Hemodynamics of Prefrontal Cortex in Ornithine Transcarbamylase Deficiency: A Twin Case Study.

abstract：:Subcortical circuits mediating sleep-wake functions have been well characterized in animal models, and corroborated by more recent human studies. Disruptions in these circuits have been identified in hypersomnia disorders (HDs) such as narcolepsy and Kleine-Levin Syndrome, as well as in neurodegenerative disorders exp...

journal_title：Frontiers in neurology

authors： Larson-Prior LJ,Ju YE,Galvin JE

更新日期：2014-09-11 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely characterized by the selective vulnerability of motor neurons and the poor life expectancy of afflicted patients. Limited disease-modifying therapies currently exist, which only further attests to the substantial heterogeneity...

journal_title：Frontiers in neurology

authors： Gaur N,Perner C,Witte OW,Grosskreutz J

更新日期：2020-05-27 00:00:00

abstract：:Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measu...

journal_title：Frontiers in neurology

authors： Czekóová K,Shaw DJ,Saxunová K,Dufek M,Mareček R,Vaníček J,Brázdil M

更新日期：2019-05-21 00:00:00

abstract：:Epilepsy is a common neurological disorder that affects over 70 million people worldwide. Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients with epilepsy have seizures refractory to pharmacotherapy. Early identification of patients who will become refractory to ASDs could hel...

journal_title：Frontiers in neurology

authors： Tang F,Hartz AMS,Bauer B

更新日期：2017-07-06 00:00:00

abstract：:Expansion of the neural progenitor pool in the developing cerebral cortex is crucial for controlling brain size, since proliferation defects have been associated with the pathogenesis of microcephaly in humans. Cell cycle regulators play important roles in proliferation of neural progenitors. Here, we show that the cy...

journal_title：Frontiers in neurology

authors： Chen Y,Bian S,Zhang J,Zhang H,Tang B,Sun T

更新日期：2014-07-18 00:00:00

abstract：:The pool of neural stem and progenitor cells (NSPCs) in the dentate gyrus of the hippocampus is reduced by ionizing radiation. This explains, at least partly, the learning deficits observed in patients after radiotherapy, particularly in pediatric cases. An 8 Gy single irradiation dose was delivered to the whole brain...

journal_title：Frontiers in neurology

authors： Sato Y,Shinjyo N,Sato M,Nilsson MKL,Osato K,Zhu C,Pekna M,Kuhn HG,Blomgren K

更新日期：2018-09-11 00:00:00

abstract：:Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. In this mini review, we focus on the hypothesis of distur...

journal_title：Frontiers in neurology

authors： Samuelsson K,Press R

更新日期：2018-02-12 00:00:00

abstract：:Seizures are an infrequent and serious neurological complication of SARS-CoV-2 infection, with limited data describing the etiology and the clinical context in which these occur or the associated electrographic and imaging findings. This series details four cases of seizures occurring in patients with COVID-19 with di...

journal_title：Frontiers in neurology

authors： Hwang ST,Ballout AA,Mirza U,Sonti AN,Husain A,Kirsch C,Kuzniecky R,Najjar S

更新日期：2020-11-05 00:00:00

abstract：:Primary angiitis of the central nervous system (PACNS) is a rare autoimmune vasculitis limited to the CNS often causing substantial disability. Understanding of this disease is impaired by the lack of available biomaterial. Here, we collected cerebrospinal fluid (CSF) from patients with PACNS and matched controls and ...

journal_title：Frontiers in neurology

authors： Ruland T,Wolbert J,Gottschalk MG,König S,Schulte-Mecklenbeck A,Minnerup J,Meuth SG,Groß CC,Wiendl H,Meyer Zu Hörste G

更新日期：2018-06-05 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of motor neurons in the spinal cord, and comprises a broad clinical spectrum. With the advent of new therapies (e.g., Nusinersen) for patients of all ages and disease stages, sensitive clinical measures are needed to det...

journal_title：Frontiers in neurology

authors： Kruse T,Lehmann HC,Braumann B,Fink GR,Wunderlich G

更新日期：2020-02-25 00:00:00

abstract：:The benefits of hemicraniectomy for malignant middle cerebral artery (MCA) stroke may not be apparent in the 3- to 6-months in which final outcomes are assessed in research studies. We present the case of a 15-year-old who underwent hemicraniectomy for malignant MCA stroke and was significantly disabled 3 and 6 months...

