Validating Rat Model of Empathy for Pain: Effects of Pain Expressions in Social Partners.

Abstract:

:Pain can be socially transferred between familiar rats due to empathic responses. To validate rat model of empathy for pain, effects of pain expressions in a cagemate demonstrator (CD) in pain on empathic pain responses in a naïve cagemate observer (CO) after 30 min priming dyadic social interactions (PDSI) were evaluated. The CD rats were prepared with four pain models: bee venom (BV), formalin, complete Freund's adjuvant (CFA), and spared nerve injury (SNI). Both BV and formalin tests are characterized by displayable and eye-identifiable spontaneous pain-related behaviors (SPRB) immediately after treatment, while CFA and SNI models are characterized by delayed occurrence of evoked pain hypersensitivity but with less eye-identifiable SPRB. After 30 min PDSI with a CD immediately after BV and formalin, respectively, the empathic mechanical pain hypersensitivity (EMPH) could be identified at both hind paws in CO rats. The BV-or formalin-induced EMPH in CO rats lasted for 4-5 h until full recovery. However, EMPH failed to develop in CO after socially interacting with a CD immediately after CFA, or 2 h after BV when SPRB completely disappeared. The CO's EMPH was partially relieved when socially interacting with an analgecized CD whose SPRB had been significantly suppressed. Moreover, repeated exposures to a CD in pain could enhance EMPH in CO. Finally, social transfer of pain hypersensitivity was also identified in CO who was being co-housed in pairs with a conspecific treated with CFA or SNI. The results suggest that development of EMPH in CO rats would be determined not only by extent of familiarity but also by visually identifiable pain expressions in the social partners during short period of PDSI. However, the visually unidentifiable pain can also be transferred to naïve cagemate when being co-housed in pairs with a distressed conspecific. In summary, the vicariously social contagion of pain between familiar rats is dependent upon not only expressions of pain in social partners but also the time that dyads spent in social communications. The rat model of empathy for pain is a highly stable, reproducible and valid model for studying the neural mechanisms of empathy in lower animals.

journal_name

Front Behav Neurosci

authors

Li CL,Yu Y,He T,Wang RR,Geng KW,Du R,Luo WJ,Wei N,Wang XL,Wang Y,Yang Y,Yu YQ,Chen J

doi

10.3389/fnbeh.2018.00242

subject

Has Abstract

pub_date

2018-10-17 00:00:00

pages

242

issn

1662-5153

journal_volume

12

pub_type

杂志文章
  • Influence of Pre-reproductive Maternal Enrichment on Coping Response to Stress and Expression of c-Fos and Glucocorticoid Receptors in Adolescent Offspring.

    abstract::Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function. Recent studies point out that parental EE experience, even occurring in the pre-reproductive phase, affects neural development...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00073

    authors: Cutuli D,Berretta E,Pasqualini G,De Bartolo P,Caporali P,Laricchiuta D,Sampedro-Piquero P,Gelfo F,Pesoli M,Foti F,Begega A,Petrosini L

    更新日期:2017-05-09 00:00:00

  • Contextual Modulation of Vocal Behavior in Mouse: Newly Identified 12 kHz "Mid-Frequency" Vocalization Emitted during Restraint.

    abstract::While several studies have investigated mouse ultrasonic vocalizations (USVs) emitted by isolated pups or by males in mating contexts, studies of behavioral contexts other than mating and vocalization categories other than USVs have been limited. By improving our understanding of the vocalizations emitted by mice acro...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00038

    authors: Grimsley JM,Sheth S,Vallabh N,Grimsley CA,Bhattal J,Latsko M,Jasnow A,Wenstrup JJ

    更新日期:2016-03-09 00:00:00

  • Lingering Effects of Prenatal Alcohol Exposure on Basal and Ethanol-Evoked Expression of Inflammatory-Related Genes in the CNS of Adolescent and Adult Rats.

