Environmental Enrichment Modulates Drug Addiction and Binge-Like Consumption of Highly Rewarding Substances: A Role for Anxiety and Compulsivity Brain Systems?

Abstract:

:Drug addiction is a chronic disorder comprising components of both impulsivity and compulsivity in the so called "addiction cycle" which develops over time from early non-dependent, repetitive, binge-consumption to later post-dependent compulsive consumption. Thus, frequent binge-like intake is a typical pattern of excessive drug intake characteristic of the pre-dependent phase of the addiction cycle, which represent an important risk factor to develop addiction in vulnerable individuals. In this framework, it is of paramount interest to further understand the earliest stage of the addiction cycle so novel approaches would emerge aimed to control repetitive episodes of binge-consumption in non-dependent subjects, protecting vulnerable individuals from transition to dependence. Environmental enrichment (EE) is a preclinical animal model in which animals are housed under novel, social enriched conditions, which allows exercising and provides sensory and cognitive stimulation. EE promotes important improvements for a variety of cognitive processes and clear therapeutic and protective effects preventing ethanol (EtOH) and drug addiction as well. Interestingly, recent observations suggest that EE might additionally modulate binge-like intake of highly palatable caloric substances, including EtOH, which suggests the ability of EE to regulate consumption during the initial stage of the addiction cycle. We have proposed that EE protective and therapeutic effects on binge-consumption of palatable substances might primarily be mediated by the modulatory control that EE exerts on anxiety and impulsivity/compulsivity traits, which are all risk factors favoring transition to drug addiction.

journal_name

Front Behav Neurosci

authors

Rodríguez-Ortega E,Cubero I

doi

10.3389/fnbeh.2018.00295

subject

Has Abstract

pub_date

2018-11-29 00:00:00

pages

295

issn

1662-5153

journal_volume

12

pub_type

杂志文章
  • Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice.

    abstract::The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of inc...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00278

    authors: Calpe-López C,García-Pardo MP,Martínez-Caballero MA,Santos-Ortíz A,Aguilar MA

    更新日期:2020-01-09 00:00:00

  • Avoidance expression in rats as a function of signal-shock interval: strain and sex differences.

    abstract::Inbred Wistar Kyoto (WKY) rats express inhibited temperament, increased sensitivity to stress, and exaggerated expressions of avoidance. A long-standing observation for lever press escape/avoidance learning in rats is the duration of the warning signal (WS) determines whether avoidance is expressed over escape. Outbre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00168

    authors: Servatius RJ,Avcu P,Ko N,Jiao X,Beck KD,Minor TR,Pang KC

    更新日期:2015-07-06 00:00:00

  • The role of dopamine in risk taking: a specific look at Parkinson's disease and gambling.

    abstract::An influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of dopamine signaling ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00196

    authors: Clark CA,Dagher A

    更新日期:2014-05-30 00:00:00

  • Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice.

    abstract::Testosterone reduces anxiety-like behaviors in rodents and increases exploration of anxiogenic parts of the environment. Effects of testosterone on innate defensive behaviors remain understudied. Here, we demonstrate that exogenous testosterone reduces aversion to cat odor in male mice. This is reflected as increased ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00033

    authors: Tong WH,Abdulai-Saiku S,Vyas A

    更新日期:2019-02-26 00:00:00

  • Chronic Nicotine Exposure Initiated in Adolescence and Unpaired to Behavioral Context Fails to Enhance Sweetened Ethanol Seeking.

    abstract::Nicotine use in adolescence is pervasive in the United States and, according to the Gateway Hypothesis, may lead to progression towards other addictive substances. Given the prevalence of nicotine and ethanol comorbidity, it is difficult to ascertain if nicotine is a gateway drug for ethanol. Our study investigated th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00153

    authors: Madayag AC,Czarnecki KS,Wangler LM,Robinson DL

    更新日期:2017-08-17 00:00:00

  • Octopamine Shifts the Behavioral Response From Indecision to Approach or Aversion in Drosophila melanogaster.

    abstract::Animals must make constant decisions whether to respond to external sensory stimuli or not to respond. The activation of positive and/or negative reinforcers might bias the behavioral response towards approach or aversion. To analyze whether the activation of the octopaminergic neurotransmitter system can shift the de...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00131

    authors: Claßen G,Scholz H

    更新日期:2018-07-03 00:00:00

  • Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability.

    abstract::The endocannabinoid (eCB) system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate. A functional interaction between eCBs and the serotonergic system has already been suggested. Previously, we showed that cannabinoid type-1 (...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00235

    authors: Häring M,Enk V,Aparisi Rey A,Loch S,Ruiz de Azua I,Weber T,Bartsch D,Monory K,Lutz B

    更新日期:2015-09-03 00:00:00

  • Prefronto-striatal physiology is associated with schizotypy and is modulated by a functional variant of DRD2.

