当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans.

Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans.

Abstract：

BACKGROUND:Preoperative prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with colorectal cancer (CRC). In this study, we sought to develop and validate a non-invasive nomogram model to preoperatively predict LN metastasis in CRC. METHODS:Development of the nomogram entailed three subsequent stages with specific patient sets. In the discovery set (n = 20), LN-status-related miRNAs were screened from high-throughput sequencing data of human CRC serum samples. In the training set (n = 218), a miRNA panel-clinicopathologic nomogram was developed by logistic regression analysis for preoperative prediction of LN metastasis. In the validation set (n = 198), we validated the above nomogram with respect to its discrimination, calibration and clinical application. FINDINGS:Four differently expressed miRNAs (miR-122-5p, miR-146b-5p, miR-186-5p and miR-193a-5p) were identified in the serum samples from CRC patients with and without LN metastasis, which also had regulatory effects on CRC cell migration. The combined miRNA panel could provide higher LN prediction capability compared with computed tomography (CT) scans (P < .0001 in both the training and validation sets). Furthermore, a nomogram integrating the miRNA-based panel and CT-reported LN status was constructed in the training set, which performed well in both the training and validation sets (AUC: 0.913 and 0.883, respectively). Decision curve analysis demonstrated the clinical usefulness of the nomogram. INTERPRETATION:Our nomogram is a reliable prediction model that can be conveniently and efficiently used to improve the accuracy of preoperative prediction of LN metastasis in patients with CRC.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Qu A,Yang Y,Zhang X,Wang W,Liu Y,Zheng G,Du L,Wang C

doi

10.1016/j.ebiom.2018.09.052

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

125-133

issn

2352-3964

pii

S2352-3964(18)30411-0

journal_volume

37

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers.

    abstract：:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Pat...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.06.026

    authors： Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

    更新日期：2017-07-01 00:00:00

  • Long non-coding RNA CDKN2B-AS1 contributes to atherosclerotic plaque formation by forming RNA-DNA triplex in the CDKN2B promoter.

    abstract：BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102694

    authors： Ou M,Li X,Zhao S,Cui S,Tu J

    更新日期：2020-05-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract：BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103129

    authors： Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期：2020-12-01 00:00:00

  • A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis.

    abstract：BACKGROUND:Tumor necrosis factor-like weak inducer of apoptosis (Tnfsf12; TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Tnfrsf12a; Fn14) participate in the inflammatory response associated with vascular remodeling. However, the functional effect of TWEAK on vascular smooth muscle cells (VSMCs) is not c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.072

    authors： Méndez-Barbero N,Gutierrez-Muñoz C,Madrigal-Matute J,Mínguez P,Egido J,Michel JB,Martín-Ventura JL,Esteban V,Blanco-Colio LM

    更新日期：2019-08-01 00:00:00

  • Co-culture of Methanobrevibacter smithii with enterobacteria during urinary infection.

    abstract：BACKGROUND:Urinary tract infections are known to be caused by bacteria, but the potential implications of archaea have never been studied in this context. METHODS:In two different university hospital centres we used specific laboratory methods for the detection and culture of archaeal methanogens in 383 urine specimen...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.037

    authors： Grine G,Lotte R,Chirio D,Chevalier A,Raoult D,Drancourt M,Ruimy R

    更新日期：2019-05-01 00:00:00

  • High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation.

    abstract：BACKGROUND:Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determin...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.049

    authors： Wang H,Huang B,Wang W,Li J,Chen Y,Flynn T,Zhao M,Zhou Z,Lin X,Zhang Y,Xu M,Li K,Tian K,Yuan D,Zhou P,Hu L,Zhong D,Zhu S,Li J,Chen D,Wang K,Liang J,He Q,Sun J,Shi J,Yan L,Sands JM,Xie Z,Lian X,Xu

    更新日期：2019-10-01 00:00:00

  • An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

    abstract：BACKGROUND:KRAS mutations are the most frequent oncogenic aberration in lung adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence drug responses. This heterogeneity challenges the development of effective therapies for patients with KRAS-driven non-small cell lung cancer (NSCLC). METH...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.012

    authors： Wang H,Lv Q,Xu Y,Cai Z,Zheng J,Cheng X,Dai Y,Jänne PA,Ambrogio C,Köhler J

