Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach Involving Wnt Pathway and KATP Channels.

Abstract:

:Epilepsy is a neurological disorder in which, in many cases, there is poor pharmacological control of seizures. Nevertheless, it may respond beneficially to alternative treatments such as dietary therapy, like the ketogenic diet or caloric restriction. One of the mechanisms of these diets is to produce a hyperpolarization mediated by the adenosine triphosphate (ATP)-sensitive potassium (KATP) channels (KATP channels). An extracellular increase of K+ prevents the release of Ca2+ by inhibiting the signaling of the Wnt pathway and the translocation of β-catenin to the cell nucleus. Wnt ligands hyperpolarize the cells by activating K+ current by Ca2+. Each of the diets described in this paper has in common a lower use of carbohydrates, which leads to biochemical, genetic processes presumed to be involved in the reduction of epileptic seizures. Currently, there is not much information about the genetic processes implicated as well as the possible beneficial effects of diet therapy on epilepsy. In this review, we aim to describe some of the possible genes involved in Wnt pathways, their regulation through the KATP channels which are implicated in each one of the diets, and how they can reduce epileptic seizures at the molecular level.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Rubio C,Luna R,Rosiles A,Rubio-Osornio M

doi

10.3389/fneur.2020.584298

subject

Has Abstract

pub_date

2020-11-05 00:00:00

pages

584298

issn

1664-2295

journal_volume

11

pub_type

杂志文章,评审
  • The Neuromodulatory Impact of Subthalamic Nucleus Deep Brain Stimulation on Gait and Postural Instability in Parkinson's Disease Patients: A Prospective Case Controlled Study.

    abstract::Background: Subthalamic nucleus deep brain stimulation (STN-DBS) has been an established method in improvement of motor disabilities in Parkinson's disease (PD) patients. It has been also claimed to have an impact on balance and gait disorders in PD patients, but the previous results are conflicting. Objective: The ai...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00906

    authors: Szlufik S,Kloda M,Friedman A,Potrzebowska I,Gregier K,Mandat T,Przybyszewski A,Dutkiewicz J,Figura M,Habela P,Koziorowski D

    更新日期:2018-10-31 00:00:00

  • CADASIL vs. Multiple Sclerosis: Is It Misdiagnosis or Concomitant? A Case Series.

    abstract::Introduction: Cerebral autosomal dominant arteriopathy and subcortical infarct leukoencephalopathy (CADASIL) is the most common form of hereditary stroke caused by a mutation in the NOTCH3 gene located on the short arm of chromosome 19. A small number of published reports describe CADASIL patients who were initially d...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.00860

    authors: Khan A,Abedi V,Li J,Malik MT,Esch M,Zand R

    更新日期:2020-09-04 00:00:00

  • Monitoring of Cerebral Blood Flow and Metabolism Bedside in Patients with Subarachnoid Hemorrhage - A Xenon-CT and Microdialysis Study.

    abstract::Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as delayed cerebral ischemia (DCI). Early detection and management of reversible ischemia is of c...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00089

    authors: Rostami E,Engquist H,Johnson U,Howells T,Ronne-Engström E,Nilsson P,Hillered L,Lewén A,Enblad P

    更新日期:2014-06-02 00:00:00

  • A Method for Whole Brain Ex Vivo Magnetic Resonance Imaging with Minimal Susceptibility Artifacts.

    abstract::Magnetic resonance imaging (MRI) is a non-destructive technique that is capable of localizing pathologies and assessing other anatomical features (e.g., tissue volume, microstructure, and white matter connectivity) in postmortem, ex vivo human brains. However, when brains are removed from the skull and cerebrospinal f...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2016.00208

    authors: Shatil AS,Matsuda KM,Figley CR

    更新日期:2016-11-29 00:00:00

  • Presence of Multiple Autoimmune Antibodies Involved in Concurrent Myositis and Myocarditis and Myasthenia Gravis Without Thymoma: A Case Report.

    abstract::Inflammatory myositis (IM) and myasthenia gravis (MG) are both immune disorders involving muscle. The concurrent presence of both conditions in the same patient is extremely rare and the diagnosis is important and challenging. Here, we report a case of concurrent myositis and myocarditis and MG without thymoma in a 69...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00770

    authors: Zhou Z,Chen X,Liu G,Pu J,Wu J

    更新日期:2019-07-16 00:00:00

  • A 3D Model of Human Trabecular Meshwork for the Research Study of Glaucoma.

