Simplified Triceps Surae Muscle Volume Assessment in Older Adults.

abstract：:Systems biology approaches provide means to study the interplay between biological processes leading to the mechanistic understanding of the properties of complex biological systems. Here, we developed a vector format rule-based Boolean logic model of the yeast S. cerevisiae cAMP-PKA, Snf1, and the Snf3-Rgt2 pathway t...

journal_title：Frontiers in physiology

authors： Welkenhuysen N,Schnitzer B,Österberg L,Cvijovic M

更新日期：2019-01-21 00:00:00

abstract：:The importance of electrolyte concentrations for cardiac function is well established. Electrolyte variations can lead to arrhythmias onset, due to their important role in the action potential (AP) genesis and in maintaining cell homeostasis. However, most of the human AP computer models available in literature were d...

journal_title：Frontiers in physiology

authors： Bartolucci C,Passini E,Hyttinen J,Paci M,Severi S

更新日期：2020-04-15 00:00:00

abstract：Background:Walking patterns can provide important indications of a person's health status and be beneficial in the early diagnosis of individuals with a potential walking disorder. For appropriate gait analysis, it is critical that natural functional walking characteristics are captured, rather than those experienced i...

journal_title：Frontiers in physiology

authors： Renggli D,Graf C,Tachatos N,Singh N,Meboldt M,Taylor WR,Stieglitz L,Schmid Daners M

更新日期：2020-02-20 00:00:00

abstract：:Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein components involved in the mitochondrial translational machinery is critical....

journal_title：Frontiers in physiology

authors： Koc EC,Cimen H,Kumcuoglu B,Abu N,Akpinar G,Haque ME,Spremulli LL,Koc H

更新日期：2013-07-30 00:00:00

abstract：:The sterile insect technique (SIT) may reduce pest populations by allowing sufficient amount of irradiation-induced sterile males to mate with wild females whilst maintaining mating ability comparable to wild males. Although the SIT methods are well understood, the optimal sterilizing dose and processing development s...

journal_title：Frontiers in physiology

authors： Cai J,Yang H,Shi S,Zhong G,Yi X

更新日期：2018-02-20 00:00:00

abstract：Background:The underlying mechanisms by which diabetes and dyslipidemia contribute to diabetic nephropathy (DN) are not fully understood. In this study, we aimed to investigate the role of high glucose (HG) on intracellular cholesterol accumulation in glomerular endothelial cells (GEnCs) and its potential mechanism. M...

journal_title：Frontiers in physiology

authors： Wang Y,Xiao S,Zhou S,Zhang R,Liu H,Lin Y,Yu P

更新日期：2020-10-19 00:00:00

abstract：:The capacity of the human brain to interpret and respond to multiple temporal scales in its surroundings suggests that its internal interactions must also be able to operate over a broad temporal range. In this paper, we utilize a recently introduced method for characterizing the rate of change of the phase difference...

journal_title：Frontiers in physiology

authors： Botcharova M,Berthouze L,Brookes MJ,Barnes GR,Farmer SF

更新日期：2015-06-17 00:00:00

abstract：:The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell. The degree of Na+ entry via ENaC largely depends on the number of active channels localized to the cell mem...

journal_title：Frontiers in physiology

authors： Cheung TT,Ismail NAS,Moir R,Arora N,McDonald FJ,Condliffe SB

更新日期：2019-02-08 00:00:00

abstract：:Invasive coronary revascularization has been shown to improve prognoses in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but the optimal timing of intervention remains unclear. This meta-analysis is to evaluate the outcomes in immediate (<2 h), early (<24 h), and delayed invasive group an...

journal_title：Frontiers in physiology

authors： Li Y,Zhang Z,Xiong X,Cho WC,Hu D,Gao Y,Shang H,Xing Y

更新日期：2017-11-27 00:00:00

abstract：:Acute beer or alcohol ingestion reduces arterial stiffness, but the dose required to reduce arterial stiffness is unclear. Therefore, this study aimed to determine the acute effects of ingesting various amounts of beer on arterial stiffness in healthy men. Nine men (20-22 years) participated, in eight trials in random...

