Centrality of Early Synaptopathy in Parkinson's Disease.


:Significant advances have been made in the understanding of the numerous mechanisms involved in Parkinson's disease (PD) pathogenesis. The identification of PD pathogenic mutations and the use of different animal models have contributed to better elucidate the processes underlying the disease. Here, we report a brief survey of some relevant cellular mechanisms, including autophagic-lysosomal dysfunction, endoplasmic reticulum stress, and mitochondrial impairment, with the main aim to focus on their potential convergent roles in determining early alterations at the synaptic level, mainly consisting in a decrease in dopamine release at nigrostriatal terminals and loss of synaptic plasticity at corticostriatal synapses. In a number of experimental models, this synaptopathy has been shown to be an initial, central event in PD pathogenesis, preceding neuronal damage, thereby representing a valuable tool for testing potential disease-modifying treatments.


Front Neurol


Frontiers in neurology


Imbriani P,Schirinzi T,Meringolo M,Mercuri NB,Pisani A




Has Abstract


2018-03-01 00:00:00








  • A Heartbeat Away From Consciousness: Heart Rate Variability Entropy Can Discriminate Disorders of Consciousness and Is Correlated With Resting-State fMRI Brain Connectivity of the Central Autonomic Network.

    abstract::Background: Disorders of consciousness are challenging to diagnose, with inconsistent behavioral responses, motor and cognitive disabilities, leading to approximately 40% misdiagnoses. Heart rate variability (HRV) reflects the complexity of the heart-brain two-way dynamic interactions. HRV entropy analysis quantifies ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Riganello F,Larroque SK,Bahri MA,Heine L,Martial C,Carrière M,Charland-Verville V,Aubinet C,Vanhaudenhuyse A,Chatelle C,Laureys S,Di Perri C

    更新日期:2018-09-12 00:00:00

  • MMP-9, Vertebrobasilar Ectasia and Vertebral Artery Dominance in Vertigo or Dizziness Patients With Vascular Risk Factors.

    abstract::Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequency, it is not clear whether this is because of altered hemodynamics caused by the effects of matrix metalloproteinases (MMPs) and/or vertebral artery dominance (VAD). Therefore, we investigate the relationship between pl...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhang HL,Peng YF,Zhang DP,Li D,Liu FX,Zhao M,Yin S,Liang JX,Wei TT

    更新日期:2020-08-25 00:00:00

  • Agreement Between High-Resolution Ultrasound and Electro-Physiological Examinations for Diagnosis of Carpal Tunnel Syndrome in the Indonesian Population.

    abstract::Carpal tunnel syndrome (CTS) is a disorder of the wrist due to narrowing of the carpal tunnel. It can be caused by trauma or tumors in the tunnel resulting in compression of the median nerve. This disorder is often diagnosed with early symptoms such as tingling, numbness, and weakness that subsequently lead to hand mu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Emril DR,Zakaria I,Amrya M

    更新日期:2019-08-26 00:00:00

  • Temporal Lobe Cavernous Malformation Caused Epileptic Amnesic Episodes and Mild Cognitive Impairment.

    abstract::Neuropathological features in Alzheimer's disease (AD) are amyloid β (Aβ) deposits and neurofibrillary changes. AD is characterized by memory impairment and cognitive dysfunction, with some reports associating these impairments with hyperexcitability caused by Aβ in the medial temporal lobe. Epileptic seizures are kno...

    journal_title:Frontiers in neurology



    authors: Hirokawa Y,Fujimoto A,Ichikawa N,Sato K,Tanaka T,Enoki H,Otsuki Y,Okanishi T

    更新日期:2019-06-12 00:00:00

  • Early Detection of Hypothermic Neuroprotection Using T2-Weighted Magnetic Resonance Imaging in a Mouse Model of Hypoxic Ischemic Encephalopathy.

    abstract::Perinatal hypoxic-ischemic encephalopathy (HIE) can lead to neurodevelopmental disorders, including cerebral palsy. Standard care for neonatal HIE includes therapeutic hypothermia, which provides partial neuroprotection; magnetic resonance imaging (MRI) is often used to assess injury and predict outcome after HIE. Imm...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Doman SE,Girish A,Nemeth CL,Drummond GT,Carr P,Garcia MS,Johnston MV,Kannan S,Fatemi A,Zhang J,Wilson MA

