Abstract:
:Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a single gene polymorphism, environmental exposure, or developmental insult. Rather, it is a complex interaction between these various influences that likely leads to the development of clinically relevant syndromes. Our lab is exploring the links between environmental exposures and neurobehavioral function by investigating how disruption of the circadian (daily) clock alters the structure and function of neural circuits, with the hypothesis that disrupting this crucial homeostatic system can directly contribute to altered vulnerability of the organism to other factors that interact to produce psychiatric illness. This review explores some historical and more recent findings that link disrupted circadian clocks to neuropsychiatric disorders, particularly depression, mania, and schizophrenia. We take a comparative approach by exploring the effects observed in human populations, as well as some experimental models used in the laboratory to unravel mechanistic and causal relationships between disruption of the circadian clock and behavioral abnormalities. This is a rich area of research that we predict will contribute greatly to our understanding of how genes, environment, and development interact to modulate an individual's vulnerability to psychiatric disorders.
journal_name
Front Behav Neuroscijournal_title
Frontiers in behavioral neuroscienceauthors
Karatsoreos INdoi
10.3389/fnbeh.2014.00162subject
Has Abstractpub_date
2014-05-06 00:00:00pages
162issn
1662-5153journal_volume
8pub_type
杂志文章,评审abstract::In humans, optimism is a cognitive construct related to motivation; optimists exert effort, whereas pessimists disengage from effort. In this study, using a recently developed ambiguous-cue interpretation (ACI) paradigm we took the unique opportunity to investigate whether "optimism" as a trait is correlated with moti...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00032
更新日期:2015-02-25 00:00:00
abstract::Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotecti...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00142
更新日期:2018-07-19 00:00:00
abstract::The ability to accurately integrate or bind stimuli from more than one sensory modality is highly dependent on the features of the stimuli, such as their intensity and relative timing. Previous studies have demonstrated that the ability to perceptually bind stimuli is impaired in various clinical conditions such as au...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00256
更新日期:2018-10-31 00:00:00
abstract::L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA). An elevated level of KYNA may have multiple effects on the synaptic transm...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00157
更新日期:2015-06-16 00:00:00
abstract::Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environmental enrichment has n...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00297
更新日期:2014-08-29 00:00:00
abstract::Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore mole...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00093
更新日期:2015-04-21 00:00:00
abstract::To study visual learning in honey bees, we developed a virtual reality (VR) system in which the movements of a tethered bee walking stationary on a spherical treadmill update the visual panorama presented in front of it (closed-loop conditions), thus creating an experience of immersion within a virtual environment. In...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00139
更新日期:2018-07-13 00:00:00
abstract::Interactions between social experiences at different stages of development (e.g., with parents as juveniles and peers as subadults) can profoundly shape the expression of social behavior. Rarely are the influences of more than one stage of developmental sensitivity to social environment investigated simultaneously. Fu...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00206
更新日期:2019-09-13 00:00:00
abstract::Nicotine use in adolescence is pervasive in the United States and, according to the Gateway Hypothesis, may lead to progression towards other addictive substances. Given the prevalence of nicotine and ethanol comorbidity, it is difficult to ascertain if nicotine is a gateway drug for ethanol. Our study investigated th...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00153
更新日期:2017-08-17 00:00:00
abstract::Cross-situational word learning is based on the notion that a learner can determine the referent of a word by finding something in common across many observed uses of that word. Here we propose an adaptive learning algorithm that contains a parameter that controls the strength of the reinforcement applied to associati...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00163
更新日期:2013-11-19 00:00:00
abstract::Testosterone reduces anxiety-like behaviors in rodents and increases exploration of anxiogenic parts of the environment. Effects of testosterone on innate defensive behaviors remain understudied. Here, we demonstrate that exogenous testosterone reduces aversion to cat odor in male mice. This is reflected as increased ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00033
更新日期:2019-02-26 00:00:00
abstract::Marijuana is a prevalent illicit substance used by adolescents, and several studies have indicated that adolescent use can lead to long-term cognitive deficits including problems with attention and memory. However, preclinical animal studies that observe cognitive deficits after cannabinoid exposure during adolescence...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00137
更新日期:2017-07-21 00:00:00
abstract::This study analyzed ethanol intake in male and female Wistar rats exposed to maternal separation (MS) during infancy (postnatal days 1-21, PD1-21) and environmental enrichment (EE) during adolescence (PD 21-42). Previous work revealed that MS enhances ethanol consumption during adulthood. It is still unknown if a simi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00195
更新日期:2016-10-13 00:00:00
abstract::β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior;...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00054
