Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients.

abstract：:Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fr...

journal_title：EBioMedicine

authors： Chen X,Su T,Chen Y,He Y,Liu Y,Xu Y,Wei Y,Li J,He R

更新日期：2017-11-01 00:00:00

abstract：:Disease-specific alterations of the cell-free DNA methylation status are frequently found in serum samples and are currently considered to be suitable biomarkers. Candidate markers were identified by bisulfite conversion-based genome-wide methylation screening of lung tissue from lung cancer, fibrotic ILD, and COPD. c...

journal_title：EBioMedicine

authors： Wielscher M,Vierlinger K,Kegler U,Ziesche R,Gsur A,Weinhäusel A

更新日期：2015-07-02 00:00:00

abstract：:Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...

journal_title：EBioMedicine

authors： Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

journal_title：EBioMedicine

authors： Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

journal_title：EBioMedicine

authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...

journal_title：EBioMedicine

authors： Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Recurrent mutations in the promoter of the telomerase reverse transcriptase (TERT) gene (C228T and C250T) detected in tumours and cells shed into urine of urothelial cancer (UC) patients are putative biomarkers for UC detection and monitoring. However, the possibility of detecting these mutations in cell-fre...

journal_title：EBioMedicine

authors： Avogbe PH,Manel A,Vian E,Durand G,Forey N,Voegele C,Zvereva M,Hosen MI,Meziani S,De Tilly B,Polo G,Lole O,Francois P,Delhomme TM,Carreira C,Monteiro-Reis S,Henrique R,Abedi-Ardekani B,Byrnes G,Foll M,Weiderpass E

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Angiogenesis improves reperfusion to the ischaemic tissue after vascular obstruction. The underlying molecular mechanisms of post-ischaemic angiogenesis are not clear. FAM3A belongs to the family with sequence similarity 3 (FAM3) genes, but its biological function in endothelial cells in regards to vascular ...

journal_title：EBioMedicine

authors： Xu W,Liang M,Zhang Y,Huang K,Wang C

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Lipid accumulation has been highlighted in cancer development and progression, but the exact mechanism remains unclear in renal cell carcinoma (RCC). MicroRNAs (miRNAs) have been confirmed to participate in the pathological processes of cancers, including tumour occurrence and inhibition. However, the role a...

journal_title：EBioMedicine

authors： Xiao W,Wang C,Chen K,Wang T,Xing J,Zhang X,Wang X

更新日期：2020-01-01 00:00:00

abstract：:Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective inhibitor of the c...

journal_title：EBioMedicine

authors： Osawa Y,Oboki K,Imamura J,Kojika E,Hayashi Y,Hishima T,Saibara T,Shibasaki F,Kohara M,Kimura K

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. METHODS:Glycoengineered cell lines were...

journal_title：EBioMedicine

authors： Freitas D,Campos D,Gomes J,Pinto F,Macedo JA,Matos R,Mereiter S,Pinto MT,Polónia A,Gartner F,Magalhães A,Reis CA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:KRAS mutations are the most frequent oncogenic aberration in lung adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence drug responses. This heterogeneity challenges the development of effective therapies for patients with KRAS-driven non-small cell lung cancer (NSCLC). METH...

journal_title：EBioMedicine

authors： Wang H,Lv Q,Xu Y,Cai Z,Zheng J,Cheng X,Dai Y,Jänne PA,Ambrogio C,Köhler J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS:We have now investigated the relationship between ...

journal_title：EBioMedicine

authors： Podlesniy P,Puigròs M,Serra N,Fernández-Santiago R,Ezquerra M,Tolosa E,Trullas R

更新日期：2019-10-01 00:00:00

abstract：:Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future off...

journal_title：EBioMedicine

authors： Wu D,Feng B,Dai Y,Wu X,Chen B,Xu C,Tang Y,Wang K,Zhang S,Wang S,Luo B,Chen Z

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with faster diseas...

journal_title：EBioMedicine

authors： Martin AR,Patel EU,Kirby C,Astemborski J,Kirk GD,Mehta SH,Marshall K,Janes H,Clayton A,Corey L,Hammer SM,Sobieszczyk ME,Arthos J,Cicala C,Redd AD,Quinn TC

