Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors.

Abstract:

:β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior; yet, the role of β-arrestin 1 in the central nervous system has been less investigated compared to β-arrestin 2. Here, we investigate how global β-arrestin 1 KO affects anxiety-like and alcohol-related behaviors in male and female C57BL/6 mice. We observed increased baseline locomotor activity in β-arrestin 1 KO animals compared with wild-type (WT) or heterozygous (HET) mice with a sex effect. KO male mice were less anxious in a light/dark transition test, although this effect may have been confounded by increased locomotor activity. No differences in sucrose intake were observed between genotypes or sexes. Female β-arrestin 1 KO mice consumed more 10% alcohol than HET females in a limited 4-h access, two-bottle choice, drinking-in-the-dark model. In a 20% alcohol binge-like access model, female KO animals consumed significantly more alcohol than HET and WT females. A significant sex effect was observed in both alcohol consumption models, with female mice consuming greater amounts of alcohol than males relative to body weight. Increased sensitivity to latency to loss of righting reflex (LORR) was observed in β-arrestin 1 KO mice although no differences were observed in duration of LORR. Overall, our efforts suggest that β-arrestin 1 may be protective against increased alcohol consumption in females and hyperactivity in both sexes.

journal_name

Front Behav Neurosci

authors

Robins MT,Chiang T,Berry JN,Ko MJ,Ha JE,van Rijn RM

doi

10.3389/fnbeh.2018.00054

subject

Has Abstract

pub_date

2018-03-20 00:00:00

pages

54

issn

1662-5153

journal_volume

12

pub_type

杂志文章
  • Distinctive Roles of 5-aza-2'-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.

    abstract::5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the mo...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00050

    authors: Liu P,Zhang J,Li M,Sui N

    更新日期:2016-03-15 00:00:00

  • Peritraumatic startle response predicts the vulnerability to develop PTSD-like behaviors in rats: a model for peritraumatic dissociation.

    abstract::Peritraumatic dissociation, a state characterized by alteration in perception and reduced awareness of surroundings, is considered to be a risk factor for the development of post-traumatic stress disorder (PTSD). However, the predictive ability of peritraumatic dissociation is questioned for the inconsistent results i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00014

    authors: Dong X,Li Y

    更新日期:2014-01-28 00:00:00

  • Facts and Misconceptions about 2D:4D, Social and Risk Preferences.

    abstract::We study how the ratio between the length of the second and fourth digit (2D:4D) correlates with choices in social and risk preferences elicitation tasks by building a large dataset from five experimental projects with more than 800 subjects. Our results confirm the recent literature that downplays the link between 2D...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00022

    authors: Alonso J,Di Paolo R,Ponti G,Sartarelli M

    更新日期:2018-02-13 00:00:00

  • Exposure to Hedione Increases Reciprocity in Humans.

    abstract::Cooperation among unrelated humans is frequently regarded as a defining feature in the evolutionary success of our species. Whereas, much research has addressed the strategic and cognitive mechanisms that underlie cooperation, investigations into chemosensory processes have received very limited research attention. To...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00079

    authors: Berger S,Hatt H,Ockenfels A

    更新日期:2017-05-02 00:00:00

  • Impaired Latent Inhibition in GDNF-Deficient Mice Exposed to Chronic Stress.

    abstract::Increased reactivity to stress is maladaptive and linked to abnormal behaviors and psychopathology. Chronic unpredictable stress (CUS) alters catecholaminergic neurotransmission and remodels neuronal circuits involved in learning, attention and decision making. Glial-derived neurotrophic factor (GDNF) is essential for...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00177

    authors: Buhusi M,Brown CK,Buhusi CV

    更新日期:2017-10-10 00:00:00

  • Duration of exclusive breastfeeding is associated with differences in infants' brain responses to emotional body expressions.

