当前位置： SCI文献检索 > Frontiers in Behavioral Neuroscience期刊下所有文献 > Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions.

Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions.

Abstract：

:Maternal exposure to infection occurring mid-gestation produces a three-fold increase in the risk of schizophrenia in the offspring. The critical initiating factor appears to be the maternal immune activation (MIA) that follows infection. This process can be induced in rodents by exposure of pregnant dams to the viral mimic Poly I:C, which triggers an immune response that results in structural, functional, behavioral, and electrophysiological phenotypes in the adult offspring that model those seen in schizophrenia. We used this model to explore the role of synchronization in brain neural networks, a process thought to be dysfunctional in schizophrenia and previously associated with positive, negative, and cognitive symptoms of schizophrenia. Exposure of pregnant dams to Poly I:C on GD15 produced an impairment in long-range neural synchrony in adult offspring between two regions implicated in schizophrenia pathology; the hippocampus and the medial prefrontal cortex (mPFC). This reduction in synchrony was ameliorated by acute doses of the antipsychotic clozapine. MIA animals have previously been shown to have impaired pre-pulse inhibition (PPI), a gold-standard measure of schizophrenia-like deficits in animal models. Our data showed that deficits in synchrony were positively correlated with the impairments in PPI. Subsequent analysis of LFP activity during the PPI response also showed that reduced coupling between the mPFC and the hippocampus following processing of the pre-pulse was associated with reduced PPI. The ability of the MIA intervention to model neurodevelopmental aspects of schizophrenia pathology provides a useful platform from which to investigate the ontogeny of aberrant synchronous processes. Further, the way in which the model expresses translatable deficits such as aberrant synchrony and reduced PPI will allow researchers to explore novel intervention strategies targeted to these changes.

journal_name

Front Behav Neurosci

journal_title

Frontiers in behavioral neuroscience

authors

Dickerson DD,Bilkey DK

doi

10.3389/fnbeh.2013.00217

subject

Has Abstract

pub_date

2013-12-27 00:00:00

pages

217

issn

1662-5153

journal_volume

pub_type

杂志文章,评审

在线工具

Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions.