Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.

Abstract:

:Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently, the primary objective of this research was to determine the central terminal projections of nerves innervating the external nose, nasal vestibule and nasal passages of rats. We injected wheat germ agglutinin (WGA) into specific external nasal locations, into the internal nasal passages of rats both with and without intact anterior ethmoidal nerves (AENs), and directly into trigeminal nerves innervating the nose and nasal region. The central terminations of these projections within the medulla were then precisely mapped. Results indicate that the internal nasal branch of the AEN and the nasopalatine nerve, but not the infraorbital nerve (ION), provide primary innervation of the internal nasal passages. The results also suggest afferent fibers from the internal nasal passages, but not external nasal region, project to the medullary dorsal horn (MDH) in an appropriate anatomical way to cause the activation of secondary neurons within the ventral MDH that express Fos protein during diving. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats.

journal_name

Front Neuroanat

authors

McCulloch PF,Lahrman KA,DelPrete B,DiNovo KM

doi

10.3389/fnana.2018.00085

subject

Has Abstract

pub_date

2018-11-13 00:00:00

pages

85

issn

1662-5129

journal_volume

12

pub_type

杂志文章
  • Histochemical characterization, distribution and morphometric analysis of NADPH diaphorase neurons in the spinal cord of the agouti.

    abstract::We evaluated the neuropil distribution of the enzymes NADPH diaphorase (NADPH-d) and cytochrome oxidase (CO) in the spinal cord of the agouti, a medium-sized diurnal rodent, together with the distribution pattern and morphometrical characteristics of NADPH-d reactive neurons across different spinal segments. Neuropil ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/neuro.05.002.2008

    authors: Freire MA,Tourinho SC,Guimarães JS,Oliveira JL,Picanço-Diniz CW,Gomes-Leal W,Pereira A

    更新日期:2008-05-26 00:00:00

  • Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats.

    abstract::In rodents, sexual behavior depends on the adequate detection of sexually relevant stimuli. The olfactory bulb (OB) is a region of the adult mammalian brain undergoing constant cell renewal by continuous integration of new granular and periglomerular neurons in the accessory (AOB) and main (MOB) olfactory bulbs. The p...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2012.00025

    authors: Portillo W,Unda N,Camacho FJ,Sánchez M,Corona R,Arzate DM,Díaz NF,Paredes RG

    更新日期:2012-07-06 00:00:00

  • Dogs Have the Most Neurons, Though Not the Largest Brain: Trade-Off between Body Mass and Number of Neurons in the Cerebral Cortex of Large Carnivoran Species.

    abstract::Carnivorans are a diverse group of mammals that includes carnivorous, omnivorous and herbivorous, domesticated and wild species, with a large range of brain sizes. Carnivory is one of several factors expected to be cognitively demanding for carnivorans due to a requirement to outsmart larger prey. On the other hand, l...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2017.00118

    authors: Jardim-Messeder D,Lambert K,Noctor S,Pestana FM,de Castro Leal ME,Bertelsen MF,Alagaili AN,Mohammad OB,Manger PR,Herculano-Houzel S

    更新日期:2017-12-12 00:00:00

  • Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks.

    abstract::A key challenge in cortical neuroscience is to gain a comprehensive understanding of how pyramidal neuron heterogeneity across different areas and species underlies the functional specialization of individual neurons, networks, and areas. Comparative studies have been important in this endeavor, providing data relevan...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2017.00011

    authors: Luebke JI

    更新日期:2017-03-07 00:00:00

  • Dopamine in the auditory brainstem and midbrain: co-localization with amino acid neurotransmitters and gene expression following cochlear trauma.

    abstract::Dopamine (DA) modulates the effects of amino acid neurotransmitters (AANs), including GABA and glutamate, in motor, visual, olfactory, and reward systems (Hnasko et al., 2010; Stuber et al., 2010; Hnasko and Edwards, 2012). The results suggest that DA may play a similar modulatory role in the auditory pathways. Previo...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00088

    authors: Fyk-Kolodziej BE,Shimano T,Gafoor D,Mirza N,Griffith RD,Gong TW,Holt AG

    更新日期:2015-07-22 00:00:00

  • Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts.

