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Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort.

Abstract：

BACKGROUND:Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS:We included 792 Normative Aging Study participants with 1-4 BTL measurements from 1999 to 2012. We used linear mixed-effects models to examine BTL attrition by cancer status (relative to increasing age and decreasing years pre-diagnosis), Cox models for time-dependent associations, and logistic regression for cancer incidence stratified by years between BTL measurement and diagnosis. FINDINGS:Age-related BTL attrition was faster in cancer cases pre-diagnosis than in cancer-free participants (pdifference = 0.017); all participants had similar age-adjusted BTL 8-14 years pre-diagnosis, followed by decelerated attrition in cancer cases resulting in longer BTL three (p = 0.003) and four (p = 0.012) years pre-diagnosis. Longer time-dependent BTL was associated with prostate cancer (HR = 1.79, p = 0.03), and longer BTL measured ≤ 4 years pre-diagnosis with any (OR = 3.27, p < 0.001) and prostate cancers (OR = 6.87, p < 0.001). INTERPRETATION:Age-related BTL attrition was faster in cancer cases but their age-adjusted BTL attrition began decelerating as diagnosis approached. This may explain prior inconsistencies and help develop BTL as a cancer detection biomarker.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Hou L,Joyce BT,Gao T,Liu L,Zheng Y,Penedo FJ,Liu S,Zhang W,Bergan R,Dai Q,Vokonas P,Hoxha M,Schwartz J,Baccarelli A

doi

10.1016/j.ebiom.2015.04.008

subject

Has Abstract

pub_date

2015-04-13 00:00:00

pages

591-6

issue

6

issn

2352-3964

pii

S2352-3964(15)00102-4

journal_volume

2

pub_type

杂志文章

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