Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment.

Abstract:

:Brain-derived neurotrophic factor (BDNF) is a trophic factor regulating cell survival and synaptic plasticity. Recent findings indicate that BDNF could be a potential regulatory factor for cognitive functioning in normal and/or neuropathological conditions. With regard to neurological disorders, recent data suggest that individuals with Parkinson's disease (PD) may be affected by cognitive deficits and that they have altered BDNF production. Therefore, the hypothesis can be advanced that BDNF levels are associated with the cognitive state of these patients. With this in mind, the present study was aimed at exploring the relationship between BDNF serum levels and cognitive functioning in PD patients with mild cognitive impairment (MCI). Thirteen PD patients with MCI were included in the study. They were administered an extensive neuropsychological test battery that investigated executive, episodic memory, attention, visual-spatial and language domains. A single score was obtained for each cognitive domain by averaging z-scores on tests belonging to that specific domain. BDNF serum levels were measured by enzyme-linked immunoassay (ELISA). Pearson's correlation analyses were performed between BDNF serum levels and cognitive performance. Results showed a significant positive correlation between BDNF serum levels and both attention (p < 0.05) and executive (p < 0.05) domains. Moreover, in the executive domain we found a significant correlation between BDNF levels and scores on tests assessing working memory and self-monitoring/inhibition. These preliminary data suggest that BDNF serum levels are associated with cognitive state in PD patients with MCI. Given the role of BDNF in regulating synaptic plasticity, the present findings give further support to the hypothesis that this trophic factor may be a potential biomarker for evaluating cognitive changes in PD and other neurological syndromes associated with cognitive decline.

journal_name

Front Behav Neurosci

authors

Costa A,Peppe A,Carlesimo GA,Zabberoni S,Scalici F,Caltagirone C,Angelucci F

doi

10.3389/fnbeh.2015.00253

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

253

issn

1662-5153

journal_volume

9

pub_type

杂志文章
  • Contextual Fear Conditioning and Fear Generalization in Individuals With Panic Attacks.

    abstract::Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a vi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00152

    authors: Neueder D,Andreatta M,Pauli P

    更新日期:2019-07-17 00:00:00

  • Extinction procedure induces pruning of dendritic spines in CA1 hippocampal field depending on strength of training in rats.

    abstract::Numerous reports indicate that learning and memory of conditioned responses are accompanied by genesis of dendritic spines in the hippocampus, although there is a conspicuous lack of information regarding spine modifications after behavioral extinction. There is ample evidence that treatments that typically produce am...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00012

    authors: Garín-Aguilar ME,Díaz-Cintra S,Quirarte GL,Aguilar-Vázquez A,Medina AC,Prado-Alcalá RA

    更新日期:2012-03-16 00:00:00

  • Neonatal stress-induced affective changes in adolescent Wistar rats: early signs of schizophrenia-like behavior.

    abstract::Psychiatric disorders are multifactorial diseases with etiology that may involve genetic factors, early life environment and stressful life events. The neurodevelopmental hypothesis of schizophrenia is based on a wealth of data on increased vulnerability in individuals exposed to insults during the perinatal period. M...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00319

    authors: Girardi CE,Zanta NC,Suchecki D

    更新日期:2014-09-10 00:00:00

  • Disruption of the Glutamate-Glutamine Cycle Involving Astrocytes in an Animal Model of Depression for Males and Females.

    abstract::Background: Women are twice as likely as men to develop major depression. The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-glutamine cycle involving...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00231

    authors: Rappeneau V,Blaker A,Petro JR,Yamamoto BK,Shimamoto A

    更新日期:2016-12-06 00:00:00

  • Theta and Alpha Oscillations in Attentional Interaction during Distracted Driving.

