Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature Review.

abstract：:Surface electromyography (sEMG) is a widely used technology in rehabilitation research and provides quantifiable information on the myoelectric output of a muscle. In this perspective, we discuss the barriers which have restricted the wide-spread use of sEMG in clinical rehabilitation of individuals with spinal cord i...

journal_title：Frontiers in neurology

authors： Pilkar R,Momeni K,Ramanujam A,Ravi M,Garbarini E,Forrest GF

更新日期：2020-12-18 00:00:00

abstract：:Infections in the post-acute phase of cerebral ischaemia impede optimal recovery by exacerbating morbidity and mortality. Our review aims to reconcile the increased infection susceptibility of patients post-stroke by consolidating our understanding of compartmentalised alterations to systemic immunity. Mounting eviden...

journal_title：Frontiers in neurology

authors： Krishnan S,Lawrence CB

更新日期：2019-07-02 00:00:00

abstract：:Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activity and slowing of the electroencephalogram, progressive memory disturbances, as well as a variety of other behavioral,...

journal_title：Frontiers in neurology

authors： Ehling P,Melzer N,Budde T,Meuth SG

更新日期：2015-07-15 00:00:00

abstract：:Purpose: Rapid muscle fatigue limits clinical applications of functional electrical stimulation (FES) for individuals with motor impairments. This study aimed to characterize the sustainability of muscle force elicited with a novel transcutaneous nerve stimulation technique. Method: A hemiplegic chronic stroke survivo...

journal_title：Frontiers in neurology

authors： Zheng Y,Shin H,Hu X

更新日期：2018-12-04 00:00:00

abstract：:In Parkinson's disease (PD), internal cueing mechanisms are impaired leading to symptoms like hypokinesia. However, external cues can improve movement execution by using cortical resources. These cortical processes can be affected by cognitive decline in dementia. It is still unclear how dementia in PD influences exte...

journal_title：Frontiers in neurology

authors： Gräber S,Liepelt-Scarfone I,Csoti I,Maetzler W,Sultan F,Berg D

更新日期：2014-11-17 00:00:00

abstract：:Expansion of the neural progenitor pool in the developing cerebral cortex is crucial for controlling brain size, since proliferation defects have been associated with the pathogenesis of microcephaly in humans. Cell cycle regulators play important roles in proliferation of neural progenitors. Here, we show that the cy...

journal_title：Frontiers in neurology

authors： Chen Y,Bian S,Zhang J,Zhang H,Tang B,Sun T

更新日期：2014-07-18 00:00:00

abstract：:Background: Recent developments in mobile technology have enabled the investigation of human movements and mobility under natural conditions, i.e., in the home environment. Iron accumulation in the basal ganglia is deleterious in Parkinson's disease (i.e., iron accumulation with lower striatal level of dopamine). The ...

journal_title：Frontiers in neurology

authors： Hopfner F,Hobert MA,Maetzler C,Hansen C,Pham MH,Moreau C,Berg D,Devos D,Maetzler W,Fair-Park II study group.

更新日期：2019-08-08 00:00:00

abstract：:Background: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease. The clinical manifestations of NIID are complex and easily misdiagnosed. Based on the current knowledge of this disease, it is usually chronic, with almost no acute cases. Stroke-like disease is an extremely rare type of NI...

journal_title：Frontiers in neurology

authors： Lin P,Jin H,Yi KC,He XS,Lin SF,Wu G,Zhang ZQ

更新日期：2020-06-10 00:00:00

abstract：:Ornithine transcarbamylase deficiency (OTCD) is the most common form of urea cycle disorder characterized by the presence of hyperammonemia (HA). In patients with OTCD, HA is known to cause impairments in domains of executive function and working memory. Monitoring OTCD progression and investigating neurocognitive bio...

journal_title：Frontiers in neurology

authors： Anderson AA,Gropman A,Le Mons C,Stratakis CA,Gandjbakhche AH

更新日期：2020-08-14 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely characterized by the selective vulnerability of motor neurons and the poor life expectancy of afflicted patients. Limited disease-modifying therapies currently exist, which only further attests to the substantial heterogeneity...

journal_title：Frontiers in neurology

authors： Gaur N,Perner C,Witte OW,Grosskreutz J

更新日期：2020-05-27 00:00:00

abstract：:Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...

