journal_title：Frontiers in neurology

authors： Hanslik KL,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:Previous consensus statements on sports concussion have highlighted the importance of Attention Deficit Hyperactivity Disorder (ADHD) and loss of consciousness (LOC) as risk factors related to concussion management. The present study investigated how self-reported history of either ADHD diagnosis or history of previou...

journal_title：Frontiers in neurology

authors： Kaye S,Sundman MH,Hall EE,Williams E,Patel K,Ketcham CJ

更新日期：2019-04-24 00:00:00

abstract：OBJECTIVE:The vestibular implant seems feasible as a clinically useful device in the near future. However, hearing preservation during intralabyrinthine implantation remains a challenge. It should be preserved to be able to treat patients with bilateral vestibulopathy and (partially) intact hearing. This case study inv...

journal_title：Frontiers in neurology

authors： van de Berg R,Lucieer F,Guinand N,van Tongeren J,George E,Guyot JP,Kingma H,van Hoof M,Temel Y,van Overbeeke J,Perez-Fornos A,Stokroos R

更新日期：2017-04-10 00:00:00

abstract：:Background: Distal posterior inferior cerebellar artery (PICA) aneurysms are uncommon intracranial vascular lesions. The coincidence of these aneurysms and Arteriovenous malformation (AVM) is even more rare. Since 1956, a total of 57 cases of distal PICA aneurysms associated with AVM have been reported with clear and ...

journal_title：Frontiers in neurology

authors： Khayat HA,Hawkes CM,Algird AR

更新日期：2020-12-18 00:00:00

abstract：Background and purpose:Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk fac...

journal_title：Frontiers in neurology

authors： Arauz A,Marquez-Romero JM,Barboza MA,Serrano F,Artigas C,Murillo-Bonilla LM,Cantú-Brito C,Ruiz-Sandoval JL,Barinagarrementeria F

更新日期：2018-04-04 00:00:00

abstract：:Background:Candida dubliniensis is closely related to Candida albicans and rarely isolated in clinical specimens. C. dubliniensis is increasingly recognized as a pathogen in immunocompromised hosts. We present the third known case of Candida dubliniensis meningitis in a young immunocompetent host. Case Presentation: A...

journal_title：Frontiers in neurology

authors： Tahir M,Peseski AM,Jordan SJ

更新日期：2020-12-08 00:00:00

abstract：:Background: In functional movement disorders, explicit movements are impaired, while implicit movements are preserved. Furthermore, there is evidence that the sense of agency is abnormal. Aim: We aimed to investigate how motor responses and sense of agency were affected by subliminal or supraliminal cues in people wit...

journal_title：Frontiers in neurology

authors： Huys AML,Edwards MJ,Bhatia KP,Haggard P

更新日期：2020-09-11 00:00:00

abstract：:Despite recent advances in our understanding of consciousness disorders, accurate diagnosis of severely brain-damaged patients is still a major clinical challenge. We here present the case of a patient who was considered in an unresponsive wakefulness syndrome/vegetative state for 20 years. Repeated standardized behav...

journal_title：Frontiers in neurology

authors： Vanhaudenhuyse A,Charland-Verville V,Thibaut A,Chatelle C,Tshibanda JL,Maudoux A,Faymonville ME,Laureys S,Gosseries O

更新日期：2018-08-28 00:00:00

abstract：:Inflammation after traumatic spinal cord injury (SCI) is non-resolving and thus still present in chronic injury stages. It plays a key role in the pathophysiology of SCI and has been associated with further neurodegeneration and development of neuropathic pain. Neural precursor cells (NPCs) have been shown to reduce t...

journal_title：Frontiers in neurology

authors： Riemann L,Younsi A,Scherer M,Zheng G,Skutella T,Unterberg AW,Zweckberger K

更新日期：2018-06-08 00:00:00

abstract：:Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furt...

journal_title：Frontiers in neurology

authors： Troncoso-Escudero P,Parra A,Nassif M,Vidal RL

更新日期：2018-10-15 00:00:00

abstract：OBJECTIVE:To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS:Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytoki...

journal_title：Frontiers in neurology

authors： Zeiler FA,Thelin EP,Czosnyka M,Hutchinson PJ,Menon DK,Helmy A

更新日期：2017-07-10 00:00:00

abstract：:Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate the individual and combined outcome prediction a...

journal_title：Frontiers in neurology

authors： Lagerstedt L,Azurmendi L,Tenovuo O,Katila AJ,Takala RSK,Blennow K,Newcombe VFJ,Maanpää HR,Tallus J,Hossain I,van Gils M,Menon DK,Hutchinson PJ,Zetterberg H,Posti JP,Sanchez JC

