Vitamin B12 Levels in Methamphetamine Addicts.


:Objective: It has been established that reduced vitamin B12 serum levels are associated with cognitive decline and mental illness. The chronic use of methamphetamine (MA), which is a highly addictive drug, can induce cognitive impairment and psychopathological symptoms. There are few studies addressing the association of MA with vitamin B12 serum levels. This study examined whether the serum levels of B12 are associated with MA addiction. Methods: Serum vitamin B12, homocysteine (Hcy), glucose and triglyceride concentrations were measured in 123 MA addicts and 108 controls. In addition, data were collected on their age, marital status, level of education and Body Mass Index (BMI) for all participants. In the patient group, the data for each subject were collected using the Fagerstrom Test for Nicotine Dependence (FTND), the Alcohol Use Disorders Identification Test (AUDIT), and a drug use history, which included the age of onset, total duration of MA use, the number of relapses and addiction severity. Results: Our results showed that MA addicts had lower vitamin B12 levels (p < 0.05) than those of healthy controls, but Hcy levels were not significantly different between the two groups (p > 0.05). Serum B12 levels were negatively correlated with the number of relapses in the MA group. Furthermore, binary logistics regression analysis indicated that the B12 was an influencing factor contributing to addiction severity. Conclusion: The findings of this study suggest that some MA addicts might have vitamin B12 deficiency, and serum B12 levels may be involved in the prognosis of MA addiction.


Front Behav Neurosci


Zhai C,Cui M,Cheng X,Ao X,Zhao T,Wu W,Shao Q,Ge D,Song H,Qi F,Ling Q,Ma M,Xu M,Jiao D




Has Abstract


2018-12-18 00:00:00








  • Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior.

    abstract::The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Porseryd T,Volkova K,Reyhanian Caspillo N,Källman T,Dinnetz P,Porsh Hällström I

    更新日期:2017-04-20 00:00:00

  • Impairments of working memory in schizophrenia and bipolar disorder: the effect of history of psychotic symptoms and different aspects of cognitive task demands.

    abstract::Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic B...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Frydecka D,Eissa AM,Hewedi DH,Ali M,Drapała J,Misiak B,Kłosińska E,Phillips JR,Moustafa AA

    更新日期:2014-11-28 00:00:00

  • Links between Circadian Rhythms and Psychiatric Disease.

    abstract::Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a singl...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Karatsoreos IN

    更新日期:2014-05-06 00:00:00

  • Traumatic Life Events in Relation to Cognitive Flexibility: Moderating Role of the BDNF Val66Met Gene Polymorphism.

    abstract::Cognitive flexibility plays an important role in an individual's ability to adapt to a continuously changing environment and is considered central to goal-oriented behavior. Accordingly, increasing attention has been devoted to understanding the factors, including genetic and early life experiences, which might contri...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Gabrys RL,Dixon K,Anisman H

    更新日期:2017-12-08 00:00:00

  • Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats.

    abstract::We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is associated in part with reduction in ethanol intake in alcohol-preferring (P) male rats. In this study, we investigated the effects of a synthetic compound, (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), known to activate ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Alhaddad H,Kim NT,Aal-Aaboda M,Althobaiti YS,Leighton J,Boddu SH,Wei Y,Sari Y

    更新日期:2014-10-30 00:00:00

  • The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

    abstract::Chronic or persistent fatigue is a common, debilitating symptom of several diseases. Persistent fatigue has been associated with low-grade inflammation in several models of fatigue, including cancer-related fatigue and chronic fatigue syndrome. However, it is unclear how low-grade inflammation leads to the experience ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Lacourt TE,Vichaya EG,Chiu GS,Dantzer R,Heijnen CJ

    更新日期:2018-04-26 00:00:00

  • A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems.

    abstract::The avoidance response is present in pathological anxiety and interferes with normal daily functions. The aim of this article is to shed light on performance markers of active avoidance (AA) using two different rat strains, Sprague-Dawley (SD) and Wistar. Specifically, good and poor performers were evaluated regarding...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: de Oliveira CC,Gouveia FV,de Castro MC,Kuroki MA,Dos Santos LC,Fonoff ET,Teixeira MJ,Otoch JP,Martinez RC

    更新日期:2016-08-24 00:00:00

  • Effects of early psychosocial deprivation on the development of memory and executive function.

    abstract::This study investigated the effects of early institutional care on memory and executive functioning. Subjects were participants in the Bucharest Early Intervention Project (BEIP) and included institutionalized children, children with a history of institutionalization who were assigned to a foster care intervention, an...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Bos KJ,Fox N,Zeanah CH,Nelson Iii CA

    更新日期:2009-09-01 00:00:00

  • Should animals navigating over short distances switch to a magnetic compass sense?