    abstract::Glaucoma is a multifactorial syndrome in which the development of pro-apoptotic signals are the causes for retinal ganglion cell (RGC) loss. Most of the research progress in the glaucoma field have been based on experimentally inducible glaucoma animal models, which provided results about RGC loss after either the cra...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.591776

    authors: Tirendi S,Saccà SC,Vernazza S,Traverso C,Bassi AM,Izzotti A

    更新日期:2020-12-01 00:00:00

  • Body Mass Index and Prognosis in Ischemic Stroke Patients With Type 2 Diabetes Mellitus.

    abstract::Background: Overweight contributes to type 2 diabetes mellitus (T2DM) development. Although the obesity paradox has been suggested in many vascular diseases, little information is available about stroke patients with T2DM. We investigated whether body mass index (BMI) has a differential impact on the incidence of majo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00563

    authors: Park H,Lee HW,Yoo J,Lee HS,Nam HS,Kim YD,Heo JH

    更新日期:2019-06-05 00:00:00

  • Lipid Profile in Patients With Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.

    abstract::Background: Studies have investigated the lipid profile in amyotrophic lateral sclerosis (ALS), including the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and higher low-density lipoprotein (LDL), and the associations with mortality of ALS, but the results were inconsistent. The...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.567753

    authors: Liu J,Luo X,Chen X,Shang H

    更新日期:2020-10-15 00:00:00

  • Eye Movements in Parkinson's Disease and Inherited Parkinsonian Syndromes.

    abstract::Despite extensive research, the functions of the basal ganglia (BG) in movement control have not been fully understood. Eye movements, particularly saccades, are convenient indicators of BG function. Here, we review the main oculomotor findings reported in Parkinson's disease (PD) and genetic parkinsonian syndromes. P...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00592

    authors: Pretegiani E,Optican LM

    更新日期:2017-11-09 00:00:00

  • Short-Term Test-Retest Reliability of Electrically Evoked Cortical Auditory Potentials in Adult Cochlear Implant Recipients.

    abstract::Background: Late latency auditory evoked potentials (LLAEPs) provide objective evidence of an individual's central auditory processing abilities. Electrically evoked cortical auditory evoked potentials (eCAEPs) are a type of LLAEP that provides an objective measure of aided speech perception and auditory processing ab...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00305

    authors: Pike M,Biagio-de Jager L,le Roux T,Hofmeyr LM

    更新日期:2020-04-28 00:00:00

  • Historical Review of the Fluid-Percussion TBI Model.

    abstract::Traumatic brain injury (TBI) is a major health concern worldwide. Laboratory studies utilizing animal models of TBI are essential for addressing pathological mechanisms of brain injury and development of innovative treatments. Over the past 75 years, pioneering head injury researchers have devised and tested a number ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2016.00217

    authors: Lyeth BG

    更新日期:2016-12-02 00:00:00

  • Mixed effects of deep brain stimulation on depressive symptomatology in Parkinson's disease: a review of randomized clinical trials.

    abstract::Although ~50% of patients with Parkinson's disease (PD) experience depression, treatment for this important and debilitating comorbidity is relatively understudied. Deep brain stimulation (DBS) has been increasingly utilized for the management of tremors in progressive PD. Several preliminary studies have shown the po...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2014.00154

    authors: Gökbayrak NS,Piryatinsky I,Gavett RA,Ahmed OJ

    更新日期:2014-08-11 00:00:00

  • Wegener's disease presenting with occipital condyle syndrome.

    abstract::Tumors or chronic inflammatory lesions of the occipital condyle may cause occipital pain associated with an ipsilateral hypoglossal nerve injury (occipital condyle syndrome). We describe a young woman with recurrent otitis media and occipital condyle syndrome associated with a limited form of Wegener's disease. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00053

    authors: Hornik A,Rodriguez-Porcel F,Ersahin CH,Kadanoff R,Biller J

    更新日期:2012-04-12 00:00:00

  • Diagnostic and Prognostic Performance of Neurofilaments in ALS.

