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The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.

Abstract：

:Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and validated cell lines derived from surgical samples of GBM patients, maintained under conditions to preserve GSC characteristics. This collection, which we call the Human Glioblastoma Cell Culture (HGCC) resource, consists of a biobank of 48 GC lines and an associated database containing high-resolution molecular data. We demonstrate that the HGCC lines are tumorigenic, harbor genomic lesions characteristic of GBMs, and represent all four transcriptional subtypes. The HGCC panel provides an open resource for in vitro and in vivo modeling of a large part of GBM diversity useful to both basic and translational GBM research.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Xie Y,Bergström T,Jiang Y,Johansson P,Marinescu VD,Lindberg N,Segerman A,Wicher G,Niklasson M,Baskaran S,Sreedharan S,Everlien I,Kastemar M,Hermansson A,Elfineh L,Libard S,Holland EC,Hesselager G,Alafuzoff I,Westerm

doi

10.1016/j.ebiom.2015.08.026

subject

Has Abstract

pub_date

2015-08-15 00:00:00

pages

1351-63

issue

10

issn

2352-3964

pii

S2352-3964(15)30114-6

journal_volume

2

pub_type

杂志文章

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