Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.


:In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.


Open Forum Infect Dis


Audemard-Verger A,Gasnault J,Faisant M,Besse MC,Martin-Silva N,Berra M,Fournier L,Boutemy J,Maigne G,De Boysson H,Ruet A,Vabret A,Chapon F,Martin-Blondel G,Aouba A




Has Abstract


2019-09-30 00:00:00












  • Antibiotic Treatment Versus No Treatment for Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Multicenter Randomized Trial.

    abstract:Background:Whether antibiotic treatment of asymptomatic bacteriuria (AB) can prevent acute graft pyelonephritis (AGP) in kidney transplant (KT) recipients has not been elucidated. Methods:In this multicenter, open-label, nonblinded, prospective, noninferiority, randomized controlled trial, we compared antibiotic treat...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sabé N,Oriol I,Melilli E,Manonelles A,Bestard O,Polo C,Los Arcos I,Perelló M,Garcia D,Riera L,Tebé C,Len Ò,Moreso F,Cruzado JM,Carratalà J

    更新日期:2019-05-21 00:00:00

  • Human Immunodeficiency Virus-Negative Men Who Have Sex With Men Have an Altered T-Cell Phenotype and Bioenergy Metabolism.

    abstract:Background:We recently reported that the levels of activation, exhaustion, and terminal differentiation within the peripheral T-cell compartment were increased in men who have sex with men (MSM) compared with blood bank donors. During activation and differentiation, T cells undergo metabolic changes to maintain their e...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kruize Z,Maurer I,van Dort KA,van den Elshout MAM,Hoornenborg E,Booiman T,Prins M,Kootstra NA

    更新日期:2020-07-05 00:00:00

  • Care Continuum and Postdischarge Outcomes Among HIV-Infected Adults Admitted to the Hospital in Zambia.

    abstract:Background:We characterized the extent of antiretroviral therapy (ART) experience and postdischarge mortality among hospitalized HIV-infected adults in Zambia. Methods:At a central hospital with an opt-out HIV testing program, we enrolled HIV-infected adults (18+ years) admitted to internal medicine using a population...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Haachambwa L,Kandiwo N,Zulu PM,Rutagwera D,Geng E,Holmes CB,Sinkala E,Claassen CW,Mugavero MJ,Wa Mwanza M,Turan JM,Vinikoor MJ

    更新日期:2019-07-16 00:00:00

  • Symptomatic Acute Toxoplasmosis in Returning Travelers.

    abstract::We report a family who acquired acute toxoplasmosis after a trip to Central America. One member developed severe clinical manifestations including bilateral chorioretinitis, hepatitis, and myocarditis requiring therapy. Symptomatic acute toxoplasmosis is unusual and possesses a diagnostic challenge. We discuss the cli...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Henao-Martínez AF,Franco-Paredes C,Palestine AG,Montoya JG

    更新日期:2018-03-09 00:00:00

  • Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome.

    abstract:BACKGROUND:Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries. METHODS:A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks' ges...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rick AM,Aguilar A,Cortes R,Gordillo R,Melgar M,Samayoa-Reyes G,Frank DN,Asturias EJ

    更新日期:2017-02-08 00:00:00

  • Occurrence of 4 Dengue Virus Serotypes and Chikungunya Virus in Kilombero Valley, Tanzania, During the Dengue Outbreak in 2018.

    abstract:Background:Dengue and Chikungunya viruses can cause large-scale epidemics, with attack rates of up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent in 2018 and 2019, mostly affecting the coastal areas. Despite the importance of these viruses, there is limited knowledge on the epi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chipwaza B,Sumaye RD,Weisser M,Gingo W,Yeo NK,Amrun SN,Okumu FO,Ng LFP

    更新日期:2020-12-26 00:00:00

  • Real-time Communication With Health Care Providers Through an Online Respiratory Pathogen Laboratory Report.

    abstract::We implemented a real-time report to distribute respiratory pathogen data for our 8-hospital system to anyone with an Internet connection and a web browser. Real-time access to accurate regional laboratory observation data during an epidemic influenza season can guide diagnostic and therapeutic strategies. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Christensen PA,Olsen RJ,Perez KK,Cernoch PL,Long SW

    更新日期:2018-11-30 00:00:00

  • Gastrointestinal Events in High-Dose vs Standard-Dose Influenza Vaccine Recipients.

    abstract::Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Talbot HK,Dunning AJ,Robertson CA,Landolfi VA,Greenberg DP,DiazGranados CA

    更新日期:2018-05-22 00:00:00

  • Is It Actionable? An Evaluation of the Rapid PCR-Based Blood Culture Identification Panel on the Management of Gram-Positive and Gram-Negative Blood Stream Infections.

    abstract:Background:There is growing interest in the use of rapid blood culture identification (BCID) in antimicrobial stewardship programs (ASPs). Although many studies have looked at its clinical and economic utility, its comparative utility in gram-positive and gram-negative blood stream infections (BSIs) has not been as wel...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tseng AS,Kasule SN,Rice F,Mi L,Chan L,Seville MT,Grys TE

    更新日期:2018-12-11 00:00:00

  • Chagas Disease in the New York City Metropolitan Area.

