Abstract：
:Introduction: Mutations in the Parkin gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in Parkin-related PD. Here, we investigated the patterns of QoL in newly diagnosed Parkin-related PD patients. Methods: Newly diagnosed PD patients (diagnosis made within 12 months) who had an age of onset (AOO) below 40 and underwent a PD-related genetic testing, were recruited (n = 148). Among them, 24 patients carried bi-allelic variants in Parkin (PD-Parkin) and 24 patients did not have any known causative PD mutations, or risk variants (GU-EOPD). The clinical materials, relevant factors and determinants of QoL were analyzed. Results: PD-Parkin patients had a younger AOO (p = 0.003) and longer disease duration (p = 0.005). After adjustment for AOO and disease duration, more dystonia (p = 0.034), and worse scores of non-motor symptoms including Beck depression inventory (BDI, p = 0.035), Epworth sleepiness scale (ESS, p = 0.044), and subdomains of depression/anxiety (p = 0.015) and sleep disorders (p = 0.005) in Non-motor symptoms questionnaire, were found in PD-Parkin comparing with GU-EOPD. PD-Parkin patients had poorer QoL (adjusted p = 0.045), especially in the mobility (adjusted p = 0.025), emotional well-being (adjusted p = 0.015) and bodily discomfort dimensions (adjusted p = 0.016). BDI scores (p = 0.005) and ESS scores (p = 0.047) were significant determinants of QoL in PD-Parkin. Conclusion: Newly diagnosed PD-Parkin patients showed worse QoL. More depression and excessive daytime sleepiness predicted worse QoL. For clinicians, management of depression and excessive daytime sleepiness is suggested to better improve QoL in patients with Parkin mutations.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Zhou XY,Liu FT,Chen C,Luo SS,Zhao J,Tang YL,Shen B,Yu WB,Zuo CT,Wu JJ,Ding ZT,Wang J,Sun YMdoi
10.3389/fneur.2020.580910subject
Has Abstractpub_date
2020-12-18 00:00:00pages
580910issn
1664-2295journal_volume
11pub_type
杂志文章abstract：:Epilepsy may reflect a focal abnormality of cerebral tissue, but the generation of seizures typically involves propagation of abnormal activity through cerebral networks. We examined epileptiform discharges (spikes) with dense array electroencephalography (dEEG) in five patients to search for the possible engagement o...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2013.00055
更新日期：2013-05-15 00:00:00
abstract：:Anticoagulation is highly effective in preventing stroke due to atrial fibrillation, but numerous studies have demonstrated low utilization of anticoagulation for these patients. Assessment of clinicians' attitudes on this topic indicate that fear of intracerebral hemorrhage (ICH), rather than appreciation of anticoag...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2013.00137
更新日期：2013-10-04 00:00:00
abstract：:Background: Magnetic resonance imaging is a key diagnostic and monitoring tool in multiple Sclerosis (MS). While the substrates of motor and neuropsychological symptoms in MS have been extensively investigated, nystagmus-associated imaging signatures are relatively under studied. Accordingly, the objective of this stu...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00691
更新日期：2018-08-23 00:00:00
abstract：Introduction:Transcranial high-resolution ultrasonography reliably allows diagnosis and monitoring of intracerebral hemorrhage in adults. Sonographic monitoring of subdural hematoma (SDH) has not been evaluated in adults so far. This study investigates the reliability of transcranial gray-scale sonography (TGS) in moni...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00374
更新日期：2018-05-28 00:00:00
abstract：:Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2020.00274
更新日期：2020-04-16 00:00:00
abstract：:Introduction: Today, half of the American homeless population is older than 50 years of age. This shift in age distribution among people experiencing homelessness has challenged our long-held views of the causes of homelessness. Age-related neurological diseases, especially neurodegenerative diseases of the brain (NDD...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.562218
更新日期：2021-01-13 00:00:00
abstract：:Objective: To investigate the effects of low frequency transcranial magnetic stimulation (LF-rTMS) combined with motor imagery (MI) on upper limb motor function during stroke rehabilitation. Background: Hemiplegic upper extremity activity obstacle is a common movement disorder after stroke. Compared with a single inte...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2019.00096
更新日期：2019-02-19 00:00:00
abstract：:We describe three patients diagnosed with bilateral vestibular dysfunction associated with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet fuel, occurred over 3-5 years' duration while working on ...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2018.00351
更新日期：2018-05-16 00:00:00
abstract：:Introduction: This study was designed to evaluate risk factors and incidence of epilepsy-related injuries and accidents (ERIA) at an outpatient clinic of a German epilepsy center providing healthcare to a mixed urban and rural population of over one million inhabitants. Methods: Data acquisition was performed between ...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00414
更新日期：2018-06-15 00:00:00
abstract：:Performance of models highly depend not only on the used algorithm but also the data set it was applied to. This makes the comparison of newly developed tools to previously published approaches difficult. Either researchers need to implement others' algorithms first, to establish an adequate benchmark on their data, o...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00679
更新日期：2018-09-13 00:00:00
abstract：:Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as delayed cerebral ischemia (DCI). Early detection and management of reversible ischemia is of c...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2014.00089
更新日期：2014-06-02 00:00:00
abstract：:Cerebral cortical microinfarct (CMI) is common in patients with dementia and cognitive decline. Emerging studies reported that intestinal dysfunction influenced the outcome of ischemic stroke and that vagus nerve stimulation (VNS) protected against ischemic stroke. However, the effects of intestinal dysfunction and VN...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00798
更新日期：2018-09-26 00:00:00
abstract：:Background: Mild traumatic brain injuries (mTBIs) are a significant social, sport, and military health issue. In spite of advances in the clinical management of these injuries, the underlying pathophysiology is not well-understood. There is a critical need to advance objective biomarkers, allowing the identification a...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00468
