Abstract:
:In this thought commentary, I highlight the discoveries made by Seto and colleagues related to HDAC11 and obesity. I discuss how their reported work fills a gap in the HDAC field and comment on the clinical implications of their findings. Overall, selective inhibition of HDAC11 could be a novel potential therapeutic avenue for both obesity and diabesity, the diabetes caused by obesity. Future studies to further dissect this mechanistic link between HDAC11 and metabolic programs will pave the way for designing mechanism-based combination therapeutic strategies for these two life style diseases.
journal_name
EBioMedicinejournal_title
EBioMedicineauthors
Bhaskara Sdoi
10.1016/j.ebiom.2018.08.008subject
Has Abstractpub_date
2018-09-01 00:00:00pages
27-28issn
2352-3964pii
S2352-3964(18)30294-9journal_volume
35pub_type
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