Abstract:
Introduction:There are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have suboptimal designs. Aim:We investigated the differences in cognitive decline in AD compared to DLB over 4 years and cognitive domain predictors of progression. Methods:In a longitudinal study, 266 patients with first-time diagnosis of mild dementia were included and followed annually. The patients were tested annually with neuropsychological tests and screening instruments [MMSE (Mini-Mental Status Examination), Clinical Dementia Rating (CDR), the second edition of California Verbal Learning Test (CVLT-II), Trail Making Test A & B (TMT A & B), Stroop test, Controlled Oral Word Associations Test (COWAT) animal naming, Boston Naming Test, Visual Object and Space Perception Battery (VOSP) Cubes and Silhouettes]. Longitudinal analyses were performed with linear mixed effects (LME) models and Cox regression. Both specific neuropsychological tests and cognitive domains were analyzed. Results:This study sample comprised 119 AD and 67 DLB patients. In TMT A, the DLB patients had a faster decline over 4 years than patients with AD (p = 0.013). No other longitudinal differences in specific neuropsychological tests were found. Higher executive domain scores at baseline were associated with a longer time to reach severe dementia (CDR = 3) or death for the total sample (p = 0.032). High or low visuospatial function at baseline was not found to be associated with cognitive decline (MMSE) or progression of dementia severity (CDR) over time. Conclusion:Over 4 years, patients with DLB had a faster decline in TMT A than patients with AD, but this should be interpreted cautiously. Beyond this, there was little support for faster decline in DLB patients neuropsychologically than in AD patients.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Breitve MH,Chwiszczuk LJ,Brønnick K,Hynninen MJ,Auestad BH,Aarsland D,Rongve Adoi
10.3389/fneur.2018.00124subject
Has Abstractpub_date
2018-03-06 00:00:00pages
124issn
1664-2295journal_volume
9pub_type
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journal_title:Frontiers in neurology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type:
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pub_type: 杂志文章
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journal_title:Frontiers in neurology
pub_type: 杂志文章,评审
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更新日期:2019-03-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-04-25 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fneur.2019.00033
更新日期:2019-01-29 00:00:00
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pub_type: 杂志文章
doi:10.3389/fneur.2017.00373
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pub_type: 杂志文章
doi:10.3389/fneur.2017.00339
更新日期:2017-07-19 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fneur.2014.00191
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pub_type: 杂志文章,评审
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更新日期:2020-12-11 00:00:00
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journal_title:Frontiers in neurology
pub_type:
doi:10.3389/fneur.2018.00700
更新日期:2018-08-27 00:00:00
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journal_title:Frontiers in neurology
pub_type: 杂志文章,评审
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2020.00214
更新日期:2020-04-15 00:00:00
abstract::[This corrects the article DOI: 10.3389/fneur.2020.578924.]. ...
journal_title:Frontiers in neurology
pub_type: 已发布勘误
doi:10.3389/fneur.2020.638735
更新日期:2021-01-12 00:00:00
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2019.01025
更新日期:2019-09-24 00:00:00
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journal_title:Frontiers in neurology
pub_type: 杂志文章,评审
doi:10.3389/fneur.2017.00331
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