Mexican-National Institute of Neurology and Neurosurgery-Stroke Registry: Results of a 25-Year Hospital-Based Study.


Background and purpose:Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk factors and outcomes. Methods:The demographic data, stroke description, ancillary tests, vascular risk factors, and modified Rankin scale (mRs) were registered. Ischemic stroke subtyping was based on the Trial of Org 10,172 of the Acute Stroke Treatment classification. We followed-up patients using multiple overlapping methods. Primary outcomes included mRs, recurrence, and death at 30 days and at the end of follow-up. Results:We included 4,481 patients with a median follow-up of 27 months, (17,281 person-years follow-up). The mean age was 52.8 ± 18 years. There were 2,229 males (50%) included in the study. CI was present in 64.9%, intracerebral hemorrhage (ICH) in 25.6%, and cerebral venous thrombosis (CVT) in 6.3%. Hypertension was the major risk factor (46.5%). The most common cause of CI was atherosclerosis (27%). ICH was mainly hypertensive (58%), and 60% of CVT were puerperal. Overall, the mortality rate was 24.5%. The recurrence rate was 16.9%. Poor outcome (mRs ≥ 3) was found in 56.2% of patients. The best outcomes were observed in CVT patients (74.5% mRs ≤ 2), whereas 72.1% ICH patients had mRs ≥3. Conclusion:This is one of the largest hospital-based registries in LA and shows significant differences with other previously published registries, including a younger age, relatively less hypertension, and larger proportion of CVT. Poor functional outcome was common. This study adds to the understanding of geographic differences in stroke characteristics and outcomes.


Front Neurol


Frontiers in neurology


Arauz A,Marquez-Romero JM,Barboza MA,Serrano F,Artigas C,Murillo-Bonilla LM,Cantú-Brito C,Ruiz-Sandoval JL,Barinagarrementeria F




Has Abstract


2018-04-04 00:00:00








  • Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case-Control Studies.

    abstract::Inconclusive results have been reported in studies investigating the association between the brain-derived neurotrophic factor (BDNF) rs6265 polymorphism and migraine. In the present study, we conducted a systematic review and meta-analysis on the published data in order to quantitatively estimate the relationship bet...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Terrazzino S,Cargnin S,Viana M,Sances G,Tassorelli C

    更新日期:2017-05-01 00:00:00

  • Cerebral Blood Flow Measurement in Healthy Children and Children Suffering Severe Traumatic Brain Injury-What Do We Know?

    abstract::Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Rostami E,Nilsson P,Enblad P

    更新日期:2020-04-16 00:00:00

  • Ophthalmoplegia Due to Miller Fisher Syndrome in a Patient With Myasthenia Gravis.

    abstract::Here, we describe a 79-year-old man, admitted to our unit for worsening diplopia and fatigue, started a few weeks after an episode of bronchitis and flu vaccination. Past medical history includes myasthenia gravis (MG), well-controlled by Pyridostigmine, Azathioprine, and Prednisone. During the first days, the patient...

    journal_title:Frontiers in neurology



    authors: Brusa R,Faravelli I,Gagliardi D,Magri F,Cogiamanian F,Saccomanno D,Cinnante C,Mauri E,Abati E,Bresolin N,Corti S,Comi GP

    更新日期:2019-08-13 00:00:00

  • Functional Connectivity Alterations Reveal Complex Mechanisms Based on Clinical and Radiological Status in Mild Relapsing Remitting Multiple Sclerosis.

    abstract::Resting state functional MRI (rs-fMRI) has provided important insights into functional reorganization in subjects with Multiple Sclerosis (MS) at different stage of disease. In this cross-sectional study we first assessed, by means of rs-fMRI, the impact of overall T2 lesion load (T2LL) and MS severity score (MSSS) on...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Castellazzi G,Debernard L,Melzer TR,Dalrymple-Alford JC,D'Angelo E,Miller DH,Gandini Wheeler-Kingshott CAM,Mason DF

    更新日期:2018-08-20 00:00:00

  • Forecast or Fall: Prediction's Importance to Postural Control.

    abstract::To interact successfully with an uncertain environment, organisms must be able to respond to both unanticipated and anticipated events. For unanticipated events, organisms have evolved stereotyped motor behaviors mapped to the statistical regularities of the environment, which can be trigged by specific sensory stimul...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Dakin CJ,Bolton DAE

    更新日期:2018-10-30 00:00:00

  • Multiplex Matrix Metalloproteinases Analysis in the Cerebrospinal Fluid Reveals Potential Specific Patterns in Multiple Sclerosis Patients.

