Emerging Aspergillus Species Almost Exclusively Associated With Primary Immunodeficiencies.


:Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patients, followed by A. nidulans, multiple poorly recognized Aspergillus species such as A. udagawae, A. quadrilineatus, A. pseudoviridinutans, A. tanneri, A. subramanianii, and A. fumisynnematus have been reported almost exclusively from patients with inborn defects in host antifungal defense pathways. Infection in PID patients exhibits patterns of disease progression distinct from those in iatrogenic immunosuppression. Specifically, the disease can be extrapulmonary and chronic with a tendency to disseminate in a contiguous manner across anatomical planes. It is also more refractory to standard antifungal therapy. This synopsis summarizes our understanding of emerging rare Aspergillus species that primarily affect patients with PIDs but not those with acquired immunodeficiencies.


Open Forum Infect Dis


Seyedmousavi S,Lionakis MS,Parta M,Peterson SW,Kwon-Chung KJ




Has Abstract


2018-09-26 00:00:00












  • High Kynurenine:Tryptophan Ratio Is Associated With Liver Fibrosis in HIV-Monoinfected and HIV/Hepatitis C Virus-Coinfected Women.

    abstract:Background:Tryptophan catabolism, measured by the kynurenine:tryptophan (kyn/trp) ratio, is associated with gut microbiota alterations in people with HIV (PWH). We examined the association of the kyn/trp ratio with liver fibrosis in women with/without HIV infection. Methods:The plasma kyn/trp ratio was measured in 137...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kardashian A,Ma Y,Yin MT,Scherzer R,Nolan O,Aweeka F,Tien PC,Price JC

    更新日期:2019-06-11 00:00:00

  • Effectiveness of Implementing a Locally Developed Antibiotic Use Guideline for Community-Acquired Cellulitis at a Large Tertiary Care University Hospital in Thailand.

    abstract:Background:To determine the effectiveness of implementing a locally developed clinical practice guideline (CPG) for antibiotic treatment in adults with community-acquired cellulitis at Siriraj Hospital in Bangkok, Thailand. Methods:The CPG for antibiotic treatment of community-acquired cellulitis was developed based o...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sirijatuphat R,Nookeu P,Thamlikitkul V

    更新日期:2020-09-07 00:00:00

  • Artificial Intelligence Platform Demonstrates High Adherence in Patients Receiving Fixed-Dose Ledipasvir and Sofosbuvir: A Pilot Study.

    abstract::This study evaluated health outcomes among people who inject drugs who are infected with hepatitis C virus using an artificial intelligence platform. Mean (SD) cumulative adherence (visual confirmation of administration) was 91.3% (10.5%). Most subjects (88.2%) achieved ≥80% adherence to treatment, and 88.2% (15 of 17...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Litwin AH,Shafner L,Norton B,Akiyama MJ,Agyemang L,Guzman M,Vera T,Heo M

    更新日期:2020-07-20 00:00:00

  • Time for Precision: A World Without Susceptibility Breakpoints.

    abstract::Interpretive criteria for in vitro susceptibility testing criteria, "susceptibility breakpoints," underpin the evaluation and selection of antimicrobial regimens. However, despite their strengths, susceptibility breakpoints are a relatively blunt instrument employed to address an extremely complex question-what is the...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bader JC,Lakota EA,Andes DR,Rubino CM,Ambrose PG,Bhavnani SM

    更新日期:2018-10-31 00:00:00

  • Ordering Patterns and Costs of Specialized Laboratory Testing by Hospitalists and House Staff in Hospitalized Patients With HIV at a County Hospital: An Opportunity for Diagnostic Stewardship.

    abstract:Background:Inpatient HIV care often requires specialized laboratory testing with which practitioners may not be familiar. In addition, computerized physician order entry allows for ordering tests without understanding test indications, but it can also provide a venue for education and diagnostic stewardship. Methods:A...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bolles K,Woc-Colburn L,Hamill RJ,Hemmige V