    abstract::Emerging data suggest that alcohol's effects on central inflammatory factors are not uniform across the lifespan. In particular, prenatal alcohol exposure (PAE) significantly alters steady-state levels of neuroimmune factors, as well as subsequent reactivity to later immune challenge. Thus, the current experiment inve...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00082

    authors: Doremus-Fitzwater TL,Youngentob SL,Youngentob L,Gano A,Vore AS,Deak T

    更新日期:2020-06-29 00:00:00

  • Differences in brain circuitry for appetitive and reactive aggression as revealed by realistic auditory scripts.

    abstract::Aggressive behavior is thought to divide into two motivational elements: The first being a self-defensively motivated aggression against threat and a second, hedonically motivated "appetitive" aggression. Appetitive aggression is the less understood of the two, often only researched within abnormal psychology. Our app...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00425

    authors: Moran JK,Weierstall R,Elbert T

    更新日期:2014-12-09 00:00:00

  • A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption.

    abstract::Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00029

    authors: Holgate JY,Shariff M,Mu EW,Bartlett S

    更新日期:2017-02-22 00:00:00

  • Amygdala activation and GABAergic gene expression in hippocampal sub-regions at the interplay of stress and spatial learning.

    abstract::Molecular processes in GABAergic local circuit neurons critically contribute to information processing in the hippocampus and to stress-induced activation of the amygdala. In the current study, we determined expression changes in GABA-related factors induced in subregions of the dorsal hippocampus as well as in the BL...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00003

    authors: Hadad-Ophir O,Albrecht A,Stork O,Richter-Levin G

    更新日期:2014-01-21 00:00:00

  • Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices.

    abstract::The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and impulsivity. Quite notably, previous research has identified a double dissociation regarding the role of this cortical territory in impulsive choice. While medial orbitofrontal lesions increase preference for a large but delay...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00022

    authors: Ucha M,Roura-Martínez D,Contreras A,Pinto-Rivero S,Orihuel J,Ambrosio E,Higuera-Matas A

    更新日期:2019-02-20 00:00:00

  • Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats.

    abstract::We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is associated in part with reduction in ethanol intake in alcohol-preferring (P) male rats. In this study, we investigated the effects of a synthetic compound, (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), known to activate ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00366

    authors: Alhaddad H,Kim NT,Aal-Aaboda M,Althobaiti YS,Leighton J,Boddu SH,Wei Y,Sari Y

    更新日期:2014-10-30 00:00:00

  • Dynamics of place, boundary and object encoding in rat anterior claustrum.

    abstract::Discrete populations of brain cells signal differing types of spatial information. These "spatial cells" are largely confined to a closely-connected network of sites. We describe here, for the first time, cells in the anterior claustrum of the freely-moving rat encoding place, boundary and object information. This nov...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00250

    authors: Jankowski MM,O'Mara SM

    更新日期:2015-10-14 00:00:00

  • Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior.

    abstract::Epilepsy is a chronic neurological disease which is usually associated with psychiatric comorbidities. Depsression and cognition impairment are considered to be the most common psychiatric comorbidities in epilepsy patients. However, the specific contribution of epilepsy made to these psychiatric comorbidities remains...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00203

    authors: Zhu X,Dong J,Han B,Huang R,Zhang A,Xia Z,Chang H,Chao J,Yao H

    更新日期:2017-10-18 00:00:00

  • Neural sensitivity to social reward and punishment anticipation in social anxiety disorder.

    abstract::An imbalance in the neural motivational system may underlie Social Anxiety Disorder (SAD). This study examines social reward and punishment anticipation in SAD, predicting a valence-specific effect: increased striatal activity for punishment avoidance compared to obtaining a reward. Individuals with SAD (n = 20) and a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00439

    authors: Cremers HR,Veer IM,Spinhoven P,Rombouts SA,Roelofs K

    更新日期:2015-01-05 00:00:00

  • Cognitive and Neurophysiological Effects of Non-invasive Brain Stimulation in Stroke Patients after Motor Rehabilitation.

    abstract::The primary aim of this study was to evaluate and compare the effectiveness of two specific Non-Invasive Brain Stimulation (NIBS) paradigms, the repetitive Transcranial Magnetic Stimulation (rTMS), and transcranial Direct Current Stimulation (tDCS), in the upper limb rehabilitation of patients with stroke. Short and l...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00135

    authors: D'Agata F,Peila E,Cicerale A,Caglio MM,Caroppo P,Vighetti S,Piedimonte A,Minuto A,Campagnoli M,Salatino A,Molo MT,Mortara P,Pinessi L,Massazza G

