Utility of a Novel Biofeedback Device for Within-Breath Modulation of Heart Rate in Rats: A Quantitative Comparison of Vagus Nerve vs. Right Atrial Pacing.

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve m...

journal_title：Frontiers in physiology

authors： Kermorgant M,Nasr N,Custaud MA,Navasiolava N,Arbeille P,Guinet P,Labrunée M,Besnier F,Arvanitis DN,Czosnyka M,Senard JM,Pavy-Le Traon A

更新日期：2019-08-27 00:00:00

abstract：:This study aims to present complex network models which analyze professional swimmers of 50-m freestyle Olympic competitions, comparing characteristics and variables that are considered performance determinants. This comparative research includes Olympic medalists' versus non-medalists' behavior. Using data from 40 at...

journal_title：Frontiers in physiology

authors： Pereira-Ferrero VH,Lewis TG,Ferrero LGP,Duarte LT

更新日期：2019-09-03 00:00:00

abstract：:Knowledge of the lung vessel morphology in healthy subjects is necessary to improve our understanding about the functional network of the lung and to recognize pathologic deviations beyond the normal inter-subject variation. Established values of normal lung morphology have been derived from necropsy material of only ...

journal_title：Frontiers in physiology

authors： Pienn M,Burgard C,Payer C,Avian A,Urschler M,Stollberger R,Olschewski A,Olschewski H,Johnson T,Meinel FG,Bálint Z

更新日期：2018-04-10 00:00:00

abstract：:Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that physiological productio...

journal_title：Frontiers in physiology

authors： Dikalov SI,Mayorov VI,Panov AV

更新日期：2017-11-07 00:00:00

abstract：:The human brain is constantly active and even small limitations to cerebral blood flow (CBF) may be critical for preserving oxygen and substrate supply, e.g., during exercise and hypoxia. Exhaustive exercise evokes a competition for the supply of oxygenated blood between the brain and the working muscles, and inabilit...

journal_title：Frontiers in physiology

authors： Kim YS,van der Ster BJP,Brassard P,Secher NH,van Lieshout JJ

更新日期：2021-01-15 00:00:00

abstract：:Breast cancer is the most common type of cancer among women and despite recent advances in the medical field, there are still some inherent limitations in the currently used screening techniques. The radiological interpretation of screening X-ray mammograms often leads to over-diagnosis and, as a consequence, to unnec...

journal_title：Frontiers in physiology

authors： Gerasimova E,Audit B,Roux SG,Khalil A,Gileva O,Argoul F,Naimark O,Arneodo A

更新日期：2014-05-08 00:00:00

abstract：:Inflammation-induced impaired function of vascular endothelium may cause leakage of plasma proteins that can lead to edema. Proteins may leave the vascular lumen through two main paracellular and transcellular pathways. As the first involves endothelial cell (EC) junction proteins and the second caveolae formation, th...

journal_title：Frontiers in physiology

authors： Muradashvili N,Tyagi R,Lominadze D

更新日期：2012-05-31 00:00:00

abstract：:Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role of ischemic endogenous cells in this context. We hypothesized that ischemic muscle cells (MC) are ...

journal_title：Frontiers in physiology

authors： McClung JM,Reinardy JL,Mueller SB,McCord TJ,Kontos CD,Brown DA,Hussain SN,Schmidt CA,Ryan TE,Green TD

更新日期：2015-05-19 00:00:00

abstract：Background:Angiotensin II (Ang II) could promote the development of atrial fibrosis in atrial fibrillation (AF). Apelin can inhibit the occurrence of myocardial fibrosis. However, the effect of apelin on Ang II-induced atrial fibrosis and subsequent AF still remains unknown. Objective:In the present study, we examined...

journal_title：Frontiers in physiology

authors： Lv W,Zhang L,Cheng X,Wang H,Qin W,Zhou X,Tang B

更新日期：2020-11-19 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：:Aim: Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion...

journal_title：Frontiers in physiology

authors： Maufrais C,Sarafian D,Dulloo A,Montani JP

更新日期：2018-04-06 00:00:00

abstract：:Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a n...

journal_title：Frontiers in physiology

authors： Semenov AN,Shirshin EA,Muravyov AV,Priezzhev AV

更新日期：2019-08-14 00:00:00

abstract：:Being the central metabolic organ of vertebrates, the liver possesses the largest repertoire of metabolic enzymes among all tissues and organs. Almost all metabolic pathways are resident in the parenchymal cell, hepatocyte, but the pathway capacities may largely differ depending on the localization of hepatocytes with...

journal_title：Frontiers in physiology

authors： Berndt N,Holzhütter HG

更新日期：2018-12-12 00:00:00

abstract：:Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an obligatory requirement of G-protein βγ subunits for its voltage dependent ...

journal_title：Frontiers in physiology

authors： Greenwood IA,Stott JB

更新日期：2020-01-14 00:00:00

abstract：:Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. ...

journal_title：Frontiers in physiology

authors： Varricchi G,Ameri P,Cadeddu C,Ghigo A,Madonna R,Marone G,Mercurio V,Monte I,Novo G,Parrella P,Pirozzi F,Pecoraro A,Spallarossa P,Zito C,Mercuro G,Pagliaro P,Tocchetti CG

更新日期：2018-03-07 00:00:00

abstract：:The hippocampus is known as a neuronal structure involved in learning, memory and spatial navigation using multi-sensory cues. However, the basic features of its response to acoustic stimuli without any behavioral tasks (conditioning) remains poorly studied. Here, we investigated the CA3 response to auditory stimuli u...

