Left Ventricular Structure and Function in Elite Swimmers and Runners.

abstract：Background:More than 30-40% of uric acid is excreted via the intestine, and the dysfunction of intestinal epithelium disrupts uric acid excretion. The involvement of gut microbiota in hyperuricemia has been reported in previous studies, but the changes and mechanisms of intestinal immunity in hyperuricemia are still un...

journal_title：Frontiers in physiology

authors： Lv Q,Xu D,Zhang X,Yang X,Zhao P,Cui X,Liu X,Yang W,Yang G,Xing S

更新日期：2020-11-27 00:00:00

abstract：:Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure a...

journal_title：Frontiers in physiology

authors： Li QF,Wang H,Zheng L,Yang F,Li HZ,Li JX,Cheng D,Lu K,Liu Y

更新日期：2020-01-21 00:00:00

abstract：:Being the central metabolic organ of vertebrates, the liver possesses the largest repertoire of metabolic enzymes among all tissues and organs. Almost all metabolic pathways are resident in the parenchymal cell, hepatocyte, but the pathway capacities may largely differ depending on the localization of hepatocytes with...

journal_title：Frontiers in physiology

authors： Berndt N,Holzhütter HG

更新日期：2018-12-12 00:00:00

abstract：:Severely affected patients with autonomic failure require pressor agents to counteract the blood pressure fall and improve presyncopal symptoms upon standing. Previous studies suggest that combination ergotamine and caffeine may be effective in the treatment of autonomic failure, but the efficacy of this drug has not ...

journal_title：Frontiers in physiology

authors： Arnold AC,Ramirez CE,Choi L,Okamoto LE,Gamboa A,Diedrich A,Raj SR,Robertson D,Biaggioni I,Shibao CA

更新日期：2014-07-24 00:00:00

abstract：:Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NL...

journal_title：Frontiers in physiology

authors： Zhao W,Zhang L,Chen R,Lu H,Sui M,Zhu Y,Zeng L

更新日期：2018-11-14 00:00:00

abstract：:Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both...

journal_title：Frontiers in physiology

authors： Nomikos NN,Nikolaidis PT,Sousa CV,Papalois AE,Rosemann T,Knechtle B

更新日期：2018-12-18 00:00:00

abstract：:Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...

journal_title：Frontiers in physiology

authors： Zhang J,Ma A,Shang L

更新日期：2018-05-29 00:00:00

abstract：:As a biomaterial, chitosan has been widely used in tissue engineering, wound healing, drug delivery, and other biomedical applications. It can be formulated in a variety of forms, such as powder, film, sphere, gel, and fiber. These features make chitosan an almost ideal biomaterial in cell culture applications, and ce...

journal_title：Frontiers in physiology

authors： Gao W,Lai JC,Leung SW

更新日期：2012-08-21 00:00:00

abstract：:The detection of error information is an essential prerequisite of a feedback-based movement. This study investigated the differential behavior and neurophysiological mechanisms of a cyclic force-tracking task using error-reducing and error-enhancing feedback. The discharge patterns of a relatively large number of mot...

journal_title：Frontiers in physiology

authors： Chen YC,Lin YT,Chang GC,Hwang IS

更新日期：2017-03-13 00:00:00

abstract：:Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth mus...

journal_title：Frontiers in physiology

authors： Lauzon AM,Bates JH,Donovan G,Tawhai M,Sneyd J,Sanderson MJ

更新日期：2012-06-11 00:00:00

abstract：:Defining variations in skeletal muscle passive mechanical properties at different size scales ranging from single muscle fibers to whole muscles is required in order to understand passive muscle function. It is also of interest from a muscle structural point-of-view to identify the source(s) of passive tension that fu...