    abstract::Performing multiple tasks simultaneously usually affects the behavioral performance as compared with executing the single task. Moreover, processing multiple tasks simultaneously often involve more cognitive demands. Two visual tasks, lane-keeping task and mental calculation, were utilized to assess the brain dynamics...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00003

    authors: Wang YK,Jung TP,Lin CT

    更新日期:2018-02-09 00:00:00

  • Individual Vulnerability to Stress Is Associated With Increased Demand for Intravenous Heroin Self-administration in Rats.

    abstract::Opioid use is a widespread epidemic, and traumatic stress exposure is a critical risk factor in opioid use and relapse. There is a significant gap in our understanding of how stress contributes to heroin use, and there are limited studies investigating individual differences underlying stress reactivity and subsequent...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00134

    authors: Stafford NP,Kazan TN,Donovan CM,Hart EE,Drugan RC,Charntikov S

    更新日期:2019-06-25 00:00:00

  • The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

    abstract::Chronic or persistent fatigue is a common, debilitating symptom of several diseases. Persistent fatigue has been associated with low-grade inflammation in several models of fatigue, including cancer-related fatigue and chronic fatigue syndrome. However, it is unclear how low-grade inflammation leads to the experience ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2018.00078

    authors: Lacourt TE,Vichaya EG,Chiu GS,Dantzer R,Heijnen CJ

    更新日期:2018-04-26 00:00:00

  • Facts and Misconceptions about 2D:4D, Social and Risk Preferences.

    abstract::We study how the ratio between the length of the second and fourth digit (2D:4D) correlates with choices in social and risk preferences elicitation tasks by building a large dataset from five experimental projects with more than 800 subjects. Our results confirm the recent literature that downplays the link between 2D...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00022

    authors: Alonso J,Di Paolo R,Ponti G,Sartarelli M

    更新日期:2018-02-13 00:00:00

  • Pain-related stress during the Neonatal Intensive Care Unit stay and SLC6A4 methylation in very preterm infants.

    abstract::Very preterm (VPT) infants need long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU) during which they are daily exposed to pain-related stress. Alterations of DNA methylation at the promoter region of the SLC6A4 have been associated with early adverse experiences in infants. The main aim of the pre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00099

    authors: Provenzi L,Fumagalli M,Sirgiovanni I,Giorda R,Pozzoli U,Morandi F,Beri S,Menozzi G,Mosca F,Borgatti R,Montirosso R

    更新日期:2015-04-21 00:00:00

  • Corrigendum: Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with β-adrenergic activity.

    abstract::[This corrects the article on p. 51 in vol. 9, PMID: 25784866.]. ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnbeh.2015.00123

    authors: Careaga MB,Tiba PA,Ota SM,Suchecki D

    更新日期:2015-05-13 00:00:00

  • Detaching from the negative by reappraisal: the role of right superior frontal gyrus (BA9/32).

    abstract::The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial prefrontal cortex, but rarely investigated...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00165

    authors: Falquez R,Couto B,Ibanez A,Freitag MT,Berger M,Arens EA,Lang S,Barnow S

    更新日期:2014-05-09 00:00:00

  • The role of semantic abstractness and perceptual category in processing speech accompanied by gestures.

    abstract::Space and shape are distinct perceptual categories. In language, perceptual information can also be used to describe abstract semantic concepts like a "rising income" (space) or a "square personality" (shape). Despite being inherently concrete, co-speech gestures depicting space and shape can accompany concrete or abs...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00181

    authors: Nagels A,Chatterjee A,Kircher T,Straube B

    更新日期:2013-12-18 00:00:00

  • Perinatal exposure to methoxychlor enhances adult cognitive responses and hippocampal neurogenesis in mice.

    abstract::During perinatal life, sex steroids, such as estradiol, have marked effects on the development and function of the nervous system. Environmental estrogens or xenoestrogens are man-made chemicals, which animal and human population encounter in the environment and which are able to disrupt the functioning of the endocri...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00202

    authors: Martini M,Calandreau L,Jouhanneau M,Mhaouty-Kodja S,Keller M

    更新日期:2014-06-16 00:00:00

  • Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices.