    更新日期:2016-06-24 00:00:00

  • Learning to smell danger: acquired associative representation of threat in the olfactory cortex.

    abstract::Neuroscience research over the past few decades has reached a strong consensus that the amygdala plays a key role in emotion processing. However, many questions remain unanswered, especially concerning emotion perception. Based on mnemonic theories of olfactory perception and in light of the highly associative nature ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00098

    authors: Li W

    更新日期:2014-04-07 00:00:00

  • Visual cues for manual control of headway.

    abstract::The ability to maintain appropriate gaps to objects in one's environment is important when navigating through a three-dimensional world. Previous research has shown that the visual angle subtended by a lead/approaching object and its rate of change are important variables for timing interceptions, collision avoidance,...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00045

    authors: Hosking SG,Davey CE,Kaiser MK

    更新日期:2013-05-21 00:00:00

  • Learning about Time within the Spinal Cord II: Evidence that Temporal Regularity Is Encoded by a Spinal Oscillator.

    abstract::How a stimulus impacts spinal cord function depends upon temporal relations. When intermittent noxious stimulation (shock) is applied and the interval between shock pulses is varied (unpredictable), it induces a lasting alteration that inhibits adaptive learning. If the same stimulus is applied in a temporally regular...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00014

    authors: Lee KH,Huang YJ,Grau JW

    更新日期:2016-02-11 00:00:00

  • The Role of Estrogen Receptor β (ERβ) in the Establishment of Hierarchical Social Relationships in Male Mice.

    abstract::Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00245

    authors: Nakata M,Ågmo A,Sagoshi S,Ogawa S

    更新日期:2018-10-22 00:00:00

  • The impact of perceived similarity on tacit coordination: propensity for matching and aversion to decoupling choices.

    abstract::Homophily, or "love for similar others," has been shown to play a fundamental role in the formation of interpersonal ties and social networks. Yet no study has investigated whether perceived similarities can affect tacit coordination. We had 68 participants attempt to maximize real monetary earnings by choosing betwee...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00202

    authors: Chierchia G,Coricelli G

    更新日期:2015-07-28 00:00:00

  • Memory accessibility and medical decision-making for significant others: the role of socially shared retrieval-induced forgetting.

    abstract::Medical decisions will often entail a broad search for relevant information. No sources alone may offer a complete picture, and many may be selective in their presentation. This selectivity may induce forgetting for previously learned material, thereby adversely affecting medical decision-making. In the study phase of...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00072

    authors: Coman D,Coman A,Hirst W

    更新日期:2013-06-14 00:00:00

  • Avoidance expression in rats as a function of signal-shock interval: strain and sex differences.

    abstract::Inbred Wistar Kyoto (WKY) rats express inhibited temperament, increased sensitivity to stress, and exaggerated expressions of avoidance. A long-standing observation for lever press escape/avoidance learning in rats is the duration of the warning signal (WS) determines whether avoidance is expressed over escape. Outbre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00168

    authors: Servatius RJ,Avcu P,Ko N,Jiao X,Beck KD,Minor TR,Pang KC

    更新日期:2015-07-06 00:00:00

  • DARPP-32, Jack of All Trades… Master of Which?

    abstract::DARPP-32 (PPP1R1B) was discovered as a substrate of cAMP-dependent protein kinase (PKA) enriched in dopamine-innervated brain areas. It is one of three related, PKA-regulated inhibitors of protein phosphatase-1 (PP1). These inhibitors seem to have appeared in early vertebrate ancestors, possibly Gnathostomes. DARPP-32...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2011.00056

    authors: Yger M,Girault JA

    更新日期:2011-09-08 00:00:00

  • Two Years Follow up of Domain Specific Cognitive Training in Relapsing Remitting Multiple Sclerosis: A Randomized Clinical Trial.

