Chronic Pulmonary Histoplasmosis-A Scoping Literature Review.


:Chronic pulmonary histoplasmosis (CPH) is an uncommon manifestation of Histoplasma infection with features similar to pulmonary tuberculosis (TB). In endemic areas, it may be misdiagnosed as smear-negative pulmonary TB. Historical case series mainly from patients with presumed TB described a high frequency of cavitation and poor prognosis, likely resulting from delayed presentation. More recent reports suggest that CPH can present with nodules, lymphadenopathy, or infiltrates, with cavities being a less common feature. Emphysema is the main risk factor for cavitary CPH. CPH is therefore an umbrella term, with chronic cavitary pulmonary histoplasmosis and Histoplasma nodules being the main long-term manifestations in nonimmunocompromised individuals. Diagnosis relies on a high index of suspicion, use of fungal culture of respiratory samples, antibody testing, and compatible radiological picture. Treatment with itraconazole for at least 12 months is recommended. Morbidity from CPH results from slow progression of cavities and gradual loss of lung function, especially if not recognized and treated. Studies on the epidemiology of CPH are needed in order to improve understanding of the disease.


Open Forum Infect Dis


Baker J,Kosmidis C,Rozaliyani A,Wahyuningsih R,Denning DW




Has Abstract


2020-04-06 00:00:00












  • Determinants of Clostridium difficile Infection Incidence Across Diverse United States Geographic Locations.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) is no longer restricted to hospital settings, and population-based incidence measures are needed. Understanding the determinants of CDI incidence will allow for more meaningful comparisons of rates and accurate national estimates. METHODS:Data from active population- an...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lessa FC,Mu Y,Winston LG,Dumyati GK,Farley MM,Beldavs ZG,Kast K,Holzbauer SM,Meek JI,Cohen J,McDonald LC,Fridkin SK

    更新日期:2014-07-28 00:00:00

  • Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort.

    abstract:Background:There are few longitudinal data on the risk factors and mediators of racial disparities in sepsis among community- dwelling US adults. Methods:This is a longitudinal study of adult participants in the 1999-2005 National Health Interview Survey with data linked to the 1999-2011 National Death Index. We utili...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kempker JA,Kramer MR,Waller LA,Martin GS

    更新日期:2018-11-15 00:00:00

  • Canada-Wide Epidemic of emm74 Group A Streptococcus Invasive Disease.

    abstract:Background:The number of invasive group A Streptococcus (iGAS) infections due to hitherto extremely rare type emm74 strains has increased in several Canadian provinces since late 2015. We hypothesized that the cases recorded in the different provinces are linked and caused by strains of an emm74 clone that recently eme...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Teatero S,McGeer A,Tyrrell GJ,Hoang L,Smadi H,Domingo MC,Levett PN,Finkelstein M,Dewar K,Plevneshi A,Athey TBT,Gubbay JB,Mulvey MR,Martin I,Demczuk W,Fittipaldi N

    更新日期:2018-04-20 00:00:00

  • Do I Have HIV or Not? Lack of RNA Detection and the Case for Sensitive DNA Testing.

    abstract::We present a case of a 20-year-old male who had ambiguous HIV test results after entering new provider care and whose status was later complicated by undetectable viral RNA off antiretroviral therapy (ART). Verifying HIV infection status may occasionally require sensitive DNA testing that might need to be considered i...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Springer SA,Masciotra S,Johnson JA,Campbell S

    更新日期:2020-10-10 00:00:00

  • Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis.

    abstract:Background:Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asy...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ahmadpour E,Foroutan-Rad M,Majidiani H,Moghaddam SM,Hatam-Nahavandi K,Hosseini SA,Rahimi MT,Barac A,Rubino S,Zarean M,Mathioudakis AG,Cevik M

    更新日期:2019-06-11 00:00:00

  • An Uncommon Site of Streptococcus pneumoniae Colonization Leading to Recurrent Pneumococcal Disease.

    abstract::This report describes a case of relapsing pneumococcal peritonitis. The postulated source of infection was vaginal colonization and secondary adherence of pneumococci to an intrauterine contraceptive device. After immunization with a conjugate pneumococcal vaccine, her antibody levels were observed. She remained infec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sendi P,Moser Schaub EM,Nirgianakis K,Hathaway LJ,Bittel P,Goldblatt D,Streit S

