Early-Onset Parkinson's Disease Caused by PLA2G6 Compound Heterozygous Mutation, a Case Report and Literature Review.

abstract：:There is increasing evidence for hippocampal involvement in Amyotrophic Lateral Sclerosis (ALS). Recent neuroimaging studies have been focused on disease-related hippocampal volume alterations while changes in hippocampal shape have been investigated less frequently. Here, we aimed to characterize the patterns of hipp...

journal_title：Frontiers in neurology

authors： Machts J,Vielhaber S,Kollewe K,Petri S,Kaufmann J,Schoenfeld MA

更新日期：2018-07-20 00:00:00

abstract：:Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. In this mini review, we focus on the hypothesis of distur...

journal_title：Frontiers in neurology

authors： Samuelsson K,Press R

更新日期：2018-02-12 00:00:00

abstract：:Background: Spinal and Bulbar Muscular Atrophy (SBMA) is caused by the extension of the polyglutamine tract within the androgen receptor (AR) gene, and results in a multisystem presentation, including the degeneration of lower motor neurons. The androgen receptor (AR) is known to modulate the expression of endogenous ...

journal_title：Frontiers in neurology

authors： Rex C,Nadeau MJ,Douville R,Schellenberg K

更新日期：2019-09-04 00:00:00

abstract：:Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healt...

journal_title：Frontiers in neurology

authors： Sartoretti E,Sartoretti T,Wyss M,Becker AS,Schwenk Á,van Smoorenburg L,Najafi A,Binkert C,Thoeny HC,Zhou J,Jiang S,Graf N,Czell D,Sartoretti-Schefer S,Reischauer C

更新日期：2019-12-10 00:00:00

abstract：:Autism Spectrum Disorders comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers. There is a...

journal_title：Frontiers in neurology

authors： Fleury-Teixeira P,Caixeta FV,Ramires da Silva LC,Brasil-Neto JP,Malcher-Lopes R

更新日期：2019-10-31 00:00:00

abstract：:Stroke is the second leading cause of death and physical disability, with a global lifetime incidence rate of 1 in 6. Currently, the only FDA approved treatment for ischemic stroke is the administration of tissue plasminogen activator (tPA). Stem cell clinical trials for stroke have been underway for close to two deca...

journal_title：Frontiers in neurology

authors： Krause M,Phan TG,Ma H,Sobey CG,Lim R

更新日期：2019-06-25 00:00:00

abstract：:The involvement of the central nervous system (CNS) in Hodgkin lymphoma (HL) has been rarely reported, especially in its primary isolated form. Herein, we present a case of a 33-year-old woman, who received immunosuppressive treatment due to ulcerative colitis (at the beginning azathioprine and sulfasalazine, changed ...

journal_title：Frontiers in neurology

authors： Szczepanek D,Szumiło J,Stoma F,Szymczyk A,Jarosz B,Szczepanek A,Hus M,Trojanowski T,Wasik-Szczepanek E

更新日期：2020-09-08 00:00:00

abstract：:Introduction: With the shift of research focus to personalized medicine in Alzheimer's Dementia (AD), there is an urgent need for tools that are capable of quantifying a patient's risk using diagnostic biomarkers. The Medical Informatics Platform (MIP) is a distributed e-infrastructure federating large amounts of data...

journal_title：Frontiers in neurology

authors： Redolfi A,De Francesco S,Palesi F,Galluzzi S,Muscio C,Castellazzi G,Tiraboschi P,Savini G,Nigri A,Bottini G,Bruzzone MG,Ramusino MC,Ferraro S,Gandini Wheeler-Kingshott CAM,Tagliavini F,Frisoni GB,Ryvlin P,Demonet JF,K

更新日期：2020-09-23 00:00:00

abstract：:Despite the advent of and exciting advances in novel endovascular therapies, t-PA remains the only proven treatment for acute ischemic stroke to date. Although a variety of reasons likely underlie why past trials of endovascular strategies have been unsuccessful, we address in this perspective piece one critical unkno...

journal_title：Frontiers in neurology

authors： Tansy AP,Liebeskind DS

更新日期：2013-10-21 00:00:00

abstract：:In Parkinson's disease (PD), internal cueing mechanisms are impaired leading to symptoms like hypokinesia. However, external cues can improve movement execution by using cortical resources. These cortical processes can be affected by cognitive decline in dementia. It is still unclear how dementia in PD influences exte...