journal_title：Frontiers in physiology

authors： Nishiwaki M,Yamaguchi T,Nishida R,Matsumoto N

更新日期：2020-08-28 00:00:00

abstract：:Extracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts. It is known that multiple P2 receptors are expressed on osteoblasts (P2X2,5,6,7 and...

journal_title：Frontiers in physiology

authors： Xing S,Grol MW,Grutter PH,Dixon SJ,Komarova SV

更新日期：2016-07-13 00:00:00

abstract：Background:Aging and changing age demographics represent critical problems of our time. Physiological functions decline with age, often ending in a systemic process that contributes to numerous impairments and age-related diseases including heart failure (HF). We aimed to analyze whether differences in composite measur...

journal_title：Frontiers in physiology

authors： Wagner J,Knaier R,Königstein K,Klenk C,Carrard J,Lichtenstein E,Scharnagl H,März W,Hanssen H,Hinrichs T,Schmidt-Trucksäss A,Arbeev K

更新日期：2020-12-15 00:00:00

abstract：Context:Strength-endurance mainly depends on the power output, which is often expressed relative to the individual's maximal power capability (Pmax). However, an individual can develop the same power, but in different combinations of force and velocity (force-velocity condition). Also, at matched power output, changing...

journal_title：Frontiers in physiology

authors： Rivière JR,Peyrot N,Cross MR,Messonnier LA,Samozino P

更新日期：2020-10-09 00:00:00

abstract：:As arteries become stiffer with aging, reflected waves move faster and augment late systolic pressure. Few studies have described the age-related changes in both peripheral and central systolic blood pressures in populations. We investigated the age dependency of peripheral (pSBP) and central (cSBP) systolic pressure ...

journal_title：Frontiers in physiology

authors： Wojciechowska W,Li Y,Stolarz-Skrzypek K,Kawecka-Jaszcz K,Staessen JA,Wang JG,European Project on Genes in Hypertension and the JingNing Study Investigators.

更新日期：2012-06-15 00:00:00

abstract：:The in vitro motility assay (IVMA) is a powerful tool commonly used in basic muscle research and for drug screenings with the aim to find treatment options for neuromuscular disorders. In brief, the sliding movement of fluorescence-labeled actin filaments on myosin motor proteins is recorded, and the sliding velocity ...

journal_title：Frontiers in physiology

authors： Bopp N,Scheid LM,Fink RHA,Rohr K

更新日期：2019-03-27 00:00:00

abstract：:High-intensity interval training (HIT) is an effective approach for improving a range of physiological markers associated with physical fitness. A considerable body of work has demonstrated substantial improvements in cardiorespiratory fitness following short-term training programmes, while emerging evidence suggests ...

journal_title：Frontiers in physiology

authors： Hurst C,Scott JPR,Weston KL,Weston M

更新日期：2019-05-22 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2016.00593.]. ...

journal_title：Frontiers in physiology

authors： Frontiers Production Office.

更新日期：2019-05-22 00:00:00

abstract：:Comparison of genomic sequences from diverse vertebrate species has revealed numerous highly conserved regions that do not appear to encode proteins or functional RNAs. Often these "conserved non-coding elements," or CNEs, can direct gene expression to specific tissues in transgenic models, demonstrating they have reg...

journal_title：Frontiers in physiology

authors： Turner EE,Cox TC

更新日期：2014-01-21 00:00:00

abstract：:As opposed to the standard tolerogenic apoptosis, immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune response. ICD has been characterized in malignant cells following cytotoxic interventions, such as chemotherapy or radiotherapy. Briefly, ICD of cancer cells releases som...

journal_title：Frontiers in physiology

authors： Checcoli A,Pol JG,Naldi A,Noel V,Barillot E,Kroemer G,Thieffry D,Calzone L,Stoll G

更新日期：2020-11-12 00:00:00

abstract：:Dentin dysplasia (DD) and dentinogenesis imperfecta (DGI) patients have abnormal structure, morphology, and function of dentin. DD-II, DGI-II, and DGI-III are caused by heterozygous mutations in the dentin sialophosphoprotein (DSPP) gene in humans. Evidences have shown that loss of function of DSPP in Dspp knockout mi...

