Neural correlates of sensorimotor gating: a metabolic positron emission tomography study in awake rats.

Abstract:

:Impaired sensorimotor gating occurs in neuropsychiatric disorders such as schizophrenia and can be measured using the prepulse inhibition (PPI) paradigm of the acoustic startle response. This assay is frequently used to validate animal models of neuropsychiatric disorders and to explore the therapeutic potential of new drugs. The underlying neural network of PPI has been extensively studied with invasive methods and genetic modifications. However, its relevance for healthy untreated animals and the functional interplay between startle- and PPI-related areas during a PPI session is so far unknown. Therefore, we studied awake rats in a PPI paradigm, startle control and background noise control, combined with behavioral [(18)F]fluoro-2-deoxyglucose positron emission tomography (FDG-PET). Subtractive analyses between conditions were used to identify brain regions involved in startle and PPI processing in well-hearing Black hooded rats. For correlative analysis with regard to the amount of PPI we also included hearing-impaired Lister hooded rats that startled more often, because their hearing threshold was just below the lowest prepulses. Metabolic imaging showed that the brain areas proposed for startle and PPI mediation are active during PPI paradigms in healthy untreated rats. More importantly, we show for the first time that the whole PPI modulation network is active during "passive" PPI sessions, where no selective attention to prepulse or startle stimulus is required. We conclude that this reflects ongoing monitoring of stimulus significance and constant adjustment of sensorimotor gating.

journal_name

Front Behav Neurosci

authors

Rohleder C,Jung F,Mertgens H,Wiedermann D,Sué M,Neumaier B,Graf R,Leweke FM,Endepols H

doi

10.3389/fnbeh.2014.00178

subject

Has Abstract

pub_date

2014-05-22 00:00:00

pages

178

issn

1662-5153

journal_volume

8

pub_type

杂志文章
  • Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task.

    abstract::The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC on prefrontal cortex-dependen...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00286

    authors: Janitzky K,Lippert MT,Engelhorn A,Tegtmeier J,Goldschmidt J,Heinze HJ,Ohl FW

    更新日期:2015-11-04 00:00:00

  • Alcohol, Self-Regulation and Partner Physical Aggression: Actor-Partner Effects Over a Three-Year Time Frame.

    abstract::The question of how individual differences related to self-regulation interact with alcohol use patterns to predict intimate partner aggression (IPA) is examined. We hypothesized that excessive drinking will be related to partner aggression among those who have low self-regulation. In addition, we explored the extent ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00130

    authors: Quigley BM,Levitt A,Derrick JL,Testa M,Houston RJ,Leonard KE

    更新日期:2018-07-05 00:00:00

  • Dynamic Echo Information Guides Flight in the Big Brown Bat.

    abstract::Animals rely on sensory feedback from their environment to guide locomotion. For instance, visually guided animals use patterns of optic flow to control their velocity and to estimate their distance to objects (e.g., Srinivasan et al., 1991, 1996). In this study, we investigated how acoustic information guides locomot...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00081

    authors: Warnecke M,Lee WJ,Krishnan A,Moss CF

    更新日期:2016-04-25 00:00:00

  • Executive function and endocrinological responses to acute resistance exercise.

    abstract:THIS STUDY HAD THE FOLLOWING TWO AIMS:First, to explore the effects of acute resistance exercise (RE, i.e., using exercise machines to contract and stretch muscles) on behavioral and electrophysiological performance when performing a cognitive task involving executive functioning in young male adults; Second, to invest...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00262

    authors: Tsai CL,Wang CH,Pan CY,Chen FC,Huang TH,Chou FY

    更新日期:2014-08-01 00:00:00

  • Inactivation of medial prefrontal cortex impairs time interval discrimination in rats.

    abstract::Several lines of evidence suggest the involvement of prefrontal cortex in time interval estimation. The underlying neural processes are poorly understood, however, in part because of the paucity of physiological studies. The goal of this study was to establish an interval timing task for physiological recordings in ra...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.038.2009

    authors: Kim J,Jung AH,Byun J,Jo S,Jung MW

    更新日期:2009-11-03 00:00:00

  • Extinction procedure induces pruning of dendritic spines in CA1 hippocampal field depending on strength of training in rats.

    abstract::Numerous reports indicate that learning and memory of conditioned responses are accompanied by genesis of dendritic spines in the hippocampus, although there is a conspicuous lack of information regarding spine modifications after behavioral extinction. There is ample evidence that treatments that typically produce am...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00012

    authors: Garín-Aguilar ME,Díaz-Cintra S,Quirarte GL,Aguilar-Vázquez A,Medina AC,Prado-Alcalá RA

    更新日期:2012-03-16 00:00:00

  • The RUB Cage: Respiration-Ultrasonic Vocalizations-Behavior Acquisition Setup for Assessing Emotional Memory in Rats.