更新日期：2020-12-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

journal_title：EBioMedicine

authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

更新日期：2021-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is a highly prevalent component of disorders associated with disrupted energy homeostasis. Although dysregulation of the energy sensor AMP-activated protein kinase (AMPK) is viewed as a pathogenic factor in the development of fatty liver its role has not been directly demonstrated. Une...

journal_title：EBioMedicine

authors： Boudaba N,Marion A,Huet C,Pierre R,Viollet B,Foretz M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans. METHODS:We obtained skin-biopsy, bloo...

journal_title：EBioMedicine

authors： Jia N,Liu HB,Ni XB,Bell-Sakyi L,Zheng YC,Song JL,Li J,Jiang BG,Wang Q,Sun Y,Wei R,Yuan TT,Xia LY,Chu YL,Wei W,Li LF,Ye JL,Lv QY,Cui XM,Guan Y,Tong YG,Jiang JF,Lam TT,Cao WC

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death during childhood. Due to their diffuse growth characteristics, chemoresistance and location behind the blood-brain barrier (BBB), the prognosis of pHGG has barely improved in the past decades. As such, there is a dire need for ...

journal_title：EBioMedicine

authors： Metselaar DS,Meel MH,Benedict B,Waranecki P,Koster J,Kaspers GJL,Hulleman E

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...

journal_title：EBioMedicine

authors： Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the administration of neuron d...

journal_title：EBioMedicine

authors： Kasagi S,Wang D,Zhang P,Zanvit P,Chen H,Zhang D,Li J,Che L,Maruyama T,Nakatsukasa H,Wu R,Jin W,Sun L,Chen W

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The prognosis of Chinese patients with eyelid sebaceous carcinoma (SC) has not been updated for >3 decades. The prognostic predictors are multifactorial, and there is no validated prognostic model for eyelid SC. METHODS:This study included 238 consecutive patients with eyelid SC. All eligible patients were ...

journal_title：EBioMedicine

authors： Zhou C,Shi Y,Chai P,Wu F,Xia W,He X,Shi Y,Huang H,Jia R,Fan X

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. METHODS:We identified all patients (cases) with incident cancer in Denmark during 2000-2012 (n=278,485) and matched each case to 10 controls. Compl...

journal_title：EBioMedicine

authors： Pottegård A,Friis S,Christensen Rd,Habel LA,Gagne JJ,Hallas J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

journal_title：EBioMedicine

authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

更新日期：2019-02-01 00:00:00

abstract：:Metabolites have emerged as the quintessential effectors mediating the impact of the commensal microbiome on human physiology, both locally at the sites of microbial colonization and systemically. The endocrine activity of the microbiome and its involvement in a multitude of complex diseases has made microbiome-modula...

journal_title：EBioMedicine

authors： Descamps HC,Herrmann B,Wiredu D,Thaiss CA

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Human endogenous retroviruses HERV-W encode a pro-inflammatory protein, named MSRV-Env from its original identification in Multiple Sclerosis. Though not detected in various neurological controls, MSRV-Env was found in patients with chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs). This st...

journal_title：EBioMedicine

authors： Faucard R,Madeira A,Gehin N,Authier FJ,Panaite PA,Lesage C,Burgelin I,Bertel M,Bernard C,Curtin F,Lang AB,Steck AJ,Perron H,Kuntzer T,Créange A

更新日期：2016-04-01 00:00:00

abstract：:Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and v...

journal_title：EBioMedicine

authors： Xie Y,Bergström T,Jiang Y,Johansson P,Marinescu VD,Lindberg N,Segerman A,Wicher G,Niklasson M,Baskaran S,Sreedharan S,Everlien I,Kastemar M,Hermansson A,Elfineh L,Libard S,Holland EC,Hesselager G,Alafuzoff I,Westerm

更新日期：2015-08-15 00:00:00

abstract：BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

journal_title：EBioMedicine

authors： Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

更新日期：2020-12-01 00:00:00

abstract：:Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window of vulnerability in the latent HIV reservoir, defined as the triggering of viral antigen producti...

journal_title：EBioMedicine

authors： Sung JA,Sholtis K,Kirchherr J,Kuruc JD,Gay CL,Nordstrom JL,Bollard CM,Archin NM,Margolis DM

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple is...

journal_title：EBioMedicine

authors： Bankhead A 3rd,McMaster T,Wang Y,Boonstra PS,Palmbos PL

更新日期：2020-01-01 00:00:00