Abstract:
BACKGROUND:Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS:We recruited 86 Chinese children born to OHSS women and 172 children conceived with non-OHSS In Vitro Fertilization (IVF) in this cohort study. Their intellectual ability was assessed according to the Revised Chinese Version of the Wechsler Intelligence Scale for Children (C-WISC). Verbal Intelligence Quotient (VIQ), Performance Intelligence Quotient (PIQ), and Full Intelligence Quotient (FIQ) were calculated. The investigation was registered in Chinese Clinical Trial Registry (ChiCTR-SOC-16009555). FINDINGS:OHSS offspring scored less on C-WISC (mean (standard deviation [SD]): (VIQ=92.7 (14.7), PIQ=108.9 (13.1), FIQ=100.6 (13.4)) compared with non-OHSS IVF offspring (VIQ=100.1 (13.2), PIQ=113.7 (10.8), FIQ=107.4 (11.5)). The prevalence of low IQ (<80) children was 4.7 times higher in OHSS offspring compared with non-OHSS offspring. Maternal estradiol level on hCG administration day was negatively associated with FIQ in offspring. INTERPRETATION:OHSS offspring displayed reduced intellectual ability. Prenatal estradiol exposure might be involved in underlying mechanism.
journal_name
EBioMedicinejournal_title
EBioMedicineauthors
Xu GF,Zhou CL,Xiong YM,Li JY,Yu TT,Tian S,Lin XH,Liao Y,Lv Y,Zhang FH,Liu ZW,Shi YY,Shen Y,Sha J,Zhang D,Zhu YM,Sheng JZ,Huang HFdoi
10.1016/j.ebiom.2017.05.020subject
Has Abstractpub_date
2017-06-01 00:00:00pages
263-267issn
2352-3964pii
S2352-3964(17)30218-9journal_volume
20pub_type
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