What's Hot in Clinical Infectious Diseases? 2019 IDWeek Summary.

abstract：:Background.  Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods.  A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results.  A total of 1001 ...

journal_title：Open forum infectious diseases

authors： Mellhammar L,Christensson B,Linder A

更新日期：2015-10-26 00:00:00

abstract：Background:Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis (VL), which is found in VL-endemic countries including Bangladesh. Because of these enigmatic cases, the success of the National Kala-azar Elimination Program is under threat. To date, diagnostic methods for PKDL cases in endemi...

journal_title：Open forum infectious diseases

authors： Ghosh P,Hasnain MG,Hossain F,Khan MAA,Chowdhury R,Faisal K,Mural MA,Baker J,Nath R,Ghosh D,Maruf S,Shomik MS,Haque R,Matlashewski G,Hamano S,Duthie MS,Mondal D

更新日期：2018-09-15 00:00:00

abstract：:Health-related quality of life (HRQoL) in outpatient parenteral antimicrobial therapy (OPAT) has not been well characterized in the United States. In an OPAT cohort, the short-form-12's median physical component score and mental component score were 40.3 and 54.4, respectively. HRQoL measures could be helpful in studi...

journal_title：Open forum infectious diseases

authors： Keller SC,Williams D,Levering M,Cosgrove SE

更新日期：2018-06-20 00:00:00

abstract：:We used ribonucleic acid sequencing to profile Candida albicans transcription within biliary fluid from a patient with cholangitis; samples were collected before and after treatment with fluconazole and drainage. Candida albicans transcriptomes at the infection site distinguished treated from untreated cholangitis. Af...

journal_title：Open forum infectious diseases

authors： Clancy CJ,Meslin C,Badrane H,Cheng S,Losada LC,Nierman WC,Vergidis P,Clark NL,Nguyen MH

更新日期：2016-06-11 00:00:00

abstract：Background:Bolstered by the high efficacy of hepatitis C virus (HCV) treatment, the World Health Organization has called for HCV elimination by 2030. People with HIV (PWH) have been identified as a population in which elimination should be prioritized. Methods:We examined progress in HCV elimination through the HCV ca...

journal_title：Open forum infectious diseases

authors： Falade-Nwulia O,Sutcliffe CG,Mehta SH,Moon J,Chander G,Keruly J,Katzianer J,Thomas DL,Moore RD,Sulkowski MS

更新日期：2019-09-30 00:00:00

abstract：: Background.  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine m...

journal_title：Open forum infectious diseases

authors： Levinson RT,Hulgan T,Kalams SA,Fessel JP,Samuels DC

更新日期：2016-10-19 00:00:00

abstract：Background:We estimated and characterized the proportion of patients living with HIV (PLWH) who missed hepatitis C (HCV) intake appointments and subsequently failed to establish HCV care. Methods:Logistic regression analyses were used to identify factors associated with missed HCV intake appointments and failure to es...

journal_title：Open forum infectious diseases

authors： Cachay ER,Hill L,Torriani F,Ballard C,Grelotti D,Aquino A,Christopher Mathews W

更新日期：2018-07-31 00:00:00

abstract：Background:Internal medicine physicians are often the first providers to encounter patients with a new diagnosis of tuberculosis. Given the public health risks of missed tuberculosis cases, assessing internal medicine residents' ability to diagnose tuberculosis is important. Methods:Internal medicine resident knowledg...

journal_title：Open forum infectious diseases

authors： Chida N,Brown C,Mathad J,Carpenter K,Nelson G,Schechter MC,Giles N,Rebolledo PA,Ray S,Fabre V,Cantillo DS,Longworth S,Amorosa V,Petrauskis C,Boulanger C,Cain N,Gupta A,McKenzie-White J,Bollinger R,Melia MT

更新日期：2018-06-27 00:00:00

abstract：:Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

journal_title：Open forum infectious diseases

authors： Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

更新日期：2016-02-08 00:00:00

abstract：Background:Non-US-born individuals account for the majority of active tuberculosis (TB) in the United States. Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result. We investigated the prevalence and predictors of an indeterminate IGRA (IND-IGRA) in...