    abstract::Background: Matrix metalloproteinases (MMPs) are pleiotropic enzymes involved in extracellular protein degradation and turnover. MMPs are implicated in the pathogenesis of many neurological diseases, including multiple sclerosis (MS). Objective: To search the level of MMPs in the cerebrospinal fluid (CSF) of MS patien...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Castellazzi M,Ligi D,Contaldi E,Quartana D,Fonderico M,Borgatti L,Bellini T,Trentini A,Granieri E,Fainardi E,Mannello F,Pugliatti M

    更新日期:2018-12-18 00:00:00

  • Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China.

    abstract::The relationship between body mass index (BMI) and stroke type has remained controversial despite studies demonstrating that BMI is related to stroke risk, especially in specific groups. We assessed the age- and sex-associated impacts of BMI on stroke type in a low-income, poorly educated population in China. The asso...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gu H,Shao S,Liu J,Fan Z,Chen Y,Ni J,Wang C,Tu J,Ning X,Lou Y,Li B,Wang J

    更新日期:2019-05-01 00:00:00

  • Gut-Brain Axis: Potential Factors Involved in the Pathogenesis of Parkinson's Disease.

    abstract::Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Chao YX,Gulam MY,Chia NSJ,Feng L,Rotzschke O,Tan EK

    更新日期:2020-08-25 00:00:00

  • Predicting Disability after Ischemic Stroke Based on Comorbidity Index and Stroke Severity-From the Virtual International Stroke Trials Archive-Acute Collaboration.

    abstract:BACKGROUND AND AIM:The availability and access of hospital administrative data [coding for Charlson comorbidity index (CCI)] in large data form has resulted in a surge of interest in using this information to predict mortality from stroke. The aims of this study were to determine the minimum clinical data set to be inc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Phan TG,Clissold BB,Ma H,Ly JV,Srikanth V

    更新日期:2017-05-19 00:00:00

  • Vagus Nerve Stimulation Attenuates Cerebral Microinfarct and Colitis-induced Cerebral Microinfarct Aggravation in Mice.

    abstract::Cerebral cortical microinfarct (CMI) is common in patients with dementia and cognitive decline. Emerging studies reported that intestinal dysfunction influenced the outcome of ischemic stroke and that vagus nerve stimulation (VNS) protected against ischemic stroke. However, the effects of intestinal dysfunction and VN...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Chen X,He X,Luo S,Feng Y,Liang F,Shi T,Huang R,Pei Z,Li Z

    更新日期:2018-09-26 00:00:00

  • Developing Cognition Endpoints for the CENTER-TBI Neuropsychological Test Battery.

    abstract::Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several neuropsychological test scores into composite, or summary, scores exists. This study examined several possible composite scores for the test battery used in the large...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Stenberg J,Karr JE,Terry DP,Saksvik SB,Vik A,Skandsen T,Silverberg ND,Iverson GL

    更新日期:2020-07-17 00:00:00

  • Transverse Strips Instead of Wearable Laser Lights Alleviate the Sequence Effect Toward a Destination in Parkinson's Disease Patients With Freezing of Gait.

    abstract::Background: The sequence effect (SE), referring to step-to-step reduction in amplitude, is considered to lead to freezing of gait (FOG) in Parkinson's disease (PD). Visual cues may alleviate SE and help reduce freezing episodes. FOG patients show significant SE prior to turning or toward a doorway, but the SE toward a...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cao SS,Yuan XZ,Wang SH,Taximaimaiti R,Wang XP

    更新日期:2020-08-12 00:00:00

  • Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage.

    abstract::Background: Intracranial carotid artery calcification (ICAC) on computed tomography (CT) is a marker of atherosclerosis and an independent predictor of vascular events including stroke. While vitamin K antagonists (VKAs) are used to prevent embolic stroke, they have been shown to increase levels of both coronary and e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Peeters MTJ,Houben R,Postma AA,van Oostenbrugge RJ,Schurgers LJ,Staals J

    更新日期:2019-12-20 00:00:00

  • Clinical Features and Correlates of Excessive Daytime Sleepiness in Parkinson's Disease.

    abstract::Objective: To explore the clinical features and correlates of excessive daytime sleepiness (EDS) in a Chinese population of Parkinson's disease (PD) patients. Methods: Patients with clinically established or clinically probable PD were recruited. Clinical and demographic data were collected, and participants were eval...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Xiang YQ,Xu Q,Sun QY,Wang ZQ,Tian Y,Fang LJ,Yang Y,Tan JQ,Yan XX,Tang BS,Guo JF