    abstract::"Schizotypy" is a latent organization of personality related to the genetic risk for schizophrenia. Some evidence suggests that schizophrenia and schizotypy share some biological features, including a link to dopaminergic D2 receptor signaling. A polymorphism in the D2 gene (DRD2 rs1076560, guanine > thymine (G > T)) ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00235

    authors: Taurisano P,Romano R,Mancini M,Giorgio AD,Antonucci LA,Fazio L,Rampino A,Quarto T,Gelao B,Porcelli A,Papazacharias A,Ursini G,Caforio G,Masellis R,Niccoli-Asabella A,Todarello O,Popolizio T,Rubini G,Blasi G,Bertolin

    更新日期:2014-07-09 00:00:00

  • Hypothalamic Gene Expression and Postpartum Behavior in a Genetic Rat Model of Depression.

    abstract::Postpartum depression is a complex illness that often occurs in genetically predisposed individuals. Closely related inbred rat strains are a great resource to identify novel causative genes and mechanisms underlying complex traits such as postpartum behavior. We report differences in these behaviors between the inbre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.589967

    authors: Luo W,Lim PH,Wert SL,Gacek SA,Chen H,Redei EE

    更新日期:2020-10-22 00:00:00

  • Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors.

    abstract::The dopaminergic system is known to be involved in working memory processed by several brain regions like prefrontal cortex (PFC), hippocampus, striatum. In an earlier study we could show that Levodopa but not Modafinil enhanced working memory in a T-maze only during the early phase of training (day 3), whereas the la...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00196

    authors: Bezu M,Maliković J,Kristofova M,Engidawork E,Höger H,Lubec G,Korz V

    更新日期:2017-10-13 00:00:00

  • Disruption of the Glutamate-Glutamine Cycle Involving Astrocytes in an Animal Model of Depression for Males and Females.

    abstract::Background: Women are twice as likely as men to develop major depression. The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-glutamine cycle involving...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00231

    authors: Rappeneau V,Blaker A,Petro JR,Yamamoto BK,Shimamoto A

    更新日期:2016-12-06 00:00:00

  • Texture dependence of motion sensing and free flight behavior in blowflies.

    abstract::MANY FLYING INSECTS EXHIBIT AN ACTIVE FLIGHT AND GAZE STRATEGY: purely translational flight segments alternate with quick turns called saccades. To generate such a saccadic flight pattern, the animals decide the timing, direction, and amplitude of the next saccade during the previous translatory intersaccadic interval...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00092

    authors: Lindemann JP,Egelhaaf M

    更新日期:2013-01-11 00:00:00

  • Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice.

    abstract::L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA). An elevated level of KYNA may have multiple effects on the synaptic transm...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00157

    authors: Varga D,Herédi J,Kánvási Z,Ruszka M,Kis Z,Ono E,Iwamori N,Iwamori T,Takakuwa H,Vécsei L,Toldi J,Gellért L

    更新日期:2015-06-16 00:00:00

  • Inactivation of medial prefrontal cortex impairs time interval discrimination in rats.

    abstract::Several lines of evidence suggest the involvement of prefrontal cortex in time interval estimation. The underlying neural processes are poorly understood, however, in part because of the paucity of physiological studies. The goal of this study was to establish an interval timing task for physiological recordings in ra...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.038.2009

    authors: Kim J,Jung AH,Byun J,Jo S,Jung MW

    更新日期:2009-11-03 00:00:00

  • Should animals navigating over short distances switch to a magnetic compass sense?

    abstract::Magnetoreception can play a substantial role in long distance navigation by animals. I hypothesize that locomotion guided by a magnetic compass sense could also play a role in short distance navigation. Animals identify mates, prey, or other short distance navigational goals using different sensory modalities (olfacti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00042

    authors: Wyeth RC

    更新日期:2010-07-30 00:00:00

  • Duration of exclusive breastfeeding is associated with differences in infants' brain responses to emotional body expressions.

    abstract::Much research has recognized the general importance of maternal behavior in the early development and programing of the mammalian offspring's brain. Exclusive breastfeeding (EBF) duration, the amount of time in which breastfed meals are the only source of sustenance, plays a prominent role in promoting healthy brain a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00459

    authors: Krol KM,Rajhans P,Missana M,Grossmann T

    更新日期:2015-01-22 00:00:00

  • Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice.

    abstract::Many epidemiological studies have described an adolescent-related psychiatric illness and sensorimotor deficits after Glyphosate based herbicide (GBH) exposure. GBH exposure in animal models of various ages suggests that it may be neurotoxic and could impact brain development and subsequently, behavior in adulthood. H...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00146

    authors: Ait Bali Y,Ba-Mhamed S,Bennis M

    更新日期:2017-08-08 00:00:00

  • The role of semantic abstractness and perceptual category in processing speech accompanied by gestures.

    abstract::Space and shape are distinct perceptual categories. In language, perceptual information can also be used to describe abstract semantic concepts like a "rising income" (space) or a "square personality" (shape). Despite being inherently concrete, co-speech gestures depicting space and shape can accompany concrete or abs...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00181

    authors: Nagels A,Chatterjee A,Kircher T,Straube B

    更新日期:2013-12-18 00:00:00

  • Repeated, Intermittent Social Defeat across the Entire Juvenile Period Resulted in Behavioral, Physiological, Hormonal, Immunological, and Neurochemical Alterations in Young Adult Male Golden Hamsters.

