Association Between Peripapillary Bruch's Membrane Shape and Intracranial Pressure: Effect of Image Acquisition Pattern and Image Analysis Method, a Preliminary Study.


:Background/Aims: High intracranial pressure (ICP) is associated with changes in peripapillary Bruch's membrane (pBM) shape on optical coherence tomography (OCT) images of the optic nerve head. It is not known if image acquisition pattern and analysis method impact this association. Materials and Methods: Cross sectional OCT scans of the optic nerve head were obtained at six angles using a radial scan pattern in 21 subjects immediately prior to ICP measurement via lumbar puncture. On each image, Bruch's membrane was manually segmented and defined by either 14 or 16 semi-landmarks and either rater identified, or distance identified boundaries. For each of these four image analysis strategies, geometric morphometric analysis identified the first principal component of Bruch's membrane shape for all images and for the set of images taken at each angle. Repeated measures ANOVA of the first principal component magnitude (PC1) for all images assessed for shape difference between image angles. Linear generalized estimating equation models assessed association between angle specific first principal component magnitudes (PC1) and ICP for each angle. Receiver operating characteristic analysis assessed angle specific PC1s' ability to differentiate elevated from normal ICP. Results: The first principal component represented deflection into the vitreous for all scan angles, but quantitatively differed across scan angles (p < 0.005, repeated measures ANOVA). Angle specific first principal components were positively correlated with ICP (p < 0.005 for all angles, generalized estimating equation models). All angle specific first principal components showed excellent ability to classify ICP (area under curve ≥ 0.8 for all). These results were independent from image analysis strategy. Discussion: Though qualitative changes in Bruch's membrane shape are similar regardless of cross-sectional angle of the 2-D OCT scan, they differ quantitatively between OCT scan angles, meaning that pBM is not axially symmetric and therefore PC1 extracted from different 2-D scan angles can't be compared between individuals. However, we do not identify an optimal scan angle for classification of ICP since there is a similarly strong linear relationship between the first principal component of shape and ICP and angle specific first principal components of Bruch's membrane shape showed similarly excellent ability to differentiate elevated from normal ICP. The results support development of Bruch's membrane shape extracted from 2-D cross sectional optic nerve head OCT scans as a biomarker of ICP and emphasize the importance of consistency of scan angle. This is relevant for developing diagnostic protocols that use OCT to detect high ICP states.


Front Neurol


Frontiers in neurology


Malhotra K,Patel MD,Shirazi Z,Moss HE




Has Abstract


2018-12-21 00:00:00








  • Advanced Myoelectric Control for Robotic Hand-Assisted Training: Outcome from a Stroke Patient.

    abstract::A hand exoskeleton driven by myoelectric pattern recognition was designed for stroke rehabilitation. It detects and recognizes the user's motion intent based on electromyography (EMG) signals, and then helps the user to accomplish hand motions in real time. The hand exoskeleton can perform six kinds of motions, includ...

    journal_title:Frontiers in neurology



    authors: Lu Z,Tong KY,Shin H,Li S,Zhou P

    更新日期:2017-03-20 00:00:00

  • Hemodynamic Significance of Middle Cerebral Artery Stenosis Associated With the Severity of Ipsilateral White Matter Changes.

    abstract::Background: Previous studies conflicted in the association between intracranial atherosclerotic stenosis (ICAS) and the severity of white matter changes (WMC). Aims: We aimed to investigate the relationships between the severity of luminal stenosis and the hemodynamic significance of middle cerebral artery (MCA) steno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Fang H,Leng X,Pu Y,Zou X,Pan Y,Song B,Soo YOY,Leung TWH,Wang C,Zhao X,Wang Y,Wang Y,Wong KS,Liu L,Xu Y,CICAS Study Group.