更新日期：2020-06-02 00:00:00

abstract：OBJECT:Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen a...

journal_title：Frontiers in neurology

authors： Kiiski H,Jalkanen V,Ala-Peijari M,Hämäläinen M,Moilanen E,Peltola J,Tenhunen J

更新日期：2017-04-18 00:00:00

abstract：:To interact successfully with an uncertain environment, organisms must be able to respond to both unanticipated and anticipated events. For unanticipated events, organisms have evolved stereotyped motor behaviors mapped to the statistical regularities of the environment, which can be trigged by specific sensory stimul...

journal_title：Frontiers in neurology

authors： Dakin CJ,Bolton DAE

更新日期：2018-10-30 00:00:00

abstract：:Objective: This study aimed to screen gene mutations in Chinese patients with benign essential blepharospasm (BEB) to understand its etiology. Methods: Twenty BEB patients diagnosed by clinical manifestations between April 2015 and October 2015 were enrolled. All the cases were investigated by questionnaires about gen...

journal_title：Frontiers in neurology

authors： Dong H,Luo Y,Fan S,Yin B,Weng C,Peng B

更新日期：2020-01-23 00:00:00

abstract：:Aim: The aim of the study was to investigate the effect of the onset of Parkinson's disease (PD) on life satisfaction. Method: Data from 2008, 2011, and 2014 were used from a population-based prospective cohort (German Ageing Survey; 8,982 observations in FE regression analysis) of community-residing individuals in th...

journal_title：Frontiers in neurology

authors： Buczak-Stec EW,König HH,Hajek A

更新日期：2018-07-25 00:00:00

abstract：:Eye trauma and blindness are common in the United States, with an incidence of over 2 million cases/year and 25 million blind adults, respectively. However, literature is surprisingly scarce on the potential confounding effect of eye trauma or blindness on the diagnosis of myasthenia gravis (MG), an autoimmune neuromu...

journal_title：Frontiers in neurology

authors： Leis AA,Moore AR

更新日期：2014-07-01 00:00:00

abstract：:Current efficacious treatments for traumatic brain injury (TBI) are lacking. Establishment of a protective gut microbiota population offers a compelling therapeutic avenue, as brain injury induces disruptions in the composition of the gut microbiota, i.e., gut dysbiosis, which has been shown to contribute to TBI-relat...

journal_title：Frontiers in neurology

authors： Rice MW,Pandya JD,Shear DA

更新日期：2019-08-16 00:00:00

abstract：:Introduction: Cerebral autosomal dominant arteriopathy and subcortical infarct leukoencephalopathy (CADASIL) is the most common form of hereditary stroke caused by a mutation in the NOTCH3 gene located on the short arm of chromosome 19. A small number of published reports describe CADASIL patients who were initially d...

journal_title：Frontiers in neurology

authors： Khan A,Abedi V,Li J,Malik MT,Esch M,Zand R

更新日期：2020-09-04 00:00:00

abstract：:Objectives: To identify and compare the cerebrospinal fluid (CSF) parameters that predict the presence of neonatal bacterial meningitis using optimal cutoff values, and to derive and compare predictive profiles based on a combination of individual parameters for the same purpose. Study Design: The retrospective compon...

journal_title：Frontiers in neurology

authors： Huang H,Tan J,Gong X,Li J,Wang L,Xu M,Zhang X,Zhang Y,Huang L

更新日期：2019-01-23 00:00:00

abstract：:Background: Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke. In Asians, intracranial atherosclerotic disease leads to 33-50% of ischemic events. At present, treatment with medication vs. endovascular therapy (EVT) for symptomatic ICAS (sICAS) patients is still debatable. The clini...

journal_title：Frontiers in neurology

authors： Zhang J,Zhang K,Jia B,Qi Z,Mo D,Ma N,Gao F,Miao Z

更新日期：2020-11-06 00:00:00

abstract：:Genetic findings of the past years have provided ample evidence for a substantial etiologic heterogeneity of dystonic syndromes. While an increasing number of genes are being identified for Mendelian forms of isolated and combined dystonias using classical genetic mapping and whole-exome sequencing techniques, their p...

journal_title：Frontiers in neurology

authors： Verbeek DS,Gasser T

更新日期：2017-01-16 00:00:00

abstract：:Children and adolescent athletes are at a higher risk for concussion than adults, and also experience longer recovery times and increased associated symptoms. It has also recently been demonstrated that multiple, seemingly mild concussions may result in exacerbated and prolonged neurological deficits. Objective assess...

journal_title：Frontiers in neurology

authors： Kiefer AW,Barber Foss K,Reches A,Gadd B,Gordon M,Rushford K,Laufer I,Weiss M,Myer GD

更新日期：2015-11-20 00:00:00