    更新日期:2019-03-29 00:00:00

  • Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia.

    abstract:Background:Penicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, we examined the effect of reported penicillin allergy on clinical outcomes in patients with MSSA bacteremia. Methods:In this retros...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Turner NA,Moehring R,Sarubbi C,Wrenn RH,Drew RH,Cunningham CK,Fowler VG,Anderson DJ

    更新日期:2018-02-19 00:00:00

  • Control of a Nosocomial Outbreak of COVID-19 in a University Hospital.

    abstract:Background:Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective co...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Harada S,Uno S,Ando T,Iida M,Takano Y,Ishibashi Y,Uwamino Y,Nishimura T,Takeda A,Uchida S,Hirata A,Sata M,Matsumoto M,Takeuchi A,Obara H,Yokoyama H,Fukunaga K,Amagai M,Kitagawa Y,Takebayashi T,Hasegawa N

    更新日期:2020-10-22 00:00:00

  • Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians.

    abstract:Background:In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gundlapalli AV,Beekmann SE,Graham DR,Polgreen PM,Members of the Emerging Infections Network.

    更新日期:2018-04-23 00:00:00

  • Physician Decisions to Defer Antiretroviral Therapy in Key Populations: Implications for Reducing Human Immunodeficiency Virus Incidence and Mortality in Malaysia.

    abstract:BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

    更新日期:2017-01-25 00:00:00

  • Successful Fecal Microbiota Transplantation in a Patient Suffering From Irritable Bowel Syndrome and Recurrent Urinary Tract Infections.

    abstract:Background:Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%-23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods:We describe the...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Hocquart M,Pham T,Kuete E,Tomei E,Lagier JC,Raoult D

    更新日期:2019-10-14 00:00:00

  • Human Challenge Studies With Wild-Type Severe Acute Respiratory Sydrome Coronavirus 2 Violate Longstanding Codes of Human Subjects Research.

    abstract::This manuscript explores the ethics of human inoculation experiments in young healthy adults with wild-type severe acute respiratory sydrome coronavirus 2 (SARS-CoV-2) as a tool to evaluate vaccine efficacy in the context of the Nuremberg Code, the Declaration of Helsinki, and the Belmont Report, and in the context of...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Spinola SM,Broderick C,Zimet GD,Ott MA

    更新日期:2020-12-28 00:00:00

  • Symptomatic Acute Toxoplasmosis in Returning Travelers.

    abstract::We report a family who acquired acute toxoplasmosis after a trip to Central America. One member developed severe clinical manifestations including bilateral chorioretinitis, hepatitis, and myocarditis requiring therapy. Symptomatic acute toxoplasmosis is unusual and possesses a diagnostic challenge. We discuss the cli...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Henao-Martínez AF,Franco-Paredes C,Palestine AG,Montoya JG

    更新日期:2018-03-09 00:00:00

  • Diabetes Modifies the Clinic Presentation of Cutaneous Leishmaniasis.

    abstract:Background:Cutaneous leishmaniasis (CL) caused by L. braziliensis is characterized by 1 or multiple well-limited ulcerated lesions. Diabetes mellitus (DM) impairs neutrophil and monocyte function, and there is a report of vegetative lesions in a patient with both diseases in Morocco. Here we evaluate the influence of D...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lago AS,Lima FR,Carvalho AM,Sampaio C,Lago N,Guimarães LH,Lago J,Machado PRL,Carvalho LP,Arruda S,Carvalho EM

    更新日期:2020-10-19 00:00:00

  • Occurrence of 4 Dengue Virus Serotypes and Chikungunya Virus in Kilombero Valley, Tanzania, During the Dengue Outbreak in 2018.

    abstract:Background:Dengue and Chikungunya viruses can cause large-scale epidemics, with attack rates of up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent in 2018 and 2019, mostly affecting the coastal areas. Despite the importance of these viruses, there is limited knowledge on the epi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chipwaza B,Sumaye RD,Weisser M,Gingo W,Yeo NK,Amrun SN,Okumu FO,Ng LFP

