Bilateral Vestibular Dysfunction Associated With Chronic Exposure to Military Jet Propellant Type-Eight Jet Fuel.

Abstract:

:We describe three patients diagnosed with bilateral vestibular dysfunction associated with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet fuel, occurred over 3-5 years' duration while working on or near the flight line. Exposure to toxic hydrocarbons was substantiated by the presence of JP-8 metabolite n-hexane in the blood of one of the cases. The presenting symptoms were dizziness, headache, fatigue, and imbalance. Rotational chair testing confirmed bilateral vestibular dysfunction in all the three patients. Vestibular function improved over time once the exposure was removed. Bilateral vestibular dysfunction has been associated with hydrocarbon exposure in humans, but only recently has emphasis been placed specifically on the detrimental effects of JP-8 jet fuel and its numerous hydrocarbon constituents. Data are limited on the mechanism of JP-8-induced vestibular dysfunction or ototoxicity. Early recognition of JP-8 toxicity risk, cessation of exposure, and customized vestibular therapy offer the best chance for improved balance. Bilateral vestibular impairment is under-recognized in those chronically exposed to all forms of jet fuel.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Fife TD,Robb MJA,Steenerson KK,Saha KC

doi

10.3389/fneur.2018.00351

subject

Has Abstract

pub_date

2018-05-16 00:00:00

pages

351

issn

1664-2295

journal_volume

9

pub_type

  • Takotsubo Cardiomyopathy-Acute Cardiac Dysfunction Associated With Neurological and Psychiatric Disorders.

    abstract::Takotsubo cardiomyopathy (TTC) is an acute and reversible cardiac wall motion abnormality of the left myocardium. Although many studies focused on etiology, diagnostic and treatment of TTC, precise clinical guidelines on TTC are not available. Research revealed emotional and physical triggering factors of TTC and emph...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00917

    authors: Buchmann SJ,Lehmann D,Stevens CE

    更新日期:2019-08-22 00:00:00

  • Elevated Percentage of CD3+ T-Cells and CD4+/CD8+ Ratios in Multiple System Atrophy Patients.

    abstract::α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00658

    authors: Cao B,Chen X,Zhang L,Wei Q,Liu H,Feng W,Chen Y,Shang H

    更新日期:2020-07-07 00:00:00

  • Brain Structural and Functional Imaging Findings in Medication-Overuse Headache.

    abstract::This chapter overviews research neuroimaging findings of patients with medication-overuse headache (MOH). Results indicate; (i) correlations between neuropathology and medication-overuse; (ii) changes in brain morphology and cortical function; and (iii) brain recovery subsequent to withdrawal of medication that was ov...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01336

    authors: Chong CD

    更新日期:2020-01-28 00:00:00

  • Macroscale White Matter Alterations Due to Traumatic Cerebral Microhemorrhages Are Revealed by Diffusion Tensor Imaging.

    abstract::With the advent of susceptibility-weighted imaging (SWI), the ability to identify cerebral microbleeds (CMBs) associated with mild traumatic brain injury (mTBI) has become increasingly commonplace. Nevertheless, the clinical significance of post-traumatic CMBs remains controversial partly because it is unclear whether...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00948

    authors: Rostowsky KA,Maher AS,Irimia A

    更新日期:2018-11-13 00:00:00

  • Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex.

    abstract:BACKGROUND:Recent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation. CASE PRESENTATION:Her...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00469

    authors: Vlaskamp C,Poil SS,Jansen F,Linkenkaer-Hansen K,Durston S,Oranje B,Bruining H

    更新日期:2017-09-08 00:00:00

  • Accuracy and Feasibility of an Android-Based Digital Assessment Tool for Post Stroke Visual Disorders-The StrokeVision App.

    abstract:Background:Visual impairment affects up to 70% of stroke survivors. We designed an app (StrokeVision) to facilitate screening for common post stroke visual issues (acuity, visual fields, and visual inattention). We sought to describe the test time, feasibility, acceptability, and accuracy of our app-based digital visua...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00146

    authors: Quinn TJ,Livingstone I,Weir A,Shaw R,Breckenridge A,McAlpine C,Tarbert CM

