Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.

abstract：:Naegleria fowleri is a thermophilic free-living amoeba that is found in warm, fresh water and causes primary amebic meningoencephalitis (PAM). The following report demonstrates the rapid and destructive clinical features of PAM in an 8-year-old male who presented with severe headaches approximately 12 days after swimm...

journal_title：Open forum infectious diseases

authors： Vareechon C,Tarro T,Polanco C,Anand V,Pannaraj PS,Dien Bard J

更新日期：2019-07-29 00:00:00

abstract：:Fusarium species are ubiquitous fungi causing a wide array of infections, including invasive disease in the immunosuppressed. We present a fusarium bone infection in a child with Pearson syndrome and review the literature. Ten cases of fusarium osteomyelitis were reported in the past 40 years, and we review the treatm...

journal_title：Open forum infectious diseases

authors： Hiebert RM,Welliver RC,Yu Z

更新日期：2016-10-07 00:00:00

abstract：Background:Cryptococcal meningitis is a major cause of death among people with human immunodeficiency virus (PWH). Cryptococcal antigen (CrAg) testing of asymptomatic patients is an important public health measure to reduce mortality in high-incidence areas. However, limited data exist on CrAg prevalence in Central Ame...

journal_title：Open forum infectious diseases

authors： Zuniga-Moya JC,Romero-Reyes LE,Saavedra EB,Montoya S,Varela D,Borjas M,Cerna A,Bejarano S,Martinez P,Lujan K,Erazo K,Lainez I,Pineda L,Yanes D,O'Halloran JA,Spec A

更新日期：2020-11-13 00:00:00

abstract：:Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients ...

journal_title：Open forum infectious diseases

authors： Talbot HK,Dunning AJ,Robertson CA,Landolfi VA,Greenberg DP,DiazGranados CA

更新日期：2018-05-22 00:00:00

abstract：Background:Patients with suspected tuberculosis are often overtreated with antituberculosis drugs. We evaluated the diagnostic value of the focused assessment with sonography for HIV-associated tuberculosis (FASH) in rural Tanzania. Methods:In a prospective cohort study, the frequency of FASH signs was compared betwee...

journal_title：Open forum infectious diseases

authors： Ndege R,Weisser M,Elzi L,Diggelmann F,Bani F,Gingo W,Sikalengo G,Mapesi H,Mchomvu E,Kamwela L,Mnzava D,Battegay M,Reither K,Paris DH,Rohacek M

更新日期：2019-04-25 00:00:00

abstract：Background:The Short Physical Performance Battery (SPPB) is a well regarded physical functioning assessment including balance, gait speed, and chair-stand tests. Its use has not been widely assessed in human immunodeficiency virus (HIV) care. We evaluated the feasibility of integrating the SPPB into care of aging peopl...

journal_title：Open forum infectious diseases

authors： Crane HM,Miller ME,Pierce J,Willig AL,Case ML,Wilkin AM,Brown S,Asirot MG,Fredericksen RJ,Saag MS,Landay AL,High KP

更新日期：2019-03-11 00:00:00

abstract：BACKGROUND:Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated. METHODS:Th...

journal_title：Open forum infectious diseases

authors： Connolly-Andersen AM,Thunberg T,Ahlm C

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:A multicenter, randomized, blinded phase 1 clinical trial evaluated safety and ...

journal_title：Open forum infectious diseases

authors： Mulligan MJ,Bernstein DI,Frey S,Winokur P,Rouphael N,Dickey M,Edupuganti S,Spearman P,Anderson E,Graham I,Noah DL,Mangal B,Kim S,Hill H,Whitaker J,Emery W,Beck A,Stephens K,Hartwell B,Ogilvie M,Rimann N,Osinski

更新日期：2014-11-18 00:00:00

abstract：:We report on a case of loiasis revealed during an assisted reproductive technology (ART) cycle. Loa loa could limit implantation outcome. We propose to focus on an ART strategy with frozen embryos to treat the patient before any transfer. ...

journal_title：Open forum infectious diseases

authors： Puy V,Scheffler F,Tinez C,Belhadri-Mansouri N,Huguenin A,Capelle S,Agnamey P,Devaux A,Frydman N,Copin H,Benkhalifa M