    更新日期:2020-12-26 00:00:00

  • Risk Factors for Herpes Zoster Among Adults.

    abstract::Background.  The causes of varicella-zoster virus reactivation and herpes zoster (HZ) are largely unknown. We assessed potential risk factors for HZ, the data for which cannot be obtained from the medical sector. Methods.  We conducted a matched case-control study. We established active surveillance in Olmsted County,...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Marin M,Harpaz R,Zhang J,Wollan PC,Bialek SR,Yawn BP

    更新日期:2016-06-11 00:00:00

  • Missed Visits Associated With Future Preexposure Prophylaxis (PrEP) Discontinuation Among PrEP Users in a Municipal Primary Care Health Network.

    abstract:Background:Maintaining retention in preexposure prophylaxis (PrEP) care among diverse patient populations will be needed to support PrEP's efficacy. We characterized patterns of PrEP care retention in a US municipal primary care health network and examined whether missed visits, a metric of care retention that is easy ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Spinelli MA,Scott HM,Vittinghoff E,Liu AY,Gonzalez R,Morehead-Gee A,Gandhi M,Buchbinder SP

    更新日期:2019-02-26 00:00:00

  • Disseminated Mycobacterium abscessus Infection Secondary to an Infected Vascular Stent: Case Report and Review of the Literature.

    abstract::Mycobacterium abscessus is a rapidly growing, multidrug-resistant mycobacteria, commonly associated with pulmonary, skin, and soft tissue infections. We describe a rare case of M abscessus endovascular stent infection; only 3 cases of graft infections have previously been reported. ...

    journal_title:Open forum infectious diseases



    authors: Tejura N,Bontempo G,Chew D

    更新日期:2018-08-23 00:00:00

  • Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial.

    abstract:BACKGROUND:Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:A multicenter, randomized, blinded phase 1 clinical trial evaluated safety and ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Mulligan MJ,Bernstein DI,Frey S,Winokur P,Rouphael N,Dickey M,Edupuganti S,Spearman P,Anderson E,Graham I,Noah DL,Mangal B,Kim S,Hill H,Whitaker J,Emery W,Beck A,Stephens K,Hartwell B,Ogilvie M,Rimann N,Osinski

    更新日期:2014-11-18 00:00:00

  • Lack of Tularemia Among Health Care Providers With Close Contact With Infected Patients-A Case Series.

    abstract::Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

    更新日期:2019-11-19 00:00:00

  • Clofazimine in Nontuberculous Mycobacterial Infections: A Growing Niche.

    abstract::Infection secondary to rapidly growing mycobacteria (RGM) is associated with significant morbidity and mortality, especially in individuals with underlying structural lung disease or immune compromise. Such infections, particularly those caused by the Mycobacterium abscessus group, are challenging to treat due to high...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: McGuffin SA,Pottinger PS,Harnisch JP

    更新日期:2017-07-20 00:00:00

  • Prevalence of Cryptococcal Antigen and Outcomes in People With Human Immunodeficiency Virus in Honduras: A Cohort Study.

    abstract:Background:Cryptococcal meningitis is a major cause of death among people with human immunodeficiency virus (PWH). Cryptococcal antigen (CrAg) testing of asymptomatic patients is an important public health measure to reduce mortality in high-incidence areas. However, limited data exist on CrAg prevalence in Central Ame...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zuniga-Moya JC,Romero-Reyes LE,Saavedra EB,Montoya S,Varela D,Borjas M,Cerna A,Bejarano S,Martinez P,Lujan K,Erazo K,Lainez I,Pineda L,Yanes D,O'Halloran JA,Spec A

    更新日期:2020-11-13 00:00:00

  • Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia.

    abstract::We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated...

    journal_title:Open forum infectious diseases



    authors: Cruz RJ,Dasso JF,Duff C,Krasnopero D,Long Z,Ellison M,Nieves D,Sriaroon P,Asante-Korang A,Walter JE