journal_title：Frontiers in physiology

authors： Ward SR,Winters TM,O'Connor SM,Lieber RL

更新日期：2020-03-20 00:00:00

abstract：:Introduction: Heart Rate Variability (HRV) and Pulse Rate Variability (PRV), are non-invasive techniques for monitoring changes in the cardiac cycle. Both techniques have been used for assessing the autonomic activity. Although highly correlated in healthy subjects, differences in HRV and PRV have been observed under ...

journal_title：Frontiers in physiology

authors： Mejía-Mejía E,Budidha K,Abay TY,May JM,Kyriacou PA

更新日期：2020-07-23 00:00:00

abstract：:Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations impart a "leaky" character to the affected hemichannels, i.e., m...

journal_title：Frontiers in physiology

authors： Ziraldo G,Buratto D,Kuang Y,Xu L,Carrer A,Nardin C,Chiani F,Salvatore AM,Paludetti G,Lerner RA,Yang G,Zonta F,Mammano F

更新日期：2019-06-11 00:00:00

abstract：:Triceps surae (TS) muscle volume can be estimated in young adults by only considering the maximal anatomical cross-sectional area (ACSAmax) and the length of the muscle due to the presence of a constant muscle-specific shape factor. This study aimed to investigate if this simplified muscle volume assessment is also ap...

journal_title：Frontiers in physiology

authors： Karamanidis K,Epro G,König M,Mersmann F,Arampatzis A

更新日期：2019-10-10 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:Objective: Neuromuscular injury prevention programs (IPP) can reduce injury rate by about 40% in youth sport. Multimodal IPP include, for instance, balance, strength, power, and agility exercises. Our systematic review and meta-analysis aimed to evaluate the effects of multimodal IPP on neuromuscular performance in yo...

journal_title：Frontiers in physiology

authors： Faude O,Rössler R,Petushek EJ,Roth R,Zahner L,Donath L

更新日期：2017-10-12 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD. However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known. Furthermore, the impact upon heterozygous femal...

journal_title：Frontiers in physiology

authors： Moore TM,Lin AJ,Strumwasser AR,Cory K,Whitney K,Ho T,Ho T,Lee JL,Rucker DH,Nguyen CQ,Yackly A,Mahata SK,Wanagat J,Stiles L,Turcotte LP,Crosbie RH,Zhou Z

更新日期：2020-06-19 00:00:00

abstract：:We examined structural properties of the marine mammal respiratory system, and tested Scholander's hypothesis that the chest is highly compliant by measuring the mechanical properties of the respiratory system in five species of pinniped under anesthesia (Pacific harbor seal, Phoca vitulina; northern elephant seal, Mi...

journal_title：Frontiers in physiology

authors： Fahlman A,Loring SH,Johnson SP,Haulena M,Trites AW,Fravel VA,Van Bonn WG

更新日期：2014-11-10 00:00:00

abstract：:People over 65 years of age constitute over 80% of patients with heart failure (HF) and the incidence of HF is 10 per 1,000 in people aged above 65 years. Approximately 25% of older patients with HF exhibit evidence of frailty. Frail patients with cardiovascular disease (CVD) have a worse prognosis than non-frail pati...

journal_title：Frontiers in physiology

authors： Uchmanowicz I,Nessler J,Gobbens R,Gackowski A,Kurpas D,Straburzynska-Migaj E,Kałuzna-Oleksy M,Jankowska EA

更新日期：2019-07-03 00:00:00

abstract：Objective:Varicose veins are a common problem worldwide and can cause significant impairments in health-related quality of life, but the etiology and pathogenesis remain not well defined. This study aims to elucidate transcriptomic regulations of varicose veins by detecting differentially expressed genes, pathways and ...

journal_title：Frontiers in physiology

authors： Zhang J,Nie Q,Si C,Wang C,Chen Y,Sun W,Pan L,Guo J,Kong J,Cui Y,Wang F,Fan X,Ye Z,Wen J,Liu P

更新日期：2019-03-19 00:00:00

abstract：Objectives:Carotid artery geometry influences blood flow disturbances and is thus an important risk factor for carotid atherosclerosis. Extracellular matrix (ECM) and yes-associated protein (YAP) expression may play essential roles in the pathophysiology of carotid artery stenosis, but the effect of blood flow disturba...