    abstract:Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chaga...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zheng C,Quintero O,Revere EK,Oey MB,Espinoza F,Puius YA,Ramirez-Baron D,Salama CR,Hidalgo LF,Machado FS,Saeed O,Shin J,Patel SR,Coyle CM,Tanowitz HB

    更新日期:2020-05-06 00:00:00

  • Development and Validation of a Model to Predict Growth of Potentially Antibiotic-Resistant Gram-Negative Bacilli in Critically Ill Children With Suspected Infection.

    abstract:Background:Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Karsies T,Moore-Clingenpeel M,Hall M

    更新日期:2018-10-24 00:00:00

  • Multidrug Resistant Pseudomonas aeruginosa Causing Prosthetic Valve Endocarditis: A Genetic-Based Chronicle of Evolving Antibiotic Resistance.

    abstract:: Background.  Successful treatment of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa is thwarted by the emergence of antibiotic resistance and biofilm formation on prosthetic devices. Our aims were to decipher the molecular basis of resistance in a un...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Domitrovic TN,Hujer AM,Perez F,Marshall SH,Hujer KM,Woc-Colburn LE,Parta M,Bonomo RA

    更新日期:2016-10-21 00:00:00

  • Artificial Intelligence Platform Demonstrates High Adherence in Patients Receiving Fixed-Dose Ledipasvir and Sofosbuvir: A Pilot Study.

    abstract::This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. Mean (SD) cumulative adherence (visual confirmation of administration) was 91.3% (10.5%). Most subjects (88.2%) achieved ≥80% adherence to treatment, and 88.2% (15 of 17...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Litwin AH,Shafner L,Norton B,Akiyama MJ,Agyemang L,Guzman M,Vera T,Heo M

    更新日期:2020-07-20 00:00:00

  • Errors in Diagnostic Test Use and Interpretation Contribute to the High Number of Lyme Disease Referrals in a Low-Incidence State.

    abstract::Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyce RM,Speight C,Lin JT,Farel CE

    更新日期:2020-01-11 00:00:00

  • Rethinking risk for pneumococcal disease in adults: the role of risk stacking.

    abstract::Using data from 3 private healthcare claims repositories, we evaluated the incidence of pneumococcal disease among adults with US Advisory Committee on Immunization Practices (ACIP) defined at-risk conditions or rheumatoid arthritis, lupus, Crohn's disease, and neuromuscular disorder/seizures and those with traditiona...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Pelton SI,Shea KM,Weycker D,Farkouh RA,Strutton DR,Edelsberg J

    更新日期:2015-03-20 00:00:00

  • Soluble Tumor Necrosis Factor-α Receptor 2 in Urine Is a Potential Biomarker for Noninvasive Diagnosis of Malaria During Pregnancy.

    abstract::Background.  During pregnancy, the placenta is inaccessible for diagnosis of placental malaria (PM), but soluble tumor necrosis factor-α receptors (sTNFR) are elevated in the plasma of women with PM. Methods.  In this study, sTNFR-1 and sTNFR-2 were quantified in urine of pregnant and nonpregnant Cameroonian women who...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tassi Yunga S,Thévenon AD,Leke RG,Taylor DW

    更新日期:2016-04-26 00:00:00

  • Comparison of Adverse Drug Reactions Between Patients Treated With Ceftaroline or Ceftriaxone: A Single-Center, Matched Cohort Study.

    abstract:Background:Little information is available on the relative tolerability of ceftaroline versus other cephalosporins in clinical practice. We sought to compare adverse drug reactions (ADRs) associated with ceftaroline with those associated with ceftriaxone in hospitalized patients. Materials and Methods:This was a retro...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Jansen JW,Linneman TW,Tan X,Moenster RP

    更新日期:2019-06-13 00:00:00

  • Considerations for the Selection and Use of Disinfectants Against SARS-CoV-2 in a Health Care Setting.

    abstract::Proper disinfection using adequate disinfecting agents will be necessary for infection control strategies against coronavirus disease 2019 (COVID-19). However, limited guidance exists on effective surface disinfectants or best practices for their use against severe acute respiratory coronavirus 2. We outlined a proces...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tyan K,Levin A,Avalos-Pacheco A,Plana D,Rand EA,Yang H,Maliszewski LE,Chylek LA,Atta L,Tye MA,Carmack MM,Oglesby NS,Burgin S,Yu SH,LeBoeuf NR,Kemp JM

    更新日期:2020-08-31 00:00:00

  • Toxoplasma Encephalitis in Atypical Hosts at an Academic Cancer Center.

    abstract::Toxoplasma encephalitis is a well recognized complication of acquired immune deficiency syndrome, solid organ transplantation, and allogeneic hematopoietic stem cell transplantation (HSCT). However, patients with hematologic malignancies not treated with allogeneic HSCT may also develop this condition, which requires ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Morjaria S,Epstein DJ,Romero FA,Taur Y,Seo SK,Papanicolaou GA,Hatzoglou V,Rosenblum M,Perales MA,Scordo M,Kaltsas A

    更新日期:2016-03-30 00:00:00

  • Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial.

