Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis.


BACKGROUND:Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern neurosurgical techniques have reported a prohibitive operative morbidity for this surgery. These early experiences have dictated the non-surgical management of PCNSL, whereas resection for cytoreduction is a mainstay of treatment in other CNS malignancies. Recent studies have suggested that craniotomy with the goal of cytoreduction might be associated with a favorable overall and progression-free survival for some patients with PCNSL. To challenge the traditional non-surgical paradigm, it is essential to first investigate the safety of resection for PCNSL. METHODS:To determine the operative morbidity of resection for this disease, we performed a population-based assessment of complications using the nationwide inpatient sample database for the years 1998-2013 for biopsies and open craniotomies for PCNSL and other brain tumors. RESULTS:Among 95 patients who underwent biopsy and 34 patients who underwent craniotomy, we found no significant difference in complication rates between craniotomy for resection and biopsy procedures for PCNSL (23.16 versus 20.59%). The types of complications differ between diagnoses, with the PCNSL cohort suffering mainly medical complications and the non-PCNSL cohort suffering mainly from neurological complications. CONCLUSION:These findings support the safety of craniotomies in PCNSL and help provide a rationale for future prospective studies to evaluate the safety and efficacy of resection for this disease.


Front Neurol


Frontiers in neurology


Yun J,Yang J,Cloney M,Mehta A,Singh S,Iwamoto FM,Neugut AI,Sonabend AM




Has Abstract


2017-09-12 00:00:00








  • Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage.

    abstract::Background: Intracranial carotid artery calcification (ICAC) on computed tomography (CT) is a marker of atherosclerosis and an independent predictor of vascular events including stroke. While vitamin K antagonists (VKAs) are used to prevent embolic stroke, they have been shown to increase levels of both coronary and e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Peeters MTJ,Houben R,Postma AA,van Oostenbrugge RJ,Schurgers LJ,Staals J

    更新日期:2019-12-20 00:00:00

  • Distinctive Patterns of Seizure-Related White Matter Alterations in Right and Left Temporal Lobe Epilepsy.

    abstract::Background: We hypothesized that right and left temporal lobe epilepsy (RTLE and LTLE, respectively) have distinctive spatial patterns of white matter (WM) changes that can be differentiated and interpreted with the use of multiple diffusion parameters. We compared the global microstructure of fiber bundles with regar...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Buksakowska I,Szabó N,Martinkovič L,Faragó P,Király A,Vrána J,Kincses ZT,Meluzín J,Šulc V,Kynčl M,Roček M,Tichý M,Charvát F,Hořínek D,Marusič P

    更新日期:2019-10-01 00:00:00

  • Cerebral Blood Flow Measurement in Healthy Children and Children Suffering Severe Traumatic Brain Injury-What Do We Know?

    abstract::Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Rostami E,Nilsson P,Enblad P

    更新日期:2020-04-16 00:00:00

  • Daith Piercing in a Case of Chronic Migraine: A Possible Vagal Modulation.

    abstract::Daith piercing is an ear piercing located at the crus of the helix, bilaterally. It is getting great consent on social media as alternative treatment in chronic migraine. No data about its efficacy and action are available in scientific literature so far. We present the case of a 54-year-old male patient suffering fro...

    journal_title:Frontiers in neurology



    authors: Cascio Rizzo A,Paolucci M,Altavilla R,Brunelli N,Assenza F,Altamura C,Vernieri F

    更新日期:2017-11-27 00:00:00

  • Serum Lactic Acid Following Aneurysmal Subarachnoid Hemorrhage Is a Marker of Disease Severity but Is Not Associated With Hospital Outcomes.

    abstract::Background: Following aneurysmal subarachnoid hemorrhage, peripherally-drawn lactic acid has been associated with poor outcomes; however, its clinical significance is unknown. We investigated admission factors and patient outcomes associated with serum lactic acid in this population. Methods: This was a retrospective ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Poblete RA,Cen SY,Zheng L,Emanuel BA