    abstract::The development of light-sheet fluorescence microscopy (LSFM) has greatly expanded the experimental capabilities in many biological and biomedical research fields, enabling for example live studies of murine and zebrafish neural activity or of cell growth and division. The key feature of the method is the selective il...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00007

    authors: Sancataldo G,Gavryusev V,de Vito G,Turrini L,Locatelli M,Fornetto C,Tiso N,Vanzi F,Silvestri L,Pavone FS

    更新日期:2019-02-08 00:00:00

  • Antineuroinflammatory and neurotrophic effects of CNTF and C16 peptide in an acute experimental autoimmune encephalomyelitis rat model.

    abstract::Experimentalallergic encephalomyelitis (EAE) is an animal model for inflammatory demyelinating autoimmune disease, i.e., multiple sclerosis (MS). In the present study, we investigated the antineuroinflammatory/neuroprotective effects of C16, an ανβ3 integrin-binding peptide, and recombinant rat ciliary neurotrophic fa...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2013.00044

    authors: Fang M,He D,Zhang F,Hu Z,Yang J,Jiang H,Han S

    更新日期:2013-12-30 00:00:00

  • Neurons in the white matter of the adult human neocortex.

    abstract::The white matter (WM) of the adult human neocortex contains the so-called "interstitial neurons". They are most numerous in the superficial WM underlying the cortical gyri, and decrease in density toward the deep WM. They are morphologically heterogeneous. A subgroup of interstitial neurons display pyramidal-cell like...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/neuro.05.007.2009

    authors: Suárez-Solá ML,González-Delgado FJ,Pueyo-Morlans M,Medina-Bolívar OC,Hernández-Acosta NC,González-Gómez M,Meyer G

    更新日期:2009-06-09 00:00:00

  • Do We Need a Human post mortem Whole-Brain Anatomical Ground Truth in in vivo Magnetic Resonance Imaging?

    abstract::Non-invasive in vivo neuroimaging techniques provide a wide array of possibilities to study human brain function. A number of approaches are available that improve our understanding of the anatomical location of brain activation patterns, including the development of probabilistic conversion tools to register individu...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2018.00110

    authors: Alkemade A,Groot JM,Forstmann BU

    更新日期:2018-12-05 00:00:00

  • Some predictions of Rafael Lorente de Nó 80 years later.

    abstract::Rafael Lorente de Nó, the youngest of Santiago Ramón y Cajal disciples, was one of the last Century's more influential researches in neuroscience. This assay highlights two fundamental contributions of Rafael Lorente de Nó to neurobiology: the intrinsic organization of the mammalian cerebral cortex and the basic physi...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2014.00147

    authors: Larriva-Sahd JA

    更新日期:2014-12-03 00:00:00

  • Long-range projection neurons of the mouse ventral tegmental area: a single-cell axon tracing analysis.

    abstract::Pathways arising from the ventral tegmental area (VTA) release dopamine and other neurotransmitters during the expectation and achievement of reward, and are regarded as central links of the brain networks that create drive, pleasure, and addiction. While the global pattern of VTA projections is well-known, the actual...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00059

    authors: Aransay A,Rodríguez-López C,García-Amado M,Clascá F,Prensa L

    更新日期:2015-05-19 00:00:00

  • Patterns of hypothalamic regionalization in amphibians and reptiles: common traits revealed by a genoarchitectonic approach.

    abstract::Most studies in mammals and birds have demonstrated common patterns of hypothalamic development highlighted by the combination of developmental regulatory genes (genoarchitecture), supporting the notion of the hypothalamus as a component of the secondary prosencephalon, topologically rostral to the diencephalon. In ou...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2015.00003

    authors: Domínguez L,González A,Moreno N

    更新日期:2015-02-03 00:00:00

  • Laminar Pattern of Projections Indicates the Hierarchical Organization of the Anterior Cingulate-Temporal Lobe Emotion System.

    abstract::The anterior cingulate cortex (ACC), surrounding the genu of the corpus callosum, plays important roles in emotional processing and is functionally divided into the dorsal, perigenual, and subgenual subregions (dACC, pgACC, and sgACC, respectively). Previous studies have suggested that the pgACC and sgACC have distinc...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00074

    authors: Sakata H,Kim Y,Nejime M,Konoike N,Miyachi S,Nakamura K

    更新日期:2019-07-31 00:00:00

  • A stereotaxic, population-averaged T1w ovine brain atlas including cerebral morphology and tissue volumes.