    更新日期:2018-03-28 00:00:00

  • Extracranial Trigger Site Surgery for Migraine: A Systematic Review With Meta-Analysis on Elimination of Headache Symptoms.

    abstract::Introduction: The headache phase of migraine could in selected cases potentially be treated by surgical decompression of one or more "trigger sites," located at frontal, temporal, nasal, and occipital sites. This systematic review with subsequent meta-analysis aims at critically evaluating the currently available evid...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00089

    authors: Vincent AJPE,van Hoogstraten WS,Maassen Van Den Brink A,van Rosmalen J,Bouwen BLJ

    更新日期:2019-02-14 00:00:00

  • Gut-Brain Axis: Potential Factors Involved in the Pathogenesis of Parkinson's Disease.

    abstract::Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00849

    authors: Chao YX,Gulam MY,Chia NSJ,Feng L,Rotzschke O,Tan EK

    更新日期:2020-08-25 00:00:00

  • Old Dog New Tricks; Revisiting How Stroke Modulates the Systemic Immune Landscape.

    abstract::Infections in the post-acute phase of cerebral ischaemia impede optimal recovery by exacerbating morbidity and mortality. Our review aims to reconcile the increased infection susceptibility of patients post-stroke by consolidating our understanding of compartmentalised alterations to systemic immunity. Mounting eviden...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00718

    authors: Krishnan S,Lawrence CB

    更新日期:2019-07-02 00:00:00

  • A fully integrated wireless system for intracranial direct cortical stimulation, real-time electrocorticography data transmission, and smart cage for wireless battery recharge.

    abstract::Wireless transmission of cortical signals is an essential step to improve the safety of epilepsy procedures requiring seizure focus localization and to provide chronic recording of brain activity for Brain Computer Interface (BCI) applications. Our group developed a fully implantable and externally rechargeable device...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00156

    authors: Piangerelli M,Ciavarro M,Paris A,Marchetti S,Cristiani P,Puttilli C,Torres N,Benabid AL,Romanelli P

    更新日期:2014-08-25 00:00:00

  • Hemorrhagic transformation: a review of the rate of hemorrhage in the major clinical trials of acute ischemic stroke.

    abstract::Acute ischemic stroke is a devastating disease that is often complicated by hemorrhagic transformation. While significant advances have been made over the past two decades with regard to emergent treatment of AIS, many of the therapeutic options are limited by an increased risk of hemorrhage. Here, we sought to review...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2013.00069

    authors: Sussman ES,Connolly ES Jr

    更新日期:2013-06-10 00:00:00

  • Interferons in Traumatic Brain and Spinal Cord Injury: Current Evidence for Translational Application.

    abstract::This review article provides a general perspective of the experimental and clinical work surrounding the role of type-I, type-II, and type-III interferons (IFNs) in the pathophysiology of brain and spinal cord injury. Since IFNs are themselves well-known therapeutic targets (as well as pharmacological agents), and ant...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.00458

    authors: Roselli F,Chandrasekar A,Morganti-Kossmann MC

    更新日期:2018-06-19 00:00:00

  • Single Molecule Molecular Inversion Probes for High Throughput Germline Screenings in Dystonia.

    abstract::Background: This study's aim was to investigate a large cohort of dystonia patients for pathogenic and rare variants in the ATM gene, making use of a new, cost-efficient enrichment technology for NGS-based screening. Methods: Single molecule Molecular Inversion Probes (smMIPs) were used for targeted enrichment and seq...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01332

    authors: Pogoda M,Hilke FJ,Lohmann E,Sturm M,Lenz F,Matthes J,Muyas F,Ossowski S,Hoischen A,Faust U,Sepahi I,Casadei N,Poths S,Riess O,Schroeder C,Grundmann K

    更新日期:2019-12-18 00:00:00

  • Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature Review.

    abstract::Mutations in the Potassium channel subfamily T member 1 (KCNT1) gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from the age of 10. The patient had four types of epileptic seizures,...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00064

    authors: Jia Y,Lin Y,Li J,Li M,Zhang Y,Hou Y,Liu A,Zhang L,Li L,Xiang P,Ye J,Huang Z,Wang Y