    更新日期:2018-07-23 00:00:00

  • A Case Report of a Female Patient With Hodgkin Lymphoma Localized in the Central Nervous System and With Concomitant Pulmonary Lymphomatoid Granulomatosis.

    abstract::The involvement of the central nervous system (CNS) in Hodgkin lymphoma (HL) has been rarely reported, especially in its primary isolated form. Herein, we present a case of a 33-year-old woman, who received immunosuppressive treatment due to ulcerative colitis (at the beginning azathioprine and sulfasalazine, changed ...

    journal_title:Frontiers in neurology



    authors: Szczepanek D,Szumiło J,Stoma F,Szymczyk A,Jarosz B,Szczepanek A,Hus M,Trojanowski T,Wasik-Szczepanek E

    更新日期:2020-09-08 00:00:00

  • Wegener's disease presenting with occipital condyle syndrome.

    abstract::Tumors or chronic inflammatory lesions of the occipital condyle may cause occipital pain associated with an ipsilateral hypoglossal nerve injury (occipital condyle syndrome). We describe a young woman with recurrent otitis media and occipital condyle syndrome associated with a limited form of Wegener's disease. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hornik A,Rodriguez-Porcel F,Ersahin CH,Kadanoff R,Biller J

    更新日期:2012-04-12 00:00:00

  • Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.

    abstract::Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Choudhury S,Singh R,Chatterjee P,Trivedi S,Shubham S,Baker MR,Kumar H,Baker SN

    更新日期:2018-07-02 00:00:00

  • Follow-up Analysis of Serum TNF-Related Apoptosis-Inducing Ligand Protein and mRNA Expression in Peripheral Blood Mononuclear Cells from Patients with Ischemic Stroke.

    abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), which is TNF receptor superfamily member, contributes to several diseases pathogenesis. The aim of this research was to investigate the relevance of serum TRAIL protein levels and mRNA expression in peripheral blood mononuclear cells (PBMC) of pati...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Tufekci KU,Vurgun U,Yigitaslan O,Keskinoglu P,Yaka E,Kutluk K,Genc S

    更新日期:2018-03-05 00:00:00

  • Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury.

    abstract::Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate the individual and combined outcome prediction a...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lagerstedt L,Azurmendi L,Tenovuo O,Katila AJ,Takala RSK,Blennow K,Newcombe VFJ,Maanpää HR,Tallus J,Hossain I,van Gils M,Menon DK,Hutchinson PJ,Zetterberg H,Posti JP,Sanchez JC

    更新日期:2020-06-02 00:00:00

  • The Role of Palliative Care in Chronic Progressive Neurological Diseases-A Survey Amongst Neurologists in the Netherlands.

    abstract::Background: Chronic progressive neurological diseases like high grade glioma (HGG), Parkinson's disease (PD), and multiple sclerosis (MS) are incurable, and associated with increasing disability including cognitive impairment, and reduced life expectancy. Patients with these diseases have complex care needs. Therefore...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Walter HAW,Seeber AA,Willems DL,de Visser M

    更新日期:2019-01-14 00:00:00

  • Cluster Analysis to Identify Possible Subgroups in Tinnitus Patients.

    abstract:INTRODUCTION:In tinnitus treatment, there is a tendency to shift from a "one size fits all" to a more individual, patient-tailored approach. Insight in the heterogeneity of the tinnitus spectrum might improve the management of tinnitus patients in terms of choice of treatment and identification of patients with severe ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: van den Berge MJC,Free RH,Arnold R,de Kleine E,Hofman R,van Dijk JMC,van Dijk P

    更新日期:2017-04-03 00:00:00

  • The Role of NLRP3 and IL-1β in Refractory Epilepsy Brain Injury.

