The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia.

abstract：:Behaviorally controllable stressors confer protection from the neurochemical and behavioral consequences of future uncontrollable stressors, a phenomenon termed "behavioral immunization". Recent data implicate protein synthesis within the ventromedial prefrontal cortex (mPFC) as critical to behavioral immunization. Ad...

journal_title：Frontiers in behavioral neuroscience

authors： Christianson JP,Flyer-Adams JG,Drugan RC,Amat J,Daut RA,Foilb AR,Watkins LR,Maier SF

更新日期：2014-10-02 00:00:00

abstract：:Opioid use is a widespread epidemic, and traumatic stress exposure is a critical risk factor in opioid use and relapse. There is a significant gap in our understanding of how stress contributes to heroin use, and there are limited studies investigating individual differences underlying stress reactivity and subsequent...

journal_title：Frontiers in behavioral neuroscience

authors： Stafford NP,Kazan TN,Donovan CM,Hart EE,Drugan RC,Charntikov S

更新日期：2019-06-25 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are used extensively in the treatment of depression and anxiety disorders. The therapeutic benefits of SSRIs typically require several weeks of continuous treatment. Intriguingly, according to clinical reports, symptoms of anxiety may actually increase during the early s...

journal_title：Frontiers in behavioral neuroscience

authors： Ravinder S,Pillai AG,Chattarji S

更新日期：2011-12-28 00:00:00

abstract：:First-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (SSRI), yet studies suggest that remission rates following two trials of an SSRI are <50%. The authors examine the putative biological substrates underlying "treatment resistant depression (TRD)" with the goal ...

journal_title：Frontiers in behavioral neuroscience

authors： Coplan JD,Gopinath S,Abdallah CG,Berry BR

更新日期：2014-05-20 00:00:00

abstract：:Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In th...

journal_title：Frontiers in behavioral neuroscience

authors： Zhang K,Lian N,Ding R,Guo C,Dong X,Li Y,Wei S,Jiao Q,Yu Y,Shen H

更新日期：2020-11-23 00:00:00

abstract：:Space and shape are distinct perceptual categories. In language, perceptual information can also be used to describe abstract semantic concepts like a "rising income" (space) or a "square personality" (shape). Despite being inherently concrete, co-speech gestures depicting space and shape can accompany concrete or abs...

journal_title：Frontiers in behavioral neuroscience

authors： Nagels A,Chatterjee A,Kircher T,Straube B

更新日期：2013-12-18 00:00:00

abstract：Background:Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigate...

journal_title：Frontiers in behavioral neuroscience

authors： von Düring F,Ristow I,Li M,Denzel D,Colic L,Demenescu LR,Li S,Borchardt V,Liebe T,Vogel M,Walter M

更新日期：2019-10-02 00:00:00

abstract：:The underlying mechanisms of paternal responses to infant signals are poorly understood. Vasopressin has previously been proposed to affect these responses. Using a double-blind, placebo-controlled, within-subject design (N = 25 expectant fathers), we examined the effect of vasopressin administration on the use of exc...

journal_title：Frontiers in behavioral neuroscience

authors： Alyousefi-van Dijk K,van 't Veer AE,Meijer WM,Lotz AM,Rijlaarsdam J,Witteman J,Bakermans-Kranenburg MJ

更新日期：2019-05-21 00:00:00

abstract：:Reduction of mu activity within the EEG is an indicator of cognitive empathy and can be generated in response to visual depictions of others in pain. The current study tested whether this brain response can be modulated by an auditory and a chemosensory context. Participants observed pictures of painful and non-painfu...

journal_title：Frontiers in behavioral neuroscience

authors： Hoenen M,Lübke KT,Pause BM

更新日期：2018-10-16 00:00:00

abstract：:Rats use their whiskers to extract a wealth of information about their immediate environment, such as the shape, position or texture of an object. The information is conveyed to mechanoreceptors located within the whisker follicle in the form of a sequence of whisker deflections induced by the whisker/object contact i...