    更新日期:2019-02-05 00:00:00

  • Dynamic Alterations of Spontaneous Neural Activity in Parkinson's Disease: A Resting-State fMRI Study.

    abstract::Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs. Methods: Twenty-eight patients with PD and 28 demographically...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01052

    authors: Zhang C,Dou B,Wang J,Xu K,Zhang H,Sami MU,Hu C,Rong Y,Xiao Q,Chen N,Li K

    更新日期:2019-10-01 00:00:00

  • Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals.

    abstract::Objective: A number of studies have reported that aldehyde dehydrogenase-2 (ALDH2) polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between ALDH...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00290

    authors: Chen J,Huang W,Cheng CH,Zhou L,Jiang GB,Hu YY

    更新日期:2019-03-28 00:00:00

  • Hemodynamic Characteristics Associated With Paraclinoid Aneurysm Recurrence in Patients After Embolization.

    abstract::Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using hemodynamic numerical simulation and the influence of embolization on recurrence after embolization. Methods: From January 2016 to December 2017, we enrolled a total of 113 paraclinoidal aneurysms treated ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00429

    authors: Sheng B,Wu D,Yuan J,Xu S,Li Z,Dong J,Lai N,Fang X

    更新日期:2019-04-25 00:00:00

  • lop-DWI: A Novel Scheme for Pre-Processing of Diffusion-Weighted Images in the Gradient Direction Domain.

    abstract::We describe and evaluate a pre-processing method based on a periodic spiral sampling of diffusion-gradient directions for high angular resolution diffusion magnetic resonance imaging. Our pre-processing method incorporates prior knowledge about the acquired diffusion-weighted signal, facilitating noise reduction. Peri...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00290

    authors: Sepehrband F,Choupan J,Caruyer E,Kurniawan ND,Gal Y,Tieng QM,McMahon KL,Vegh V,Reutens DC,Yang Z

    更新日期:2015-01-12 00:00:00

  • Cerebral Blood Flow Measurement in Healthy Children and Children Suffering Severe Traumatic Brain Injury-What Do We Know?

    abstract::Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00274

    authors: Rostami E,Nilsson P,Enblad P

    更新日期:2020-04-16 00:00:00

  • Differential Expression of Brain Cannabinoid Receptors between Repeatedly Stressed Males and Females may Play a Role in Age and Gender-Related Difference in Traumatic Brain Injury: Implications from Animal Studies.

    abstract::Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits. Because females are more likely to develop anxiety after stress and...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00161

    authors: Xing G,Carlton J,Jiang X,Wen J,Jia M,Li H

    更新日期:2014-08-28 00:00:00

  • Ventricular Tract Hemorrhage Following Intracranial Nail Removal: Utility of Real-time Endovascular Assistance.

    abstract::Penetrating brain trauma commonly results in occult neurovascular injury. Detailed cerebrovascular imaging can evaluate the relationship of intracranial foreign bodies to major vascular structures, assess for traumatic pseudoaneurysms, and ensure hemostasis during surgical removal. We report a case of a self-inflicted...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2016.00112

    authors: Rennert RC,Steinberg JA,Sack J,Pannell JS,Khalessi AA

    更新日期:2016-07-14 00:00:00

  • Intracochlear Perfusion of Tumor Necrosis Factor-Alpha Induces Sensorineural Hearing Loss and Synaptic Degeneration in Guinea Pigs.

    abstract::Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, including sensorineural h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01353

    authors: Katsumi S,Sahin MI,Lewis RM,Iyer JS,Landegger LD,Stankovic KM

    更新日期:2020-02-10 00:00:00

  • Can I Discharge My Stroke Patient Home After Inpatient Neurorehabilitation? LIMOS Cut-Off Scores for Stroke Patients "Living Alone" and "Living With Family".