journal_title：Frontiers in neurology

authors： Guingab-Cagmat JD,Cagmat EB,Hayes RL,Anagli J

更新日期：2013-05-31 00:00:00

abstract：:Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using hemodynamic numerical simulation and the influence of embolization on recurrence after embolization. Methods: From January 2016 to December 2017, we enrolled a total of 113 paraclinoidal aneurysms treated ...

journal_title：Frontiers in neurology

authors： Sheng B,Wu D,Yuan J,Xu S,Li Z,Dong J,Lai N,Fang X

更新日期：2019-04-25 00:00:00

abstract：:Epilepsy is a common neurological disorder that affects over 70 million people worldwide. Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients with epilepsy have seizures refractory to pharmacotherapy. Early identification of patients who will become refractory to ASDs could hel...

journal_title：Frontiers in neurology

authors： Tang F,Hartz AMS,Bauer B

更新日期：2017-07-06 00:00:00

abstract：:For epileptic patients requiring resective surgery, a modality called stereo-electroencephalography (SEEG) may be used to monitor the patient's brain signals to help identify epileptogenic regions that generate and propagate seizures. SEEG involves the insertion of multiple depth electrodes into the patient's brain, e...

journal_title：Frontiers in neurology

authors： Greene P,Li A,González-Martínez J,Sarma SV

更新日期：2021-01-06 00:00:00

abstract：:Gaze stability exercises are a critical component of vestibular rehabilitation for individuals with vestibular hypofunction and many studies reveal the rehabilitation improves functional performance. However, few studies have examined the vestibular physiologic mechanisms (semicircular canal; otolith) responsible for ...

journal_title：Frontiers in neurology

authors： Millar JL,Gimmon Y,Roberts D,Schubert MC

更新日期：2020-02-20 00:00:00

abstract：:Sleep disturbances such as excessive daytime sleepiness, central and obstructive sleep apneas, restless legs syndrome, and rapid eye movement sleep dysregulation are prominent in patients with myotonic dystrophy type 1 (DM1). Mild intellectual deficits presented in many patients with DM1. In addition, psychosocial iss...

journal_title：Frontiers in neurology

authors： Urata Y,Nakamura M,Shiokawa N,Yasuniwa A,Takamori N,Imamura K,Hayashi T,Ishizuka T,Kasugai M,Sano A

更新日期：2020-02-14 00:00:00

abstract：:Background: In people with multiple sclerosis (MS), optic neuritis (ON) results in inner retinal layer thinning, and reduced density of the retinal microvasculature. Objective: To compare inter-eye differences (IEDs) in macular optical coherence tomography (OCT) and OCT angiography (OCTA) measures in MS patients with ...

journal_title：Frontiers in neurology

authors： Murphy OC,Kalaitzidis G,Vasileiou E,Filippatou AG,Lambe J,Ehrhardt H,Pellegrini N,Sotirchos ES,Luciano NJ,Liu Y,Fitzgerald KC,Prince JL,Calabresi PA,Saidha S

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVE:Effective stroke care does not end with acute treatment during hospitalization, but extends through rehabilitation and secondary stroke prevention. In transitions across care environments, stroke patients are vulnerable to errors in communication of diagnosis and treatment. This study aimed to demonstrate tha...

journal_title：Frontiers in neurology

authors： Hill CE,Varma P,Lenrow D,Price RS,Kasner SE

更新日期：2015-10-27 00:00:00

abstract：:Objective: Hybrid recanalization for vertebral artery (VA) long-segmental occlusion using a combination of ostial vertebral endarterectomy and distal endovascular stenting has achieved technical success. The safety and efficacy of the hybrid technique should be further evaluated. Methods: We examined a cohort of refra...

journal_title：Frontiers in neurology

authors： Ma Y,Yang B,Lu X,Gao P,Jiao L,Ling F

更新日期：2020-05-12 00:00:00

abstract：:Background: Late latency auditory evoked potentials (LLAEPs) provide objective evidence of an individual's central auditory processing abilities. Electrically evoked cortical auditory evoked potentials (eCAEPs) are a type of LLAEP that provides an objective measure of aided speech perception and auditory processing ab...