journal_title：Frontiers in behavioral neuroscience

authors： Boubenec Y,Shulz DE,Debrégeas G

更新日期：2012-11-06 00:00:00

abstract：:Although habituation is possibly the simplest form of learning, we still do not fully understand the neurobiological basis of habituation in any organism. To advance the goal of a comprehensive understanding of habituation, we have studied long-term habituation (LTH) of the gill-withdrawal reflex (GWR) in the marine s...

journal_title：Frontiers in behavioral neuroscience

authors： Esdin J,Pearce K,Glanzman DL

更新日期：2010-11-29 00:00:00

abstract：:Adolescence is a time of unique sensitivity to socially salient stimuli such as social rewards. This period overlaps with the onset of psychopathology such as internalizing and externalizing symptoms. In the current studies, we examined behavioral and neural patterns of dysregulation to social rewards and threats, and...

journal_title：Frontiers in behavioral neuroscience

authors： Kwon SJ,Ivory SL,McCormick EM,Telzer EH

更新日期：2019-07-23 00:00:00

abstract：:Negative social experiences during adolescence increase the risk of psychiatric disorders in adulthood. Using "resident-intruder" stress, the present study aimed to investigate the effects of adolescent social defeat on emotional and cognitive symptoms associated with psychiatric disorders during adulthood and the eff...

journal_title：Frontiers in behavioral neuroscience

authors： Zhang F,Yuan S,Shao F,Wang W

更新日期：2016-07-20 00:00:00

abstract：:Neonatal pain and stress induce long-term changes in pain sensitivity and behavior. Previously we found alterations in pain sensitivity in adolescent rats exposed to early-life adverse events. We tested whether these alterations have long-lasting effects and if those effects can be improved by the 5-hydroxytryptamine ...

journal_title：Frontiers in behavioral neuroscience

authors： Butkevich IP,Mikhailenko VA,Vershinina EA,Aloisi AM,Barr GA

更新日期：2017-01-26 00:00:00

abstract：:Major advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy (NC) caused by the early loss of hypothalamic hypocretin neurons. Although a role for hypocretin in the regulation of sleep/wakefulness state is widely recognized, other functions, not necessarily rela...

journal_title：Frontiers in behavioral neuroscience

authors： Bayard S,Dauvilliers YA

更新日期：2013-05-23 00:00:00

abstract：:Exergames are increasingly used to train both physical and cognitive functioning, but direct evidence whether and how exergames affect cortical activity is lacking. Although portable electroencephalography (EEG) can be used while exergaming, it is unknown whether brain activity will be obscured by movement artifacts. ...

journal_title：Frontiers in behavioral neuroscience

authors： Anders P,Lehmann T,Müller H,Grønvik KB,Skjæret-Maroni N,Baumeister J,Vereijken B

更新日期：2018-05-18 00:00:00

abstract：:The honeybee has been established as an important model organism in studies on visual learning. So far the emphasis has been on appetitive conditioning, simulating floral discrimination, and homing behavior, where bees perform exceptionally well in visual discrimination tasks. However, bees in the wild also face dange...

journal_title：Frontiers in behavioral neuroscience

authors： Kirkerud NH,Schlegel U,Giovanni Galizia C

更新日期：2017-05-22 00:00:00

abstract：:Although previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inh...

journal_title：Frontiers in behavioral neuroscience

authors： Wang N,Li SG,Lin XX,Su YL,Qi WJ,Wang JY,Luo F

更新日期：2016-09-28 00:00:00

abstract：:Honeybees (Apis mellifera) have fascinating navigational skills and learning capabilities in the field. To decipher the mechanisms underlying place learning in honeybees, we need paradigms to study place learning of individual honeybees under controlled laboratory conditions. Here, we present a novel visual place lear...

journal_title：Frontiers in behavioral neuroscience

authors： Scheiner R,Frantzmann F,Jäger M,Mitesser O,Helfrich-Förster C,Pauls D

更新日期：2020-04-15 00:00:00

abstract：:According to recent WHO reports, alcohol remains the number one substance used and abused by adolescents, despite public health efforts to curb its use. Adolescence is a critical period of biological maturation where brain development, particularly the mesocorticolimbic dopamine system, undergoes substantial remodelin...