    更新日期:2019-02-19 00:00:00

  • Nurse-Led Intervention to Improve Knowledge of Medications in Survivors of Stroke or Transient Ischemic Attack: A Cluster Randomized Controlled Trial.

    abstract:INTRODUCTION:Limited evidence exists on effective interventions to improve knowledge of preventive medications in patients with chronic diseases, such as stroke. We investigated the effectiveness of a nurse-led intervention, where a component was to improve knowledge of prevention medications, in patients with stroke o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Olaiya MT,Cadilhac DA,Kim J,Ung D,Nelson MR,Srikanth VK,Bladin CF,Gerraty RP,Fitzgerald SM,Phan TG,Frayne J,Thrift AG

    更新日期:2016-11-18 00:00:00

  • Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke.

    abstract:BACKGROUND:The present review investigated which findings in vascular imaging techniques can be used to predict clinical outcome and the risk of symptomatic intracerebral hemorrhage (sICH) in patients who underwent intravenous thrombolytic treatment. METHODS:Publications were searched, and the inclusion criteria were ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Nogueira RC,Bor-Seng-Shu E,Saeed NP,Teixeira MJ,Panerai RB,Robinson TG

    更新日期:2016-05-18 00:00:00

  • Parkinson's Disease Caregiver Strain in Singapore.

    abstract::Background: Caregiver strain is recognized globally with Parkinson's disease (PD). Comparatively little is understood about caregiver burden and strain in Asia. Objective: To investigate caregiver strain for families living with PD in Singapore, in light of international data. Methods: Ninety-four caregivers were recr...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Tan SB,Williams AF,Tan EK,Clark RB,Morris ME

    更新日期:2020-06-23 00:00:00

  • Body Mass Index and Prognosis in Ischemic Stroke Patients With Type 2 Diabetes Mellitus.

    abstract::Background: Overweight contributes to type 2 diabetes mellitus (T2DM) development. Although the obesity paradox has been suggested in many vascular diseases, little information is available about stroke patients with T2DM. We investigated whether body mass index (BMI) has a differential impact on the incidence of majo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Park H,Lee HW,Yoo J,Lee HS,Nam HS,Kim YD,Heo JH

    更新日期:2019-06-05 00:00:00

  • Non-fluent/Agrammatic Variant of Primary Progressive Aphasia With Generalized Auditory Agnosia.

    abstract::Cortical neurodegeneration-induced non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a clinical syndrome characterized by non-fluent speech, such as apraxia of speech or agrammatism. We describe the case of an 80-year-old right-handed woman who exhibited nfvPPA. Atypically, our patient also pres...

    journal_title:Frontiers in neurology



    authors: Watanabe H,Ikeda M,Mori E

    更新日期:2020-06-26 00:00:00

  • The Video Head Impulse Test to Assess the Efficacy of Vestibular Implants in Humans.

    abstract::The purpose of this study was to evaluate whether it is possible to restore the high-frequency angular vestibulo-ocular reflex (aVOR) in patients suffering from a severe bilateral vestibulopathy (BV) and implanted with a vestibular implant prototype. Three patients (S1-3) participated in the study. They received a pro...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Guinand N,Van de Berg R,Cavuscens S,Ranieri M,Schneider E,Lucieer F,Kingma H,Guyot JP,Pérez Fornos A

    更新日期:2017-11-14 00:00:00

  • Transcranial Direct Current Stimulation in Patients with Prolonged Disorders of Consciousness: Combined Behavioral and Event-Related Potential Evidence.

    abstract:Background:The electrophysiological evidence supporting the therapeutic efficacy of multiple transcranial direct current stimulation (tDCS) sessions on consciousness improvement in patients with prolonged disorders of consciousness (DOCs) has not been firmly established. Objectives:To assess the effects of repeated tD...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhang Y,Song W,Du J,Huo S,Shan G,Li R

    更新日期:2017-11-21 00:00:00

  • Including a Lower-Extremity Component during Hand-Arm Bimanual Intensive Training does not Attenuate Improvements of the Upper Extremities: A Retrospective Study of Randomized Trials.

    abstract::Hand-Arm Bimanual Intensive Therapy (HABIT) promotes hand function using intensive practice of bimanual functional and play tasks. This intervention has shown to be efficacious to improve upper-extremity (UE) function in children with unilateral spastic cerebral palsy (USCP). In addition to UE function deficits, lower...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Saussez G,Brandão MB,Gordon AM,Bleyenheuft Y