    abstract::In animals, emotional memory is classically assessed through pavlovian fear conditioning in which a neutral novel stimulus (conditioned stimulus) is paired with an aversive unconditioned stimulus. After conditioning, the conditioned stimulus elicits a fear response characterized by a wide range of behavioral and physi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2011.00025

    authors: Hegoburu C,Shionoya K,Garcia S,Messaoudi B,Thévenet M,Mouly AM

    更新日期:2011-05-19 00:00:00

  • Seeing what you want to see: priors for one's own actions represent exaggerated expectations of success.

    abstract::People perceive the consequences of their own actions differently to how they perceive other sensory events. A large body of psychology research has shown that people also consistently overrate their own performance relative to others, yet little is known about how these "illusions of superiority" are normally maintai...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00232

    authors: Wolpe N,Wolpert DM,Rowe JB

    更新日期:2014-06-27 00:00:00

  • Exposure to Hedione Increases Reciprocity in Humans.

    abstract::Cooperation among unrelated humans is frequently regarded as a defining feature in the evolutionary success of our species. Whereas, much research has addressed the strategic and cognitive mechanisms that underlie cooperation, investigations into chemosensory processes have received very limited research attention. To...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00079

    authors: Berger S,Hatt H,Ockenfels A

    更新日期:2017-05-02 00:00:00

  • Whisking Kinematics Enables Object Localization in Head-Centered Coordinates Based on Tactile Information from a Single Vibrissa.

    abstract::During active tactile exploration with their whiskers (vibrissae), rodents can rapidly orient to an object even though there are very few proprioceptors in the whisker muscles. Thus a long-standing question in the study of the vibrissal system is how the rat can localize an object in head-centered coordinates without ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00145

    authors: Yang AE,Hartmann MJ

    更新日期:2016-07-19 00:00:00

  • Boldness in Male and Female Zebrafish (Danio rerio) Is Dependent on Strain and Test.

    abstract::Differences in selection pressure in nature and labs have profound effects on zebrafish strains. The widely used AB strain of zebrafish has been domesticated over several decades. Recently, there has been an upsurge in the availability of genetically modified lines, e.g., the spiegeldanio (spd), which has a mutation i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00248

    authors: Mustafa A,Roman E,Winberg S

    更新日期:2019-11-19 00:00:00

  • Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.

    abstract::Behaviorally controllable stressors confer protection from the neurochemical and behavioral consequences of future uncontrollable stressors, a phenomenon termed "behavioral immunization". Recent data implicate protein synthesis within the ventromedial prefrontal cortex (mPFC) as critical to behavioral immunization. Ad...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00348

    authors: Christianson JP,Flyer-Adams JG,Drugan RC,Amat J,Daut RA,Foilb AR,Watkins LR,Maier SF

    更新日期:2014-10-02 00:00:00

  • Visual cues for manual control of headway.

    abstract::The ability to maintain appropriate gaps to objects in one's environment is important when navigating through a three-dimensional world. Previous research has shown that the visual angle subtended by a lead/approaching object and its rate of change are important variables for timing interceptions, collision avoidance,...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00045

    authors: Hosking SG,Davey CE,Kaiser MK

    更新日期:2013-05-21 00:00:00

  • Human Novelty Response to Emotional Animal Vocalizations: Effects of Phylogeny and Familiarity.

    abstract::Darwin (1872) postulated that emotional expressions contain universals that are retained across species. We recently showed that human rating responses were strongly affected by a listener's familiarity with vocalization types, whereas evidence for universal cross-taxa emotion recognition was limited. To disentangle t...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00204

    authors: Scheumann M,Hasting AS,Zimmermann E,Kotz SA

    更新日期:2017-10-24 00:00:00

  • EEG-microstate dependent emergence of perceptual awareness.

    abstract::We investigated whether the differences in perceptual awareness for stimuli at the threshold of awareness can arise from different global brain states before stimulus onset indexed by the EEG microstate. We used a metacontrast backward masking paradigm in which subjects had to discriminate between two weak stimuli and...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00163

    authors: Britz J,Díaz Hernàndez L,Ro T,Michel CM

    更新日期:2014-05-14 00:00:00

  • Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.

    abstract::Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a f...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00361

    authors: Curtin PC,Farrar AM,Oakeshott S,Sutphen J,Berger J,Mazzella M,Cox K,He D,Alosio W,Park LC,Howland D,Brunner D

    更新日期:2016-01-11 00:00:00

  • Electrophysiological and neuropsychological predictors of conversion to schizophrenia in at-risk subjects.

    abstract::Patients with schizophrenia show neurophysiological and psychological disturbances before the onset of the illness. Mismatch negativity (MMN), an event-related potential, has been shown to be associated with cognitive function. Specifically, duration MMN (dMMN) amplitudes have been indicated to predict progression to ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2013.00148

    authors: Sumiyoshi T,Miyanishi T,Seo T,Higuchi Y

    更新日期:2013-10-21 00:00:00

  • The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia.

    abstract::PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson's disease and haloperidol-induced extrapyramidal movement disorders. PAOPA's unique allosteric mechanism and dopamine D2 ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00302

    authors: Daya RP,Bhandari J,Kooner SK,Ho J,Rowley CD,Bock NA,Farncombe T,Mishra RK