journal_title：Frontiers in physiology

authors： Wang N,Gan X,Liu Y,Xiao Z

更新日期：2017-11-21 00:00:00

abstract：:Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA myopathy (TAM). TAM is a muscular disease characterized by muscle pain, cramping, and weakness that has been recently linked to mutations in STIM1 and ORAI...

journal_title：Frontiers in physiology

authors： Boncompagni S,Pecorai C,Michelucci A,Pietrangelo L,Protasi F

更新日期：2021-01-05 00:00:00

abstract：Context:Strength-endurance mainly depends on the power output, which is often expressed relative to the individual's maximal power capability (Pmax). However, an individual can develop the same power, but in different combinations of force and velocity (force-velocity condition). Also, at matched power output, changing...

journal_title：Frontiers in physiology

authors： Rivière JR,Peyrot N,Cross MR,Messonnier LA,Samozino P

更新日期：2020-10-09 00:00:00

abstract：:In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β42 oligomers (Aβ42-os). In neurons and astrocytes, Aβ42-os enhance the transcription of Aβ precursor protein (APP) and β-secretase/...

journal_title：Frontiers in physiology

authors： Chiarini A,Armato U,Liu D,Dal Prà I

更新日期：2016-04-26 00:00:00

abstract：:Plant-insect interactions constitute a complex of system, whereby plants synthesize toxic compounds as the main defense strategy to combat herbivore assault, and insects deploy detoxification systems to cope with toxic plant compounds. Cytochrom P450s are among the main detoxification enzymes employed by insects to co...

journal_title：Frontiers in physiology

authors： Peng L,Zhao Y,Wang H,Song C,Shangguan X,Ma Y,Zhu L,He G

更新日期：2017-11-30 00:00:00

abstract：:Huntington's disease (HD) is an inherited neurodegenerative disorder typified by involuntary body movements, and psychiatric and cognitive abnormalities. Many HD patients also exhibit metabolic changes including progressive weight loss and appetite dysfunction. Here we have investigated metabolic function in pre-manif...

journal_title：Frontiers in physiology

authors： Wang R,Ross CA,Cai H,Cong WN,Daimon CM,Carlson OD,Egan JM,Siddiqui S,Maudsley S,Martin B

更新日期：2014-06-23 00:00:00

abstract：:Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease ge...

journal_title：Frontiers in physiology

authors： Zheng T,Ni Y,Li J,Chow BKC,Panagiotou G

更新日期：2017-09-28 00:00:00

abstract：:The impact of peritoneal dialysis (PD) associated peritonitis on peritoneal membrane integrity is incompletely understood. Children are particularly suited to address this question, since they are largely devoid of preexisting tissue damage and life-style related alterations. Within the International Peritoneal Bioban...

journal_title：Frontiers in physiology

authors： Bartosova M,Schaefer B,Vondrak K,Sallay P,Taylan C,Cerkauskiene R,Dzierzega M,Milosevski-Lomic G,Büscher R,Zaloszyc A,Romero P,Lasitschka F,Warady BA,Schaefer F,Ujszaszi A,Schmitt CP

更新日期：2019-04-02 00:00:00

abstract：PURPOSE:We investigated if oral ingestion of ibuprofen influenced leucocyte recruitment and infiltration following an acute bout of traditional resistance exercise Methods: Sixteen male subjects were divided into two groups that received the maximum over-the-counter dose of ibuprofen (1200mg d(-1)) or a similarly admin...

journal_title：Frontiers in physiology

authors： Vella L,Markworth JF,Paulsen G,Raastad T,Peake JM,Snow RJ,Cameron-Smith D,Russell AP

更新日期：2016-03-29 00:00:00

abstract：:Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is regulated by three transcription factors-OCT3/4, SOX2, and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pl...

journal_title：Frontiers in physiology

authors： Peterson H,Abu Dawud R,Garg A,Wang Y,Vilo J,Xenarios I,Adjaye J

更新日期：2013-10-28 00:00:00

abstract：:Nitric oxide serves essential roles in normal vascular physiology, but paradoxically contributes to vascular pathology in disease. During brain ischemia, aberrant nitric oxide levels can cause cellular injury through induction of nitrosative/oxidative stress and post-translational activation of matrix-metalloproteinas...

journal_title：Frontiers in physiology

authors： Underly RG,Shih AY

更新日期：2021-01-11 00:00:00

abstract：:Obesity is a multi-factor chronic disease caused by the mixed influence of genetics, environments and an imbalance of energy intake and expenditure. Due to lifestyle changes, modern society sees a rapid increase in obesity occurrence along with an aggravated risk of metabolic syndromes in the general population, inclu...

journal_title：Frontiers in physiology

authors： Xu L,Zhao W,Wang D,Ma X

更新日期：2018-07-06 00:00:00

abstract：:RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3. Homozygotes present with a phenotype characteristic of bone marrow failure that is accompanied by alternat...

journal_title：Frontiers in physiology

authors： Hartman ES,Brindley EC,Papoin J,Ciciotte SL,Zhao Y,Peters LL,Blanc L

更新日期：2018-06-05 00:00:00

abstract：:Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated. During early development, communications between cells from the oral epithelium and the underlying mesenchyme govern the dental morphogenesis w...

journal_title：Frontiers in physiology

authors： Gama A,Navet B,Vargas JW,Castaneda B,Lézot F

更新日期：2015-11-05 00:00:00