Abstract:
:The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability of a Y-deleted mouse model, that is subfertile, we studied the effect of a partial deletion of Y-chromosomal heterochromatin on mouse behavior when compared to its wild type. The partial Y-deleted mice exhibited anxiety like phenotype under stress when different anxiety (open field test and elevated plus maze, EPM test) and depression related tests (tail suspension and force swim) were performed. The mutant mice also showed reduction in hippocampal neurogenesis and altered expression of neurogenesis markers such as Nestin, Sox2, Gfap, NeuroD1 and Dcx using quantitative real time PCR (qPCR) analysis. The genes with altered expression contained short stretches of homology to Y-derived transcripts only in their Untranslated Regions (UTRs). Our study suggests putative regulation of these genes by the Y chromosome in mouse brain altering stress related behavior.
journal_name
Front Behav Neuroscijournal_title
Frontiers in behavioral neuroscienceauthors
Dey SK,Kamle A,Dereddi RR,Thomas SM,Thummala SR,Kumar A,Chakravarty S,Jesudasan RAdoi
10.3389/fnbeh.2018.00215subject
Has Abstractpub_date
2018-09-21 00:00:00pages
215issn
1662-5153journal_volume
12pub_type
杂志文章abstract::Emotionally arousing experiences and stress influence cognitive processes and vice versa. Understanding the relations and interactions between these three systems forms the core of this study. We tested two inbred mouse strains (BALB/c, C57BL/6J; male; 3-month-old) for glucocorticoid stress system markers (expression ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.08.008.2007
更新日期:2007-12-30 00:00:00
abstract::Neuroplasticity accounts for the ability of the brain to change in both structure and function in consequence of life experiences. An enhanced stimulation provided by the environment is able to create a form of brain, neural, and cognitive reserve, which allows an individual to cope better with the environmental deman...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00150
更新日期:2019-07-09 00:00:00
abstract::β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior;...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00054
更新日期:2018-03-20 00:00:00
abstract::Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system has been traditionally associated with decision-making. The endocannabinoid system through its actions on inhibitory and excitatory synapses modulates dopamin...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2015.00336
更新日期:2015-12-17 00:00:00
abstract::There is a high degree of intra-individual variation in how individuals respond to stress. This becomes evident when exploring the development of posttraumatic symptoms or stress-related disorders after exposure to trauma. Whether or not an individual develops posttraumatic symptoms after experiencing a traumatic even...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00039
更新日期:2013-05-07 00:00:00
abstract::Anesthetics are often used to characterize the activity of single neurons in vivo for their advantages such as reduction of noise level and convenience in noxious stimulations. Urethane has been a widely used anesthetic in thalamic studies under the assumption that sensory signals are still relayed to the thalamus und...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00141
更新日期:2013-10-10 00:00:00
abstract::The pond snail Lymnaea stagnalis learns and forms long-term memory (LTM) following both operant conditioning of aerial respiratory behavior and classical conditioning of taste aversive behavior. In the present study, we examined whether there are interstrain differences in the ability to form LTM following these two t...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00161
更新日期:2017-09-11 00:00:00
abstract::Medical decisions will often entail a broad search for relevant information. No sources alone may offer a complete picture, and many may be selective in their presentation. This selectivity may induce forgetting for previously learned material, thereby adversely affecting medical decision-making. In the study phase of...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00072
更新日期:2013-06-14 00:00:00
abstract::Performing multiple tasks simultaneously usually affects the behavioral performance as compared with executing the single task. Moreover, processing multiple tasks simultaneously often involve more cognitive demands. Two visual tasks, lane-keeping task and mental calculation, were utilized to assess the brain dynamics...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00003
更新日期:2018-02-09 00:00:00
abstract::The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) and the lateral nuclei (lHb). The mHb is characterized by the expression of specific nicotinic acetylcholine receptor isoforms and the release of acetylcholine to the interpeduncular nucleus (IPN), the sole output regio...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00017
更新日期:2013-03-12 00:00:00
abstract::"Social facilitation" refers to the enhancement or impairment of performance engendered by the mere presence of others. It has been demonstrated for a diversity of behaviors. This study assessed whether it also concerns attention and eye movements and if yes, which decision-making mechanisms it affects. Human voluntee...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00280
更新日期:2020-01-08 00:00:00
abstract::Visual attention is an important condition for consumer decision-making. However, not much is known on individuals' determinants of this visual attention. Using eye tracking, this study investigated how psychological values (i.e., materialism) modulate visual attention to specific sources of information (i.e., product...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00172
更新日期:2018-08-24 00:00:00
abstract::Infant vocalizations are one of the most fundamental and innate forms of behavior throughout avian and mammalian orders. They have a critical role in motivating parental care and contribute significantly to fitness and reproductive success. Dysregulation of these vocalizations has been reported to predict risk of cent...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00250