    更新日期：2019-11-01 00:00:00

  • Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II.

    abstract：:The intracellular human bacterial pathogen Chlamydia trachomatis pursues effective strategies to protect infected cells against death-inducing stimuli. Here, we show that Chlamydia trachomatis infection evokes 3-phosphoinositide-dependent protein kinase-1 (PDPK1) signaling to ensure the completion of its developmental...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.08.005

    authors： Al-Zeer MA,Xavier A,Abu Lubad M,Sigulla J,Kessler M,Hurwitz R,Meyer TF

    更新日期：2017-09-01 00:00:00

  • Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology.

    abstract：:Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haem...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2014.12.006

    authors： Brousse V,Colin Y,Pereira C,Arnaud C,Odièvre MH,Boutemy A,Guitton C,de Montalembert M,Lapouméroulie C,Picot J,Le Van Kim C,El Nemer W

    更新日期：2014-12-18 00:00:00

  • Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.

    abstract：:Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, the full spectrum of reverse transcriptase (RT) mutations selected in individuals with VF on such...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.03.024

    authors： Rhee SY,Varghese V,Holmes SP,Van Zyl GU,Steegen K,Boyd MA,Cooper DA,Nsanzimana S,Saravanan S,Charpentier C,de Oliveira T,Etiebet MA,Garcia F,Goedhals D,Gomes P,Günthard HF,Hamers RL,Hoffmann CJ,Hunt G,Jiamsakul A,

    更新日期：2017-04-01 00:00:00

  • Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study.

    abstract：BACKGROUND:Early diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. METHODS:In this prospective observational study, we used real-time, online, pro...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103154

    authors： Grassin-Delyle S,Roquencourt C,Moine P,Saffroy G,Carn S,Heming N,Fleuriet J,Salvator H,Naline E,Couderc LJ,Devillier P,Thévenot EA,Annane D,Garches COVID-19 Collaborative Group RECORDS Collaborators and Exhalomics® Collaborator

    更新日期：2021-01-01 00:00:00

  • Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

    abstract：BACKGROUND:While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103024

    authors： Sleiman Y,Souidi M,Kumar R,Yang E,Jaffré F,Zhou T,Bernardin A,Reiken S,Cazorla O,Kajava AV,Moreau A,Pasquié JL,Marks AR,Lerman BB,Chen S,Cheung JW,Evans T,Lacampagne A,Meli AC

    更新日期：2020-10-01 00:00:00

  • Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis.

    abstract：OBJECTIVE:The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS:Seventy-five patients with GPA and a PR3-ANCA rise d...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.01.033

    authors： Kemna MJ,Plomp R,van Paassen P,Koeleman CAM,Jansen BC,Damoiseaux JGMC,Cohen Tervaert JW,Wuhrer M

    更新日期：2017-03-01 00:00:00

  • Anti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical Trial.

    abstract：BACKGROUND:Dupuytren's disease is a common fibrotic condition of the hand that causes irreversible flexion contractures of the fingers, with no approved therapy for early stage disease. Our previous analysis of surgically-excised tissue defined tumour necrosis factor (TNF) as a potential therapeutic target. Here we ass...

    journal_title：EBioMedicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2018.06.022

    authors： Nanchahal J,Ball C,Davidson D,Williams L,Sones W,McCann FE,Cabrita M,Swettenham J,Cahoon NJ,Copsey B,Anne Francis E,Taylor PC,Black J,Barber VS,Dutton S,Feldmann M,Lamb SE

    更新日期：2018-07-01 00:00:00

  • Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial.

    abstract：BACKGROUND:Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS:A double-blind, placebo-cont...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2015.11.022

    authors： Park SB,Vucic S,Cheah BC,Lin CS,Kirby A,Mann KP,Zoing MC,Winhammar J,Kiernan MC

    更新日期：2015-12-01 00:00:00

  • Developed and validated a prognostic nomogram for recurrence-free survival after complete surgical resection of local primary gastrointestinal stromal tumors based on deep learning.

    abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.028

    authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

    更新日期：2019-01-01 00:00:00

  • PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.

