Emerging Aspergillus Species Almost Exclusively Associated With Primary Immunodeficiencies.

Abstract:

:Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patients, followed by A. nidulans, multiple poorly recognized Aspergillus species such as A. udagawae, A. quadrilineatus, A. pseudoviridinutans, A. tanneri, A. subramanianii, and A. fumisynnematus have been reported almost exclusively from patients with inborn defects in host antifungal defense pathways. Infection in PID patients exhibits patterns of disease progression distinct from those in iatrogenic immunosuppression. Specifically, the disease can be extrapulmonary and chronic with a tendency to disseminate in a contiguous manner across anatomical planes. It is also more refractory to standard antifungal therapy. This synopsis summarizes our understanding of emerging rare Aspergillus species that primarily affect patients with PIDs but not those with acquired immunodeficiencies.

journal_name

Open Forum Infect Dis

authors

Seyedmousavi S,Lionakis MS,Parta M,Peterson SW,Kwon-Chung KJ

doi

10.1093/ofid/ofy213

subject

Has Abstract

pub_date

2018-09-26 00:00:00

pages

ofy213

issue

9

issn

2328-8957

pii

ofy213

journal_volume

5

pub_type

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