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Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.

Abstract：

:Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring. The transmission was associated with DNA methylation. Thus, our study supports a "Lamarckian"-like mechanism of pathogenesis and the crucial role of epigenetic factors in neurological conditions.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Wu D,Feng B,Dai Y,Wu X,Chen B,Xu C,Tang Y,Wang K,Zhang S,Wang S,Luo B,Chen Z

doi

10.1016/j.ebiom.2017.02.006

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

206-215

issn

2352-3964

pii

S2352-3964(17)30065-8

journal_volume

17

pub_type

杂志文章

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