    abstract：:Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyro...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.09.007

    authors： Lopez-Campistrous A,Adewuyi EE,Benesch MGK,Ko YM,Lai R,Thiesen A,Dewald J,Wang P,Chu K,Ghosh S,Williams DC,Vos LJ,Brindley DN,McMullen TPW

    更新日期：2016-10-01 00:00:00

  • Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study.

    abstract：PURPOSE:We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. METHODS:We identified all patients (cases) with incident cancer in Denmark during 2000-2012 (n=278,485) and matched each case to 10 controls. Compl...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.03.018

    authors： Pottegård A,Friis S,Christensen Rd,Habel LA,Gagne JJ,Hallas J

    更新日期：2016-05-01 00:00:00

  • An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.

    abstract：BACKGROUND:Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associated with the pathophysiology of sepsis, but repeated exposure can also ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2014.10.003

    authors： Pena OM,Hancock DG,Lyle NH,Linder A,Russell JA,Xia J,Fjell CD,Boyd JH,Hancock RE

    更新日期：2014-11-01 00:00:00

  • Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.

    abstract：BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102763

    authors： Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

    更新日期：2020-05-01 00:00:00

  • A prognostic gene expression signature for oropharyngeal squamous cell carcinoma.

    abstract：BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102805

    authors： Liu X,Liu P,Chernock RD,Kuhs KAL,Lewis JS Jr,Luo J,Gay HA,Thorstad WL,Wang X

    更新日期：2020-11-01 00:00:00

  • Impact of the host environment on the antitubercular action of pyrazinamide.

    abstract：:Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberculosis. While the m...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2019.10.014

    authors： Lamont EA,Baughn AD

    更新日期：2019-11-01 00:00:00

  • Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

    abstract：BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.005

    authors： Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

    更新日期：2019-03-01 00:00:00

  • Pathophysiologic Response to Burns in the Elderly.

    abstract：:Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. Th...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.07.040

    authors： Jeschke MG,Patsouris D,Stanojcic M,Abdullahi A,Rehou S,Pinto R,Chen P,Burnett M,Amini-Nik S

    更新日期：2015-07-31 00:00:00

  • Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury.

    abstract：:Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown. Here we identify two enzymes that regulate the balance of LPA1 ubiquitinati...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.07.020

    authors： Zhao J,Wei J,Dong S,Bowser RK,Zhang L,Jacko AM,Zhao Y

    更新日期：2016-08-01 00:00:00

  • Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug.

    abstract：:The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking alone. However, virtually all glioblastoma patients experience disease progression...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.08.013

    authors： Sharpe MA,Livingston AD,Gist TL,Ghosh P,Han J,Baskin DS

    更新日期：2015-08-08 00:00:00

  • The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.

    abstract：:Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and v...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.08.026

    authors： Xie Y,Bergström T,Jiang Y,Johansson P,Marinescu VD,Lindberg N,Segerman A,Wicher G,Niklasson M,Baskaran S,Sreedharan S,Everlien I,Kastemar M,Hermansson A,Elfineh L,Libard S,Holland EC,Hesselager G,Alafuzoff I,Westerm

    更新日期：2015-08-15 00:00:00

  • Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

    abstract：BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC inci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.017

    authors： Tan TZ,Ye J,Yee CV,Lim D,Ngoi NYL,Tan DSP,Huang RY

    更新日期：2019-12-01 00:00:00

  • Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort.

    abstract：:Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood syndrome affecting up to 6.5% of adult women in the U.S. The lack of broadly accepted objective laboratory markers for this condition hampers efforts to diagnose and treat this condition. To identify biochemical markers for IC/BPS, we applied ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.03.040

    authors： Parker KS,Crowley JR,Stephens-Shields AJ,van Bokhoven A,Lucia MS,Lai HH,Andriole GL,Hooton TM,Mullins C,Henderson JP

    更新日期：2016-05-01 00:00:00

  • TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formation.

    abstract：BACKGROUND:Metastatic bladder cancer (BLCA) is a lethal disease with an unmet need for study. Transgelin (TAGLN) is an actin-binding protein that affects the dynamics of the actin cytoskeleton indicating its robust potential as a metastasis initiator. Here, we sought to explore the expression pattern of TAGLN and eluci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.08.012

    authors： Chen Z,He S,Zhan Y,He A,Fang D,Gong Y,Li X,Zhou L

    更新日期：2019-09-01 00:00:00