journal_title：Open forum infectious diseases

authors： Sharninghausen JC,Shapiro AE,Koelle DM,Kim HN

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:A multicenter, randomized, blinded phase 1 clinical trial evaluated safety and ...

journal_title：Open forum infectious diseases

authors： Mulligan MJ,Bernstein DI,Frey S,Winokur P,Rouphael N,Dickey M,Edupuganti S,Spearman P,Anderson E,Graham I,Noah DL,Mangal B,Kim S,Hill H,Whitaker J,Emery W,Beck A,Stephens K,Hartwell B,Ogilvie M,Rimann N,Osinski

更新日期：2014-11-18 00:00:00

abstract：:Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a syste...

journal_title：Open forum infectious diseases

authors： Bowen AC,Carapetis JR,Currie BJ,Fowler V Jr,Chambers HF,Tong SYC

更新日期：2017-11-02 00:00:00

abstract：:The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encep...

journal_title：Open forum infectious diseases

authors： Gomez CA,Pinsky BA,Liu A,Banaei N

更新日期：2016-12-07 00:00:00

abstract：:Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

journal_title：Open forum infectious diseases

authors： Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

更新日期：2019-11-19 00:00:00

abstract：:Both dengue virus (DENV) and hepatitis C virus (HCV) belong to the Flaviviridae family and could induce hepatitis. We aimed to investigate the interference between them. In total, 515 patients confirmed with dengue fever (DF) were enrolled. Thirty-two patients (6.21%) were seropositive for anti-HCV; 12 of 32 anti-HCV-...

journal_title：Open forum infectious diseases

authors： Liang PC,Chen KY,Huang CH,Chang K,Lu PL,Yeh ML,Huang CF,Huang CI,Hsieh MH,Dai CY,Lin ZY,Chen SC,Chuang WL,Chen YH,Huang JF,Yu ML

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Because hospitals in a region are connected via patient sharing, a norovirus outbreak in one hospital may spread to others. METHODS:We utilized our Regional Healthcare Ecosystem Analyst software to generate an agent-based model of all the acute care facilities in Orange County (OC), California and simulated...

journal_title：Open forum infectious diseases

authors： Bartsch SM,Huang SS,Wong KF,Avery TR,Lee BY

更新日期：2014-07-02 00:00:00

abstract：Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...

journal_title：Open forum infectious diseases

authors： Jung S,Sexton ME,Owens S,Spell N,Fridkin S

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) is no longer restricted to hospital settings, and population-based incidence measures are needed. Understanding the determinants of CDI incidence will allow for more meaningful comparisons of rates and accurate national estimates. METHODS:Data from active population- an...

journal_title：Open forum infectious diseases

authors： Lessa FC,Mu Y,Winston LG,Dumyati GK,Farley MM,Beldavs ZG,Kast K,Holzbauer SM,Meek JI,Cohen J,McDonald LC,Fridkin SK

更新日期：2014-07-28 00:00:00

abstract：Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

journal_title：Open forum infectious diseases

authors： Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

更新日期：2019-10-21 00:00:00

abstract：Background:Although existing literature supports durations of 5-7 days for skin and soft tissue infections (SSTIs), longer durations are commonly used. Obesity and heart failure (HF) have been associated with increased risk for treatment failure of SSTIs; however, whether prolonged antibiotic durations reduce the risk ...

journal_title：Open forum infectious diseases

authors： Ihm C,Sutton JD,Timbrook TT,Spivak ES

更新日期：2019-05-07 00:00:00

abstract：:Jails represent a critical component of the public health response to HCV elimination. We report on outcomes of 104 patients receiving HCV treatment from January 1, 2014 to June 30, 2016 in a large urban jail setting. Our data demonstrate that treatment in jails is feasible, but many barriers remain. ...