journal_title：Frontiers in neurology

authors： Gräber S,Liepelt-Scarfone I,Csoti I,Maetzler W,Sultan F,Berg D

更新日期：2014-11-17 00:00:00

abstract：:Epilepsy is a neurological disorder in which, in many cases, there is poor pharmacological control of seizures. Nevertheless, it may respond beneficially to alternative treatments such as dietary therapy, like the ketogenic diet or caloric restriction. One of the mechanisms of these diets is to produce a hyperpolariza...

journal_title：Frontiers in neurology

authors： Rubio C,Luna R,Rosiles A,Rubio-Osornio M

更新日期：2020-11-05 00:00:00

abstract：:Genetic findings of the past years have provided ample evidence for a substantial etiologic heterogeneity of dystonic syndromes. While an increasing number of genes are being identified for Mendelian forms of isolated and combined dystonias using classical genetic mapping and whole-exome sequencing techniques, their p...

journal_title：Frontiers in neurology

authors： Verbeek DS,Gasser T

更新日期：2017-01-16 00:00:00

abstract：BACKGROUND:Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern neurosurgical techniques have reported a prohibitive operative morbidity for this surgery. T...

journal_title：Frontiers in neurology

authors： Yun J,Yang J,Cloney M,Mehta A,Singh S,Iwamoto FM,Neugut AI,Sonabend AM

更新日期：2017-09-12 00:00:00

abstract：:Background and Purpose: Recent findings suggested that non-stenosing atherosclerosis (NSA) may play an important pathogenic role, especially in cryptogenic strokes. Furthermore, arterial stiffness has been suggested to be a useful tool in identifying patients with embolic stroke of undetermined source (ESUS) with poor...

journal_title：Frontiers in neurology

authors： Acampa M,Lazzerini PE,Manfredi C,Guideri F,Tassi R,Domenichelli C,Cartocci A,Martini G

更新日期：2020-07-24 00:00:00

abstract：:Several studies have demonstrated the advantages of the bilateral vs. unilateral cochlear implantation in listeners with bilateral severe to profound hearing loss. However, it remains unclear to what extent bilaterally implanted listeners have access to binaural cues, e.g., accurate processing of interaural timing dif...

journal_title：Frontiers in neurology

authors： Ausili SA,Agterberg MJH,Engel A,Voelter C,Thomas JP,Brill S,Snik AFM,Dazert S,Van Opstal AJ,Mylanus EAM

更新日期：2020-09-30 00:00:00

abstract：:Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and epilepsy. Comprehending how these interact with each other may help to advance our understanding of the pathophysiology of epilepsy and develop new treatment strategies to improve seizure control by reducing the medication side ...

journal_title：Frontiers in neurology

authors： Jin B,Aung T,Geng Y,Wang S

更新日期：2020-05-08 00:00:00

abstract：:Background and Purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted a cross-sectional study using data from a nationwide epidemiological sur...

journal_title：Frontiers in neurology

authors： Nakajima M,Miyajima M,Ogino I,Akiba C,Kawamura K,Kurosawa M,Kuriyama N,Watanabe Y,Fukushima W,Mori E,Kato T,Sugano H,Karagiozov K,Arai H

更新日期：2018-06-07 00:00:00

abstract：:Purpose: Rapid muscle fatigue limits clinical applications of functional electrical stimulation (FES) for individuals with motor impairments. This study aimed to characterize the sustainability of muscle force elicited with a novel transcutaneous nerve stimulation technique. Method: A hemiplegic chronic stroke survivo...

journal_title：Frontiers in neurology

authors： Zheng Y,Shin H,Hu X

更新日期：2018-12-04 00:00:00

abstract：:Successful implementation of a randomized clinical trial (RCT) for neuro-vascular emergencies such as cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage is extraordinarily challenging. Besides establishing an accurate, hyper-expedited diagnosis among many mimics in a person with acute neurologic...

journal_title：Frontiers in neurology

authors： Rose DZ,Kasner SE

更新日期：2011-10-17 00:00:00

abstract：:Background: Headache associated with Moyamoya disease (HAMD) in the Chinese population is not well-described. The long-term outcome of surgical revascularization and natural course of HAMD has not been disclosed either. Methods: A headache screening questionnaire in China based on the ICHD2 and a face-to-face intervie...

journal_title：Frontiers in neurology

authors： Gao B,Kang K,Zhang J,Zhang D,Zhao X

更新日期：2020-11-26 00:00:00

abstract：:Performance of models highly depend not only on the used algorithm but also the data set it was applied to. This makes the comparison of newly developed tools to previously published approaches difficult. Either researchers need to implement others' algorithms first, to establish an adequate benchmark on their data, o...