    abstract::Background: Discharge planning of stroke patients during inpatient neurorehabilitation is often difficult since it depends both on the patient's ability to perform activities of daily living (ADL) and the social context. The aim of this study was to define ADL cut-off scores using the Lucerne ICF-based multidisciplina...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.601725

    authors: Ottiger B,Lehnick D,Pflugshaupt T,Vanbellingen T,Nyffeler T

    更新日期:2020-11-25 00:00:00

  • An Enigmatic Case of Acute Mercury Poisoning: Clinical, Immunological Findings and Platelet Function.

    abstract::Severe mercury intoxication is very rare in developed countries, but still occurs as the result of volatile substance abuse, suicide attempts, occupational hazards, or endemic food ingestion as reported in the cases of public health disasters in Iraq and in Minamata Bay, Japan. Here, we describe the dramatic physical ...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00517

    authors: Kleffner I,Eichler S,Ruck T,Schüngel L,Pfeuffer S,Polzer P,Dittrich R,Dziewas R,Gross CC,Göbel K,Wiendl H,Kehrel BE,Meuth SG

    更新日期:2017-09-28 00:00:00

  • Eye Movements in Parkinson's Disease and Inherited Parkinsonian Syndromes.

    abstract::Despite extensive research, the functions of the basal ganglia (BG) in movement control have not been fully understood. Eye movements, particularly saccades, are convenient indicators of BG function. Here, we review the main oculomotor findings reported in Parkinson's disease (PD) and genetic parkinsonian syndromes. P...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00592

    authors: Pretegiani E,Optican LM

    更新日期:2017-11-09 00:00:00

  • Damage in the Thalamocortical Tracts is Associated With Subsequent Thalamus Atrophy in Early Multiple Sclerosis.

    abstract::Background: In early multiple sclerosis (MS), thalamus atrophy and decreased integrity of the thalamocortical white matter (WM) tracts have been observed. Objective: To investigate the temporal association between thalamus volume and WM damage in the thalamocortical tract in subjects with early MS. Methods: At two tim...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.575611

    authors: Weeda MM,Pruis IJ,Westerveld ASR,Brouwer I,Bellenberg B,Barkhof F,Vrenken H,Lukas C,Schneider R,Pouwels PJW

    更新日期:2020-11-17 00:00:00

  • Nurse-Led Intervention to Improve Knowledge of Medications in Survivors of Stroke or Transient Ischemic Attack: A Cluster Randomized Controlled Trial.

    abstract:INTRODUCTION:Limited evidence exists on effective interventions to improve knowledge of preventive medications in patients with chronic diseases, such as stroke. We investigated the effectiveness of a nurse-led intervention, where a component was to improve knowledge of prevention medications, in patients with stroke o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2016.00205

    authors: Olaiya MT,Cadilhac DA,Kim J,Ung D,Nelson MR,Srikanth VK,Bladin CF,Gerraty RP,Fitzgerald SM,Phan TG,Frayne J,Thrift AG

    更新日期:2016-11-18 00:00:00

  • Corrigendum: Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases.

    abstract::[This corrects the article DOI: 10.3389/fneur.2020.00696.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误

    doi:10.3389/fneur.2020.607331

    authors: Lin N,Hao H,Guan H,Sun H,Liu Q,Lu Q,Jin L,Ren H,Huang Y

    更新日期:2020-10-30 00:00:00

  • Risk Factors of External Ventricular Drain Infection: Proposing a Model for Future Studies.

    abstract::Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this rev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00226

    authors: Sorinola A,Buki A,Sandor J,Czeiter E

    更新日期:2019-03-15 00:00:00

  • Examining the Utility of Resective Epilepsy Surgery in Children With Electrical Status Epilepticus in Sleep: Long Term Clinical and Electrophysiological Outcomes.

    abstract::Background: Electrical Status Epilepticus in Sleep (ESES) is an epileptic encephalopathy syndrome characterized by infrequent clinical seizures and prominent interictal burden during slow wave sleep associated with cognitive deficits and behavioral dysfunction. Medical treatment with anti-epileptic drugs is often unsu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01397

    authors: Marashly A,Koop J,Loman M,Lee YW,Lew SM

    更新日期:2020-01-15 00:00:00