    abstract::Much research has recognized the general importance of maternal behavior in the early development and programing of the mammalian offspring's brain. Exclusive breastfeeding (EBF) duration, the amount of time in which breastfed meals are the only source of sustenance, plays a prominent role in promoting healthy brain a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00459

    authors: Krol KM,Rajhans P,Missana M,Grossmann T

    更新日期:2015-01-22 00:00:00

  • Urethane anesthesia depresses activities of thalamocortical neurons and alters its response to nociception in terms of dual firing modes.

    abstract::Anesthetics are often used to characterize the activity of single neurons in vivo for their advantages such as reduction of noise level and convenience in noxious stimulations. Urethane has been a widely used anesthetic in thalamic studies under the assumption that sensory signals are still relayed to the thalamus und...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00141

    authors: Huh Y,Cho J

    更新日期:2013-10-10 00:00:00

  • Effects of sleep deprivation on different phases of memory in the rat: dissociation between contextual and tone fear conditioning tasks.

    abstract::Numerous studies show that sleep deprivation (SD) impacts negatively on cognitive processes, including learning and memory. Memory formation encompasses distinct phases of which acquisition, consolidation and retrieval are better known. Previous studies with pre-training SD induced by the platform method have shown im...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00389

    authors: Rossi VC,Tiba PA,Moreira KD,Ferreira TL,Oliveira MG,Suchecki D

    更新日期:2014-11-07 00:00:00

  • An updated animal model capturing both the cognitive and emotional features of post-traumatic stress disorder (PTSD).

    abstract::The new-released Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines post-traumatic stress disorder (PTSD) as a "trauma and stressor-related disorder". PTSD pathogenesis relies on paradoxical changes of emotional memory processing induced by the trauma exposure and associated with emotional dysfuncti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00142

    authors: Berardi A,Trezza V,Palmery M,Trabace L,Cuomo V,Campolongo P

    更新日期:2014-04-29 00:00:00

  • Common Recruitment of Angular Gyrus in Episodic Autobiographical Memory and Bodily Self-Consciousness.

    abstract::Parietal cortex and adjacent parts of the temporal cortex have recently been associated with bodily self-consciousness (BSC). Similarly, growing evidence suggests that the lateral parietal cortex is crucial for the subjective aspects of episodic autobiographical memory (EAM), which is based on the conscious experience...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00270

    authors: Bréchet L,Grivaz P,Gauthier B,Blanke O

    更新日期:2018-11-14 00:00:00

  • Corrigendum: Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with β-adrenergic activity.

    abstract::[This corrects the article on p. 51 in vol. 9, PMID: 25784866.]. ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnbeh.2015.00123

    authors: Careaga MB,Tiba PA,Ota SM,Suchecki D

    更新日期:2015-05-13 00:00:00

  • Whisker encoding of mechanical events during active tactile exploration.

    abstract::Rats use their whiskers to extract a wealth of information about their immediate environment, such as the shape, position or texture of an object. The information is conveyed to mechanoreceptors located within the whisker follicle in the form of a sequence of whisker deflections induced by the whisker/object contact i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00074

    authors: Boubenec Y,Shulz DE,Debrégeas G

    更新日期:2012-11-06 00:00:00

  • Searching for learning-dependent changes in the antennal lobe: simultaneous recording of neural activity and aversive olfactory learning in honeybees.

    abstract::Plasticity in the honeybee brain has been studied using the appetitive olfactory conditioning of the proboscis extension reflex, in which a bee learns the association between an odor and a sucrose reward. In this framework, coupling behavioral measurements of proboscis extension and invasive recordings of neural activ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00155

    authors: Roussel E,Sandoz JC,Giurfa M

    更新日期:2010-09-01 00:00:00

  • Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task.

    abstract::The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC on prefrontal cortex-dependen...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00286

    authors: Janitzky K,Lippert MT,Engelhorn A,Tegtmeier J,Goldschmidt J,Heinze HJ,Ohl FW

