Cell-Based Therapies for Stroke: Are We There Yet?

Abstract:

:Stroke is the second leading cause of death and physical disability, with a global lifetime incidence rate of 1 in 6. Currently, the only FDA approved treatment for ischemic stroke is the administration of tissue plasminogen activator (tPA). Stem cell clinical trials for stroke have been underway for close to two decades, with data suggesting that cell therapies are safe, feasible, and potentially efficacious. However, clinical trials for stroke account for <1% of all stem cell trials. Nevertheless, the resources devoted to clinical research to identify new treatments for stroke is still significant (53-64 million US$, Phase 1-4). Notably, a quarter of cell therapy clinical trials for stroke have been withdrawn (15.2%) or terminated (6.8%) to date. This review discusses the bottlenecks in delivering a successful cell therapy for stroke, and the cost-to-benefit ratio necessary to justify these expensive trials. Further, this review will critically assess the currently available data from completed stroke trials, the importance of standardization in outcome reporting, and the role of industry-led research in the development of cell therapies for stroke.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Krause M,Phan TG,Ma H,Sobey CG,Lim R

doi

10.3389/fneur.2019.00656

subject

Has Abstract

pub_date

2019-06-25 00:00:00

pages

656

issn

1664-2295

journal_volume

10

pub_type

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