journal_title：Frontiers in physiology

authors： Shi C,Ma N,Zhang W,Ye J,Shi H,Xiang D,Wu C,Song L,Zhang N,Liu Q

更新日期：2020-11-09 00:00:00

abstract：:Lactic acid and short chain fatty acids (SCFAs) produced by vaginal microbiota have reported antimicrobial and immune modulatory activities indicating their potential as biomarkers of disease and/or disease susceptibility. In asymptomatic women of reproductive-age the vaginal microbiota is comprised of lactic acid-pro...

journal_title：Frontiers in physiology

authors： Aldunate M,Srbinovski D,Hearps AC,Latham CF,Ramsland PA,Gugasyan R,Cone RA,Tachedjian G

更新日期：2015-06-02 00:00:00

abstract：:Renal fibrosis is a common pathway of virtually all progressive kidney diseases. Osthole (OST, 7-Methoxy-8-(3-methylbut-2-enyl)-2-chromenone), a derivative of coumarin mainly found in plants of the Apiaceae family, has shown inhibitory effects on inflammation, oxidative stress, fibrosis and tumor progression. The pres...

journal_title：Frontiers in physiology

authors： Zhang S,Huang Q,Cai X,Jiang S,Xu N,Zhou Q,Cao X,Hultström M,Tian J,Lai EY

更新日期：2018-11-21 00:00:00

abstract：:Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

journal_title：Frontiers in physiology

authors： Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

更新日期：2020-08-14 00:00:00

abstract：:Endothelial dysfunction has been considered as pivotal in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin is well known for its endothelial protection and anti-inflammatory properties, and its protection against DCS has been proved in a rat mod...

journal_title：Frontiers in physiology

authors： Qing L,Meng W,Zhang W,Yi HJ,Zhang K,Ariyadewa DK,Xu WG

更新日期：2019-05-21 00:00:00

abstract：:Glucagon counterregulation (GCR) protects against hypoglycemia, but is impaired in type 1 diabetes (T1DM). A model-based analysis of in vivo animal data predicts that the GCR defects are linked to basal hyperglucagonemia. To test this hypothesis we studied the relationship between basal glucagon (BasG) and the GCR res...

journal_title：Frontiers in physiology

authors： Farhy LS,Chan A,Breton MD,Anderson SM,Kovatchev BP,McCall AL

更新日期：2012-02-28 00:00:00

abstract：:Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease ge...

journal_title：Frontiers in physiology

authors： Zheng T,Ni Y,Li J,Chow BKC,Panagiotou G

更新日期：2017-09-28 00:00:00

abstract：:Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which...

journal_title：Frontiers in physiology

authors： Yang CH,Zhuang WL,Shen YJ,Lai CJ,Kou YR

更新日期：2016-05-09 00:00:00

abstract：:The "Woody" or "Wooden" breast disease is a severe myopathy of pectoralis major muscle recently identified within rapidly growing broiler lines all around the world with a prevalence rate around 20%, or even higher. Although of significant ethical and economic impact, little is known regarding the structural and funct...

journal_title：Frontiers in physiology

authors： Liu J,Puolanne E,Schwartzkopf M,Arner A

更新日期：2020-04-09 00:00:00

abstract：:In an emerging bioelectronics era, there is a clinical need for physiological devices incorporating biofeedback that permits natural and demand-dependent control in real time. Here, we describe a novel device termed a central pattern generator (CPG) that uses cutting edge analog circuitry producing temporally controll...

journal_title：Frontiers in physiology

authors： O'Callaghan EL,Chauhan AS,Zhao L,Lataro RM,Salgado HC,Nogaret A,Paton JF

更新日期：2016-02-04 00:00:00

abstract：:Knowledge of the lung vessel morphology in healthy subjects is necessary to improve our understanding about the functional network of the lung and to recognize pathologic deviations beyond the normal inter-subject variation. Established values of normal lung morphology have been derived from necropsy material of only ...

journal_title：Frontiers in physiology

authors： Pienn M,Burgard C,Payer C,Avian A,Urschler M,Stollberger R,Olschewski A,Olschewski H,Johnson T,Meinel FG,Bálint Z

更新日期：2018-04-10 00:00:00