    更新日期:2015-11-04 00:00:00

  • A New 3-Day Standardized Eyeblink Conditioning Protocol to Assess Extinction Learning From Infancy to Adulthood.

    abstract::Associative learning can be observed from the neonatal period onward, providing opportunities to examine changes in basic learning and memory abilities. One method that is suitable to study associative learning is classical eyeblink conditioning (EBC) which is dependent on the cerebellum. Extinction learning can be sy...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00135

    authors: Konrad C,Adolph D,Herbert JS,Neuhoff L,Mohr C,Jagusch-Poirier J,Seehagen S,Weigelt S,Schneider S

    更新日期:2020-08-14 00:00:00

  • Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder.

    abstract::Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic-pituitary-adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to identify a specific aspect of HPA dysfunction that characterizes PTSD have been marked by considera...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.040.2009

    authors: Radant AD,Dobie DJ,Peskind ER,Murburg MM,Petrie EC,Kanter ED,Raskind MA,Wilkinson CW

    更新日期:2009-10-30 00:00:00

  • Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators.

    abstract::The extant literature supports the role of stress in enhancing the susceptibility of drug abuse progressing to a substance use disorder diagnosis. However, the molecular mediators by which stress enhances the progression from cocaine abuse to cocaine use disorder via the mesolimbic pathway remain elusive. In this mini...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2018.00309

    authors: Mukhara D,Banks ML,Neigh GN

    更新日期:2018-12-21 00:00:00

  • Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.

    abstract::Background: Hypothesis-driven functional connectivity (FC) analyses have revealed abnormal functional interaction of regions or networks involved in pain processing in episodic migraine patients. We aimed to investigate the resting-state FC patterns in episodic migraine by combining data-driven voxel-wise degree centr...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.567588

    authors: Ke J,Yu Y,Zhang X,Su Y,Wang X,Hu S,Dai H,Hu C,Zhao H,Dai L

    更新日期:2020-10-06 00:00:00

  • Endocannabinoids Interact With the Dopaminergic System to Increase Sexual Motivation: Lessons From the Sexual Satiety Phenomenon.

    abstract::In male rats, copulation to satiety induces a long-lasting sexual inhibitory state, considered to rely on a decreased sexual motivation. Dopaminergic transmission at the mesolimbic system plays a central role in the regulation of male sexual motivation. Endocannabinoids (eCBs) modulate the activity of the mesolimbic s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00184

    authors: Canseco-Alba A,Rodríguez-Manzo G

    更新日期:2019-08-14 00:00:00

  • Male Ejaculatory Endophenotypes: Revealing Internal Inconsistencies of the Concept in Heterosexual Copulating Rats.

    abstract::Distinct manifestations of sexual behavior are conceived as separate phenotypes. Each sexual phenotype is assumed to be associated with a characteristic brain. These notions have justified the phenotyping of heterosexual copulator males based upon their ejaculation's latencies (EL) or frequencies (i.e., cumulative eja...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00090

    authors: Trejo-Sánchez I,Pérez-Monter C,Huerta-Pacheco S,Gutiérrez-Ospina G

    更新日期:2020-06-26 00:00:00

  • Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: a case report.

    abstract::Dopaminergic medication for motor symptoms in Parkinson's disease (PD) recently has been linked with impulse control disorders, including pathological gambling (PG), which affects up to 8% of patients. PG often is considered a behavioral addiction associated with disinhibition, risky decision-making, and altered stria...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00095

    authors: Callesen MB,Hansen KV,Gjedde A,Linnet J,Møller A

    更新日期:2013-07-29 00:00:00

  • Reinforcement and inference in cross-situational word learning.

    abstract::Cross-situational word learning is based on the notion that a learner can determine the referent of a word by finding something in common across many observed uses of that word. Here we propose an adaptive learning algorithm that contains a parameter that controls the strength of the reinforcement applied to associati...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00163

    authors: Tilles PF,Fontanari JF

    更新日期:2013-11-19 00:00:00

  • Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices.