    更新日期:2016-12-07 00:00:00

  • Cytomegalovirus Retinitis Screening and Treatment in Human Immunodeficiency Virus Patients in Malawi: A Feasibility Study.

    abstract:Background:Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm3. Diagnosis is with indirect fundoscopy, and treatment is with intravitreal ganciclovir injections or systemic therapy. However, diagnosis and treatment are not...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ocieczek P,Barnacle JR,Gumulira J,Phiri S,Heller T,Grabska-Liberek I

    更新日期:2019-11-06 00:00:00

  • Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.

    abstract::Background.  The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease becoming endemic in the southeast. Methods.  We collected confirm...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lantos PM,Nigrovic LE,Auwaerter PG,Fowler VG Jr,Ruffin F,Brinkerhoff RJ,Reber J,Williams C,Broyhill J,Pan WK,Gaines DN

    更新日期:2015-09-27 00:00:00

  • INSTI-Based Triple Regimens in Treatment-Naïve HIV-Infected Patients Are Associated With HIV-RNA Viral Load Suppression at Ultralow Levels.

    abstract:Background:During antiretroviral therapy (ART), HIV-1-infected patients may present with ultralow (UL) HIV-RNA viral loads (VLs) below quantification levels of current assays. Reasons for UL-VL detection and its relation to virological rebound (VR) are unclear. Methods:HIV-1-infected, ART-naïve patients followed at 2 ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lambert-Niclot S,Boyd A,Fofana D,Valin N,Wirden M,Meynard JL,Palich R,Agher R,Valantin MA,Calvez V,Katlama C,Girard PM,Marcelin AG,Morand-Joubert L

    更新日期:2019-04-10 00:00:00

  • Seroprevalence of Strongyloides stercoralis and Evaluation of Universal Screening in Kidney Transplant Candidates: A Single-Center Experience in Houston (2012-2017).

    abstract:BACKGROUND:Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented a universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility of universal screening for strongyloidiasis in our center. METH...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Al-Obaidi M,Hasbun R,Vigil KJ,Edwards AR,Chavez V,Hall DR,Dar WA,De Golovine A,Ostrosky-Zeichner L,Bynon JS,Nigo M

    更新日期:2019-07-01 00:00:00

  • Congenital Parvovirus B19 Infection: Persistent Viremia and Red Blood Cell Aplasia.

    abstract::We describe a case of fetal parvovirus B19 infection resulting in preterm birth and leading to hydrops fetalis requiring multiple in utero transfusions. The infant developed chronic postnatal anemia responsive to intravenous immunoglobulin therapy. Serum viral load decreased after immunoglobulin treatment but remained...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Nadimpalli SS,Miller RS,Kamath VM,Farkouh CR,Nhan-Chang CL,Rathe JA,Collins A,Duchon JM,Neu N,Simpson LL,Ratner AJ

    更新日期:2015-04-15 00:00:00

  • Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial.

    abstract:Background:Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation. Methods:Treatment effects of edoxaban (30 mg), a direct ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Baker JV,Wolfson J,Peterson T,Mooberry M,Gissel M,Mystakelis H,Henderson MW,Garcia-Myers K,Rhame FS,Schacker TW,Brummel-Ziedins KE,Sereti I,Key NS,Tracy RP

    更新日期:2020-02-01 00:00:00

  • Disparities in CD4+ T-Lymphocyte Monitoring Among Human Immunodeficiency Virus-Positive Medicaid Beneficiaries: Evidence of Differential Treatment at the Point of Care.

    abstract:BACKGROUND:Monitoring of immune function, measured by CD4 cell count, is an essential service for people with Human Immunodeficiency Virus (HIV). Prescription of antiretroviral (ARV) medications is contingent on CD4 cell count; patients without regular CD4 monitoring are unlikely to receive ARVs when indicated. This st...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Davis AC,Watson G,Pourat N,Kominski GF,Roby DH

    更新日期:2014-06-05 00:00:00

  • Appropriateness of gram-negative agent use at a tertiary care hospital in the setting of significant antimicrobial resistance.

    abstract::Background.  Practicing antimicrobial stewardship in the setting of widespread antimicrobial resistance among gram-negative bacilli, particularly in urban areas, is challenging. Methods.  We conducted a retrospective cross-sectional study at a tertiary care hospital with an established antimicrobial stewardship progra...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Vora NM,Kubin CJ,Furuya EY