    abstract::Cognitive rehabilitation in multiple sclerosis (MS) has been reported to induce neuropsychological improvements, but the persistence of these effects has been scarcely investigated over long follow ups. Here, the results of a multicenter randomized clinical trial are reported, in which the efficacy of 15 week domain s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00028

    authors: Mattioli F,Bellomi F,Stampatori C,Provinciali L,Compagnucci L,Uccelli A,Pardini M,Santuccio G,Fregonese G,Pattini M,Allegri B,Clerici R,Lattuada A,Montomoli C,Corso B,Gallo P,Riccardi A,Ghezzi A,Roscio M,Tola MR,C

    更新日期:2016-02-23 00:00:00

  • Dscam2 affects visual perception in Drosophila melanogaster.

    abstract::Dscam2, a cell surface protein that mediates cellular repulsion, plays a crucial role in the development of the Drosophila melanogaster visual system. Dscam2 generates boundaries between neighboring modules in the fly optic lobe; in Dscam2 mutants this visual system modularity is compromised. Although developmental wi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00149

    authors: Bosch DS,van Swinderen B,Millard SS

    更新日期:2015-06-09 00:00:00

  • Contextual Fear Conditioning and Fear Generalization in Individuals With Panic Attacks.

    abstract::Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a vi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00152

    authors: Neueder D,Andreatta M,Pauli P

    更新日期:2019-07-17 00:00:00

  • Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice.

    abstract::Testosterone reduces anxiety-like behaviors in rodents and increases exploration of anxiogenic parts of the environment. Effects of testosterone on innate defensive behaviors remain understudied. Here, we demonstrate that exogenous testosterone reduces aversion to cat odor in male mice. This is reflected as increased ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00033

    authors: Tong WH,Abdulai-Saiku S,Vyas A

    更新日期:2019-02-26 00:00:00

  • The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia.

    abstract::PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson's disease and haloperidol-induced extrapyramidal movement disorders. PAOPA's unique allosteric mechanism and dopamine D2 ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00302

    authors: Daya RP,Bhandari J,Kooner SK,Ho J,Rowley CD,Bock NA,Farncombe T,Mishra RK

    更新日期:2018-12-12 00:00:00

  • Links between Circadian Rhythms and Psychiatric Disease.

    abstract::Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a singl...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00162

    authors: Karatsoreos IN

    更新日期:2014-05-06 00:00:00

  • Impaired Latent Inhibition in GDNF-Deficient Mice Exposed to Chronic Stress.

    abstract::Increased reactivity to stress is maladaptive and linked to abnormal behaviors and psychopathology. Chronic unpredictable stress (CUS) alters catecholaminergic neurotransmission and remodels neuronal circuits involved in learning, attention and decision making. Glial-derived neurotrophic factor (GDNF) is essential for...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00177

    authors: Buhusi M,Brown CK,Buhusi CV

    更新日期:2017-10-10 00:00:00

  • Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.

    abstract::Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a f...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00361

    authors: Curtin PC,Farrar AM,Oakeshott S,Sutphen J,Berger J,Mazzella M,Cox K,He D,Alosio W,Park LC,Howland D,Brunner D

    更新日期:2016-01-11 00:00:00

  • Vitamin B12 Levels in Methamphetamine Addicts.

    abstract::Objective: It has been established that reduced vitamin B12 serum levels are associated with cognitive decline and mental illness. The chronic use of methamphetamine (MA), which is a highly addictive drug, can induce cognitive impairment and psychopathological symptoms. There are few studies addressing the association...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00320

    authors: Zhai C,Cui M,Cheng X,Ao X,Zhao T,Wu W,Shao Q,Ge D,Song H,Qi F,Ling Q,Ma M,Xu M,Jiao D

    更新日期:2018-12-18 00:00:00

  • Event-related brain potential correlates of prospective memory in symptomatically remitted male patients with schizophrenia.

    abstract::Prospective memory (PM) refers to the ability to remember to perform intended actions in the future. Although PM deficits are a prominent impairment in schizophrenia, little is still known about the nature of PM in symptomatically remitted patients with schizophrenia. To address this issue, event-related brain potenti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00262

    authors: Chen G,Zhang L,Ding W,Zhou R,Xu P,Lu S,Sun L,Jiang Z,Li H,Li Y,Cui H

    更新日期:2015-09-30 00:00:00