journal_title：Open forum infectious diseases

authors： MacDonald R,Akiyama MJ,Kopolow A,Rosner Z,McGahee W,Joseph R,Jaffer M,Venters H

更新日期：2017-07-07 00:00:00

abstract：:This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. Mean (SD) cumulative adherence (visual confirmation of administration) was 91.3% (10.5%). Most subjects (88.2%) achieved ≥80% adherence to treatment, and 88.2% (15 of 17...

journal_title：Open forum infectious diseases

authors： Litwin AH,Shafner L,Norton B,Akiyama MJ,Agyemang L,Guzman M,Vera T,Heo M

更新日期：2020-07-20 00:00:00

abstract：Background:Hepatitis C remains a major cause of liver disease globally and is responsible for approximately 500 000 deaths annually. Newer direct-acting antivirals achieve cure rates at or above 90% with excellent tolerability for most patients. The literature focusing on identification of predictors of efficacy and sa...

journal_title：Open forum infectious diseases

authors： Jansen JW,Linneman TW,Powderly GM,Moenster RP,Nayak L

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated. METHODS:Th...

journal_title：Open forum infectious diseases

authors： Connolly-Andersen AM,Thunberg T,Ahlm C

更新日期：2014-05-29 00:00:00

abstract：:Immune suppression is a recognized risk factor for necrotizing fasciitis. In patients with hematological malignancies, a profoundly immunocompromised group, the predominant causative organisms are Gram negative. Clinical presentation and outcomes in these patients are similar to the immunocompetent. The Laboratory Ris...

journal_title：Open forum infectious diseases

authors： Foo RM,Tung ML,Poon LM,Chan D,Smitasin N,Koh LP,Chng WJ,Chai LY

更新日期：2015-06-12 00:00:00

abstract：Background:Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%-23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods:We describe the...

journal_title：Open forum infectious diseases

authors： Hocquart M,Pham T,Kuete E,Tomei E,Lagier JC,Raoult D

更新日期：2019-10-14 00:00:00

abstract：Background:Tryptophan catabolism, measured by the kynurenine:tryptophan (kyn/trp) ratio, is associated with gut microbiota alterations in people with HIV (PWH). We examined the association of the kyn/trp ratio with liver fibrosis in women with/without HIV infection. Methods:The plasma kyn/trp ratio was measured in 137...

journal_title：Open forum infectious diseases

authors： Kardashian A,Ma Y,Yin MT,Scherzer R,Nolan O,Aweeka F,Tien PC,Price JC

更新日期：2019-06-11 00:00:00

abstract：:Chronic pulmonary histoplasmosis (CPH) is an uncommon manifestation of Histoplasma infection with features similar to pulmonary tuberculosis (TB). In endemic areas, it may be misdiagnosed as smear-negative pulmonary TB. Historical case series mainly from patients with presumed TB described a high frequency of cavitati...

journal_title：Open forum infectious diseases

authors： Baker J,Kosmidis C,Rozaliyani A,Wahyuningsih R,Denning DW

更新日期：2020-04-06 00:00:00

abstract：:We investigated the microbial burden on the operating room environment when patients on contact precautions for a multidrug-resistant pathogen received surgery. Our study demonstrated that the perioperative environment was contaminated with aerobic bacteria and methicillin-resistant Staphylococcus aureus (MRSA) after ...

journal_title：Open forum infectious diseases

authors： Kanamori H,Rutala WA,Gergen MF,Weber DJ

更新日期：2020-10-27 00:00:00

abstract：Background:The 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) were both recommended to adults aged ≥65 years. The study examines adults ≥65 years for risk of adverse events (AEs) requiring medical attention following vaccination with PCV13 as compared wit...

journal_title：Open forum infectious diseases

authors： Tseng HF,Sy LS,Qian L,Liu IA,Mercado C,Lewin B,Tartof SY,Nelson J,Jackson LA,Daley MF,Weintraub E,Klein NP,Belongia E,Liles EG,Jacobsen SJ

更新日期：2018-05-02 00:00:00