    abstract::The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and impulsivity. Quite notably, previous research has identified a double dissociation regarding the role of this cortical territory in impulsive choice. While medial orbitofrontal lesions increase preference for a large but delay...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00022

    authors: Ucha M,Roura-Martínez D,Contreras A,Pinto-Rivero S,Orihuel J,Ambrosio E,Higuera-Matas A

    更新日期:2019-02-20 00:00:00

  • The impact of perceived similarity on tacit coordination: propensity for matching and aversion to decoupling choices.

    abstract::Homophily, or "love for similar others," has been shown to play a fundamental role in the formation of interpersonal ties and social networks. Yet no study has investigated whether perceived similarities can affect tacit coordination. We had 68 participants attempt to maximize real monetary earnings by choosing betwee...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00202

    authors: Chierchia G,Coricelli G

    更新日期:2015-07-28 00:00:00

  • Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects.

    abstract::Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression. Prenatal alcohol exposure (PAE) may result in HPA dysregulation, which in turn may predispose individuals to the effects of stress exposure throu...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00042

    authors: Lam VYY,Raineki C,Takeuchi LE,Ellis L,Woodward TS,Weinberg J

    更新日期:2018-03-09 00:00:00

  • Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior.

    abstract::Epilepsy is a chronic neurological disease which is usually associated with psychiatric comorbidities. Depsression and cognition impairment are considered to be the most common psychiatric comorbidities in epilepsy patients. However, the specific contribution of epilepsy made to these psychiatric comorbidities remains...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00203

    authors: Zhu X,Dong J,Han B,Huang R,Zhang A,Xia Z,Chang H,Chao J,Yao H

    更新日期:2017-10-18 00:00:00

  • Early handling and repeated cross-fostering have opposite effect on mouse emotionality.

    abstract::Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore mole...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00093

    authors: Luchetti A,Oddi D,Lampis V,Centofante E,Felsani A,Battaglia M,D'Amato FR

    更新日期:2015-04-21 00:00:00

  • Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors.

    abstract::There is conflicting evidence regarding whether calcium-permeable receptors are removed during group I mGluR-mediated synaptic depression. In support of this hypothesis, AMPAR rectification, a correlative index of the synaptic expression of GluA2-lacking calcium-permeable AMPARs (CP-AMPARs), is known to decrease after...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00269

    authors: Park K,Song S,Hong I,Song B,Kim J,Park S,Lee J,Song S,An B,Kim J,Lee CJ,Shin KS,Choi S,Lee S

    更新日期:2014-08-08 00:00:00

  • Evidence for spatially-responsive neurons in the rostral thalamus.

    abstract::Damage involving the anterior thalamic and adjacent rostral thalamic nuclei may result in a severe anterograde amnesia, similar to the amnesia resulting from damage to the hippocampal formation. Little is known, however, about the information represented in these nuclei. To redress this deficit, we recorded units in t...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00256

    authors: Jankowski MM,Passecker J,Islam MN,Vann S,Erichsen JT,Aggleton JP,O'Mara SM

    更新日期:2015-10-13 00:00:00

  • Monetary, Food, and Social Rewards Induce Similar Pavlovian-to-Instrumental Transfer Effects.

    abstract::Multiple types of reward, such as money, food or social approval, are capable of driving behavior. However, most previous investigations have only focused on one of these reward classes in isolation, as such it is not clear whether different reward classes have a unique influence on instrumental responding or whether ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00247

    authors: Lehner R,Balsters JH,Herger A,Hare TA,Wenderoth N

    更新日期:2017-01-04 00:00:00

  • More Than Meets the Eye: The Impact of Materialism on Information Selection During Luxury Choices.

    abstract::Visual attention is an important condition for consumer decision-making. However, not much is known on individuals' determinants of this visual attention. Using eye tracking, this study investigated how psychological values (i.e., materialism) modulate visual attention to specific sources of information (i.e., product...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00172

    authors: Audrin C,Brosch T,Sander D,Chanal J

    更新日期:2018-08-24 00:00:00

  • Differences in brain circuitry for appetitive and reactive aggression as revealed by realistic auditory scripts.