journal_title：Frontiers in behavioral neuroscience

authors： Kruse LC,Schindler AG,Williams RG,Weber SJ,Clark JJ

更新日期：2017-07-25 00:00:00

abstract：:Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a singl...

journal_title：Frontiers in behavioral neuroscience

authors： Karatsoreos IN

更新日期：2014-05-06 00:00:00

abstract：:As a model of anxiety disorder vulnerability, male Wistar-Kyoto (WKY) rats acquire lever-press avoidance behavior more readily than outbred Sprague-Dawley rats, and their acquisition is enhanced by the presence of a discrete signal presented during the inter-trial intervals (ITIs), suggesting that it is perceived as a...

journal_title：Frontiers in behavioral neuroscience

authors： Beck KD,Jiao X,Smith IM,Myers CE,Pang KC,Servatius RJ

更新日期：2014-11-21 00:00:00

abstract：:Work and study increasingly rely on the use of technologies requiring individuals to switch attention rapidly between emails, texts and tasks. This has led to healthy people having problems of attention and concentration and difficulties getting into the "flow," which impedes goal attainment and task completion. Possi...

journal_title：Frontiers in behavioral neuroscience

authors： Savulich G,Thorp E,Piercy T,Peterson KA,Pickard JD,Sahakian BJ

更新日期：2019-01-21 00:00:00

abstract：:Patients with schizophrenia show neurophysiological and psychological disturbances before the onset of the illness. Mismatch negativity (MMN), an event-related potential, has been shown to be associated with cognitive function. Specifically, duration MMN (dMMN) amplitudes have been indicated to predict progression to ...

journal_title：Frontiers in behavioral neuroscience

authors： Sumiyoshi T,Miyanishi T,Seo T,Higuchi Y

更新日期：2013-10-21 00:00:00

abstract：:Animals rely on sensory feedback from their environment to guide locomotion. For instance, visually guided animals use patterns of optic flow to control their velocity and to estimate their distance to objects (e.g., Srinivasan et al., 1991, 1996). In this study, we investigated how acoustic information guides locomot...

journal_title：Frontiers in behavioral neuroscience

authors： Warnecke M,Lee WJ,Krishnan A,Moss CF

更新日期：2016-04-25 00:00:00

abstract：:Adolescent behavior is typified by increased risk-taking, reward- and novelty-seeking, as well as an augmented need for social and environmental stimulation. This behavioral phenotype may result from alterations in outcome valuation or reward learning. In the present set of experiments, we directly compared adult and ...

journal_title：Frontiers in behavioral neuroscience

authors： Stolyarova A,Izquierdo A

更新日期：2015-05-07 00:00:00

abstract：:Somatostatin (SOM) and somatostatin receptors (SSTR1-4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. In this work, histological, viral tracing and transgenic approaches were used to characterize SOM c...

journal_title：Frontiers in behavioral neuroscience

authors： Nocera S,Simon A,Fiquet O,Chen Y,Gascuel J,Datiche F,Schneider N,Epelbaum J,Viollet C

更新日期：2019-04-09 00:00:00

abstract：:Since the discovery of place cells, the hippocampus is thought to be the neural substrate of a cognitive map. The later discovery of head direction cells, grid cells and border cells, as well as of cells with more complex spatial signals, has led to the idea that there is a brain system devoted to providing the animal...

journal_title：Frontiers in behavioral neuroscience

authors： Poucet B,Chaillan F,Truchet B,Save E,Sargolini F,Hok V

更新日期：2015-10-30 00:00:00

abstract：:Magnetoreception can play a substantial role in long distance navigation by animals. I hypothesize that locomotion guided by a magnetic compass sense could also play a role in short distance navigation. Animals identify mates, prey, or other short distance navigational goals using different sensory modalities (olfacti...

journal_title：Frontiers in behavioral neuroscience

authors： Wyeth RC

更新日期：2010-07-30 00:00:00

abstract：:One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety, and post-traumatic stress disorder. We investigated t...

journal_title：Frontiers in behavioral neuroscience

authors： Griffiths BB,Schoonheim PJ,Ziv L,Voelker L,Baier H,Gahtan E

更新日期：2012-10-11 00:00:00