    更新日期:2020-04-15 00:00:00

  • Impaired Firing Behavior of Individually Tracked Paretic Motor Units During Fatiguing Contractions of the Dorsiflexors and Functional Implications Post Stroke.

    abstract::Introduction: This study quantified stroke-related changes in the following: (1) the averaged discharge rate of motor units (individually tracked and untracked) identified from high-density electromyography (HD-EMG) recordings, (2) global muscle EMG properties of the dorsiflexors during a fatiguing contraction, and th...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Negro F,Bathon KE,Nguyen JN,Bannon CG,Orizio C,Hunter SK,Hyngstrom AS

    更新日期:2020-10-29 00:00:00

  • Cognitive gains from gist reasoning training in adolescents with chronic-stage traumatic brain injury.

    abstract::Adolescents with traumatic brain injury (TBI) typically demonstrate good recovery of previously acquired skills. However, higher-order and later emergent cognitive functions are often impaired and linked to poor outcomes in academic and social/behavioral domains. Few control trials exist that test cognitive treatment ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cook LG,Chapman SB,Elliott AC,Evenson NN,Vinton K

    更新日期:2014-06-11 00:00:00

  • Clinical Profile and Outcome of Pediatric Mitochondrial Myopathy in China.

    abstract::Introduction: Mitochondrial myopathy in children has notable clinical and genetic heterogeneity, but detailed data is lacking. Patients and Methods: In this study, we retrospectively reviewed the clinical presentation, laboratory investigation, genetic and histopathological characteristics, and follow-ups of 21 pediat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hu C,Li X,Zhao L,Shi Y,Zhou S,Wang Y

    更新日期:2020-09-08 00:00:00

  • Reconsidering the role of neuronal intrinsic properties and neuromodulation in vestibular homeostasis.

    abstract::The sensorimotor transformations performed by central vestibular neurons constantly adapt as the animal faces conflicting sensory information or sustains injuries. To ensure the homeostasis of vestibular-related functions, neural changes could in part rely on the regulation of 2° VN intrinsic properties. Here we revie...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Beraneck M,Idoux E

    更新日期:2012-02-28 00:00:00

  • Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis.

    abstract::Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Czekóová K,Shaw DJ,Saxunová K,Dufek M,Mareček R,Vaníček J,Brázdil M

    更新日期:2019-05-21 00:00:00

  • Efficacy of Tasimelteon (HETLIOZ®) in the Treatment of Jet Lag Disorder Evaluated in an 8-h Phase Advance Model; a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

    abstract::Background: Most travelers experience Jet Lag Disorder (JLD) symptoms due to misalignment of their circadian rhythms with respect to the new time zone. We assessed the efficacy and safety of tasimelteon (HETLIOZ®) in healthy participants using a laboratory model of JLD induced by an 8-h phase advance of the sleep-wake...

    journal_title:Frontiers in neurology



    authors: Polymeropoulos CM,Mohrman MA,Keefe MS,Brzezynski JL,Wang J,Prokosch LS,Polymeropoulos VM,Xiao C,Birznieks G,Polymeropoulos MH

    更新日期:2020-07-09 00:00:00

  • Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach Involving Wnt Pathway and KATP Channels.

    abstract::Epilepsy is a neurological disorder in which, in many cases, there is poor pharmacological control of seizures. Nevertheless, it may respond beneficially to alternative treatments such as dietary therapy, like the ketogenic diet or caloric restriction. One of the mechanisms of these diets is to produce a hyperpolariza...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Rubio C,Luna R,Rosiles A,Rubio-Osornio M

    更新日期:2020-11-05 00:00:00

  • Clinical Characteristics and Long-Term Outcome of Headaches Associated With Moyamoya Disease in the Chinese Population-A Cohort Study.

    abstract::Background: Headache associated with Moyamoya disease (HAMD) in the Chinese population is not well-described. The long-term outcome of surgical revascularization and natural course of HAMD has not been disclosed either. Methods: A headache screening questionnaire in China based on the ICHD2 and a face-to-face intervie...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gao B,Kang K,Zhang J,Zhang D,Zhao X

    更新日期:2020-11-26 00:00:00

  • Camera-Based, Non-Contact, Vital-Signs Monitoring Technology May Provide a Way for the Early Prevention of SIDS in Infants.

    abstract::Sudden infant death syndrome (SIDS) is the unexplained death, usually during sleep, of a baby younger than 1-year-old. Even though researchers have discovered some factors that may put babies at extra risk, SIDS remains unpredictable up until now. One hypothesis is that impaired cardiovascular control may play a role ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhao F,Li M,Jiang Z,Tsien JZ,Lu Z

    更新日期:2016-12-23 00:00:00

  • Elevated Percentage of CD3+ T-Cells and CD4+/CD8+ Ratios in Multiple System Atrophy Patients.

    abstract::α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cao B,Chen X,Zhang L,Wei Q,Liu H,Feng W,Chen Y,Shang H

    更新日期:2020-07-07 00:00:00

  • Predictive factors of neurological complications and one-month mortality after liver transplantation.

