Abstract：
BACKGROUND:Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of corneal host endothelial cells involved in neovascularization are largely unexplored. METHODS:Liquid chromatography-mass spectrometry, immunoblotting, and ELISA were used to screen and identify potential neovascularization-related factors in human full-thickness vascularized corneal tissues. Lipopolysaccharide was used to induce inflammation in three kinds of corneal host cells in vitro, including corneal epithelial, stromal, and endothelial cells. Fungus was used to establish an animal model of corneal neovascularization in vivo. Tube formation and spheroid sprouting assays were used to evaluate the contribution of three kinds of corneal host cells to the degree of neovascularization under various stimuli. Matrix metalloproteinase (MMP)-2, alpha-crystallin A chain (CRYAA), galectin-8, Bcl-2, neuropilin-2, MMP-9 plasmids, and recombinant human fibronectin were used to identify the key proteins of corneal host cells involved in corneal inflammatory neovascularization. FINDINGS:All three kinds of corneal host cells influenced corneal neovascularization to varying degrees. MMP-9 in human corneal epithelial cells, MMP-2, and CRYAA in human corneal stromal cells, and MMP-2 and galectin-8 in human corneal endothelial cells are potential key proteins that participate in corneal inflammatory neovascularization. INTERPRETATION:Our data indicated that both the effects of key proteins and corneal host cells involved should be considered for the treatment of corneal inflammatory neovascularization.
journal_name
EBioMedicinejournal_title
EBioMedicineauthors
Yu H,Sun L,Cui J,Li Y,Yan Y,Wei X,Wang C,Song F,Jiang W,Liu Y,Ge H,Qian H,Li X,Tang X,Liu Pdoi
10.1016/j.ebiom.2019.05.026subject
Has Abstractpub_date
2019-06-01 00:00:00pages
542-553issn
2352-3964pii
S2352-3964(19)30327-5journal_volume
44pub_type
杂志文章相关文献
EBioMedicine文献大全abstract：:A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially decreases Aβ42 levels. H...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2017.08.028
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS:We recruited 86 Chinese children born to OHSS women and 172 c...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2017.05.020
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeat...
journal_title：EBioMedicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ebiom.2018.03.031
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2020.102805
更新日期：2020-11-01 00:00:00
abstract：:Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future off...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2017.02.006
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Anti-angiogenic treatment failure is often attributed to drug resistance, unsuccessful drug delivery, and tumor heterogeneity. Recent studies have speculated that anti-angiogenic treatments may fail due to characteristics inherent to tumor-associated blood vessels. Tumor-associated blood vessels are phenotyp...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.03.026
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND/AIMS:The genome-wide association study has shown that MHC class I chain-related A (MICA) genetic variants were associated with hepatitis C virus (HCV) related hepatocellular carcinoma (HCC). The impact of the genetic variants and its serum levels on post-treatment cohort is elusive [corrected]. METHODS:MICA...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2016.11.031
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive study, novel therapeuti...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.01.063
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.01.053
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. METHODS:Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs' vagina, which were made up of poly (β-amino este...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2020.102897
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Active immunotherapy is an effective, long-lasting, cheap, and safe approach to suppress cancer progression; however, the key issue is to develop appropriate tumour vaccines. Oncoproteins are up-regulated under various stress conditions and promote cell survival. Oncoproteins and their immunogenic domains co...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.10.025
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Citizen science, scientific research conducted by non-specialists, has the potential to facilitate biomedical research using available large-scale data, however validating the results is challenging. The Cell Slider is a citizen science project that intends to share images from tumors with the general public...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2015.05.009
更新日期：2015-05-09 00:00:00
abstract：:Although licensed human papillomavirus (HPV) vaccines are most efficacious in persons never infected with HPV, they also reduce infection and disease in previously infected subjects, indicating natural immunity is not entirely protective against HPV re-infection. The aim of this exploratory study was to examine the B ...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2016.06.042
更新日期：2016-08-01 00:00:00
abstract：:In this thought commentary, I highlight the discoveries made by Seto and colleagues related to HDAC11 and obesity. I discuss how their reported work fills a gap in the HDAC field and comment on the clinical implications of their findings. Overall, selective inhibition of HDAC11 could be a novel potential therapeutic a...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2018.08.008
更新日期：2018-09-01 00:00:00
abstract：:The nascent field of 'Nutritional Psychiatry' offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depressi...
journal_title：EBioMedicine
pub_type： 杂志文章,评审
doi：10.1016/j.ebiom.2017.02.020
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to t...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.07.015
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:We developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA and Decipher. ...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2020.103163
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVE:The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS:Seventy-five patients with GPA and a PR3-ANCA rise d...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2017.01.033
更新日期：2017-03-01 00:00:00
abstract：:Intestinal damage in malnutrition constitutes a threat to the survival of many thousands of children globally. We studied children in Lusaka, Zambia, with severe acute malnutrition (SAM) and persistent diarrhea using endoscopy, biopsy and analysis of markers and protective proteins in blood and intestinal secretions. ...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2017.07.017
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS:We included 792 Normative A...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2015.04.008
更新日期：2015-04-13 00:00:00
abstract：BACKGROUND:Population-level monitoring of hepatitis C virus (HCV) infected people across the cascade of care identifies gaps in access and engagement in care and treatment. We characterized a population-level cascade of care for HCV in British Columbia (BC), Canada and identified factors associated with leakage at each...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2016.08.035
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD phenotype (PF-ILD), with similar persistent lung function decline suggesting common molecular pathways involved. Nintedanib, a tyrosine kinase inhibitor targeting the PDGF, FGF, VEGF and M-CSF pathways, has shown comparable eff...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.10.050
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. METHODS:Utilising 915 colon and rectal carcinomas in...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2020.102860
更新日期：2020-07-01 00:00:00
abstract：:Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although prior studies have explored the functional consequences of macrophage aging, less is known about its cellular basis or what defines the transition from physiolog...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2018.05.035
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps1...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.10.018
更新日期：2019-12-01 00:00:00
abstract：:Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberculosis. While the m...
journal_title：EBioMedicine
pub_type： 杂志文章,评审
doi：10.1016/j.ebiom.2019.10.014
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans. METHODS:We obtained skin-biopsy, bloo...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.04.004
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS:Clozapine and norclozapine ste...
journal_title：EBioMedicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ebiom.2017.11.030
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The identification of new biomarkers and the development of novel, targetable contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal cancer (mCRC). Aryl-Hydrocarbon-Receptor-Nuclear-Translocator-Like (ARNTL/BMAL1) is a circadian clock-regulated transcription factor prom...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2019.07.004
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...
journal_title：EBioMedicine
pub_type： 杂志文章
doi：10.1016/j.ebiom.2020.102694
更新日期：2020-05-01 00:00:00