更新日期：2018-06-20 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the functional network effects of corpus callosotomy (CC), a well-recognized palliative surgical therapy for patients with Lennox-Gastaut syndrome (LGS). Specifically, we sought to gain insight into the effects of CC on LGS remission, based on brain networks in LGS by calculat...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2017.00456
更新日期：2017-09-04 00:00:00
abstract：:Background: Recent developments in mobile technology have enabled the investigation of human movements and mobility under natural conditions, i.e., in the home environment. Iron accumulation in the basal ganglia is deleterious in Parkinson's disease (i.e., iron accumulation with lower striatal level of dopamine). The ...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2019.00833
更新日期：2019-08-08 00:00:00
abstract：:Background and Purpose: Internal carotid artery stenosis (ICAS)≥70% is a leading cause of ischemic cerebrovascular events (ICVEs). However, a considerable percentage of stroke survivors with symptomatic ICAS (sICAS) have <70% stenosis with a vulnerable plaque. Whether the length of ICAS is associated with high risk of...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00317
更新日期：2019-04-09 00:00:00
abstract：:Hand-Arm Bimanual Intensive Therapy (HABIT) promotes hand function using intensive practice of bimanual functional and play tasks. This intervention has shown to be efficacious to improve upper-extremity (UE) function in children with unilateral spastic cerebral palsy (USCP). In addition to UE function deficits, lower...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2017.00495
更新日期：2017-09-26 00:00:00
abstract：:Alzheimer's disease is the most common neurodegenerative form of dementia that steadily worsens and eventually leads to death. Its set of symptoms include loss of cognitive function and memory decline. Structural and functional imaging methods such as CT, MRI, and PET scans play an essential role in the diagnosis proc...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2017.00647
更新日期：2017-12-07 00:00:00
abstract：:Background and Purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted a cross-sectional study using data from a nationwide epidemiological sur...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00421
更新日期：2018-06-07 00:00:00
abstract：:Background:Candida dubliniensis is closely related to Candida albicans and rarely isolated in clinical specimens. C. dubliniensis is increasingly recognized as a pathogen in immunocompromised hosts. We present the third known case of Candida dubliniensis meningitis in a young immunocompetent host. Case Presentation: A...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2020.601242
更新日期：2020-12-08 00:00:00
abstract：:Background/Aims: High intracranial pressure (ICP) is associated with changes in peripapillary Bruch's membrane (pBM) shape on optical coherence tomography (OCT) images of the optic nerve head. It is not known if image acquisition pattern and analysis method impact this association. Materials and Methods: Cross section...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.01137
更新日期：2018-12-21 00:00:00
abstract：:We previously reported that persistent application of the non-specific cholinergic agonist carbachol (CAR) increased the frequency of calcium channel-mediated oscillatory activity in pedunculopontine nucleus (PPN) neurons, which we identified as dependent on voltage-gated, high-threshold P/Q-type channels. Here, we te...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2013.00176
更新日期：2013-11-06 00:00:00
abstract：Background and purpose:Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk fac...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00207
更新日期：2018-04-04 00:00:00
abstract：:Introduction: Symptoms following a mild traumatic brain injury (mTBI) usually resolve quickly but may persist past 3 months in up to 15% of children. Mechanisms of mTBI recovery are poorly understood, but may involve alterations in cortical neurophysiology. Transcranial Magnetic Stimulation (TMS) can non-invasively in...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00451
更新日期：2019-05-17 00:00:00
abstract：:We describe and evaluate a pre-processing method based on a periodic spiral sampling of diffusion-gradient directions for high angular resolution diffusion magnetic resonance imaging. Our pre-processing method incorporates prior knowledge about the acquired diffusion-weighted signal, facilitating noise reduction. Peri...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2014.00290
更新日期：2015-01-12 00:00:00
abstract：:Non-motor symptoms of Parkinson's disease (PD) have been receiving increasing attention. Approximately half of patients with PD have experience PD-related pain. We investigated the effect and mechanism of acupuncture in patients with PD who have pain. PD patients with pain were divided into acupuncture group and contr...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.01114
更新日期：2019-10-22 00:00:00
abstract：:Objectives: This article aims to evaluate the safety and effectiveness of endoscope-assisted surgery for chronic subdural hematoma (cSDH) in comparison with the burr-hole craniostomy. Methods: An electronic literature research was performed in MEDLINE, the Cochrane library, and EMBASE from the inception to February 18...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2020.540911
更新日期：2020-11-05 00:00:00
abstract：:Background: Overweight contributes to type 2 diabetes mellitus (T2DM) development. Although the obesity paradox has been suggested in many vascular diseases, little information is available about stroke patients with T2DM. We investigated whether body mass index (BMI) has a differential impact on the incidence of majo...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00563
更新日期：2019-06-05 00:00:00
abstract：OBJECTIVE:Evaluate medical students' communication and professionalism skills from the perspective of the ambulatory patient and later compare these skills in their first year of residency. METHODS:Students in third year neurology clerkship clinics see patients alone followed by a revisit with an attending neurologist...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2012.00098
更新日期：2012-06-20 00:00:00
abstract：:The aim of the present study was to evaluate the correlation between the end of an Oxford sleep resistance (OSLER) test session and a neurophysiological marker of sleep onset in Parkinson's disease (PD) patients. Single center study was conducted in PD patients with excessive daytime sleepiness [Epworth sleepiness sca...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2015.00200
更新日期：2015-09-24 00:00:00
