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Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment.

Abstract：

BACKGROUND/AIMS:The genome-wide association study has shown that MHC class I chain-related A (MICA) genetic variants were associated with hepatitis C virus (HCV) related hepatocellular carcinoma (HCC). The impact of the genetic variants and its serum levels on post-treatment cohort is elusive [corrected]. METHODS:MICA rs2596542 genotype and serum MICA (sMICA) levels were evaluated in 705 patients receiving antiviral therapy. RESULTS:Fifty-eight (8·2%) patients developed HCC, with a median follow-up period of 48·2 months (range: 6–129 months). The MICA A allele was associated with a significantly increased risk of HCC development in cirrhotic non-SVR patients but not in patients of non-cirrhotic and/or with SVR. For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development. The risk A allele or GG genotype with sMICA > 175 ng/mL provided the best accuracy (79%) and a negative predictive value of 100% in predicting HCC. CONCLUSIONS:Cirrhotic patients who carry MICA risk alleles and those without risk alleles but with high sMICA levels possessed the highest risk of HCC development once they failed antiviral therapy.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Huang CF,Huang CY,Yeh ML,Wang SC,Chen KY,Ko YM,Lin CC,Tsai YS,Tsai PC,Lin ZY,Chen SC,Dai CY,Huang JF,Chuang WL,Yu ML

doi

10.1016/j.ebiom.2016.11.031

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

81-89

issn

2352-3964

pii

S2352-3964(16)30549-7

journal_volume

15

pub_type

杂志文章

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