更新日期:2018-03-20 00:00:00
abstract::Selective serotonin reuptake inhibitors (SSRIs) are used extensively in the treatment of depression and anxiety disorders. The therapeutic benefits of SSRIs typically require several weeks of continuous treatment. Intriguingly, according to clinical reports, symptoms of anxiety may actually increase during the early s...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2011.00088
更新日期:2011-12-28 00:00:00
abstract::Adolescent behavior is typified by increased risk-taking, reward- and novelty-seeking, as well as an augmented need for social and environmental stimulation. This behavioral phenotype may result from alterations in outcome valuation or reward learning. In the present set of experiments, we directly compared adult and ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00115
更新日期:2015-05-07 00:00:00
abstract::Several lines of evidence suggest the involvement of prefrontal cortex in time interval estimation. The underlying neural processes are poorly understood, however, in part because of the paucity of physiological studies. The goal of this study was to establish an interval timing task for physiological recordings in ra...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.08.038.2009
更新日期:2009-11-03 00:00:00
abstract::Darwin (1872) postulated that emotional expressions contain universals that are retained across species. We recently showed that human rating responses were strongly affected by a listener's familiarity with vocalization types, whereas evidence for universal cross-taxa emotion recognition was limited. To disentangle t...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00204
更新日期:2017-10-24 00:00:00
abstract::Glutamatergic dysregulation is known to contribute to altered emotional regulation. Astrocytic glutamate transporter 1 (GLT1) is responsible for the majority of glutamate clearance from synapse. However, the role of astrocytic GLT1 in affective processes such as anxiety- and depression-like behavior is not fully under...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.00057
更新日期:2020-04-22 00:00:00
abstract::The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothala...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00091
更新日期:2016-05-18 00:00:00
abstract::Once acquired, a fearful memory can persist for a lifetime. Although learned fear can be extinguished, extinction memories are fragile. The resilience of fear memories to extinction may contribute to the maintenance of disorders of fear and anxiety, including post-traumatic stress disorder (PTSD). As such, considerabl...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2015.00298
更新日期:2015-11-09 00:00:00
abstract::Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI) to study brain responses to soft brush stroking of both glabrous (palm) and hairy (forearm) ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00024
更新日期:2014-02-04 00:00:00
abstract::Social cognition and social behaviors are complex phenomena that involve numerous brain areas and underlying neurobiological mechanisms. Embryonic alcohol exposure may lead to the development of Fetal Alcohol Spectrum Disorder (FASD), a disorder that manifests with varying symptoms including abnormal social behavior a...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2020.572175
更新日期:2020-09-25 00:00:00
abstract::When making decisions, people are typically differently sensitive to gains and losses according to the motivational context in which the choice is performed. As hypothesized by Regulatory Focus Theory (RFT), indeed, goals are supposed to change in relation to the set of possible outcomes. In particular, in a promotion...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00071
更新日期:2018-04-24 00:00:00
abstract::The role of Y chromosome in sex determination and male fertility is well established. It is also known that infertile men are prone to psychological disturbances. Earlier studies in the laboratory identified genes expressed in testes that are putatively regulated by Y chromosome in man and mouse. With the availability...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00215
更新日期:2018-09-21 00:00:00
abstract::Stress-related neuropsychiatric (e.g., anxiety, depression) and cardiovascular diseases are frequently comorbid, though discerning the directionality of their association has been challenging. One of the most controllable risk factors for cardiovascular disease is salt intake. Though high salt intake is implicated in ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00271
更新日期:2019-12-13 00:00:00
abstract::Recent research suggests that conceptual or emotional factors could influence the perceptual processing of stimuli. In this article, we aimed to evaluate the effect of social information (positive, negative, or no information related to the character of the target) on subjective (perceived and felt valence and arousal...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00231
更新日期:2018-01-09 00:00:00
abstract::The endocannabinoid (eCB) system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate. A functional interaction between eCBs and the serotonergic system has already been suggested. Previously, we showed that cannabinoid type-1 (...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00235
更新日期:2015-09-03 00:00:00
abstract::While several studies have investigated mouse ultrasonic vocalizations (USVs) emitted by isolated pups or by males in mating contexts, studies of behavioral contexts other than mating and vocalization categories other than USVs have been limited. By improving our understanding of the vocalizations emitted by mice acro...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00038
更新日期:2016-03-09 00:00:00
abstract::Dscam2, a cell surface protein that mediates cellular repulsion, plays a crucial role in the development of the Drosophila melanogaster visual system. Dscam2 generates boundaries between neighboring modules in the fly optic lobe; in Dscam2 mutants this visual system modularity is compromised. Although developmental wi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00149
更新日期:2015-06-09 00:00:00