    abstract:Background:Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation. Methods:Treatment effects of edoxaban (30 mg), a direct ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Baker JV,Wolfson J,Peterson T,Mooberry M,Gissel M,Mystakelis H,Henderson MW,Garcia-Myers K,Rhame FS,Schacker TW,Brummel-Ziedins KE,Sereti I,Key NS,Tracy RP

    更新日期:2020-02-01 00:00:00

  • Peritoneal Dialysis-Associated Peritonitis Caused by Mycobacterium abscessus in Children-A Case Report.

    abstract::Peritoneal dialysis (PD)-associated peritonitis constitutes a major complication associated with the procedure. PD-associated peritonitis caused by nontuberculous mycobacteria, usually as a result of an infection related to the PD catheter, has been reported in adults and is associated with significant complications a...

    journal_title:Open forum infectious diseases



    authors: Imam O,Al-Zubaidi K,Janahi M,Imam A,Leghrouz B,Dobson S,Sundararaju S,Tsui KM,Hasan MR,Perez-Lopez A

    更新日期:2020-11-27 00:00:00

  • Do I Have HIV or Not? Lack of RNA Detection and the Case for Sensitive DNA Testing.

    abstract::We present a case of a 20-year-old male who had ambiguous HIV test results after entering new provider care and whose status was later complicated by undetectable viral RNA off antiretroviral therapy (ART). Verifying HIV infection status may occasionally require sensitive DNA testing that might need to be considered i...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Springer SA,Masciotra S,Johnson JA,Campbell S

    更新日期:2020-10-10 00:00:00

  • A Targeted Screening Program for Latent Tuberculosis Infection Among Hematopoietic Cell Transplant Recipients.

    abstract:Background:US hematopoietic cell transplantation (HCT) recipients have a low prevalence of latent tuberculosis infection (LTBI), but if latently infected they are at risk for progression to active tuberculosis. At our center, all HCT recipients underwent LTBI testing pretransplant by tuberculin skin testing (TST) until...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sosa-Moreno A,Narita M,Spitters C,Swetky M,Podczervinski S,Lind ML,Holmberg L,Liu C,Edelstein R,Pergam SA

    更新日期:2020-06-10 00:00:00

  • Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis?

    abstract::Splenic infarction is a rare complication of infectious mononucleosis. We describe 3 cases of splenic infarction attributed to infectious mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious mononucleosis and discuss the differential diagno...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Li Y,George A,Arnaout S,Wang JP,Abraham GM

    更新日期:2018-02-17 00:00:00

  • Hepatitis C Elimination in People With HIV Is Contingent on Closing Gaps in the HIV Continuum.

    abstract:Background:Bolstered by the high efficacy of hepatitis C virus (HCV) treatment, the World Health Organization has called for HCV elimination by 2030. People with HIV (PWH) have been identified as a population in which elimination should be prioritized. Methods:We examined progress in HCV elimination through the HCV ca...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Falade-Nwulia O,Sutcliffe CG,Mehta SH,Moon J,Chander G,Keruly J,Katzianer J,Thomas DL,Moore RD,Sulkowski MS

    更新日期:2019-09-30 00:00:00

  • Antimicrobial Susceptibility Trends Observed in Urinary Pathogens Obtained From New York State.

    abstract::International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rank EL,Lodise T,Avery L,Bankert E,Dobson E,Dumyati G,Hassett S,Keller M,Pearsall M,Lubowski T,Carreno JJ

    更新日期:2018-11-16 00:00:00

  • Diagnosing diabetic foot osteomyelitis: narrative review and a suggested 2-step score-based diagnostic pathway for clinicians.

    abstract::The diabetic foot infection remains a major cause of morbidity and mortality in many patients and remains a challenging diagnosis for most clinicians. Diagnosis is largely based on clinical signs supplemented by various imaging tests. Magnetic resonance imaging (MRI) is not readily available to many clinicians, and bo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Markanday A

    更新日期:2014-08-07 00:00:00

  • Corrigendum: Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.

    abstract::[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,已发布勘误


    authors: Abdullahi A,Fopoussi OM,Torimiro J,Atkins M,Kouanfack C,Geretti AM

    更新日期:2019-04-03 00:00:00

  • Implementing a Comprehensive HCV Clinic within an HIV Clinic: A Model of Care for HCV Micro-elimination.

    abstract:BACKGROUND:Among the 1.2 M persons living with HIV in the United States, 25% are co- infected with HCV. The availability of effective direct antiviral agents (DAAs) makes the goal of HCV elimination feasible, but implementation requires improvements to the HCV treatment cascade, especially linkage to and initiation of ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rizk C,Miceli J,Shiferaw B,Malinis M,Barakat L,Ogbuagu O,Villanueva M

    更新日期:2019-08-14 00:00:00

  • Changes in Waist Circumference in HIV-Infected Individuals Initiating a Raltegravir or Protease Inhibitor Regimen: Effects of Sex and Race.

    abstract:Background:This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size. Methods:We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 ant...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bhagwat P,Ofotokun I,McComsey GA,Brown TT,Moser C,Sugar CA,Currier JS

    更新日期:2018-11-16 00:00:00