    更新日期:2018-05-08 00:00:00

  • Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy.

    abstract::The electrophysiological EEG features such as high frequency oscillations, spikes and functional connectivity are often used for delineation of epileptogenic tissue and study of the normal function of the brain. The epileptogenic activity is also known to be suppressed by cognitive processing. However, differences bet...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cimbalnik J,Pail M,Klimes P,Travnicek V,Roman R,Vajcner A,Brazdil M

    更新日期:2020-10-27 00:00:00

  • Natural history of intracranial atherosclerotic disease.

    abstract::Intracranial atherosclerotic disease was very common among stroke patients of Asians, Blacks, and Hispanics ancestry. Furthermore, stroke patients with intracranial atherosclerosis (ICAS) have higher recurrence rate of cerebral ischemia and death than those without ICAS. However, the natural history of intracranial at...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Pu Y,Dou X,Liu L

    更新日期:2014-07-10 00:00:00

  • Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy.

    abstract::Mutations of the voltage-gated sodium channel SCN8A have been identified in approximately 1% of nearly 1,500 children with early-infantile epileptic encephalopathies (EIEE) who have been tested by DNA sequencing. EIEE caused by mutation of SCN8A is designated EIEE13 (OMIM #614558). Affected children have seizure onset...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Wagnon JL,Meisler MH

    更新日期:2015-05-15 00:00:00

  • Gut-Brain Axis: Potential Factors Involved in the Pathogenesis of Parkinson's Disease.

    abstract::Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Chao YX,Gulam MY,Chia NSJ,Feng L,Rotzschke O,Tan EK

    更新日期:2020-08-25 00:00:00

  • Quality of Life in Newly Diagnosed Patients With Parkin-Related Parkinson's Disease.

    abstract::Introduction: Mutations in the Parkin gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in Parkin-related PD. Here, we investigated the patterns of QoL in newly diagnosed Parkin-related PD patients. Methods: Newly diagno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhou XY,Liu FT,Chen C,Luo SS,Zhao J,Tang YL,Shen B,Yu WB,Zuo CT,Wu JJ,Ding ZT,Wang J,Sun YM

    更新日期:2020-12-18 00:00:00

  • Biases in the Visual and Haptic Subjective Vertical Reveal the Role of Proprioceptive/Vestibular Priors in Child Development.

    abstract::Investigation of the perception of verticality permits to disclose the perceptual mechanisms that underlie balance control and spatial navigation. Estimation of verticality in unusual body orientation with respect to gravity (e.g., laterally tilted in the roll plane) leads to biases that change depending on the encodi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cuturi LF,Gori M

    更新日期:2019-01-07 00:00:00

  • Current Conceptual Understanding of the Epileptogenic Network From Stereoelectroencephalography-Based Connectivity Inferences.

    abstract::Localization of the epileptogenic zone (EZ) is crucial in the surgical treatment of focal epilepsy. Recently, EEG studies have revealed that the EZ exhibits abnormal connectivity, which has led investigators to now consider connectivity as a biomarker to localize the EZ. Further, abnormal connectivity of the EZ may pr...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Gupta K,Grover P,Abel TJ

    更新日期:2020-11-25 00:00:00

  • Hashimoto's Encephalopathy and Seizure Disorders.

    abstract::Hashimoto's encephalopathy (HE) is a rare, clinically heterogeneous condition associated with positive thyroid autoantibodies. It is increasingly recognized as an important and treatable cause of autoimmune encephalopathy. Thyroid-associated antibodies such as thyroperoxidase (TPO) antibody, thyroglobulin (TG) antibod...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Li J,Li F

    更新日期:2019-05-08 00:00:00

  • Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy.

    abstract::Introduction: Eslicarbazepine acetate (ESL) is an antiepileptic drug approved as monotherapy or add-on for the treatment of epilepsy with seizures of focal onset. ESL owns a good profile in terms of efficacy and tolerability, but its effects on EEG activity and connectivity are unknown. The purpose of this study was t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Pellegrino G,Mecarelli O,Pulitano P,Tombini M,Ricci L,Lanzone J,Brienza M,Davassi C,Di Lazzaro V,Assenza G