    abstract::Standard stereotaxic reference systems play a key role in human brain studies. Stereotaxic coordinate systems have also been developed for experimental animals including non-human primates, dogs, and rodents. However, they are lacking for other species being relevant in experimental neuroscience including sheep. Here,...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00069

    authors: Nitzsche B,Frey S,Collins LD,Seeger J,Lobsien D,Dreyer A,Kirsten H,Stoffel MH,Fonov VS,Boltze J

    更新日期:2015-06-04 00:00:00

  • An In vivo Multi-Modal Structural Template for Neonatal Piglets Using High Angular Resolution and Population-Based Whole-Brain Tractography.

    abstract::An increasing number of applications use the postnatal piglet model in neuroimaging studies, however, these are based primarily on T1 weighted image templates. There is a growing need for a multimodal structural brain template for a comprehensive depiction of the piglet brain, particularly given the growing applicatio...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2016.00092

    authors: Zhong J,Chen DQ,Walker M,Waspe A,Looi T,Piorkowska K,Drake JM,Hodaie M

    更新日期:2016-09-27 00:00:00

  • The dendritic spine story: an intriguing process of discovery.

    abstract::Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study o...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2015.00014

    authors: DeFelipe J

    更新日期:2015-03-05 00:00:00

  • A stereological study of synapse number in the epileptic human hippocampus.

    abstract::Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obt...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2011.00008

    authors: Alonso-Nanclares L,Kastanauskaite A,Rodriguez JR,Gonzalez-Soriano J,Defelipe J

    更新日期:2011-02-24 00:00:00

  • Comparative Analysis of Nkx2.1 and Islet-1 Expression in Urodele Amphibians and Lungfishes Highlights the Pattern of Forebrain Organization in Early Tetrapods.

    abstract::Expression patterns of Nkx2.1 and Islet-1 (Isl1), which encode transcription factors that are key in the regionalization of the forebrain, were analyzed by combined immunohistochemical methods in young adult specimens of two lungfishes (Neoceratodus forsteri and Protopterus dolloi) and a urodele amphibian (Pleurodeles...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2018.00042

    authors: Moreno N,López JM,Morona R,Lozano D,Jiménez S,González A

    更新日期:2018-05-18 00:00:00

  • Effects of the Genetic Depletion of Polysialyltransferases on the Structure and Connectivity of Interneurons in the Adult Prefrontal Cortex.

    abstract::Polysialic acid (polySia) is a complex sugar that in the nervous system appears mainly as a posttranslational modification of the neural cell adhesion molecule (NCAM). PolySia plays important roles during brain development, but also in its plasticity during adulthood. Two polysialyltransferases (polyST), ST8SIA2 and S...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00006

    authors: Curto Y,Alcaide J,Röckle I,Hildebrandt H,Nacher J

    更新日期:2019-02-06 00:00:00

  • Pío del Río-Hortega: A Pioneer in the Pathology of Central Nervous System Tumors.

    abstract::The last 140 years have seen considerable advances in knowledge of central nervous system tumors. However, the main tumor types had already been described during the early years of the twentieth century. The studies of Dr. Pío del Río Hortega have been ones of the most exhaustive histology and cytology-based studies o...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2016.00013

    authors: Ramon Y Cajal Agüeras S

    更新日期:2016-03-01 00:00:00

  • Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes.

    abstract::Gaucher's disease (GD) is the most prevalent lysosomal storage disorder. GD is caused by homozygous mutations of the GBA1 gene, which codes for beta-glucocerebrosidase (GCase). Although GD primarily affects peripheral tissues, the presence of neurological symptoms has been reported in several GD subtypes. GBA1 mutatio...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2018.00052

    authors: Franco R,Sánchez-Arias JA,Navarro G,Lanciego JL

    更新日期:2018-06-28 00:00:00

  • Using Teleost Fish to Discern Developmental Signatures of Evolutionary Adaptation From Phenotypic Plasticity in Brain Structure.