journal_title：Frontiers in neurology

authors： Winzeck S,Hakim A,McKinley R,Pinto JAADSR,Alves V,Silva C,Pisov M,Krivov E,Belyaev M,Monteiro M,Oliveira A,Choi Y,Paik MC,Kwon Y,Lee H,Kim BJ,Won JH,Islam M,Ren H,Robben D,Suetens P,Gong E,Niu Y,Xu J,Pauly

更新日期：2018-09-13 00:00:00

abstract：:Purpose: To assess the efficacy and safety of rituximab treatment as second-line immunotherapy in pediatric cases of anti-NMDA receptor (NMDAR) encephalitis. Methods: We retrospectively recruited 8 patients with anti-NMDAR encephalitis who were treated with rituximab as second-line immunotherapy. We evaluated the clin...

journal_title：Frontiers in neurology

authors： Dou X,Li D,Wu Y,Wang Z,Yang L,Ma N,Wang D,Li X

更新日期：2020-12-14 00:00:00

abstract：:Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials of endovascular thrombectomy (EVT). Meta-analysis of "real world" studies evaluating 90-day outcomes in elderly patients ≥80 years have been limited to small numbers undergoing EVT with...

journal_title：Frontiers in neurology

authors： Sharobeam A,Cordato DJ,Manning N,Cheung A,Wenderoth J,Cappelen-Smith C

更新日期：2019-03-20 00:00:00

abstract：:There is increasing evidence that neuroplastic changes can occur even years after spinal cord injury, leading to reduced disability and better health which should reduce the cost of healthcare. In motor-incomplete spinal cord injury, recovery of leg function may occur if repetitive training causes afferent input to th...

journal_title：Frontiers in neurology

authors： Duffell LD,Donaldson NN

更新日期：2020-06-30 00:00:00

abstract：Introduction:There are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have suboptimal designs. Aim:We investigated the differences in cognitive decline in AD compared to DLB over 4 ye...

journal_title：Frontiers in neurology

authors： Breitve MH,Chwiszczuk LJ,Brønnick K,Hynninen MJ,Auestad BH,Aarsland D,Rongve A

更新日期：2018-03-06 00:00:00

abstract：:This study aims to quantify passive muscle stiffness of spastic wrist flexors in stroke survivors using shear wave elastography (SWE) and to correlate with neural and non-neural contributors estimated from a biomechanical model to hyper-resistance measured during passive wrist extension. Fifteen hemiplegic individuals...

journal_title：Frontiers in neurology

authors： Leng Y,Wang Z,Bian R,Lo WLA,Xie X,Wang R,Huang D,Li L

更新日期：2019-07-10 00:00:00

abstract：:This study aimed to assess the efficacy and safety of self-designed Ningxin Anshen (NXAS) Formula for post-ischemic stroke insomnia of blood-deficient and liver-heat syndrome. Ninety patients were randomized into NXAS group, Placebo group and Zopiclone group. Patients in the NXAS group, Placebo group and Zopiclone gro...

journal_title：Frontiers in neurology

authors： Dai N,Li Y,Sun J,Li F,Xiong H

更新日期：2020-11-09 00:00:00

abstract：:Background and Purpose: Stroke-related functional risk scores are used to predict patients' functional outcomes following a stroke event. We evaluate the predictive accuracy of machine-learning algorithms for predicting functional outcomes in acute ischemic stroke patients after endovascular treatment. Methods: Data w...

journal_title：Frontiers in neurology

authors： Alaka SA,Menon BK,Brobbey A,Williamson T,Goyal M,Demchuk AM,Hill MD,Sajobi TT

更新日期：2020-08-25 00:00:00

abstract：:Aims: To examine trajectories of employment probability up to 10 years following moderate-to-severe traumatic brain injury (TBI) and identify significant predictors from baseline socio-demographic and injury characteristics. Methods: A longitudinal observational study followed 97 individuals with moderate-to-severe TB...

journal_title：Frontiers in neurology

authors： Howe EI,Andelic N,Perrin PB,Røe C,Sigurdardottir S,Arango-Lasprilla JC,Lu J,Løvstad M,Forslund MV

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacun...

journal_title：Frontiers in neurology

authors： Leonards CO,Wang L,Fiebach JB,Endres M,Ebinger M

更新日期：2013-07-10 00:00:00