    更新日期:2020-03-12 00:00:00

  • Cost of Public Health Response and Outbreak Control With a Third Dose of Measles-Mumps-Rubella Vaccine During a University Mumps Outbreak-Iowa, 2015-2016.

    abstract:Background:The United States is experiencing mumps outbreaks in settings with high 2-dose measles-mumps-rubella (MMR) vaccine coverage, mainly universities. The economic impact of mumps outbreaks on public health systems is largely unknown. During a 2015-2016 mumps outbreak at the University of Iowa, we estimated the c...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Marin M,Kitzmann TL,James L,Quinlisk P,Aldous WK,Zhang J,Cardemil CV,Galeazzi C,Patel M,Ortega-Sanchez IR

    更新日期:2018-10-04 00:00:00

  • A 7-Year-Old Child With Headaches and Prolonged Fever Associated With Oral and Nail Lesions.

    abstract::A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by...

    journal_title:Open forum infectious diseases



    authors: Martin S,Balligand E,Peeters J,Nassogne MC,Mondovits B,Loop M,de Selys A,Vanclaire J,Vermylen C,De Bruyckere JJ,Chatzis O,Puel A,Gilliaux O,Van Der Linden D

    更新日期:2019-11-03 00:00:00

  • HIV Testing After a First Positive Rapid Diagnostic Test: A Role for Nucleic Acid Testing?

    abstract::We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve out...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Neilan AM,Cohn JE,Lemaire JF,Sacks E,Alban R,Freedberg KA,Walensky RP,Ciaranello AL

    更新日期:2018-08-29 00:00:00

  • Corrigendum: Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.

    abstract::[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,已发布勘误


    authors: Abdullahi A,Fopoussi OM,Torimiro J,Atkins M,Kouanfack C,Geretti AM

    更新日期:2019-04-03 00:00:00

  • Errors in Diagnostic Test Use and Interpretation Contribute to the High Number of Lyme Disease Referrals in a Low-Incidence State.

    abstract::Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyce RM,Speight C,Lin JT,Farel CE

    更新日期:2020-01-11 00:00:00

  • Substance Use, Demographic and Socioeconomic Factors Are Independently Associated With Postpartum HIV Care Engagement in the Southern United States, 1999-2016.

    abstract:Background:Retention in care (RIC) and viral suppression (VS) are associated with reduced HIV transmission and mortality. Studies addressing postpartum engagement in HIV care have been limited by small sample size, short follow-up, and a lack of data from the Southeast United States. Methods:HIV-positive adult women w...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Oliver C,Rebeiro PF,Hopkins MJ,Byram B,Carpenter L,Clouse K,Castilho JL,Rogers W,Turner M,Bebawy SS,Pettit AC

    更新日期:2019-01-19 00:00:00

  • A Clinical Prediction Score Including Trial of Antibiotics and C-Reactive Protein to Improve the Diagnosis of Tuberculosis in Ambulatory People With HIV.

    abstract:Background:The use of a "trial of antibiotics" as empiric therapy for bacterial pneumonia as a diagnostic tool for tuberculosis in people with HIV (PWH) was removed from World Health Organization (WHO) recommendations in 2007, based on expert opinion. Current guidelines recommend antibiotics only after 2 Xpert MTB/RIF ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyles TH,Nduna M,Pitsi T,Scott L,Fox MP,Maartens G

    更新日期:2020-01-06 00:00:00

  • Evaluation of the Clinical, Laboratory, and Radiological Findings and Treatment of 19 Cases of Pancreatic Echinococcosis.

    abstract:Background:Hydatid disease is a severe health problem in endemic areas. In recent years, the incidence of this disease in China has been increasing. As the imaging characteristics of pancreatic echinococcosis (PE) are similar to those of cystic diseases, such as cysts, tuberculosis, and tumors, PE is often misdiagnosed...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gou L,Gao F,Tiheiran M,Guo H

    更新日期:2020-04-03 00:00:00