    更新日期:2015-02-19 00:00:00

  • The Effect of Shorter Treatment Regimens for Hepatitis C on Population Health and Under Fixed Budgets.

    abstract:Background:Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Morgan JR,Kim AY,Naggie S,Linas BP

    更新日期:2017-12-08 00:00:00

  • In Utero ART Exposure and Birth and Early Growth Outcomes Among HIV-Exposed Uninfected Infants Attending Immunization Services: Results From National PMTCT Surveillance, South Africa.

    abstract:BACKGROUND:Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant in utero HIV and ART exposure on preterm delivery (PTD), low birth weight (LBW), small for gestationa...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ramokolo V,Goga AE,Lombard C,Doherty T,Jackson DJ,Engebretsen IM

    更新日期:2017-08-30 00:00:00

  • Counterfeit Rabies Vaccines: The Philippine Experience.

    abstract:Background:In December 2018, a large, tertiary, university-affiliated hospital in the Philippines discovered that their legitimate supply chain was infiltrated with counterfeit rabies vaccines. Methods:All vials suspected to be counterfeit were quarantined and surrendered to the Philippine Food and Drug Administration...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Henson KER,Santiago AAC,Namqui SS

    更新日期:2020-07-22 00:00:00

  • Atherosclerotic Cardiovascular Disease Risk Profile of Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate.

    abstract:Background:In human immunodeficiency virus (HIV) treatment, tenofovir alafenamide (TAF) is associated with greater increases in all fasting cholesterol subgroups compared with tenofovir disoproxil fumarate (TDF). Because lipid abnormalities may contribute to cardiovascular morbidity and mortality, cardiovascular risk a...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Huhn GD,Shamblaw DJ,Baril JG,Hsue PY,Mills BL,Nguyen-Cleary T,McCallister S,Das M

    更新日期:2019-11-11 00:00:00

  • A 7-Year-Old Child With Headaches and Prolonged Fever Associated With Oral and Nail Lesions.

    abstract::A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by...

    journal_title:Open forum infectious diseases



    authors: Martin S,Balligand E,Peeters J,Nassogne MC,Mondovits B,Loop M,de Selys A,Vanclaire J,Vermylen C,De Bruyckere JJ,Chatzis O,Puel A,Gilliaux O,Van Der Linden D

    更新日期:2019-11-03 00:00:00

  • Missed Visits Associated With Future Preexposure Prophylaxis (PrEP) Discontinuation Among PrEP Users in a Municipal Primary Care Health Network.

    abstract:Background:Maintaining retention in preexposure prophylaxis (PrEP) care among diverse patient populations will be needed to support PrEP's efficacy. We characterized patterns of PrEP care retention in a US municipal primary care health network and examined whether missed visits, a metric of care retention that is easy ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Spinelli MA,Scott HM,Vittinghoff E,Liu AY,Gonzalez R,Morehead-Gee A,Gandhi M,Buchbinder SP

    更新日期:2019-02-26 00:00:00

  • Prognostic Value of Transient Elastography in Human Immunodeficiency Virus-Infected Patients With Chronic Hepatitis C.

    abstract:BACKGROUND:Our objective was to study the prognostic value of liver stiffness (LS) in HIV-infected patients with chronic hepatitis C (CHC). METHODS:We analyzed HIV-infected patients with compensated CHC and at least 1 determination of LS. The primary outcome was the occurrence of liver-related events (LRE), namely, de...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Pérez-Latorre L,Rivero-Juárez A,Hontañón V,Díez C,Cuenca F,Martín-Carbonero ML,Montes ML,Bellón JM,Aldámiz-Echevarría T,Carrero A,Rivero A,González-García J,Berenguer J

    更新日期:2016-10-03 00:00:00

  • Risk Factors for Herpes Zoster Among Adults.

    abstract::Background.  The causes of varicella-zoster virus reactivation and herpes zoster (HZ) are largely unknown. We assessed potential risk factors for HZ, the data for which cannot be obtained from the medical sector. Methods.  We conducted a matched case-control study. We established active surveillance in Olmsted County,...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Marin M,Harpaz R,Zhang J,Wollan PC,Bialek SR,Yawn BP