更新日期：2017-10-06 00:00:00

abstract：Background:Cytomegalovirus (CMV) mononucleosis is a manifestation of primary CMV infection. This study aims to establish the link between long-term population CMV seroepidemiological trends and incidence of CMV mononucleosis requiring hospitalization. Furthermore, by analyzing serial laboratory data of patients hospita...

journal_title：Open forum infectious diseases

authors： Sridhar S,Chung TWH,Chan JFW,Cheng VCC,Lau SKP,Yuen KY,Woo PCY

更新日期：2018-10-20 00:00:00

abstract：Background:Preventing severe complications of influenza such as hospitalization is a public health priority; however, estimates of influenza vaccine effectiveness (VE) against influenza-associated acute lower respiratory tract infection (LRTI) hospitalizations are limited. We examined influenza VE against influenza-ass...

journal_title：Open forum infectious diseases

authors： Chow EJ,Rolfes MA,Carrico RL,Furmanek S,Ramirez JA,Ferdinands JM,Fry AM,Patel MM

更新日期：2020-06-30 00:00:00

abstract：Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

journal_title：Open forum infectious diseases

authors： Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

journal_title：Open forum infectious diseases

authors： Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

更新日期：2017-01-25 00:00:00

abstract：Background:Inpatient HIV care often requires specialized laboratory testing with which practitioners may not be familiar. In addition, computerized physician order entry allows for ordering tests without understanding test indications, but it can also provide a venue for education and diagnostic stewardship. Methods:A...

journal_title：Open forum infectious diseases

authors： Bolles K,Woc-Colburn L,Hamill RJ,Hemmige V

更新日期：2019-03-29 00:00:00

abstract：Background:Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a human immunodeficiency virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with new psychoactive subs...

journal_title：Open forum infectious diseases

authors： Hanke K,Fiedler S,Grumann C,Ratmann O,Hauser A,Klink P,Meixenberger K,Altmann B,Zimmermann R,Marcus U,Bremer V,Auwärter V,Bannert N

更新日期：2020-05-27 00:00:00

abstract：:In this brief report, we describe a 76-year-old patient with thymoma who underwent craniotomy for a left parietal lobe mass with pathologic findings consistent with Toxoplasma gondii encephalitis in the absence of any features of thymoma with immunodeficiency/Good's syndrome. His clinical course suggested likely Toxop...

journal_title：Open forum infectious diseases

authors： Chastain DB,Sams JI,Steele GM,Lowder LO,Franco-Paredes C

更新日期：2018-07-07 00:00:00

abstract：:We describe a case of fetal parvovirus B19 infection resulting in preterm birth and leading to hydrops fetalis requiring multiple in utero transfusions. The infant developed chronic postnatal anemia responsive to intravenous immunoglobulin therapy. Serum viral load decreased after immunoglobulin treatment but remained...

journal_title：Open forum infectious diseases

authors： Nadimpalli SS,Miller RS,Kamath VM,Farkouh CR,Nhan-Chang CL,Rathe JA,Collins A,Duchon JM,Neu N,Simpson LL,Ratner AJ

更新日期：2015-04-15 00:00:00

abstract：Background:Residual monocyte activation may contribute to increased risk for endothelial dysfunction and subsequent atherosclerotic cardiovascular diseases (CVDs) among people with HIV (PWH) on antiretroviral therapy (ART). We examined the relationship between monocyte activation and endothelial activation in PWH in Ke...

journal_title：Open forum infectious diseases

authors： Temu TM,Polyak SJ,Zifodya JS,Wanjalla CN,Koethe JR,Masyuko S,Nyabiage J,Kinuthia J,Gervassi AL,Oyugi J,Page S,Farquhar C

更新日期：2020-09-12 00:00:00

abstract：Background:We characterized the extent of antiretroviral therapy (ART) experience and postdischarge mortality among hospitalized HIV-infected adults in Zambia. Methods:At a central hospital with an opt-out HIV testing program, we enrolled HIV-infected adults (18+ years) admitted to internal medicine using a population...

journal_title：Open forum infectious diseases

authors： Haachambwa L,Kandiwo N,Zulu PM,Rutagwera D,Geng E,Holmes CB,Sinkala E,Claassen CW,Mugavero MJ,Wa Mwanza M,Turan JM,Vinikoor MJ