    abstract::Aggressive behavior is thought to divide into two motivational elements: The first being a self-defensively motivated aggression against threat and a second, hedonically motivated "appetitive" aggression. Appetitive aggression is the less understood of the two, often only researched within abnormal psychology. Our app...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00425

    authors: Moran JK,Weierstall R,Elbert T

    更新日期:2014-12-09 00:00:00

  • Traumatic Life Events in Relation to Cognitive Flexibility: Moderating Role of the BDNF Val66Met Gene Polymorphism.

    abstract::Cognitive flexibility plays an important role in an individual's ability to adapt to a continuously changing environment and is considered central to goal-oriented behavior. Accordingly, increasing attention has been devoted to understanding the factors, including genetic and early life experiences, which might contri...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00241

    authors: Gabrys RL,Dixon K,Anisman H

    更新日期:2017-12-08 00:00:00

  • Alcohol, Self-Regulation and Partner Physical Aggression: Actor-Partner Effects Over a Three-Year Time Frame.

    abstract::The question of how individual differences related to self-regulation interact with alcohol use patterns to predict intimate partner aggression (IPA) is examined. We hypothesized that excessive drinking will be related to partner aggression among those who have low self-regulation. In addition, we explored the extent ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00130

    authors: Quigley BM,Levitt A,Derrick JL,Testa M,Houston RJ,Leonard KE

    更新日期:2018-07-05 00:00:00

  • A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption.

    abstract::Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00029

    authors: Holgate JY,Shariff M,Mu EW,Bartlett S

    更新日期:2017-02-22 00:00:00

  • No Evidence for a Relationship Between Hair Testosterone Concentrations and 2D:4D Ratio or Risk Taking.

    abstract::Using a recently developed alternative assay procedure to measure hormone levels from hair samples, we examined the relationships between testosterone, cortisol, 2D:4D ratio, overconfidence and risk taking. A total of 162 (53 male) participants provided a 3 cm sample of hair, a scanned image of their right and left ha...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00030

    authors: Ronay R,van der Meij L,Oostrom JK,Pollet TV

    更新日期:2018-03-05 00:00:00

  • ITI-Signals and Prelimbic Cortex Facilitate Avoidance Acquisition and Reduce Avoidance Latencies, Respectively, in Male WKY Rats.

    abstract::As a model of anxiety disorder vulnerability, male Wistar-Kyoto (WKY) rats acquire lever-press avoidance behavior more readily than outbred Sprague-Dawley rats, and their acquisition is enhanced by the presence of a discrete signal presented during the inter-trial intervals (ITIs), suggesting that it is perceived as a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00403

    authors: Beck KD,Jiao X,Smith IM,Myers CE,Pang KC,Servatius RJ

    更新日期:2014-11-21 00:00:00

  • Behavioral Plasticity of Audiovisual Perception: Rapid Recalibration of Temporal Sensitivity but Not Perceptual Binding Following Adult-Onset Hearing Loss.

    abstract::The ability to accurately integrate or bind stimuli from more than one sensory modality is highly dependent on the features of the stimuli, such as their intensity and relative timing. Previous studies have demonstrated that the ability to perceptually bind stimuli is impaired in various clinical conditions such as au...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00256

    authors: Schormans AL,Allman BL

    更新日期:2018-10-31 00:00:00

  • Bumblebees Learn a Relational Rule but Switch to a Win-Stay/Lose-Switch Heuristic After Extensive Training.

    abstract::Mapping animal performance in a behavioral task to underlying cognitive mechanisms and strategies is rarely straightforward, since a task may be solvable in more than one manner. Here, we show that bumblebees perform well on a concept-based visual discrimination task but spontaneously switch from a concept-based solut...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00137

    authors: MaBouDi H,Solvi C,Chittka L

    更新日期:2020-08-12 00:00:00