    abstract::Objective: The objective of this study was to investigate the roles and mechanisms of inflammatory mediators NLRP3 and IL-1β in refractory temporal epilepsy brain injury. Method: First, the brain tissue and the peripheral blood of children undergoing intractable temporal lobe epilepsy surgery were analyzed as research...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wu C,Zhang G,Chen L,Kim S,Yu J,Hu G,Chen J,Huang Y,Zheng G,Huang S

    更新日期:2020-02-07 00:00:00

  • Elevated Percentage of CD3+ T-Cells and CD4+/CD8+ Ratios in Multiple System Atrophy Patients.

    abstract::α-synuclein is involved in the pathogenesis of multiple system atrophy (MSA) and can be regulated by peripheral immune activation (PIA). We aimed to clarify the correlations between PIA and the prevalence of MSA and to analyze the role of PIA in the progression of the disease. A total of 321 patients with probable MSA...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cao B,Chen X,Zhang L,Wei Q,Liu H,Feng W,Chen Y,Shang H

    更新日期:2020-07-07 00:00:00

  • The Impact of Cerebral Microbleeds Presence on Outcome Following Minor Stroke Treated With Antiplatelet Therapy.

    abstract::Background and Purpose: The relationship between cerebral microbleeds (CMBs) and prognosis in patients with ischemic stroke is still unclear. Our aim here was to verify the relationship between CMBs and functional outcomes in patients with minor ischemic stroke treated with antiplatelet therapy. Methods: We retrospect...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sakuta K,Yaguchi H,Sato T,Komatsu T,Sakai K,Mitsumura H,Matsushima S,Iguchi Y

    更新日期:2020-06-16 00:00:00

  • Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

    abstract::Objective: The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigate...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Seo T,Shiraishi K,Kobayashi T,Fujita T,Saito K,Doi K

    更新日期:2018-08-03 00:00:00

  • Case Report: Extreme Levels of Serum S-100B in a Patient with Chronic Subdural Hematoma.

    abstract::The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This case report studied the course of a 46-year-old gentl...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Persson ME,Thelin EP,Bellander BM

    更新日期:2012-12-05 00:00:00

  • Accuracy and Feasibility of an Android-Based Digital Assessment Tool for Post Stroke Visual Disorders-The StrokeVision App.

    abstract:Background:Visual impairment affects up to 70% of stroke survivors. We designed an app (StrokeVision) to facilitate screening for common post stroke visual issues (acuity, visual fields, and visual inattention). We sought to describe the test time, feasibility, acceptability, and accuracy of our app-based digital visua...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Quinn TJ,Livingstone I,Weir A,Shaw R,Breckenridge A,McAlpine C,Tarbert CM

    更新日期:2018-03-28 00:00:00

  • Microangiopathy-A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review.

    abstract::Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. In this mini review, we focus on the hypothesis of distur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Samuelsson K,Press R

    更新日期:2018-02-12 00:00:00

  • Decoding Circadian Rhythm and Epileptic Activities: Clues From Animal Studies.

    abstract::The relationship between circadian rhythm and epilepsy has been recognized for decades. Yet many questions underlying the complex mechanisms of their interaction remain elusive. A better understanding on this topic allows the development of accurate seizure-detection algorithm and alternative precise therapeutic strat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Xu C,Yu J,Ruan Y,Wang Y,Chen Z

    更新日期:2020-07-24 00:00:00

  • Muscle Fatigue Post-stroke Elicited From Kilohertz-Frequency Subthreshold Nerve Stimulation.

    abstract::Purpose: Rapid muscle fatigue limits clinical applications of functional electrical stimulation (FES) for individuals with motor impairments. This study aimed to characterize the sustainability of muscle force elicited with a novel transcutaneous nerve stimulation technique. Method: A hemiplegic chronic stroke survivo...

    journal_title:Frontiers in neurology



    authors: Zheng Y,Shin H,Hu X

    更新日期:2018-12-04 00:00:00

  • High Compliance with Scheduled Nimodipine Is Associated with Better Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Cotreated with Heparin Infusion.