    abstract::Magnetoreception can play a substantial role in long distance navigation by animals. I hypothesize that locomotion guided by a magnetic compass sense could also play a role in short distance navigation. Animals identify mates, prey, or other short distance navigational goals using different sensory modalities (olfacti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Wyeth RC

    更新日期:2010-07-30 00:00:00

  • Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches.

    abstract::In the present review, we provide evidence indicating that although post traumatic stress disorder (PTSD) and substance use disorder (SUD) are two distinct pathologies with very different impacts on people affected by these chronic illnesses, they share numerous common characteristics, present high rates of co-morbidi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Gisquet-Verrier P,Le Dorze C

    更新日期:2019-02-13 00:00:00

  • The Interplay of Achievement Motive-Goal Incongruence and State and Trait Self-Control: A Pilot Study Considering Cortical Correlates of Self-Control.

    abstract::Objective: This study utilized different theoretical perspectives to better understand motor performance. We refered to concepts of achievement motive-goal incongruence and assessed cortical correlates of self-control. We assumed that more self-control is required when people act in conformance with an incongruent goa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Schüler J,Hofstetter J,Wolff W

    更新日期:2019-10-04 00:00:00

  • Frontal and temporal lobe contributions to emotional enhancement of memory in behavioral-variant frontotemporal dementia and Alzheimer's disease.

    abstract::Emotional events gain special priority in how they are remembered, with emotionally arousing events typically recalled more vividly and with greater confidence than non-emotional events. In dementia, memory and emotion processing are affected to varying degrees, however, whether emotional enhancement of memory for com...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Kumfor F,Irish M,Hodges JR,Piguet O

    更新日期:2014-06-24 00:00:00

  • An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality.

    abstract::The gradual accumulation of sensory evidence is a crucial component of perceptual decision making, but its neural mechanisms are still poorly understood. Given the wide availability of genetic and optical tools for mice, they can be useful model organisms for the study of these phenomena; however, behavioral tools are...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Pinto L,Koay SA,Engelhard B,Yoon AM,Deverett B,Thiberge SY,Witten IB,Tank DW,Brody CD

    更新日期:2018-03-06 00:00:00

  • Slips of Action and Sequential Decisions: A Cross-Validation Study of Tasks Assessing Habitual and Goal-Directed Action Control.

    abstract::Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

    更新日期:2016-12-20 00:00:00

  • A Central Component of the N1 Event-Related Brain Potential Could Index the Early and Automatic Inhibition of the Actions Systematically Activated by Objects.

    abstract::Stimuli of the environment, like objects, systematically activate the actions they are associated to. These activations occur extremely fast. Nevertheless, behavioral data reveal that, in most cases, these activations are then automatically inhibited, around 100 ms after the occurrence of the stimulus. We thus tested ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Debruille JB,Touzel M,Segal J,Snidal C,Renoult L

    更新日期:2019-05-08 00:00:00

  • Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice.

    abstract::L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA). An elevated level of KYNA may have multiple effects on the synaptic transm...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Varga D,Herédi J,Kánvási Z,Ruszka M,Kis Z,Ono E,Iwamori N,Iwamori T,Takakuwa H,Vécsei L,Toldi J,Gellért L

    更新日期:2015-06-16 00:00:00

  • Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity.

    abstract::Recent studies have used conditional knockout mice to selectively delete the D2 autoreceptor; however, these approaches result in global deletion of D2 autoreceptors early in development. The present study takes a different approach using RNA interference (RNAi) to knockdown the expression of the D2 receptors (D2R) in...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Budygin EA,Oleson EB,Lee YB,Blume LC,Bruno MJ,Howlett AC,Thompson AC,Bass CE

    更新日期:2017-01-19 00:00:00

  • CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

    abstract::It is suggested that striatal cAMP responsive element binding protein (CREB) regulates sensitivity to psychostimulants. To test the cell-specificity of this hypothesis we examined the effects of a dominant-negative CREB protein variant expressed in dopamine receptor D1 (D1R) neurons on cocaine-induced behaviors. A tra...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Bilbao A,Rieker C,Cannella N,Parlato R,Golda S,Piechota M,Korostynski M,Engblom D,Przewlocki R,Schütz G,Spanagel R,Parkitna JR

    更新日期:2014-06-11 00:00:00

  • Ecstatic Epileptic Seizures: A Glimpse into the Multiple Roles of the Insula.

    abstract::Ecstatic epileptic seizures are a rare but compelling epileptic entity. During the first seconds of these seizures, ecstatic auras provoke feelings of well-being, intense serenity, bliss, and "enhanced self-awareness." They are associated with the impression of time dilation, and can be described as a mystic experienc...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Gschwind M,Picard F

    更新日期:2016-02-17 00:00:00

  • Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze.

    abstract::Globally, it is estimated that nearly 10 million people sustain severe brain injuries leading to hospitalization and/or death every year. Amongst survivors, traumatic brain injury (TBI) results in a wide variety of physical, emotional and cognitive deficits. The most common cognitive deficit associated with TBI is mem...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Sebastian V,Diallo A,Ling DS,Serrano PA

