Association Between Baseline Creatinine Clearance and Treatment Failure in Patients With Hepatitis C Virus Treated With Ledipasvir and Sofosbuvir.

abstract：:Background.  First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness. The focus of this study was to compare the safety and immunogenicity of...

journal_title：Open forum infectious diseases

authors： Overton ET,Stapleton J,Frank I,Hassler S,Goepfert PA,Barker D,Wagner E,von Krempelhuber A,Virgin G,Meyer TP,Müller J,Bädeker N,Grünert R,Young P,Rösch S,Maclennan J,Arndtz-Wiedemann N,Chaplin P

更新日期：2015-05-05 00:00:00

abstract：Background:Preventing severe complications of influenza such as hospitalization is a public health priority; however, estimates of influenza vaccine effectiveness (VE) against influenza-associated acute lower respiratory tract infection (LRTI) hospitalizations are limited. We examined influenza VE against influenza-ass...

journal_title：Open forum infectious diseases

authors： Chow EJ,Rolfes MA,Carrico RL,Furmanek S,Ramirez JA,Ferdinands JM,Fry AM,Patel MM

更新日期：2020-06-30 00:00:00

abstract：Background:Concomitant dosing of ledipasvir (LDV) and tenofovir disoproxil fumarate (TDF) results in an increased tenofovir (TFV) area under the curve (AUC). The aim of this study was to examine whether there was a correlation between the renal biomarkers retinol binding protein-4 (RBP-4) and β2 microglobulin (β2M) and...

journal_title：Open forum infectious diseases

authors： Chan A,Park L,Collins LF,Cooper C,Saag M,Dieterich D,Sulkowski M,Naggie S

更新日期：2019-01-24 00:00:00

abstract：:[This corrects the article DOI: 10.1093/ofid/ofv111.]. ...

journal_title：Open forum infectious diseases

authors：

更新日期：2015-09-04 00:00:00

abstract：Background:Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%-23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods:We describe the...

journal_title：Open forum infectious diseases

authors： Hocquart M,Pham T,Kuete E,Tomei E,Lagier JC,Raoult D

更新日期：2019-10-14 00:00:00

abstract：:This report describes a case of relapsing pneumococcal peritonitis. The postulated source of infection was vaginal colonization and secondary adherence of pneumococci to an intrauterine contraceptive device. After immunization with a conjugate pneumococcal vaccine, her antibody levels were observed. She remained infec...

journal_title：Open forum infectious diseases

authors： Sendi P,Moser Schaub EM,Nirgianakis K,Hathaway LJ,Bittel P,Goldblatt D,Streit S

更新日期：2016-12-07 00:00:00

abstract：Background:Patients with suspected tuberculosis are often overtreated with antituberculosis drugs. We evaluated the diagnostic value of the focused assessment with sonography for HIV-associated tuberculosis (FASH) in rural Tanzania. Methods:In a prospective cohort study, the frequency of FASH signs was compared betwee...

journal_title：Open forum infectious diseases

authors： Ndege R,Weisser M,Elzi L,Diggelmann F,Bani F,Gingo W,Sikalengo G,Mapesi H,Mchomvu E,Kamwela L,Mnzava D,Battegay M,Reither K,Paris DH,Rohacek M

更新日期：2019-04-25 00:00:00

abstract：:We report on a case of loiasis revealed during an assisted reproductive technology (ART) cycle. Loa loa could limit implantation outcome. We propose to focus on an ART strategy with frozen embryos to treat the patient before any transfer. ...

journal_title：Open forum infectious diseases

authors： Puy V,Scheffler F,Tinez C,Belhadri-Mansouri N,Huguenin A,Capelle S,Agnamey P,Devaux A,Frydman N,Copin H,Benkhalifa M

更新日期：2017-10-06 00:00:00

abstract：:The year 2019 brought about a multitude of innovations in clinical infectious diseases. With the continued rise of antimicrobial resistance (AMR), advances in diagnostics and newly available antibiotics offer additional strategies for combating this threat, but the broken antibiotic market serves as an impediment to f...

journal_title：Open forum infectious diseases

authors： Moss S,Boucher HW

更新日期：2020-03-23 00:00:00

abstract：:In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophag...

journal_title：Open forum infectious diseases

authors： Audemard-Verger A,Gasnault J,Faisant M,Besse MC,Martin-Silva N,Berra M,Fournier L,Boutemy J,Maigne G,De Boysson H,Ruet A,Vabret A,Chapon F,Martin-Blondel G,Aouba A