    更新日期:2018-12-12 00:00:00

  • Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice.

    abstract::Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.589176

    authors: Zhang K,Lian N,Ding R,Guo C,Dong X,Li Y,Wei S,Jiao Q,Yu Y,Shen H

    更新日期:2020-11-23 00:00:00

  • Deafferented controllers: a fundamental failure mechanism in cortical neuroprosthetic systems.

    abstract::Brain-machine interface (BMI) research assumes that patients with disconnected neural pathways could naturally control a prosthetic device by volitionally modulating sensorimotor cortical activity usually responsible for movement coordination. However, computational approaches to motor control challenge this view. Thi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00186

    authors: Galán F,Baker SN

    更新日期:2015-07-17 00:00:00

  • Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system.

    abstract::Dysregulations in the brain serotonergic system and exposure to environmental stressors have been implicated in the development of major depressive disorder. Here, we investigate the interactions between the stress and serotonergic systems by characterizing the behavioral and biochemical effects of chronic stress appl...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00094

    authors: Wong P,Sze Y,Gray LJ,Chang CC,Cai S,Zhang X

    更新日期:2015-04-27 00:00:00

  • Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.

    abstract::Identifying the biological substrates of complex neurobehavioral traits such as alcohol dependency pose a tremendous challenge given the diverse model systems and phenotypic assessments used. To address this problem we have developed a platform for integrated analysis of high-throughput or genome-wide functional genom...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00001

    authors: Bubier JA,Wilcox TD,Jay JJ,Langston MA,Baker EJ,Chesler EJ

    更新日期:2016-01-21 00:00:00

  • Event-related brain potential correlates of prospective memory in symptomatically remitted male patients with schizophrenia.

    abstract::Prospective memory (PM) refers to the ability to remember to perform intended actions in the future. Although PM deficits are a prominent impairment in schizophrenia, little is still known about the nature of PM in symptomatically remitted patients with schizophrenia. To address this issue, event-related brain potenti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00262

    authors: Chen G,Zhang L,Ding W,Zhou R,Xu P,Lu S,Sun L,Jiang Z,Li H,Li Y,Cui H

    更新日期:2015-09-30 00:00:00

  • CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

    abstract::It is suggested that striatal cAMP responsive element binding protein (CREB) regulates sensitivity to psychostimulants. To test the cell-specificity of this hypothesis we examined the effects of a dominant-negative CREB protein variant expressed in dopamine receptor D1 (D1R) neurons on cocaine-induced behaviors. A tra...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00212

    authors: Bilbao A,Rieker C,Cannella N,Parlato R,Golda S,Piechota M,Korostynski M,Engblom D,Przewlocki R,Schütz G,Spanagel R,Parkitna JR

    更新日期:2014-06-11 00:00:00

  • The role of dopamine in risk taking: a specific look at Parkinson's disease and gambling.

    abstract::An influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of dopamine signaling ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2014.00196

    authors: Clark CA,Dagher A

    更新日期:2014-05-30 00:00:00

  • Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy.

    abstract::Major advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy (NC) caused by the early loss of hypothalamic hypocretin neurons. Although a role for hypocretin in the regulation of sleep/wakefulness state is widely recognized, other functions, not necessarily rela...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00050

    authors: Bayard S,Dauvilliers YA

    更新日期:2013-05-23 00:00:00

  • Theta and Alpha Oscillations in Attentional Interaction during Distracted Driving.

    abstract::Performing multiple tasks simultaneously usually affects the behavioral performance as compared with executing the single task. Moreover, processing multiple tasks simultaneously often involve more cognitive demands. Two visual tasks, lane-keeping task and mental calculation, were utilized to assess the brain dynamics...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00003

    authors: Wang YK,Jung TP,Lin CT

    更新日期:2018-02-09 00:00:00

  • Individual Vulnerability to Stress Is Associated With Increased Demand for Intravenous Heroin Self-administration in Rats.

    abstract::Opioid use is a widespread epidemic, and traumatic stress exposure is a critical risk factor in opioid use and relapse. There is a significant gap in our understanding of how stress contributes to heroin use, and there are limited studies investigating individual differences underlying stress reactivity and subsequent...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00134

    authors: Stafford NP,Kazan TN,Donovan CM,Hart EE,Drugan RC,Charntikov S

    更新日期:2019-06-25 00:00:00

  • Amygdala activation and GABAergic gene expression in hippocampal sub-regions at the interplay of stress and spatial learning.

    abstract::Molecular processes in GABAergic local circuit neurons critically contribute to information processing in the hippocampus and to stress-induced activation of the amygdala. In the current study, we determined expression changes in GABA-related factors induced in subregions of the dorsal hippocampus as well as in the BL...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00003

    authors: Hadad-Ophir O,Albrecht A,Stork O,Richter-Levin G

    更新日期:2014-01-21 00:00:00

  • A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption.

    abstract::Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00029

    authors: Holgate JY,Shariff M,Mu EW,Bartlett S

    更新日期:2017-02-22 00:00:00