    更新日期:2013-05-03 00:00:00

  • The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia.

    abstract::PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson's disease and haloperidol-induced extrapyramidal movement disorders. PAOPA's unique allosteric mechanism and dopamine D2 ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Daya RP,Bhandari J,Kooner SK,Ho J,Rowley CD,Bock NA,Farncombe T,Mishra RK

    更新日期:2018-12-12 00:00:00

  • Searching for learning-dependent changes in the antennal lobe: simultaneous recording of neural activity and aversive olfactory learning in honeybees.

    abstract::Plasticity in the honeybee brain has been studied using the appetitive olfactory conditioning of the proboscis extension reflex, in which a bee learns the association between an odor and a sucrose reward. In this framework, coupling behavioral measurements of proboscis extension and invasive recordings of neural activ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Roussel E,Sandoz JC,Giurfa M

    更新日期:2010-09-01 00:00:00

  • More Than Meets the Eye: The Impact of Materialism on Information Selection During Luxury Choices.

    abstract::Visual attention is an important condition for consumer decision-making. However, not much is known on individuals' determinants of this visual attention. Using eye tracking, this study investigated how psychological values (i.e., materialism) modulate visual attention to specific sources of information (i.e., product...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Audrin C,Brosch T,Sander D,Chanal J

    更新日期:2018-08-24 00:00:00

  • Neural Dynamics of Emotional Salience Processing in Response to Voices during the Stages of Sleep.

    abstract::Sleep has been related to emotional functioning. However, the extent to which emotional salience is processed during sleep is unknown. To address this concern, we investigated night sleep in healthy adults regarding brain reactivity to the emotionally (happily, fearfully) spoken meaningless syllables dada, along with ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Chen C,Sung JY,Cheng Y

    更新日期:2016-06-14 00:00:00

  • Changes in Functional Connectivity Following Treatment With Emotion Regulation Therapy.

    abstract::Emotion regulation therapy (ERT) is an efficacious treatment for distress disorders (i.e., depression and anxiety), predicated on a conceptual model wherein difficult to treat distress arises from intense emotionality (e.g., neuroticism, dispositional negativity) and is prolonged by negative self-referentiality (e.g.,...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Scult MA,Fresco DM,Gunning FM,Liston C,Seeley SH,García E,Mennin DS

    更新日期:2019-02-04 00:00:00

  • Octopamine Shifts the Behavioral Response From Indecision to Approach or Aversion in Drosophila melanogaster.

    abstract::Animals must make constant decisions whether to respond to external sensory stimuli or not to respond. The activation of positive and/or negative reinforcers might bias the behavioral response towards approach or aversion. To analyze whether the activation of the octopaminergic neurotransmitter system can shift the de...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Claßen G,Scholz H

    更新日期:2018-07-03 00:00:00

  • Reinforcement and inference in cross-situational word learning.

    abstract::Cross-situational word learning is based on the notion that a learner can determine the referent of a word by finding something in common across many observed uses of that word. Here we propose an adaptive learning algorithm that contains a parameter that controls the strength of the reinforcement applied to associati...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Tilles PF,Fontanari JF

    更新日期:2013-11-19 00:00:00

  • At the frontier of epigenetics of brain sex differences.

    abstract::The notion that epigenetics may play an important role in the establishment and maintenance of sex differences in the brain has garnered great enthusiasm but the reality in terms of actual advances has been slow. Two general approaches include the comparison of a particular epigenetic mark in males vs. females and the...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: McCarthy MM,Nugent BM

    更新日期:2015-08-21 00:00:00

  • Boldness in Male and Female Zebrafish (Danio rerio) Is Dependent on Strain and Test.

    abstract::Differences in selection pressure in nature and labs have profound effects on zebrafish strains. The widely used AB strain of zebrafish has been domesticated over several decades. Recently, there has been an upsurge in the availability of genetically modified lines, e.g., the spiegeldanio (spd), which has a mutation i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Mustafa A,Roman E,Winberg S

    更新日期:2019-11-19 00:00:00

  • Genetically-Driven Enhancement of Dopaminergic Transmission Affects Moral Acceptability in Females but Not in Males: A Pilot Study.

    abstract::Moral behavior has been a key topic of debate for philosophy and psychology for a long time. In recent years, thanks to the development of novel methodologies in cognitive sciences, the question of how we make moral choices has expanded to the study of neurobiological correlates that subtend the mental processes invol...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章


    authors: Pellegrini S,Palumbo S,Iofrida C,Melissari E,Rota G,Mariotti V,Anastasio T,Manfrinati A,Rumiati R,Lotto L,Sarlo M,Pietrini P

    更新日期:2017-08-29 00:00:00