更新日期：2019-09-30 00:00:00

abstract：Background:To determine the effectiveness of implementing a locally developed clinical practice guideline (CPG) for antibiotic treatment in adults with community-acquired cellulitis at Siriraj Hospital in Bangkok, Thailand. Methods:The CPG for antibiotic treatment of community-acquired cellulitis was developed based o...

journal_title：Open forum infectious diseases

authors： Sirijatuphat R,Nookeu P,Thamlikitkul V

更新日期：2020-09-07 00:00:00

abstract：: Background.  Many human immunodeficiency virus (HIV)-infected patients remain on nevirapine-based antiretroviral therapy (ART) despite safety and efficacy concerns. Switching to a rilpivirine-based regimen is an alternative, but there is little experience with rilpivirine ...

journal_title：Open forum infectious diseases

authors： Collins SE,Grant PM,Uwinkindi F,Talbot A,Seruyange E,Slamowitz D,Mugeni A,Remera E,Niyonsenga SP,Nyirimigabo J,Uwizihiwe JP,Dongier P,Muhayimpundu R,Mazarati JB,Zolopa A,Nsanzimana S

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Among the 1.2 M persons living with HIV in the United States, 25% are co- infected with HCV. The availability of effective direct antiviral agents (DAAs) makes the goal of HCV elimination feasible, but implementation requires improvements to the HCV treatment cascade, especially linkage to and initiation of ...

journal_title：Open forum infectious diseases

authors： Rizk C,Miceli J,Shiferaw B,Malinis M,Barakat L,Ogbuagu O,Villanueva M

更新日期：2019-08-14 00:00:00

abstract：:The complexity and cost of current diagnostics for hepatitis C virus (HCV) may act as a prevention to the scale-up of treatment in the developing world. Currently, ribonucleic acid (RNA)-polymerase chain reaction tests are the gold standard. However, there is potential for the use of simpler and cheaper antigen tests ...

journal_title：Open forum infectious diseases

authors： Khan H,Hill A,Main J,Brown A,Cooke G

更新日期：2017-05-26 00:00:00

abstract：Background:We estimated and characterized the proportion of patients living with HIV (PLWH) who missed hepatitis C (HCV) intake appointments and subsequently failed to establish HCV care. Methods:Logistic regression analyses were used to identify factors associated with missed HCV intake appointments and failure to es...

journal_title：Open forum infectious diseases

authors： Cachay ER,Hill L,Torriani F,Ballard C,Grelotti D,Aquino A,Christopher Mathews W

更新日期：2018-07-31 00:00:00

abstract：BACKGROUND:Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:A multicenter, randomized, blinded phase 1 clinical trial evaluated safety and ...

journal_title：Open forum infectious diseases

authors： Mulligan MJ,Bernstein DI,Frey S,Winokur P,Rouphael N,Dickey M,Edupuganti S,Spearman P,Anderson E,Graham I,Noah DL,Mangal B,Kim S,Hill H,Whitaker J,Emery W,Beck A,Stephens K,Hartwell B,Ogilvie M,Rimann N,Osinski

更新日期：2014-11-18 00:00:00

abstract：:A patient with multiple sclerosis presented with seronegative C. burnetii endocarditis diagnosed using C. burnetii-specific polymerase chain reaction and fluorescence in situ hybridization on cardiovascular biopsy. This case supports the necessity of a systematic polymerase chain reaction testing of removed cardiac va...

journal_title：Open forum infectious diseases

authors： Melenotte C,Loukil A,Rico A,Lepidi H,Raoult D

更新日期：2019-10-04 00:00:00

abstract：Background:Staphylococcus aureus is the most common cause of native septic arthritis. Few studies have characterized this disease during the US opioid epidemic. The role of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening in this disease has not been elucidated. We sought to identify risk factors and ...

journal_title：Open forum infectious diseases

authors： Gobao VC,Alfishawy M,Smith C,Byers KE,Yassin M,Urish KL,Shah NB

更新日期：2020-12-18 00:00:00

abstract：Background:Hematogenous dissemination of Talaromyces marneffei can result in multiorgan involvement (skin, lung, and reticuloendothelial system involvement); however, few studies have reported intestinal T marneffei infections. We investigated clinical features, management, and patient outcomes concerning Talaromyces-r...

journal_title：Open forum infectious diseases

authors： Pan M,Huang J,Qiu Y,Zeng W,Li Z,Tang S,Wei X,Zhang J

更新日期：2020-04-27 00:00:00

abstract：:Despite the widespread outbreak, few cases of Zika virus associated with cardiac manifestations have been described. We present a case of pericarditis in the setting of an acute, symptomatic Zika virus infection in a traveler returning from St. Thomas. Clinicians should be alert for this potential complication of Zika...