    abstract:INTRODUCTION:We sought to determine whether compliance with scheduled nimodipine in subarachnoid hemorrhage patients impacted patient outcomes, with the intent of guiding future nimodipine management in patients who experience nimodipine-induced hypotension. METHODS:We performed a retrospective analysis of 118 consecu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wessell A,Kole MJ,Badjatia N,Parikh G,Albrecht JS,Schreibman DL,Simard JM

    更新日期:2017-06-09 00:00:00

  • The Affective Nature of Formulaic Language: A Right-Hemisphere Subcortical Process.

    abstract::Formulaic expressions naturally convey affective content. The unique formal and functional characteristics of idioms, slang, expletives, proverbs, conversational speech formulas, and the many other conventional expressions in this repertory have been well-described: these include unitary form, conventionalized and non...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sidtis DVL,Sidtis JJ

    更新日期:2018-07-24 00:00:00

  • Cochlear Implantation of Bilaterally Deafened Patients with Tinnitus Induces Sustained Decrease of Tinnitus-Related Distress.

    abstract:OBJECTIVE:Tinnitus is a common symptom of hearing impairment. Patients who are bilaterally hard of hearing are often affected by tinnitus. However, they cannot undergo any of the standard tinnitus therapies, since they rely on hearing. Cochlear implantation (CI) used to treat severe hearing disabilities, such as bilate...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Knopke S,Szczepek AJ,Häussler SM,Gräbel S,Olze H

    更新日期:2017-04-25 00:00:00

  • Sex-Specific Differences in Rodents Following a Single Primary Blast Exposure: Focus on the Monoamine and Galanin Systems.

    abstract::Most blast-induced traumatic brain injuries (bTBI) are mild in severity and culpable for the lingering and persistent neuropsychological complaints in affected individuals. There is evidence that the prevalence of symptoms post-exposure may be sex-specific. Our laboratory has focused on changes in the monoamine and th...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kawa L,Arborelius UP,Hökfelt T,Risling M

    更新日期:2020-10-15 00:00:00

  • Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease.

    abstract:INTRODUCTION:Alzheimer's disease (AD) is a long term progressive neurodegenerative disease and might affect the retinal nerve fiber layer thickness (RNFLT) of the eye. There is increasing evidence that visual evoked potentials (VEP), which are an objective way to indicate visual field loss, might be affected by the dis...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kromer R,Serbecic N,Hausner L,Froelich L,Beutelspacher SC

    更新日期:2013-12-16 00:00:00

  • Optical Coherence Tomography in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

    abstract::Purpose: The use of optical coherence tomography (OCT) of the retina to detect inner retinal degeneration is being investigated as a potential biomarker for mild cognitive impairment (MCI) and Alzheimer's disease (AD), and an overwhelming body of evidence indicates that discovery of disease-modifying treatments for AD...

    journal_title:Frontiers in neurology



    authors: Mejia-Vergara AJ,Restrepo-Jimenez P,Pelak VS

    更新日期:2020-10-16 00:00:00

  • Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.

    abstract::Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during normal aging, suggesting t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Martín-Segura A,Casadomé-Perales Á,Fazzari P,Mas JM,Artigas L,Valls R,Nebreda AR,Dotti CG

    更新日期:2019-06-25 00:00:00

  • Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals.

    abstract::Objective: A number of studies have reported that aldehyde dehydrogenase-2 (ALDH2) polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between ALDH...

    journal_title:Frontiers in neurology



    authors: Chen J,Huang W,Cheng CH,Zhou L,Jiang GB,Hu YY

    更新日期:2019-03-28 00:00:00

  • Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders.

    abstract::Preterm-born infants frequently suffer from an array of neurological damage, collectively termed encephalopathy of prematurity (EoP). They also have an increased risk of presenting with a neurodevelopmental disorder (e.g., autism spectrum disorder; attention deficit hyperactivity disorder) later in life. It is hypothe...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Fleiss B,Gressens P,Stolp HB

    更新日期:2020-07-14 00:00:00