    abstract::There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal flu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.01167

    authors: Poesen K,Van Damme P

    更新日期:2019-01-18 00:00:00

  • The Role of Maternal Smoking in Sudden Fetal and Infant Death Pathogenesis.

    abstract::Maternal smoking is a risk factor for both sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death syndrome (SIUDS). Both SIDS and SIUDS are more frequently observed in infants of smoking mothers. The global prevalence of smoking during pregnancy is 1.7% and up to 8.1% of women in Europe smoke du...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.586068

    authors: Bednarczuk N,Milner A,Greenough A

    更新日期:2020-10-23 00:00:00

  • Endovascular Treatment of Congenital Internal Carotid-Jugular Fistula.

    abstract::A carotid-jugular fistula is a direct communication between the carotid artery and the jugular vein. Both congenital and spontaneous internal carotid-jugular fistulas are extremely rare. We describe the first case of successful endovascular treatment for a congenital internal carotid-jugular fistula. We report a 64-ye...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2018.01118

    authors: Wang M,Fan W,Mungur R,Gu J,Wan S

    更新日期:2018-12-18 00:00:00

  • Spinocerebellar Ataxia Type 2 Is Associated with the Extracellular Loss of Superoxide Dismutase but Not Catalase Activity.

    abstract:BACKGROUND:Spinocerebellar ataxia type 2 (SCA2) is an inherited and still incurable neurodegenerative disorder. Evidence suggests that pro-oxidant agents as well as factors involved in antioxidant cellular defenses are part of SCA2 physiopathology. AIM:To assess the influence of superoxide dismutase (SOD3) and catalas...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00276

    authors: Almaguer-Gotay D,Almaguer-Mederos LE,Aguilera-Rodríguez R,Rodríguez-Labrada R,Cuello-Almarales D,Estupiñán-Domínguez A,Velázquez-Pérez LC,González-Zaldívar Y,Vázquez-Mojena Y

    更新日期:2017-06-13 00:00:00

  • Skilled reaching and grasping in the rat: lacking effect of corticospinal lesion.

    abstract::The corticospinal system is a major motor pathway in the control of skilled voluntary movements such as reaching and grasping. It has developed considerably phylogenetically to reach a peak in humans. Because rodents possess advanced forelimb movements that can be used for reaching and grasping food, it is commonly co...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00103

    authors: Alstermark B,Pettersson LG

    更新日期:2014-06-20 00:00:00

  • Motor Nerve Conduction Block Predicting Outcome of Guillain-Barre Syndrome.

    abstract::Introduction: Motor nerve conduction blocks (CBs) could be detected in both acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). We aimed to identify the correlation between CBs and functional outcome in the two subtypes of GBS. Methods: Motor nerve conduction studie...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00399

    authors: Niu J,Liu M,Sun Q,Li Y,Wu S,Ding Q,Guan Y,Cui L

    更新日期:2018-06-01 00:00:00

  • Occipital Lobe Epilepsy With Ictal Fear: Evidence From a Stereo-Electroencephalography (sEEG) Case.

    abstract::Ictal fear-a relatively rare phenomenon-is a semiological characteristic of epilepsy. Most patients with epilepsy with ictal fear have an epileptic zone in the mesial temporal lobe, which is the classical brain area involved in emotion processing. Herein, we report a case of epilepsy with ictal fear as the first manif...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2018.00644

    authors: Wang J,Wang Q,Wang M,Luan G,Zhou J,Guan Y,Yan Z

    更新日期:2018-08-07 00:00:00

  • Injuries to the Immature Optic Radiation Show Correlated Thinning of the Macular Ganglion Cell Layer.

    abstract::Injuries to the immature optic radiation (OR) are associated with thinning of the retinal nerve fiber layer and corresponding visual field (VF) defects. The aim of the current study was to seek evidence for causal retrograde trans-synaptic degeneration by exploring the correspondence between the localization and exten...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00321

    authors: Lennartsson F,Nilsson M,Flodmark O,Jacobson L,Larsson J

    更新日期:2018-05-07 00:00:00

  • Lateral Fluid Percussion Injury Impairs Hippocampal Synaptic Soluble N-Ethylmaleimide Sensitive Factor Attachment Protein Receptor Complex Formation.