    更新日期:2018-12-11 00:00:00

  • Classification of Stereo-EEG Contacts in White Matter vs. Gray Matter Using Recorded Activity.

    abstract::For epileptic patients requiring resective surgery, a modality called stereo-electroencephalography (SEEG) may be used to monitor the patient's brain signals to help identify epileptogenic regions that generate and propagate seizures. SEEG involves the insertion of multiple depth electrodes into the patient's brain, e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Greene P,Li A,González-Martínez J,Sarma SV

    更新日期:2021-01-06 00:00:00

  • Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology.

    abstract::Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: La Morgia C,Carelli V,Carbonelli M

    更新日期:2018-12-07 00:00:00

  • Intranasal Administration of the Antisecretory Peptide AF-16 Reduces Edema and Improves Cognitive Function Following Diffuse Traumatic Brain Injury in the Rat.

    abstract::A synthetic peptide with antisecretory activity, antisecretory factor (AF)-16, improves injury-related deficits in water and ion transport and decreases intracranial pressure after experimental cold lesion injury and encephalitis although its role in traumatic brain injury (TBI) is unknown. AF-16 or an inactive refere...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Clausen F,Hansson HA,Raud J,Marklund N

    更新日期:2017-02-14 00:00:00

  • Skilled reaching and grasping in the rat: lacking effect of corticospinal lesion.

    abstract::The corticospinal system is a major motor pathway in the control of skilled voluntary movements such as reaching and grasping. It has developed considerably phylogenetically to reach a peak in humans. Because rodents possess advanced forelimb movements that can be used for reaching and grasping food, it is commonly co...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Alstermark B,Pettersson LG

    更新日期:2014-06-20 00:00:00

  • Effects of Age and Sex on Optic Nerve Sheath Diameter in Healthy Volunteers and Patients With Traumatic Brain Injury.

    abstract::The measurement of optic nerve sheath diameter (ONSD) has been reported as a non-invasive marker for intracranial pressure (ICP). Nevertheless, it is uncertain whether possible ONSD differences occur with age and sex in healthy and brain-injured populations. The aim of this study was to investigate the effects of sex ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cardim D,Czosnyka M,Chandrapatham K,Badenes R,Bertuccio A,Noto AD,Donnelly J,Pelosi P,Ball L,Hutchinson PJ,Robba C

    更新日期:2020-08-07 00:00:00

  • The Vestibular Implant: Hearing Preservation during Intralabyrinthine Electrode Insertion-A Case Report.

    abstract:OBJECTIVE:The vestibular implant seems feasible as a clinically useful device in the near future. However, hearing preservation during intralabyrinthine implantation remains a challenge. It should be preserved to be able to treat patients with bilateral vestibulopathy and (partially) intact hearing. This case study inv...

    journal_title:Frontiers in neurology



    authors: van de Berg R,Lucieer F,Guinand N,van Tongeren J,George E,Guyot JP,Kingma H,van Hoof M,Temel Y,van Overbeeke J,Perez-Fornos A,Stokroos R

    更新日期:2017-04-10 00:00:00

  • Employment Probability Trajectories Up To 10 Years After Moderate-To-Severe Traumatic Brain Injury.

    abstract::Aims: To examine trajectories of employment probability up to 10 years following moderate-to-severe traumatic brain injury (TBI) and identify significant predictors from baseline socio-demographic and injury characteristics. Methods: A longitudinal observational study followed 97 individuals with moderate-to-severe TB...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Howe EI,Andelic N,Perrin PB,Røe C,Sigurdardottir S,Arango-Lasprilla JC,Lu J,Løvstad M,Forslund MV

    更新日期:2018-12-05 00:00:00

  • Differential Diagnosis of Vertigo in the Emergency Department: A Prospective Validation Study of the STANDING Algorithm.

    abstract:Objective:We investigated the reliability and accuracy of a bedside diagnostic algorithm for patients presenting with vertigo/unsteadiness to the emergency department. Methods:We enrolled consecutive adult patients presenting with vertigo/unsteadiness at a tertiary hospital. STANDING, the acronym for the four-step alg...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Vanni S,Pecci R,Edlow JA,Nazerian P,Santimone R,Pepe G,Moretti M,Pavellini A,Caviglioli C,Casula C,Bigiarini S,Vannucchi P,Grifoni S