journal_title：Frontiers in physiology

authors： Cui Y,Lv X,Wang F,Kong J,Zhao H,Ye Z,Si C,Pan L,Liu P,Wen J

更新日期：2020-01-21 00:00:00

abstract：:Pancreatic cancer shows a characteristic tissue structure called desmoplasia, which consists of dense fibrotic stroma surrounding cancer cells. Interactions between pancreatic cancer cells and stromal cells promote invasive growth of cancer cells and establish a specific microenvironment such as hypoxia which further ...

journal_title：Frontiers in physiology

authors： Hamada S,Masamune A,Shimosegawa T

更新日期：2013-11-01 00:00:00

abstract：:Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is regulated by three transcription factors-OCT3/4, SOX2, and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pl...

journal_title：Frontiers in physiology

authors： Peterson H,Abu Dawud R,Garg A,Wang Y,Vilo J,Xenarios I,Adjaye J

更新日期：2013-10-28 00:00:00

abstract：:Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This study aimed to identify expression of human β defens...

journal_title：Frontiers in physiology

authors： Zhai Y,Wang Y,Rao N,Li J,Li X,Fang T,Zhao Y,Ge L

更新日期：2019-10-22 00:00:00

abstract：:Since the mid-1980s magnetic resonance imaging (MRI) has been investigated as a non- or minimally invasive tool to probe kidney allograft function. Despite this long-standing interest, MRI still plays a subordinate role in daily practice of transplantation nephrology. With the introduction of new functional MRI techni...

journal_title：Frontiers in physiology

authors： van Eijs MJM,van Zuilen AD,de Boer A,Froeling M,Nguyen TQ,Joles JA,Leiner T,Verhaar MC

更新日期：2017-05-16 00:00:00

abstract：:Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve m...

journal_title：Frontiers in physiology

authors： Kermorgant M,Nasr N,Custaud MA,Navasiolava N,Arbeille P,Guinet P,Labrunée M,Besnier F,Arvanitis DN,Czosnyka M,Senard JM,Pavy-Le Traon A

更新日期：2019-08-27 00:00:00

abstract：:Mitochondrial redox imbalance has been implicated in mechanisms of aging, various degenerative diseases and drug-induced toxicity. Statins are safe and well-tolerated therapeutic drugs that occasionally induce myotoxicity such as myopathy and rhabdomyolysis. Previous studies indicate that myotoxicity caused by statins...

journal_title：Frontiers in physiology

authors： La Guardia PG,Alberici LC,Ravagnani FG,Catharino RR,Vercesi AE

更新日期：2013-05-15 00:00:00

abstract：:Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it allows for the investigation of molecular activities without the cont...

journal_title：Frontiers in physiology

authors： Sarkar J,Simanian EJ,Tuggy SY,Bartlett JD,Snead ML,Sugiyama T,Paine ML

更新日期：2014-07-25 00:00:00

abstract：:As verbal encouragement (VE) is used in high intensity functional exercise testing, this randomized controlled crossover study aimed at investigating whether VE affects high intensity functional strength and endurance performance testing. We further examined between-day variability of high intensity functional strengt...

journal_title：Frontiers in physiology

authors： Engel FA,Faude O,Kölling S,Kellmann M,Donath L

更新日期：2019-04-25 00:00:00

abstract：:The effect of Withania somnifera a medicinal plant seed extract was tested against lesser mulberry pyralid, a potential pest of mulberry. The mulberry leaves were used for silk production in rural areas of northern Iran. The extract was administered orally by leaf dipping method in two lower (5%W/V) and higher (15%W/V...

journal_title：Frontiers in physiology

authors： Afraze Z,Sendi JJ,Karimi-Malati A,Zibaee A

更新日期：2020-08-07 00:00:00