journal_title：Frontiers in neurology

authors： Mittal A,Mittal G,Partikian A,Liebeskind D,Sanossian N

更新日期：2012-08-02 00:00:00

abstract：:Background and Purpose: The effect of uric acid (UA) levels on severity and prognosis of spontaneous intracerebral hemorrhage (ICH) remains controversial. We aimed to explore the association of admission UA levels with stroke severity and outcomes in ICH patients. Materials and Methods: The patients enrolled in this s...

journal_title：Frontiers in neurology

authors： Liu X,Cao Z,Gu H,Yang K,Ji R,Li Z,Zhao X,Wang Y

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and tolerability of a clonidine transdermal patch in the treatment of children with tic disorders (TD) and to establish a predictive model for patients. METHODS:Forty-one patients who met the inclusion criteria entered into 12 weeks of prospective, open, single-group, self-controlle...

journal_title：Frontiers in neurology

authors： Song PP,Jiang L,Li XJ,Hong SQ,Li SZ,Hu Y

更新日期：2017-02-23 00:00:00

abstract：Objective:The aim of this study was to detect the key changes during sit-to-stand (STS) movement cycle in hemiparetic stroke survivors using a five-phase kinematic and kinetic analysis. Methods:Twenty-five subacute stroke survivors and 17 age-matched healthy adults participated in this study. The kinematic and kinetic...

journal_title：Frontiers in neurology

authors： Mao YR,Wu XQ,Zhao JL,Lo WLA,Chen L,Ding MH,Xu ZQ,Bian RH,Huang DF,Li L

更新日期：2018-03-26 00:00:00

abstract：:Ischemic stroke is a multi-factorial cerebrovascular disease with high worldwide morbidity and mortality. In the past few years, multiple studies have revealed the underlying mechanism of ischemia/reperfusion injury, including calcium overload, amino acid toxicity, oxidative stress, and inflammation. Connexin 43 (Cx43...

journal_title：Frontiers in neurology

authors： Liang Z,Wang X,Hao Y,Qiu L,Lou Y,Zhang Y,Ma D,Feng J

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Accurate recognition of stroke symptoms by Emergency Medical Services (EMS) is necessary for timely care of acute stroke patients. We assessed the accuracy of stroke diagnosis by EMS in clinical practice in a major US city. METHODS AND RESULTS:Philadelphia Fire Department data were merged with data from a s...

journal_title：Frontiers in neurology

authors： Jia J,Band R,Abboud ME,Pajerowski W,Guo M,David G,Mechem CC,Messé SR,Carr BG,Mullen MT

更新日期：2017-09-14 00:00:00

abstract：:Introduction: Few studies have examined the motor, cognitive, and emotional factors involved in effective money management in persons with multiple sclerosis (MS). The aim of this study was to assess money management in persons MS and examine whether cognitive, motor, and emotional processes can predict money manageme...

journal_title：Frontiers in neurology

authors： Yael G,Nancy C,John D

更新日期：2019-10-23 00:00:00

abstract：:Narcolepsy with cataplexy is a rare, but important differential diagnosis for daytime sleepiness and atonic paroxysms in an adolescent. A recent increase in incidence in the pediatric age group probably linked to the use of the Pandemrix influenza vaccine in 2009, has increased awareness that different environmental f...

journal_title：Frontiers in neurology

authors： Rosch RE,Farquhar M,Gringras P,Pal DK

更新日期：2016-08-10 00:00:00

abstract：:Therapeutic hypothermia (HT) is a currently accepted treatment for neonatal asphyxia and is a promising strategy in adult stroke therapy. We previously reported that acute administration of docosahexaenoic acid (DHA) triglyceride emulsion (tri-DHA) protects against hypoxic-ischemic (HI) injury in neonatal mice. We que...

journal_title：Frontiers in neurology

authors： Manual Kollareth DJ,Zirpoli H,Ten VS,Deckelbaum RJ

更新日期：2021-01-15 00:00:00

abstract：:Introduction: This study quantified stroke-related changes in the following: (1) the averaged discharge rate of motor units (individually tracked and untracked) identified from high-density electromyography (HD-EMG) recordings, (2) global muscle EMG properties of the dorsiflexors during a fatiguing contraction, and th...