    abstract::The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and impulsivity. Quite notably, previous research has identified a double dissociation regarding the role of this cortical territory in impulsive choice. While medial orbitofrontal lesions increase preference for a large but delay...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00022

    authors: Ucha M,Roura-Martínez D,Contreras A,Pinto-Rivero S,Orihuel J,Ambrosio E,Higuera-Matas A

    更新日期:2019-02-20 00:00:00

  • Contextual Fear Conditioning and Fear Generalization in Individuals With Panic Attacks.

    abstract::Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a vi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00152

    authors: Neueder D,Andreatta M,Pauli P

    更新日期:2019-07-17 00:00:00

  • Cellular correlates of enhanced anxiety caused by acute treatment with the selective serotonin reuptake inhibitor fluoxetine in rats.

    abstract::Selective serotonin reuptake inhibitors (SSRIs) are used extensively in the treatment of depression and anxiety disorders. The therapeutic benefits of SSRIs typically require several weeks of continuous treatment. Intriguingly, according to clinical reports, symptoms of anxiety may actually increase during the early s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2011.00088

    authors: Ravinder S,Pillai AG,Chattarji S

    更新日期:2011-12-28 00:00:00

  • Gender Differences in Global Functional Connectivity During Facial Emotion Processing: A Visual MMN Study.

    abstract::To investigate gender differences in functional connectivity during the unattended processing of facial expressions, we recorded visual mismatch negativity (vMMN) in 34 adults using a deviant-standard reverse oddball paradigm. Using wavelet analysis, we calculated the time-frequency (TF) power at each electrode associ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00220

    authors: Zhang J,Dong X,Wang L,Zhao L,Weng Z,Zhang T,Sui J,Go R,Huang Q,Wu J,Yan T

    更新日期:2018-09-25 00:00:00

  • Embodying an outgroup: the role of racial bias and the effect of multisensory processing in somatosensory remapping.

    abstract::We come to understand other people's physical and mental states by re-mapping their bodily states onto our sensorimotor system. This process, also called somatosensory resonance, is an essential ability for social cognition and is stronger when observing ingroup than outgroup members. Here we investigated, first, whet...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00165

    authors: Fini C,Cardini F,Tajadura-Jiménez A,Serino A,Tsakiris M

    更新日期:2013-11-18 00:00:00

  • Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment.

    abstract::Brain-derived neurotrophic factor (BDNF) is a trophic factor regulating cell survival and synaptic plasticity. Recent findings indicate that BDNF could be a potential regulatory factor for cognitive functioning in normal and/or neuropathological conditions. With regard to neurological disorders, recent data suggest th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00253

    authors: Costa A,Peppe A,Carlesimo GA,Zabberoni S,Scalici F,Caltagirone C,Angelucci F

    更新日期:2015-09-15 00:00:00

  • Neural Substrates of Food Valuation and Its Relationship With BMI and Healthy Eating in Higher BMI Individuals.

    abstract::Considerable evidence points to a link between body mass index (BMI), eating behavior, and the brain's reward system. However, much of this research focuses on food cue reactivity without examining the subjective valuation process as a potential mechanism driving individual differences in BMI and eating behavior. The ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.578676

    authors: Merchant JS,Cosme D,Giuliani NR,Dirks B,Berkman ET

    更新日期:2020-12-04 00:00:00

  • A Novel Thermal-Visual Place Learning Paradigm for Honeybees (Apis mellifera).

    abstract::Honeybees (Apis mellifera) have fascinating navigational skills and learning capabilities in the field. To decipher the mechanisms underlying place learning in honeybees, we need paradigms to study place learning of individual honeybees under controlled laboratory conditions. Here, we present a novel visual place lear...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00056

    authors: Scheiner R,Frantzmann F,Jäger M,Mitesser O,Helfrich-Förster C,Pauls D

    更新日期:2020-04-15 00:00:00