    abstract::Traditionally, the impact of evolution on the central nervous system has been studied by comparing the sizes of brain regions between species. However, more recent work has demonstrated that environmental factors, such as sensory experience, modulate brain region sizes intraspecifically, clouding the distinction betwe...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2020.00010

    authors: Hall ZJ,Tropepe V

    更新日期:2020-03-18 00:00:00

  • Distribution of vasotocin- and vasoactive intestinal peptide-like immunoreactivity in the brain of blue tit (Cyanistes coeruleus).

    abstract::Blue tits (Cyanistes coeruleus) are songbirds, used as model animals in numerous studies covering a wide field of research. Nevertheless, the distribution of neuropeptides in the brain of this avian species remains largely unknown. Here we present some of the first results on distribution of Vasotocine (AVT) and Vasoa...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00090

    authors: Montagnese CM,Székely T,Csillag A,Zachar G

    更新日期:2015-07-14 00:00:00

  • A period of structural plasticity at the axon initial segment in developing visual cortex.

    abstract::Cortical networks are shaped by sensory experience and are most susceptible to modifications during critical periods characterized by enhanced plasticity at the structural and functional level. A system particularly well-studied in this context is the mammalian visual system. Plasticity has been documented for the som...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2014.00011

    authors: Gutzmann A,Ergül N,Grossmann R,Schultz C,Wahle P,Engelhardt M

    更新日期:2014-03-11 00:00:00

  • Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum.

    abstract::Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zeb...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2020.00015

    authors: Furlan S,Campione M,Murgia M,Mosole S,Argenton F,Volpe P,Nori A

    更新日期:2020-04-21 00:00:00

  • Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size.

    abstract::Enough species have now been subject to systematic quantitative analysis of the relationship between the morphology and cellular composition of their brain that patterns begin to emerge and shed light on the evolutionary path that led to mammalian brain diversity. Based on an analysis of the shared and clade-specific ...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章,评审

    doi:10.3389/fnana.2014.00077

    authors: Herculano-Houzel S,Manger PR,Kaas JH

    更新日期:2014-08-11 00:00:00

  • Descriptive Analysis of Cerebral Arterial Vascular Architecture in Dromedary Camel (Camelus dromedarius).

    abstract::The artiodactyl brain has multiple levels of vascular pooling and the rostral epidural rete mirabile (RERM) at its base. The current study is the first of its kind to precisely demonstrate the arterial vasculature of the dromedary brain, utilizing a new casting method with colored latex and epoxy paint. In total, 35 f...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00067

    authors: Al Aiyan A,Menon P,AlDarwich A,Almuhairi F,Alnuaimi S,Bulshawareb A,Qablan M,Shehab S

    更新日期:2019-07-05 00:00:00

  • A comparison of manual neuronal reconstruction from biocytin histology or 2-photon imaging: morphometry and computer modeling.

    abstract::Accurate 3D reconstruction of neurons is vital for applications linking anatomy and physiology. Reconstructions are typically created using Neurolucida after biocytin histology (BH). An alternative inexpensive and fast method is to use freeware such as Neuromantic to reconstruct from fluorescence imaging (FI) stacks a...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2014.00065

    authors: Blackman AV,Grabuschnig S,Legenstein R,Sjöström PJ

    更新日期:2014-07-11 00:00:00

  • Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains.

    abstract::Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Ou...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2015.00022

    authors: Goto S,Morigaki R,Okita S,Nagahiro S,Kaji R

    更新日期:2015-03-03 00:00:00

  • Expansion Light Sheet Microscopy Resolves Subcellular Structures in Large Portions of the Songbird Brain.

    abstract::Expansion microscopy and light sheet imaging (ExLSM) provide a viable alternative to existing tissue clearing and large volume imaging approaches. The analysis of intact volumes of brain tissue presents a distinct challenge in neuroscience. Recent advances in tissue clearing and light sheet microscopy have re-addresse...

    journal_title:Frontiers in neuroanatomy

    pub_type: 杂志文章

    doi:10.3389/fnana.2019.00002

    authors: Düring DN,Rocha MD,Dittrich F,Gahr M,Hahnloser RHR

    更新日期:2019-01-31 00:00:00