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) is no longer restricted to hospital settings, and population-based incidence measures are needed. Understanding the determinants of CDI incidence will allow for more meaningful comparisons of rates and accurate national estimates. METHODS:Data from active population- an...

journal_title：Open forum infectious diseases

authors： Lessa FC,Mu Y,Winston LG,Dumyati GK,Farley MM,Beldavs ZG,Kast K,Holzbauer SM,Meek JI,Cohen J,McDonald LC,Fridkin SK

更新日期：2014-07-28 00:00:00

abstract：:Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

journal_title：Open forum infectious diseases

authors： Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

更新日期：2019-11-19 00:00:00

abstract：: Background.  School closures are an important mitigation strategy during influenza pandemic: if implemented early in a local outbreak, they can slow the disease spread in the surrounding community. During seasonal influenza epidemics, school closures may occur reactively, ...

journal_title：Open forum infectious diseases

authors： Russell ES,Zheteyeva Y,Gao H,Shi J,Rainey JJ,Thoroughman D,Uzicanin A

更新日期：2016-05-25 00:00:00

abstract：: Background.  Many human immunodeficiency virus (HIV)-infected patients remain on nevirapine-based antiretroviral therapy (ART) despite safety and efficacy concerns. Switching to a rilpivirine-based regimen is an alternative, but there is little experience with rilpivirine ...

journal_title：Open forum infectious diseases

authors： Collins SE,Grant PM,Uwinkindi F,Talbot A,Seruyange E,Slamowitz D,Mugeni A,Remera E,Niyonsenga SP,Nyirimigabo J,Uwizihiwe JP,Dongier P,Muhayimpundu R,Mazarati JB,Zolopa A,Nsanzimana S

更新日期：2016-07-01 00:00:00

abstract：Background:Oncological patients have several additional risk factors for developing a cardiac implantable electronic device (CIED)-related infection. Therefore, we evaluated the clinical impact of our comprehensive bundle approach that includes the novel minocycline and rifampin antimicrobial mesh (TYRX) for the preven...

journal_title：Open forum infectious diseases

authors： Khalil M,Karimzad K,Durand JB,Malek AE,Raad II,Viola GM

更新日期：2020-09-13 00:00:00

abstract：: Background.  Successful treatment of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa is thwarted by the emergence of antibiotic resistance and biofilm formation on prosthetic devices. Our aims were to decipher the molecular basis of resistance in a un...

journal_title：Open forum infectious diseases

authors： Domitrovic TN,Hujer AM,Perez F,Marshall SH,Hujer KM,Woc-Colburn LE,Parta M,Bonomo RA

更新日期：2016-10-21 00:00:00

abstract：Background:Kindergarten-entry vaccination requirements have played an important role in controlling vaccine-preventable diseases in the United States. Forty-eight states and the District of Colombia offer nonmedical exemptions to vaccines, ranging in stringency. Methods:We analyzed state-level exemption data from 2011...

journal_title：Open forum infectious diseases

authors： Omer SB,Porter RM,Allen K,Salmon DA,Bednarczyk RA

更新日期：2017-11-15 00:00:00

abstract：:Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

journal_title：Open forum infectious diseases

authors： Boyce RM,Speight C,Lin JT,Farel CE

更新日期：2020-01-11 00:00:00

abstract：Background:Little information is available on the relative tolerability of ceftaroline versus other cephalosporins in clinical practice. We sought to compare adverse drug reactions (ADRs) associated with ceftaroline with those associated with ceftriaxone in hospitalized patients. Materials and Methods:This was a retro...

journal_title：Open forum infectious diseases

authors： Jansen JW,Linneman TW,Tan X,Moenster RP

更新日期：2019-06-13 00:00:00

abstract：Background:Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting ...

journal_title：Open forum infectious diseases

authors： Karsies T,Moore-Clingenpeel M,Hall M

更新日期：2018-10-24 00:00:00

abstract：Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...

journal_title：Open forum infectious diseases

authors： Jung S,Sexton ME,Owens S,Spell N,Fridkin S

更新日期：2019-01-18 00:00:00