    abstract::The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00110

    authors: Yu WC,Liu CY,Lai WS

    更新日期:2016-06-10 00:00:00

  • Contextual Fear Conditioning and Fear Generalization in Individuals With Panic Attacks.

    abstract::Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a vi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00152

    authors: Neueder D,Andreatta M,Pauli P

    更新日期:2019-07-17 00:00:00

  • Does temporal discounting explain unhealthy behavior? A systematic review and reinforcement learning perspective.

    abstract::The tendency to make unhealthy choices is hypothesized to be related to an individual's temporal discount rate, the theoretical rate at which they devalue delayed rewards. Furthermore, a particular form of temporal discounting, hyperbolic discounting, has been proposed to explain why unhealthy behavior can occur despi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00076

    authors: Story GW,Vlaev I,Seymour B,Darzi A,Dolan RJ

    更新日期:2014-03-12 00:00:00

  • Differences in social interaction- vs. cocaine reward in mouse vs. rat.

    abstract::We previously developed rat experimental models based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of dyadic social interaction with a sex- and weight-matched male Sprague Dawley (SD) rat (1) reversed CPP from cocaine to social interaction despite continuing cocaine training, a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00363

    authors: Kummer KK,Hofhansel L,Barwitz CM,Schardl A,Prast JM,Salti A,El Rawas R,Zernig G

    更新日期:2014-10-17 00:00:00

  • Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.

    abstract::We performed whole-cell recordings from basal forebrain (BF) cholinergic neurons in transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the choline acetyltransferase promoter. BF cholinergic neurons can be differentiated into two electrophysiologically identifiable subtypes: early...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00021

    authors: Unal CT,Golowasch JP,Zaborszky L

    更新日期:2012-05-08 00:00:00

  • Both the COMT Val158Met single-nucleotide polymorphism and sex-dependent differences influence response inhibition.

    abstract::Reactive and proactive controls of actions are cognitive abilities that allow one to deal with a continuously changing environment by adjusting already programmed actions. They also set forthcoming actions by evaluating the outcome of the previous ones. Earlier studies highlighted sex-related differences in the strate...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00127

    authors: Mione V,Canterini S,Brunamonti E,Pani P,Donno F,Fiorenza MT,Ferraina S

    更新日期:2015-05-19 00:00:00

  • Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches.

    abstract::In the present review, we provide evidence indicating that although post traumatic stress disorder (PTSD) and substance use disorder (SUD) are two distinct pathologies with very different impacts on people affected by these chronic illnesses, they share numerous common characteristics, present high rates of co-morbidi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00026

    authors: Gisquet-Verrier P,Le Dorze C

    更新日期:2019-02-13 00:00:00

  • Perception of biological motion in visual agnosia.

    abstract::Over the past 25 years, visual processing has been discussed in the context of the dual stream hypothesis consisting of a ventral ("what") and a dorsal ("where") visual information processing pathway. Patients with brain damage of the ventral pathway typically present with signs of visual agnosia, the inability to ide...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00056

    authors: Huberle E,Rupek P,Lappe M,Karnath HO

    更新日期:2012-08-28 00:00:00

  • Consequences of Adolescent Exposure to the Cannabinoid Receptor Agonist WIN55,212-2 on Working Memory in Female Rats.

    abstract::Marijuana is a prevalent illicit substance used by adolescents, and several studies have indicated that adolescent use can lead to long-term cognitive deficits including problems with attention and memory. However, preclinical animal studies that observe cognitive deficits after cannabinoid exposure during adolescence...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00137

    authors: Kirschmann EK,McCalley DM,Edwards CM,Torregrossa MM

    更新日期:2017-07-21 00:00:00

  • Dynamic Echo Information Guides Flight in the Big Brown Bat.

    abstract::Animals rely on sensory feedback from their environment to guide locomotion. For instance, visually guided animals use patterns of optic flow to control their velocity and to estimate their distance to objects (e.g., Srinivasan et al., 1991, 1996). In this study, we investigated how acoustic information guides locomot...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00081

    authors: Warnecke M,Lee WJ,Krishnan A,Moss CF

    更新日期:2016-04-25 00:00:00

  • A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response.

    abstract::One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety, and post-traumatic stress disorder. We investigated t...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00068

    authors: Griffiths BB,Schoonheim PJ,Ziv L,Voelker L,Baier H,Gahtan E

    更新日期:2012-10-11 00:00:00

  • Immune-Endocrine Links to Gregariousness in Wild House Mice.

    abstract::Social interactions are critically important for survival and impact overall-health, but also impose costs on animals, such as exposure to contagious agents. The immune system can play a critical role in modulating social behavior when animals are sick, as has been demonstrated within the context of "sickness behavior...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00010

    authors: Lopes PC,Carlitz EHD,Kindel M,König B

    更新日期:2020-02-05 00:00:00