journal_title：Frontiers in neurology

authors： Negro F,Bathon KE,Nguyen JN,Bannon CG,Orizio C,Hunter SK,Hyngstrom AS

更新日期：2020-10-29 00:00:00

abstract：:Traumatic brain injury (TBI) and the activation of secondary injury mechanisms have been linked to impaired cognitive function, which, as observed in TBI patients and animal models, can persist for months and years following the initial injury. Impairments in neurotransmission have been well documented in experimental...

journal_title：Frontiers in neurology

authors： Carlson SW,Henchir J,Dixon CE

更新日期：2017-10-10 00:00:00

abstract：:We describe and evaluate a pre-processing method based on a periodic spiral sampling of diffusion-gradient directions for high angular resolution diffusion magnetic resonance imaging. Our pre-processing method incorporates prior knowledge about the acquired diffusion-weighted signal, facilitating noise reduction. Peri...

journal_title：Frontiers in neurology

authors： Sepehrband F,Choupan J,Caruyer E,Kurniawan ND,Gal Y,Tieng QM,McMahon KL,Vegh V,Reutens DC,Yang Z

更新日期：2015-01-12 00:00:00

abstract：BACKGROUND:Recent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation. CASE PRESENTATION:Her...

journal_title：Frontiers in neurology

authors： Vlaskamp C,Poil SS,Jansen F,Linkenkaer-Hansen K,Durston S,Oranje B,Bruining H

更新日期：2017-09-08 00:00:00

abstract：:Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and cell biology of this cytoplasmic protein. Tau's wayward properties may derive from germline mutations in the case of frontotemporal lobar degeneration (FTLD-MAPT)...

journal_title：Frontiers in neurology

authors： Kang SG,Eskandari-Sedighi G,Hromadkova L,Safar JG,Westaway D

更新日期：2020-11-12 00:00:00

abstract：:Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in t...

journal_title：Frontiers in neurology

authors： Almendros I,Martínez-García MÁ,Campos-Rodríguez F,Riveiro-Falkenbach E,Rodríguez-Peralto JL,Nagore E,Martorell-Calatayud A,Hernández Blasco L,Bañuls Roca J,Chiner Vives E,Sánchez-de-la-Torre A,Abad-Capa J,Montserrat JM,Pérez-Gi

更新日期：2018-04-26 00:00:00

abstract：:Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation of promising findings between preclinical disease models and patients....

journal_title：Frontiers in neurology

authors： Heath CJ,O'Callaghan C,Mason SL,Phillips BU,Saksida LM,Robbins TW,Barker RA,Bussey TJ,Sahakian BJ

更新日期：2019-08-09 00:00:00

abstract：:This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine-Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functio...

journal_title：Frontiers in neurology

authors： Engström M,Hallböök T,Szakacs A,Karlsson T,Landtblom AM

更新日期：2014-06-25 00:00:00

abstract：:The corticospinal system is a major motor pathway in the control of skilled voluntary movements such as reaching and grasping. It has developed considerably phylogenetically to reach a peak in humans. Because rodents possess advanced forelimb movements that can be used for reaching and grasping food, it is commonly co...

journal_title：Frontiers in neurology

authors： Alstermark B,Pettersson LG

更新日期：2014-06-20 00:00:00

abstract：:Introduction: Novel therapies are needed for the treatment of motion sickness given the inadequate relief and bothersome and dangerous adverse effects of currently approved therapies. Neurokinin-1 (NK1) receptor antagonists have the potential to be effective in improving the symptoms of motion sickness, given the invo...

journal_title：Frontiers in neurology

authors： Polymeropoulos VM,Czeisler MÉ,Gibson MM,Anderson AA,Miglo J,Wang J,Xiao C,Polymeropoulos CM,Birznieks G,Polymeropoulos MH

更新日期：2020-09-29 00:00:00

abstract：OBJECTIVE:To assess the progress of the development of the vestibular implant (VI) and its feasibility short-term. DATA SOURCES:A search was performed in Pubmed, Medline, and Embase. Key words used were "vestibular prosth*" and "VI." The only search limit was language: English or Dutch. Additional sources were medical...

journal_title：Frontiers in neurology

authors： van de Berg R,Guinand N,Stokroos RJ,Guyot JP,Kingma H

更新日期：2011-08-11 00:00:00