    更新日期:2017-09-26 00:00:00

  • Hemodynamic Characteristics Associated With Paraclinoid Aneurysm Recurrence in Patients After Embolization.

    abstract::Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using hemodynamic numerical simulation and the influence of embolization on recurrence after embolization. Methods: From January 2016 to December 2017, we enrolled a total of 113 paraclinoidal aneurysms treated ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sheng B,Wu D,Yuan J,Xu S,Li Z,Dong J,Lai N,Fang X

    更新日期:2019-04-25 00:00:00

  • Could cord blood cell therapy reduce preterm brain injury?

    abstract::Major advances in neonatal care have led to significant improvements in survival rates for preterm infants, but this occurs at a cost, with a strong causal link between preterm birth and neurological deficits, including cerebral palsy (CP). Indeed, in high-income countries, up to 50% of children with CP were born pret...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Li J,McDonald CA,Fahey MC,Jenkin G,Miller SL

    更新日期:2014-10-09 00:00:00

  • Genetic Variants of PICALM rs541458 Modulate Brain Spontaneous Activity in Older Adults With Amnestic Mild Cognitive Impairment.

    abstract::Background: Phosphatidylinositol binding clathrin assembly protein (PICALM) rs541458 C allele has been identified and validated to be associated with a reduction of Alzheimer's disease (AD) risk. Nevertheless, the exact mechanisms through which the variant exert its disease-relevant association remain to be elucidated...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhuang L,Liu X,Shi Y,Liu X,Luo B

    更新日期:2019-05-08 00:00:00

  • Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study.

    abstract::This study presents the first implementation of functional ultrasound (fUS) imaging of the spinal cord to monitor local hemodynamic response to epidural electrical spinal cord stimulation (SCS) on two small and large animal models. SCS has been successfully applied to control chronic refractory pain and recently was e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Song P,Cuellar CA,Tang S,Islam R,Wen H,Huang C,Manduca A,Trzasko JD,Knudsen BE,Lee KH,Chen S,Lavrov IA

    更新日期:2019-03-26 00:00:00

  • Cholinergic Nociceptive Mechanisms in Rat Meninges and Trigeminal Ganglia: Potential Implications for Migraine Pain.

    abstract:BACKGROUND:Parasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches suggests contribution of cholinergic mechanisms to primary headaches. However, neurochemical mechanisms of cholinergic regulation of peripheral nociception in meninges, origin pl...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Shelukhina I,Mikhailov N,Abushik P,Nurullin L,Nikolsky EE,Giniatullin R

    更新日期:2017-04-27 00:00:00

  • Cluster Analysis to Identify Possible Subgroups in Tinnitus Patients.

    abstract:INTRODUCTION:In tinnitus treatment, there is a tendency to shift from a "one size fits all" to a more individual, patient-tailored approach. Insight in the heterogeneity of the tinnitus spectrum might improve the management of tinnitus patients in terms of choice of treatment and identification of patients with severe ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: van den Berge MJC,Free RH,Arnold R,de Kleine E,Hofman R,van Dijk JMC,van Dijk P

    更新日期:2017-04-03 00:00:00

  • The Crucial Changes of Sit-to-Stand Phases in Subacute Stroke Survivors Identified by Movement Decomposition Analysis.

    abstract:Objective:The aim of this study was to detect the key changes during sit-to-stand (STS) movement cycle in hemiparetic stroke survivors using a five-phase kinematic and kinetic analysis. Methods:Twenty-five subacute stroke survivors and 17 age-matched healthy adults participated in this study. The kinematic and kinetic...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Mao YR,Wu XQ,Zhao JL,Lo WLA,Chen L,Ding MH,Xu ZQ,Bian RH,Huang DF,Li L

    更新日期:2018-03-26 00:00:00

  • A Mindfulness-Based Stress Reduction Program via Group Video Conferencing for Adults With Cerebral Palsy - A Pilot Study.

    abstract::Purpose: Adults with cerebral palsy experience challenges related to lifelong disability, such as stress, fatigue, pain and emotional issues. E-health services can be delivered regardless of residence and level of functioning. The aim of this pilot study was to explore the potential benefits and feasibility of a mindf...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Høye H,Jahnsen RB,Løvstad M,Hartveit JF,Sørli H,Tornås S,Månum G

    更新日期:2020-04-03 00:00:00