    abstract:BACKGROUND:Neurological complications are common after orthotopic liver transplantation (OLT). We aimed to characterize the risk factors associated with neurological complications and mortality among patients who underwent OLT in the post-model for end-stage liver disease (MELD) era. METHODS:In a retrospective review,...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Fu KA,DiNorcia J,Sher L,Velani SA,Akhtar S,Kalayjian LA,Sanossian N

    更新日期:2014-12-17 00:00:00

  • Trauma-Related Guillain-Barré Syndrome: Systematic Review of an Emerging Concept.

    abstract::Guillain-Barré syndrome (GBS) is mainly associated with preceding exposure to an infectious agent, although the precise pathogenic mechanisms and causes remain unknown. Increasing evidence indicates an association between trauma-related factors and GBS. Here, we performed a systematic review, summarized the current sc...

    journal_title:Frontiers in neurology



    authors: Huang C,Zhang Y,Deng S,Ren Y,Lu W

    更新日期:2020-11-06 00:00:00

  • Methods for examining electrophysiological coherence in epileptic networks.

    abstract::Epilepsy may reflect a focal abnormality of cerebral tissue, but the generation of seizures typically involves propagation of abnormal activity through cerebral networks. We examined epileptiform discharges (spikes) with dense array electroencephalography (dEEG) in five patients to search for the possible engagement o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Song J,Tucker DM,Gilbert T,Hou J,Mattson C,Luu P,Holmes MD

    更新日期:2013-05-15 00:00:00

  • Phase 1 Trial of Amnion Cell Therapy for Ischemic Stroke.

    abstract:Background:There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive endovascular clot retrieval or thrombolysis therapies, or for whom standard treatment has failed. We have recently shown that human amniotic epithelial cells (hAECs) ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Phan TG,Ma H,Lim R,Sobey CG,Wallace EM

    更新日期:2018-06-07 00:00:00

  • Magnetic Resonance Elastography of Rodent Brain.

    abstract::Magnetic resonance elastography (MRE) is a non-invasive imaging technique, using the propagation of mechanical waves as a probe to palpate biological tissues. It consists in three main steps: production of shear waves within the tissue; encoding subsequent tissue displacement in magnetic resonance images; and extracti...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Bigot M,Chauveau F,Beuf O,Lambert SA

    更新日期:2018-11-27 00:00:00

  • Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease.

    abstract:INTRODUCTION:Alzheimer's disease (AD) is a long term progressive neurodegenerative disease and might affect the retinal nerve fiber layer thickness (RNFLT) of the eye. There is increasing evidence that visual evoked potentials (VEP), which are an objective way to indicate visual field loss, might be affected by the dis...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kromer R,Serbecic N,Hausner L,Froelich L,Beutelspacher SC

    更新日期:2013-12-16 00:00:00

  • New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features.

    abstract::New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients with NORSE who all demonstrated a typical magnetic resonance imaging (MRI) sign ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Meletti S,Giovannini G,d'Orsi G,Toran L,Monti G,Guha R,Kiryttopoulos A,Pascarella MG,Martino T,Alexopoulos H,Spilioti M,Slonkova J

    更新日期:2017-03-27 00:00:00

  • Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy-These Matters Matter.

    abstract::Animal models of concussion, traumatic brain injury (TBI), and chronic traumatic encephalopathy (CTE) are widely available and routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration of four basic principles. First, animal model use must be guided by clarity of def...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Wojnarowicz MW,Fisher AM,Minaeva O,Goldstein LE

    更新日期:2017-06-01 00:00:00

  • Rehabilitation, Using Guided Cerebral Plasticity, of a Brachial Plexus Injury Treated with Intercostal and Phrenic Nerve Transfers.

    abstract::Recovery after surgical reconstruction of a brachial plexus injury using nerve grafting and nerve transfer procedures is a function of peripheral nerve regeneration and cerebral reorganization. A 15-year-old boy, with traumatic avulsion of nerve roots C5-C7 and a non-rupture of C8-T1, was operated 3 weeks after the in...

    journal_title:Frontiers in neurology



    authors: Dahlin LB,Andersson G,Backman C,Svensson H,Björkman A

    更新日期:2017-03-03 00:00:00

  • Wegener's disease presenting with occipital condyle syndrome.