journal_title：Frontiers in neurology

authors： Pike M,Biagio-de Jager L,le Roux T,Hofmeyr LM

更新日期：2020-04-28 00:00:00

abstract：OBJECTIVE:The vestibular implant seems feasible as a clinically useful device in the near future. However, hearing preservation during intralabyrinthine implantation remains a challenge. It should be preserved to be able to treat patients with bilateral vestibulopathy and (partially) intact hearing. This case study inv...

journal_title：Frontiers in neurology

authors： van de Berg R,Lucieer F,Guinand N,van Tongeren J,George E,Guyot JP,Kingma H,van Hoof M,Temel Y,van Overbeeke J,Perez-Fornos A,Stokroos R

更新日期：2017-04-10 00:00:00

abstract：:Sleep complaints increase profoundly with age; prevalence estimates of insomnia in the elderly reach up to 37%. The three major types of nocturnal complaints are difficulties initiating (DIS) and maintaining (DMS) sleep and early morning awakening (EMA), of which the latter appears most characteristic for aging. The n...

journal_title：Frontiers in neurology

authors： Stoffers D,Moens S,Benjamins J,van Tol MJ,Penninx BW,Veltman DJ,Van der Wee NJ,Van Someren EJ

更新日期：2012-06-28 00:00:00

abstract：BACKGROUND AND PURPOSE:Cardiac myxoma is a rare etiology of stroke. Both cerebral microbleeds and cardiac myxoma may increase the risk of intracerebral hemorrhage after intravenous (IV) thrombolysis. However, data are still limited. We report a case of multiple cerebral microbleeds treated with IV thrombolysis with lat...

journal_title：Frontiers in neurology

authors： Chutinet A,Roongpiboonsopit D,Suwanwela NC

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Traumatic brain injury involving loss of consciousness has focal effects in the human brainstem, suggesting that it may have particular consequences for eye movement control. This hypothesis was investigated by measurements of vergence eye movement parameters. METHODS:Disparity vergence eye movements were meas...

journal_title：Frontiers in neurology

authors： Tyler CW,Likova LT,Mineff KN,Elsaid AM,Nicholas SC

更新日期：2015-02-03 00:00:00

abstract：:Over the last two decades, many experimental and clinical studies have provided solid evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to Parkinson's disease (PD) pathology. To provide an overview on the different roles of this protein, here we propose a synopsis of seminal...

journal_title：Frontiers in neurology

authors： Ghiglieri V,Calabrese V,Calabresi P

更新日期：2018-05-04 00:00:00

abstract：:The incidence of traumatic brain injuries (TBI) in the US has reached epidemic proportions with well over 2 million new cases reported each year. TBI can occur in both civilians and warfighters, with head injuries occurring in both combat and non-combat situations from a variety of threats, including ballistic penetra...

journal_title：Frontiers in neurology

authors： Young L,Rule GT,Bocchieri RT,Walilko TJ,Burns JM,Ling G

更新日期：2015-05-07 00:00:00

abstract：:α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA...

journal_title：Frontiers in neurology

authors： Cao B,Chen X,Zhang L,Wei Q,Liu H,Feng W,Chen Y,Shang H

更新日期：2020-07-07 00:00:00

abstract：:Autoimmune encephalitis often causes acute psychiatric symptoms and epileptic seizures. However, it is becoming increasingly clear that depending on the target antigen both symptoms and disease severity may vary. Furthermore, the identification and characterization of antibody subtypes are highly relevant for personal...

journal_title：Frontiers in neurology

authors： Edwin Thanarajah S,Prüss H,Warnke C,Barbe MT,Schroeter M,Fink GR,Onur OA

更新日期：2019-03-05 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive therapy that has been implicated in treatment of serious neurological disorders. However, the neurobiological mechanisms underlying the effects of rTMS remain unclear. Therefore, this study examined the differential effects of repetitive magnetic st...

journal_title：Frontiers in neurology

authors： Baek A,Kim JH,Pyo S,Jung JH,Park EJ,Kim SH,Cho SR

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND AND PURPOSE:The pathogenesis of spontaneous cervical artery dissections (sCAD) and its best medical treatment are debated. This may be due to a lack of clear classification of sCAD. We propose the new Borgess classification of sCAD, based on the presence or absence of intimal tear as depicted on imaging stud...

journal_title：Frontiers in neurology

authors： Perry BC,Al-Ali F

更新日期：2013-09-17 00:00:00