    更新日期:2016-06-11 00:00:00

  • Variability of Antibiotic Prescribing in a Large Healthcare Network Despite Adjusting for Patient-Mix: Reconsidering Targets for Improved Prescribing.

    abstract:Background:In the outpatient setting, the majority of antibiotic prescriptions are for acute respiratory infections (ARIs), but most of these infections are viral and antibiotics are unnecessary. We analyzed provider-specific antibiotic prescribing in a group of outpatient clinics affiliated with an academic medical ce...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Jung S,Sexton ME,Owens S,Spell N,Fridkin S

    更新日期:2019-01-18 00:00:00

  • Predictors of Missed Hepatitis C Intake Appointments and Failure to Establish Hepatitis C Care Among Patients Living With HIV.

    abstract:Background:We estimated and characterized the proportion of patients living with HIV (PLWH) who missed hepatitis C (HCV) intake appointments and subsequently failed to establish HCV care. Methods:Logistic regression analyses were used to identify factors associated with missed HCV intake appointments and failure to es...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Cachay ER,Hill L,Torriani F,Ballard C,Grelotti D,Aquino A,Christopher Mathews W

    更新日期:2018-07-31 00:00:00

  • Prognostic Role of Bacterial and Fungal Infections in Patients With Liver Cirrhosis With and Without Acute-on-Chronic Liver Failure: A Prospective 2-Center Study.

    abstract:Background:Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors. Methods:We performed a 2-center ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bartoletti M,Baldassarre M,Domenicali M,Lewis RE,Giannella M,Antognoli A,Rinaldi M,Zaccherini G,Verucchi G,Marconi L,Tamè M,Berardi S,Napoli L,Siniscalchi A,Fabbri A,Biselli M,Tufoni M,Pavarin RM,Trevisani F,Viale P

    更新日期:2020-11-04 00:00:00

  • West Nile Virus Central Nervous System Infection in Patients Treated With Rituximab: Implications for Diagnosis and Prognosis, With a Review of Literature.

    abstract::The spectrum of West Nile virus (WNV) infection continues to be elucidated. Many cases of WNV are asymptomatic; however, in immunocompromised patients, symptoms are more likely to be severe. We describe fatal WNV central nervous system disease in lymphoma patients who received rituximab, blunting the inflammatory resp...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Morjaria S,Arguello E,Taur Y,Sepkowitz K,Hatzoglou V,Nemade A,Rosenblum M,Cavalcanti MS,Palomba ML,Kaltsas A

    更新日期:2015-09-19 00:00:00

  • Ordering Patterns and Costs of Specialized Laboratory Testing by Hospitalists and House Staff in Hospitalized Patients With HIV at a County Hospital: An Opportunity for Diagnostic Stewardship.

    abstract:Background:Inpatient HIV care often requires specialized laboratory testing with which practitioners may not be familiar. In addition, computerized physician order entry allows for ordering tests without understanding test indications, but it can also provide a venue for education and diagnostic stewardship. Methods:A...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bolles K,Woc-Colburn L,Hamill RJ,Hemmige V

    更新日期:2019-03-29 00:00:00

  • Addressing the Disease Burden of Vertically Acquired Hepatitis C Virus Infection Among Opioid-Exposed Infants.

    abstract:Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

    更新日期:2019-10-21 00:00:00

  • Difficulties of Identifying the Early HIV Antibody Seroconversion Period Depending on the Confirmatory Assay.

    abstract:Background:Identification of HIV infection at the early stage is valuable for patient management, for prevention, and for research purposes. In practice, identification of a recent HIV infection at diagnosis proves challenging after HIV antibody seroconversion but can be suspected using Western blots (WBs) or immunoblo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Stefic K,Mahjoub N,Desouche C,Néré ML,Thierry D,Delaugerre C,Barin F,Chaix ML

    更新日期:2020-04-21 00:00:00

  • Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage.

    abstract::We used ribonucleic acid sequencing to profile Candida albicans transcription within biliary fluid from a patient with cholangitis; samples were collected before and after treatment with fluconazole and drainage. Candida albicans transcriptomes at the infection site distinguished treated from untreated cholangitis. Af...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Clancy CJ,Meslin C,Badrane H,Cheng S,Losada LC,Nierman WC,Vergidis P,Clark NL,Nguyen MH

    更新日期:2016-06-11 00:00:00