更新日期:2018-10-29 00:00:00
abstract::We come to understand other people's physical and mental states by re-mapping their bodily states onto our sensorimotor system. This process, also called somatosensory resonance, is an essential ability for social cognition and is stronger when observing ingroup than outgroup members. Here we investigated, first, whet...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00165
更新日期:2013-11-18 00:00:00
abstract::The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat i...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00110
更新日期:2016-06-10 00:00:00
abstract::MANY FLYING INSECTS EXHIBIT AN ACTIVE FLIGHT AND GAZE STRATEGY: purely translational flight segments alternate with quick turns called saccades. To generate such a saccadic flight pattern, the animals decide the timing, direction, and amplitude of the next saccade during the previous translatory intersaccadic interval...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00092
更新日期:2013-01-11 00:00:00
abstract::Background: Hypothesis-driven functional connectivity (FC) analyses have revealed abnormal functional interaction of regions or networks involved in pain processing in episodic migraine patients. We aimed to investigate the resting-state FC patterns in episodic migraine by combining data-driven voxel-wise degree centr...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.567588
更新日期:2020-10-06 00:00:00
abstract::Down syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), as co-adjuvant to enhance the effects of environmental enrichment (EE) in Ts65Dn mice, a segmenta...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00330
更新日期:2015-12-11 00:00:00
abstract::The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothala...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00091
更新日期:2016-05-18 00:00:00
abstract::The ventral subiculum of the hippocampus projects both to the basolateral amygdala (BLA), which is typically, associated with a response to aversive stimuli, as well as to the nucleus accumbens (NAcc), which is typically associated with a response to appetitive stimuli. Traditionally, studies of the responses to emoti...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00053
更新日期:2015-03-04 00:00:00
abstract::Humans value rewards less when these are delivered in the future as opposed to immediately, a phenomenon referred to as delay discounting. While delay discounting has been studied during the anticipation of rewards and in the context of intertemporal decision-making, little is known about its neural correlates in the ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00280
更新日期:2015-10-29 00:00:00
abstract::Animals rely on sensory feedback from their environment to guide locomotion. For instance, visually guided animals use patterns of optic flow to control their velocity and to estimate their distance to objects (e.g., Srinivasan et al., 1991, 1996). In this study, we investigated how acoustic information guides locomot...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00081
更新日期:2016-04-25 00:00:00
abstract::Adolescent behavior is typified by increased risk-taking, reward- and novelty-seeking, as well as an augmented need for social and environmental stimulation. This behavioral phenotype may result from alterations in outcome valuation or reward learning. In the present set of experiments, we directly compared adult and ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00115
更新日期:2015-05-07 00:00:00
abstract::Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The first main objective of this review is to dissect components of the endocannabinoid system, including cannabinoid 1 and cannabinoid 2 receptors; the endogenous cannabino...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2018.00041
更新日期:2018-03-27 00:00:00
abstract::Sleep has been related to emotional functioning. However, the extent to which emotional salience is processed during sleep is unknown. To address this concern, we investigated night sleep in healthy adults regarding brain reactivity to the emotionally (happily, fearfully) spoken meaningless syllables dada, along with ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00117
更新日期:2016-06-14 00:00:00
abstract::Anatomical investigations have revealed connections between the intralaminar thalamic nuclei and areas such as the superior colliculus (SC) that receive short latency input from visual and auditory primary sensory areas. The intralaminar nuclei in turn project to the major input nucleus of the basal ganglia, the stria...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2014.00115
更新日期:2014-04-02 00:00:00
abstract::Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic B...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00416
更新日期:2014-11-28 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is a trophic factor regulating cell survival and synaptic plasticity. Recent findings indicate that BDNF could be a potential regulatory factor for cognitive functioning in normal and/or neuropathological conditions. With regard to neurological disorders, recent data suggest th...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00253
更新日期:2015-09-15 00:00:00
abstract::Honeybees (Apis mellifera) have fascinating navigational skills and learning capabilities in the field. To decipher the mechanisms underlying place learning in honeybees, we need paradigms to study place learning of individual honeybees under controlled laboratory conditions. Here, we present a novel visual place lear...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.00056
更新日期:2020-04-15 00:00:00
abstract::Cannabinoid compounds may influence both emotional and cognitive processes depending on the level of environmental aversiveness at the time of drug administration. However, the mechanisms responsible for these responses remain to be elucidated. The present experiments investigated the effects induced by the endocannab...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00011
更新日期:2012-03-20 00:00:00