journal_title：Open forum infectious diseases

authors： Waggoner JJ,Rouphael N,Xu Y,Natrajan M,Lai L,Patel SM,Levit RD,Edupuganti S,Mulligan MJ

更新日期：2017-05-18 00:00:00

abstract：Background:Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asy...

journal_title：Open forum infectious diseases

authors： Ahmadpour E,Foroutan-Rad M,Majidiani H,Moghaddam SM,Hatam-Nahavandi K,Hosseini SA,Rahimi MT,Barac A,Rubino S,Zarean M,Mathioudakis AG,Cevik M

更新日期：2019-06-11 00:00:00

abstract：:Thrombocytopenia is a characteristic feature during the acute phase of dengue infection and has been found to associate with vascular leakage in severe dengue. Although dengue antigens have been observed in platelets, there is no strong evidence to suggest a direct infection of platelets by dengue virus as a contribut...

journal_title：Open forum infectious diseases

authors： Kar M,Singla M,Chandele A,Kabra SK,Lodha R,Medigeshi GR

更新日期：2017-03-23 00:00:00

abstract：Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

journal_title：Open forum infectious diseases

authors： Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

更新日期：2019-10-21 00:00:00

abstract：:Although it is intuitive that antibiotics administered before obtaining a blood culture would reduce the likelihood of obtaining a positive culture, it is not clear exactly how rapidly and to what extent blood becomes sterile after administration of intravenous (IV) antibiotics. Using a large data set of patients admi...

journal_title：Open forum infectious diseases

authors： Rand KH,Beal SG,Rivera K,Allen B,Payton T,Lipori GP

更新日期：2019-05-20 00:00:00

abstract：:Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patie...

journal_title：Open forum infectious diseases

authors： Seyedmousavi S,Lionakis MS,Parta M,Peterson SW,Kwon-Chung KJ

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:Intra-abdominal infections (IAI) constitute a common reason for hospitalization. However, there is lack of standardization in empiric management of (1) anaerobes, (2) enterococci, (3) fungi, and (4) multidrug-resistant organisms (MDRO). The recommendation is to institute empiric coverage for some of these or...

journal_title：Open forum infectious diseases

authors： Marcus G,Levy S,Salhab G,Mengesha B,Tzuman O,Shur S,Burke E,Mayeda RC,Cochavi L,Perluk I,Zaidenstein R,Lazarovitch T,Dadon M,Marchaim D

更新日期：2016-12-20 00:00:00

abstract：:The potential for transmission of severe acute respiratory syndrome coronavirus 2 shed in stool via fecal microbiota transplantation is not yet known, and the effectiveness of various testing strategies to prevent fecal microbiota transplantation-based transmission has also not yet been quantified. In this study, we u...

journal_title：Open forum infectious diseases

authors： Olesen SW,Zaman A,Osman M,Ramakrishna B

更新日期：2020-10-19 00:00:00

abstract：:During the current Zika virus (ZIKV) outbreak, acute symptomatic ZIKV infection in adults appears to be a mild-to-moderate, self-limited illness. We present a case of ZIKV rash illness that improved and then relapsed without repeat exposure to ZIKV. Clinicians should be alert for relapses in patients with ZIKV infecti...

journal_title：Open forum infectious diseases

authors： Edupuganti S,Natrajan MS,Rouphael N,Lai L,Xu Y,Feldhammer M,Hill C,Patel SM,Johnson SJ,Bower M,Gorchakov R,Berry R,Murray KO,Mulligan MJ

更新日期：2017-06-22 00:00:00

abstract：:In this brief report, we describe a 76-year-old patient with thymoma who underwent craniotomy for a left parietal lobe mass with pathologic findings consistent with Toxoplasma gondii encephalitis in the absence of any features of thymoma with immunodeficiency/Good's syndrome. His clinical course suggested likely Toxop...

journal_title：Open forum infectious diseases

authors： Chastain DB,Sams JI,Steele GM,Lowder LO,Franco-Paredes C

更新日期：2018-07-07 00:00:00

abstract：Background:The objective of this study was to investigate the difference in disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome end points. Methods:A prospective, observational study was conducted over the 2016-2018 influenza seasons in a centr...

journal_title：Open forum infectious diseases

authors： Wang Y,Fan G,Horby P,Hayden F,Li Q,Wu Q,Zou X,Li H,Zhan Q,Wang C,Cao B,CAP-China Network.

更新日期：2019-02-15 00:00:00