    abstract::Tumors or chronic inflammatory lesions of the occipital condyle may cause occipital pain associated with an ipsilateral hypoglossal nerve injury (occipital condyle syndrome). We describe a young woman with recurrent otitis media and occipital condyle syndrome associated with a limited form of Wegener's disease. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hornik A,Rodriguez-Porcel F,Ersahin CH,Kadanoff R,Biller J

    更新日期:2012-04-12 00:00:00

  • A Practical Approach to Managing Patients With Myasthenia Gravis-Opinions and a Review of the Literature.

    abstract::When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. The...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Farrugia ME,Goodfellow JA

    更新日期:2020-07-07 00:00:00

  • Perturbation-Based Balance Training to Improve Step Quality in the Chronic Phase After Stroke: A Proof-of-Concept Study.

    abstract::Introduction: People with stroke often have impaired stepping responses following balance perturbations, which increases their risk of falling. Computer-controlled movable platforms are promising tools for delivering perturbation-based balance training under safe and standardized circumstances. Purpose: This proof-of-...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: van Duijnhoven HJR,Roelofs JMB,den Boer JJ,Lem FC,Hofman R,van Bon GEA,Geurts ACH,Weerdesteyn V

    更新日期:2018-11-22 00:00:00

  • A Longitudinal Study of a Chinese Man Presenting with Non-Fluent/Agrammatic Variant of Primary Progressive Aphasia.

    abstract::Primary progressive aphasia (PPA) is a neurodegenerative disease characterized by declining language ability. However, the difficulty in defining the central clinical features in its earliest stage and establishing the dynamics of its progression has led to controversy. We report a 71-year-old man with Han language su...

    journal_title:Frontiers in neurology



    authors: Liu X,He F,Chen Z,Liu P,Peng G

    更新日期:2018-02-16 00:00:00

  • Presence of Multiple Autoimmune Antibodies Involved in Concurrent Myositis and Myocarditis and Myasthenia Gravis Without Thymoma: A Case Report.

    abstract::Inflammatory myositis (IM) and myasthenia gravis (MG) are both immune disorders involving muscle. The concurrent presence of both conditions in the same patient is extremely rare and the diagnosis is important and challenging. Here, we report a case of concurrent myositis and myocarditis and MG without thymoma in a 69...

    journal_title:Frontiers in neurology



    authors: Zhou Z,Chen X,Liu G,Pu J,Wu J

    更新日期:2019-07-16 00:00:00

  • The involvement of noradrenaline in rapid eye movement sleep mentation.

    abstract::Noradrenaline, one of the main brain monoamines, has powerful central influences on forebrain neurobiological processes which support the mental activities occurring during the sleep-waking cycle. Noradrenergic neurons are activated during waking, decrease their firing rate during slow wave sleep, and become silent du...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gottesmann C

    更新日期:2011-12-12 00:00:00

  • Levetiracetam vs. Fosphenytoin for Second-Line Treatment of Status Epilepticus: Propensity Score Matching Analysis Using a Nationwide Inpatient Database.

    abstract::Objective: Status epilepticus is a major emergency condition. The choice of antiepileptic drugs for second-line treatment after benzodiazepine remains controversial, including levetiracetam vs. fosphenytoin. We compare the safety of intravenous levetiracetam and fosphenytoin as a second-line treatment in patients with...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Nakamura K,Ohbe H,Matsui H,Takahashi Y,Marushima A,Inoue Y,Fushimi K,Yasunaga H

    更新日期:2020-07-02 00:00:00

  • Old Dog New Tricks; Revisiting How Stroke Modulates the Systemic Immune Landscape.

    abstract::Infections in the post-acute phase of cerebral ischaemia impede optimal recovery by exacerbating morbidity and mortality. Our review aims to reconcile the increased infection susceptibility of patients post-stroke by consolidating our understanding of compartmentalised alterations to systemic immunity. Mounting eviden...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Krishnan S,Lawrence CB

    更新日期:2019-07-02 00:00:00

  • Motor Nerve Conduction Tests in Carpal Tunnel Syndrome.

    abstract::Background: For the preoperatively often required confirmation of clinically defined carpal tunnel syndrome (CTS), sensory as well as motor nerve conduction studies can be applied. The aim of this study was to test the sensitivity of specific motor nerve conduction tests in comparison with, as well as in addition to, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kasius KM,Claes F,Verhagen WIM,Meulstee J

    更新日期:2019-03-14 00:00:00