    abstract::Traumatic brain injury (TBI) and the activation of secondary injury mechanisms have been linked to impaired cognitive function, which, as observed in TBI patients and animal models, can persist for months and years following the initial injury. Impairments in neurotransmission have been well documented in experimental...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00532

    authors: Carlson SW,Henchir J,Dixon CE

    更新日期:2017-10-10 00:00:00

  • Making Headway for Discussions About Concussions: Experiences of Former High School and Collegiate Student-Athletes.

    abstract::In order to better understand how to identify and treat student-athletes who experience concussions, better insight into reporting behavior of athletes is needed. This study aims to identify information influencing athletes' attitudes toward reporting their concussions and the perceived trajectory of their recovery bo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00698

    authors: Oddo A,O'Conor E,Shore S,Piraino M,Gibney K,Tsao J,Stanfill AG

    更新日期:2019-07-05 00:00:00

  • Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.

    abstract::Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00517

    authors: Choudhury S,Singh R,Chatterjee P,Trivedi S,Shubham S,Baker MR,Kumar H,Baker SN

    更新日期:2018-07-02 00:00:00

  • Damage in the Thalamocortical Tracts is Associated With Subsequent Thalamus Atrophy in Early Multiple Sclerosis.

    abstract::Background: In early multiple sclerosis (MS), thalamus atrophy and decreased integrity of the thalamocortical white matter (WM) tracts have been observed. Objective: To investigate the temporal association between thalamus volume and WM damage in the thalamocortical tract in subjects with early MS. Methods: At two tim...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.575611

    authors: Weeda MM,Pruis IJ,Westerveld ASR,Brouwer I,Bellenberg B,Barkhof F,Vrenken H,Lukas C,Schneider R,Pouwels PJW

    更新日期:2020-11-17 00:00:00

  • Cell-Based Therapies for Stroke: Are We There Yet?

    abstract::Stroke is the second leading cause of death and physical disability, with a global lifetime incidence rate of 1 in 6. Currently, the only FDA approved treatment for ischemic stroke is the administration of tissue plasminogen activator (tPA). Stem cell clinical trials for stroke have been underway for close to two deca...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00656

    authors: Krause M,Phan TG,Ma H,Sobey CG,Lim R

    更新日期:2019-06-25 00:00:00

  • Electroencephalography Network Effects of Corpus Callosotomy in Patients with Lennox-Gastaut Syndrome.

    abstract:OBJECTIVES:This study aimed to investigate the functional network effects of corpus callosotomy (CC), a well-recognized palliative surgical therapy for patients with Lennox-Gastaut syndrome (LGS). Specifically, we sought to gain insight into the effects of CC on LGS remission, based on brain networks in LGS by calculat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00456

    authors: Liang JG,Lee D,Youn SE,Kim HD,Kim NY

    更新日期:2017-09-04 00:00:00

  • Corticoreticular Tract in the Human Brain: A Mini Review.

    abstract::Previous studies have suggested that the corticoreticular tract (CRT) has an important role in motor function almost next to the corticospinal tract (CST) in the human brain. Herein, the CRT is reviewed with regard to its anatomy, function, and recovery mechanisms after injury, with particular focus on previous diffus...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01188

    authors: Jang SH,Lee SJ

    更新日期:2019-11-12 00:00:00

  • Intracochlear Perfusion of Tumor Necrosis Factor-Alpha Induces Sensorineural Hearing Loss and Synaptic Degeneration in Guinea Pigs.

    abstract::Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, including sensorineural h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01353

    authors: Katsumi S,Sahin MI,Lewis RM,Iyer JS,Landegger LD,Stankovic KM

    更新日期:2020-02-10 00:00:00

  • Temporal Lobe Cavernous Malformation Caused Epileptic Amnesic Episodes and Mild Cognitive Impairment.

    abstract::Neuropathological features in Alzheimer's disease (AD) are amyloid β (Aβ) deposits and neurofibrillary changes. AD is characterized by memory impairment and cognitive dysfunction, with some reports associating these impairments with hyperexcitability caused by Aβ in the medial temporal lobe. Epileptic seizures are kno...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00620

    authors: Hirokawa Y,Fujimoto A,Ichikawa N,Sato K,Tanaka T,Enoki H,Otsuki Y,Okanishi T

    更新日期:2019-06-12 00:00:00