    更新日期:2017-11-07 00:00:00

  • Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients.

    abstract::Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Almendros I,Martínez-García MÁ,Campos-Rodríguez F,Riveiro-Falkenbach E,Rodríguez-Peralto JL,Nagore E,Martorell-Calatayud A,Hernández Blasco L,Bañuls Roca J,Chiner Vives E,Sánchez-de-la-Torre A,Abad-Capa J,Montserrat JM,Pérez-Gi

    更新日期:2018-04-26 00:00:00

  • Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.

    abstract::Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Choudhury S,Singh R,Chatterjee P,Trivedi S,Shubham S,Baker MR,Kumar H,Baker SN

    更新日期:2018-07-02 00:00:00

  • Multiplex Matrix Metalloproteinases Analysis in the Cerebrospinal Fluid Reveals Potential Specific Patterns in Multiple Sclerosis Patients.

    abstract::Background: Matrix metalloproteinases (MMPs) are pleiotropic enzymes involved in extracellular protein degradation and turnover. MMPs are implicated in the pathogenesis of many neurological diseases, including multiple sclerosis (MS). Objective: To search the level of MMPs in the cerebrospinal fluid (CSF) of MS patien...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Castellazzi M,Ligi D,Contaldi E,Quartana D,Fonderico M,Borgatti L,Bellini T,Trentini A,Granieri E,Fainardi E,Mannello F,Pugliatti M

    更新日期:2018-12-18 00:00:00

  • Longitudinal Assessment of Cortical Excitability in Children and Adolescents With Mild Traumatic Brain Injury and Persistent Post-concussive Symptoms.

    abstract::Introduction: Symptoms following a mild traumatic brain injury (mTBI) usually resolve quickly but may persist past 3 months in up to 15% of children. Mechanisms of mTBI recovery are poorly understood, but may involve alterations in cortical neurophysiology. Transcranial Magnetic Stimulation (TMS) can non-invasively in...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: King R,Kirton A,Zewdie E,Seeger TA,Ciechanski P,Barlow KM

    更新日期:2019-05-17 00:00:00

  • Corrigendum: Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

    abstract::[This corrects the article DOI: 10.3389/fneur.2018.01033.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误


    authors: VanElzakker MB,Brumfield SA,Lara Mejia PS

    更新日期:2020-09-17 00:00:00

  • Biochemical response to hyperbaric oxygen treatment of a transhemispheric penetrating cerebral gunshot injury.

    abstract::Hyperbaric oxygen (HBO) therapy has been suggested a treatment option in order to reduce the development of secondary insults succeeding traumatic brain injury. This case report studied the course of a 23-year-old gentleman with a close range transhemispheric gunshot wound. The biochemical parameters, using a multi-mo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Thelin EP,Bellander BM,Nekludov M

    更新日期:2015-03-23 00:00:00

  • Motor Nerve Conduction Block Predicting Outcome of Guillain-Barre Syndrome.

    abstract::Introduction: Motor nerve conduction blocks (CBs) could be detected in both acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). We aimed to identify the correlation between CBs and functional outcome in the two subtypes of GBS. Methods: Motor nerve conduction studie...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Niu J,Liu M,Sun Q,Li Y,Wu S,Ding Q,Guan Y,Cui L

    更新日期:2018-06-01 00:00:00

  • HLA Polymorphism Affects Risk of de novo Mutation of dystrophin Gene and Clinical Severity of Duchenne Muscular Dystrophy in a Southern Chinese Population.

    abstract::Immune-mediated pathology has been thought to be an important factor contributing to Duchenne muscular dystrophy (DMD). Allele frequencies of certain HLA types are known to differ between patients with dystrophinopathies and healthy controls with low-resolution HLA gene typing data in limit reports. Using Polymerase c...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Li H,Xiao L,Wang L,Lin J,Luo M,Chen M,He R,Zhu Y,Zhang C

    更新日期:2018-11-15 00:00:00