Abstract:
:A key challenge in cortical neuroscience is to gain a comprehensive understanding of how pyramidal neuron heterogeneity across different areas and species underlies the functional specialization of individual neurons, networks, and areas. Comparative studies have been important in this endeavor, providing data relevant to the question of which of the many inherent properties of individual pyramidal neurons are necessary and sufficient for species-specific network and areal function. In this mini review, the importance of pyramidal neuron structural properties for signaling are outlined, followed by a summary of our recent work comparing the structural features of mouse (C57/BL6 strain) and rhesus monkey layer 3 (L3) pyramidal neurons in primary visual and frontal association cortices and their implications for neuronal and areal function. Based on these and other published data, L3 pyramidal neurons plausibly might be considered broadly "generalizable" from one area to another in the mouse neocortex due to their many similarities, but major differences in the properties of these neurons in diverse areas in the rhesus monkey neocortex rules this out in the primate. Further, fundamental differences in the dendritic topology of mouse and rhesus monkey pyramidal neurons highlight the implausibility of straightforward scaling and/or extrapolation from mouse to primate neurons and cortical networks.
journal_name
Front Neuroanatjournal_title
Frontiers in neuroanatomyauthors
Luebke JIdoi
10.3389/fnana.2017.00011subject
Has Abstractpub_date
2017-03-07 00:00:00pages
11issn
1662-5129journal_volume
11pub_type
杂志文章,评审abstract::The striatum and the subthalamic nucleus (STN) are the main entry doors for extrinsic inputs to reach the basal ganglia (BG) circuitry. The cerebral cortex, thalamus and brainstem are the key sources of glutamatergic inputs to these nuclei. There is anatomical, functional and neurochemical evidence that glutamatergic ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2015.00028
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abstract::The radial dimension expands during central nervous system development after the proliferative neuroepithelium is molecularly patterned. The process is associated with neurogenesis, radial glia scaffolding, and migration of immature neurons into the developing mantle stratum. Radial histogenetic units, defined as a de...
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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abstract::Really interesting new gene (RING) finger protein is a type of zinc-binding motif found in a large family of functionally distinct proteins. RING finger proteins are involved in diverse cellular processes including apoptosis, DNA repair, cell cycle, signal transduction, tumour suppressor, vesicular transport, and pero...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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abstract::Enough species have now been subject to systematic quantitative analysis of the relationship between the morphology and cellular composition of their brain that patterns begin to emerge and shed light on the evolutionary path that led to mammalian brain diversity. Based on an analysis of the shared and clade-specific ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2014.00077
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2016.00013
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abstract::Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study o...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2015.00014
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2013.00015
更新日期:2013-06-03 00:00:00
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pub_type: 杂志文章
doi:10.3389/fnana.2019.00073
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2019.00050
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
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abstract::[This corrects the article on p. 99 in vol. 9, PMID: 26300740.]. ...
journal_title:Frontiers in neuroanatomy
pub_type: 已发布勘误
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